discover groundbreaking research on wound repair, keloid, and hypertrophic scar treatments. laser studies show short-term improvement, but our microcurrent and ultra-low energy research demonstrates significant healing with no reoccurrence. age-independent wound healing challenges conventional beliefs.
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abstract the objective of this study was to evaluate the early osseointegration of two different...
betulin wound gel accelerated healing of superficial partial thickness burns: results of a randomized, intra‐individually controlled, phase iii trial with 12‐months follow‐up acceleration of wound healing promises advantages for patients and caregivers in reducing the burden of disease, avoiding complications such as wound infections, and improving the long-term outcome. however, medicines that can accelerate wound
skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. advances in wound healing devices have improved clinical practice but have mainly focused on treating macroscale healing versus underlying microscale pathophysiology. consensus is lacking on optimal treatment strategies using a spectrum of wound healing products, which has motivated the design of new therapies. we summarize advances in the development of novel drug, biologic products, and biomaterial therapies for wound healing for marketed therapies and those in clinical trials. we also share perspectives for successful and accelerated translation of novel integrated therapies for wound healing.
skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. advances in wound healing devices have improved clinical practice but have mainly focused on ...
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piezoelectric effect produces an electrical signal when stress is applied to the bone. when the integrity of the bone is destroyed, the biopotential within the defect site is reduced and several physiological responses are initiated to facilitate healing. during the healing of the bone defect, the b …
once the skin is broken, the body responds to repair the injured area. failure to heal can result in ulceration. a foot ulcer is thought to precede 75–85% of
self-healing of polymers became a vivid research area, but self-healing under water and its mechanistic concepts are less investigated. here, the authors report water accelerated self-healing in a pmma/nba copolymer and demonstrate that perturbation of ubiquitous van der walls forces upon mechanical damage in hydrophobic polymers in the presence of water is energetically unfavorable and accelerates self-healing.
the rebuilt woman intensive therapy for accelerated healing are you tired of feeling like you’re constantly trying to hold your head just above the water? have you spent years in therapy and feel you’re stuck with the issues you live with? maybe, you’ve tried multiple treatments including medication, weekly therapy, and even emdr, yet have […]
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rapid healing of dermatological wounds is of vital importance in preventing infection and reducing post-treatment side-effects. here we report the therapeutic effects of phytochemically stabilized gold nanoparticles (paunps) coated on a hydrocolloid membrane (hcm) for curing cutaneous wounds. furthermore, th
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researchers have found a new way of accelerating wound healing. the technology and the mode of action involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds. the research group is the first in the world to have developed the concept for topical use and the technology could turn out to be disruptive to the field of biologic drugs.
most wounds will heal naturally with time, however, there are some things a person can do to speed up the healing process. learn more.
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the goal of this study is to improve the therapeutic management of diabetic foot ulcers (dfu). the main questions to answer are if a program of non-weight bearing exercise helps the dfu heal faster than standard wound care. this randomized clinical trial will determine how blood flow to the ulcer and whole body metabolism may be improved with exercise. participants will be randomized to either exercise + standard wound care or standard wound care alone and undergo testing for leg blood flow, fitness and measures of metabolism through blood draws. the intervention period is 6-weeks. eligible participants must have an existing foot ulcer uncomplicated by infection and be medically cleared to exercise.
the food and drug administration (fda) is correcting a notice that appeared in the federal register of november 9, 1994 (59 fr 55847). the document announced the approval of the exogentm, inc., sonic accelerated fracture healing system (safhs). some information was inadvertently omitted and...
a multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial was conducted to test the efficacy of a specifically programmed, low-intensity, non-thermal, pulsed ultrasound medical device for shortening the time to...
background electrostimulation (es) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy. methods we adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven es (ng-es) effects on human skin in vivo—an essential translational step toward clinical application of the ng-es technique for wound healing. results we show that ng-es leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. ng-es accelerates the inflammatory phase of wound healing with more rapid resolution of neutrophils and macrophages and enhances wound bed perfusion with more robust neovascularization. conclusion our results support the translational evaluation and optimization of the ng-es technology to deliver convenient, efficient wound healing therapy for use in human wounds. graphic abstract
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vituity's community-based model for wound care improves outcomes, reduces system burden, and keeps patients within your network.
