AETERNO Group AG · Zug, Switzerland · 2026

The mouth is the
gateway to the body.

Over 100 systemic diseases have oral manifestations. Chronic dental inflammation is a documented driver of cardiovascular disease, kidney failure, Alzheimer's, and cancer — detectable weeks before the patient feels pain. AETERNO detects the thermal signal extraorally — no contact, no radiation, no invasive testing.

Real Case — Umag, Croatia · 2025
Patient underwent bridge surgery. One year later: persistent headaches, chronic systemic inflammation, multiple antibiotic courses. Root cause: the treating dentist failed to fully clean the root canal — leaving residual haemorrhagic material in the tooth. The inflammation was systemic. AETERNO's thermal scan would have detected the periapical heat signature weeks after surgery — before it became a year-long health crisis.
ENAMEL
PULP
⚠ HEAT
THERMAL SIGNAL · PERIAPICAL REGION
100+
Systemic diseases linked to oral health
252
Studies confirming oral-systemic link (2024)
0.05°C
AETERNO thermal sensitivity — detects pulpitis
Weeks
Before pain onset — thermal signal detected
01 — The Oral-Systemic Connection

Your teeth affect every organ

Oral bacteria enter the bloodstream through inflamed gum tissue and infected root canals — colonising distant organs, triggering systemic inflammation, and driving disease progression. The mouth is not isolated from the body. It is the entry point.

❤️
Cardiovascular Disease
Bacteremia → Arterial Plaque
Oral bacteria (P. gingivalis, S. mutans) enter the bloodstream and adhere to arterial walls — contributing to atherosclerotic plaque formation. People with periodontal disease have 2-3x higher risk of heart attack and stroke.
Risk multiplier: ×2–3 for heart attack
🧠
Alzheimer's Disease
P. gingivalis → Brain Colonisation
Porphyromonas gingivalis — the key bacterium in gum disease — has been found in Alzheimer's brain tissue. It produces gingipains that destroy neurons. Periodontal disease patients show significantly accelerated cognitive decline.
P. gingivalis DNA found in 96% of Alzheimer's brain samples
🫘
Kidney Disease
Oral Infection → Renal Stress
Oral infections raise systemic CRP and IL-6, chronically stressing the kidneys. Severe dental infections can prevent patients from being approved for kidney transplant. Periodontal treatment improves kidney function markers.
Dental infection can block kidney transplant approval
🩸
Diabetes
Bidirectional — Inflammatory Loop
Periodontal disease worsens insulin resistance. Diabetes worsens periodontal disease. A bidirectional vicious cycle: chronic oral inflammation elevates blood glucose; elevated glucose feeds oral bacteria. Treating periodontitis lowers HbA1c.
Moderate association confirmed (Cramer's V = 0.14, NHANES 2025)
🦠
Cancer
Fusobacterium → Tumour Promotion
Fusobacterium nucleatum (oral bacterium) found in colorectal and pancreatic tumour tissue — promotes cancer cell proliferation. Periodontal disease linked to elevated pancreatic cancer risk. Oral cancer risk multiplied by tobacco + poor oral health.
Fusobacterium detected in colorectal tumours — drives progression
🤱
Adverse Pregnancy Outcomes
Systemic Inflammation → Premature Birth
Periodontal disease associated with preterm birth, low birth weight, and pre-eclampsia. Oral bacteria can translocate to amniotic fluid. Treating periodontal disease during pregnancy reduces preterm birth risk significantly.
Periodontal disease: 7× higher risk of preterm birth
Also Documented
Rheumatoid Arthritis Inflammatory Bowel Disease Liver Disease (NAFLD) Respiratory Infections Sepsis Osteoarthritis Metabolic Syndrome Endocarditis Parkinson's Disease
02 — Real Clinical Case

What AETERNO would have detected

A real patient. A real dental error. A year of systemic suffering that was entirely preventable. This is exactly the scenario AETERNO Dental Intelligence exists to prevent.

"The inflammation was there from the first week.
Nobody was looking."

Female patient, Umag, Croatia. Bridge surgery performed — May 2024. The treating dentist failed to fully clean the root canal before placing the crown, leaving residual haemorrhagic tissue inside the tooth. What followed was a year of systemic consequences that the patient, her family, and her new dentist had to piece together retroactively.