delayed fracture healing is a major health issue involved with aging. therefore, strategies to improve the pace of repair and prevent non-union are needed in order to improve patient outcomes and lower healthcare costs. in order to accelerate bone fracture healing noninvasively, we sought to develop a drug delivery system that could safely and effectively be used to deliver therapeutics to the site of a bone fracture. we elected to pursue the promising strategy of using small-molecule drug conjugates that deliver therapeutics to bone in an attempt to increase the efficacy and safety of drugs for treating bone-related diseases.this strategy also opened the door for new methods of administering drugs. traditionally, administering bone anabolic agents to treat bone fractures has relied entirely on local surgical application. however, because it is so invasive, this method’s use and development has been limited. by conjugating bone anabolic agents to bone-homing molecules, bone fracture treatment can be performed through minimally invasive subcutaneous administration. the exposure of raw hydroxyapatite that occurs with a bone fracture allows these high-affinity molecules to chelate the calcium component of hydroxyapatite and localize primarily to the fracture site.many bone-homing molecules (such as bisphosphonates and tetracycline targeting) have been developed to treat osteoporosis. however, many of these molecules have toxicity associated with them. we have found that short oligopeptides of acidic amino acids can localize to bone fractures with high selectivity and with very low toxicity compared to bisphosphonates and tetracyclines.we have also demonstrated that these molecules can be used to target peptides of all chemical classes: hydrophobic, neutral, cationic, anionic, short, and long. this ability is particularly useful because many bone anabolics are peptidic in nature. we have found that acidic oligopeptides have better persistence at the site of the fracture than bisphosphonate-targeted therapeutics. this method allows for a systemic administration of bone anabolics to treat bone fractures, which it achieves by accumulating the bone anabolic at the fracture site. it also opens the door for a new way of treating the prevalent afflictions of broken bones and the deaths associated with them.we further developed this technology by using it to deliver anabolic peptides derived from growth factors, angiogenic agents, neuropeptides, and extracellular matrix fragments. we found several promising therapeutics that accelerated the healing of bone fractures by improving the mineralization of the callus and improving the overall strength. we optimized the performance of these molecules by improving their stability, targeting ligands, linkers, dose, and dosing frequency.we also found that these therapeutics could be used to accelerate bone fracture repair even in the presence of severe comorbidities (such as diabetes and osteoporosis) that typically slow the repair process. we found that, unlike the currently approved therapeutic for fracture healing (bmp2), our therapeutics improved functionality and reduced pain in addition to strengthening the bone. these optimized targeted bone anabolics were not only effective at healing bone fractures but they also demonstrated that they could be used to speed up spinal fusion. additionally, we demonstrated that acidic oligopeptides have potential to be used to treat other bone diseases with damaged bone.with these targeted therapeutics, we no longer have to limit bone fracture healing to casts or invasive surgeries. rather, we can apply these promising therapeutics that can be administered non-invasively to augment existing orthopedic practices. as these therapeutics move into clinical development, we anticipate that they will be able to reduce the immobilization time that is the source of so many of the deadly complications associated with bone fracture healing, particularly in the elderly.
satisfactory healing of the osteoporotic fracture is critically important to functional...
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exudate regulation, which helps maintain an optimal moisture content in the wound bed and protects the surrounding skin from maceration, is a prerequisite for wound healing. in this study, inspired by the natural hierarchical structure of sugarcane, in which vascular bundles are responsible for transporting water and parenchyma cells are responsible for storing sucrose, we fabricated a continuously self-draining sugarcane stem-based dressing to remove exudates from overhydrated wounds. sugarcane cellulosic frameworks (scf), obtained via alkali and de-sugaring treatments of natural sugarcane substrates (ss), were coated with gold nanorods (aunrs) to facilitate photothermal responsiveness under near-infrared (nir) irradiation. by mimicking plant transpiration and incorporating a stimulus-responsive feature, natural ss were transformed into exudate-managing dressing materials for accelerated wound healing. as the obtained sugarcane frameworks (au@scf) contained abundant vascular bundles and exhibited photothermal responsiveness, it was able to self-drain exudates continuously with a high evaporation efficiency (95%). in order to endow the dressing with antibacterial properties, ag nanoparticles (agnps) was incorporated with au@scf to form ag@au@scf. the healing process in a wound model was more rapid with ag@au@scf with nir irradiation than with a commercial dressing. moreover, as the parenchyma cells in ag@au@scf formed closed chambers after de-sugaring, ag@au@scf facilitated effective thermal insulation (thermal conductivity of 0.04 w m-1k-1) for protecting the underlying wound, even when the temperature of the top surface was high (53 °c). as this hierarchical structure is naturally existent in other poaceae plants, which are sustainable green resources, our findings may provide a new strategy for the fabrication of versatile and efficient self-draining dressings for exudate management and wound healing.
are you tired of waiting weeks for injuries to heal? cold laser therapy works at the cellular level to speed up your body
excisional debridement removes dead tissue, helping chronic wounds heal faster. learn its benefits for better recovery in oxnard and ventura.
purpose healing of a wound is a multifaceted process that involves several factors to be considered for proper completion. improper healing of wounds is a widespread phenomenon that affects millions of people across the world constantly. treatment of acute or chronic diabetic wounds has been one of the major clinical challenges past several years as diabetic patients have much more deprived wound healing which often leads to surgery of the injured site or amputation of the wounded part is usually done in severe cases. method angiogenesis plays a major role in the process of neovascularization, so angiogenesis is a potential target for wound healing as the newer blood vessels formed over the injured surface are important to provide nutrients, immune cells, and oxygen for the healing of wounds. several classes of drugs act on different growth factors for treating certain disorders and these drugs can be repurposed for the healing of different types of wounds. a vast literature survey was carried out to find potential drugs that can be repurposed for the healing of wounds. result and conclusion repurposing of drugs is economical compared to that of traditional treatment methods and it can be delivered to a wider range of people in need. these drugs might have the potential to initiate the neovascularization development through angiogenesis which aids the accelerated wound healing process. lay summary wound healing is a complex multistep process that involves several cellular infiltrations and their subsequent physiological actions. angiogenesis is the process of new blood vessel formation and it is helpful in wound healing as the newer blood vessels formed at the injured site are important to provide nutrients, immune cells, and oxygen for the healing of wounds. growth factors play a major role in initiating the angiogenesis process and several drugs act on these specific growth factors directly or indirectly which can be repurposed to activate angiogenesis and accelerate the healing of different types of wounds (burns, diabetic ulcers, and trauma wounds). future works these classes of drugs will be screened for their binding affinity with the target growth factors using the in-silico docking software (pyrx and autodock vina). the drug classes will be further suspected to in vitro studies (ex., scratch assay, and trans-well migration assay) and followed by in vivo wound healing studies on animals. artificial intelligence technology helps with drug relocation by cutting expenses and time even further. new computational techniques for identifying connections between many kinds of biological entities, including genes, proteins, and medications, can be advantageous for drug repurposing. so, this will benefit the research in finding, repurposing, and developing new therapeutic ways for wound care medications that are already on the market. it will also be used to keep track of the wound healing progress across a community.