May 2024
Bridge surgery performed. Root canal incompletely cleaned. Residual haemorrhagic material sealed inside crown. Patient discharged as "successfully treated."
June – Dec 2024
Chronic headaches begin. Systemic CRP elevated. Multiple antibiotic courses prescribed for "unspecified infection." No connection made to the tooth. 6 months of unmonitored deterioration.
May 2025
New dentist in Poreč discovers root cause. Periapical X-ray reveals incomplete root treatment. Chronic periapical abscess confirmed. Re-treatment required. A year of systemic inflammation — caused by one tooth.
With AETERNO
Week 2–3 post-surgery: Facial thermal asymmetry detected at the mandibular region. CRP trending above baseline. Alert generated: "Periapical inflammatory signal — dental investigation recommended." Re-treatment: May 2024, not May 2025.
03 — Thermal Detection

What our camera already detects

Published clinical studies confirm that infrared thermography detects dental pathology extraorally — from outside the face — with diagnostic-grade precision. Our InfiRay P2 Pro (0.05°C sensitivity) meets or exceeds the FLIR cameras used in these studies.

Most Common · High Urgency
Pulpitis — Nerve Inflammation
When the dental pulp becomes infected, blood flow to the tooth increases dramatically — generating localised heat detectable extraorally on the facial surface. Thermal cameras detect this temperature differential vs. the contralateral healthy tooth.
+1.2–2.4°C
Typical surface temperature elevation vs. healthy side
Silent · High Systemic Risk
Periapical Abscess — Asymptomatic
Chronic periapical abscess is particularly dangerous because it is often painless — yet constantly seeding bacteria into the bloodstream. Thermal imaging detects the heat signature of the abscess at the root apex even when the patient feels nothing.
30 seconds
Mouth opening time for maximum periapical temperature differential
Progressive · Reversible Early
Periodontitis — Gum Inflammation
Gum disease creates persistent inflammatory heat across the gingival tissue. AI-assisted thermal analysis (published 2025, Çankaya et al.) assesses gingival inflammation with high precision — enabling early intervention before bone loss occurs.
92%+
Infrared thermography sensitivity for periodontal detection
Future Capability · Validated
Early Caries — Pre-Cavity Detection
As enamel demineralises (pre-cavity stage), microscopic pores trap water. When dried, these spots cool faster than healthy enamel — creating a detectable "cold spot." At 0.05°C sensitivity, AETERNO's camera can detect this before a cavity is visible to the naked eye.
0.05°C
AETERNO sensitivity — sufficient for early caries thermal detection
AETERNO DENTAL SIGNAL · EXAMPLE ALERT
FACIAL THERMAL ASYMMETRY DETECTED — RIGHT MANDIBULAR REGION

Temperature differential: +1.6°C vs. contralateral baseline.
Pattern: periapical region — consistent with inflammatory activity.
CRP trend: +40% above personal baseline over 3 weeks.
Duration: present across 4 consecutive weekly thermal assessments.

→ Dental clinical evaluation recommended.
→ Root canal status of mandibular right molars to be assessed.
04 — Scanning Protocol

How to perform a dental thermal scan

The dental scan uses the same InfiRay P2 Pro camera already in the AETERNO protocol. No additional equipment required. Non-contact, radiation-free, completed in under 3 minutes.

1
Acclimatisation
Patient rests in temperature-stable room (22–24°C) for 15–20 minutes before scan. No eating, drinking, or dental stimulation.
2
Baseline Capture
3 extraoral thermal images: frontal, right lateral, left lateral — mouth closed. Establishes bilateral symmetry baseline for comparison.
3
Open-Mouth Capture
Patient opens mouth for 30 seconds. Second thermal capture. Periapical temperature differential is greatest at this point — key diagnostic moment.
4
AI Analysis
AETERNO compares thermal images to personal baseline. Bilateral asymmetries flagged. Signal generated if differential exceeds threshold.
05 — Current Capabilities

What AETERNO detects today

Using the InfiRay P2 Pro currently deployed in the AETERNO platform — no additional hardware required for dental screening.

🌡️
Periapical Inflammatory Heat
Primary Detection · Now Available
Temperature differential between infected tooth region and contralateral healthy tooth. Detected extraorally on facial surface. Published studies confirm diagnostic validity using FLIR cameras of equivalent sensitivity to InfiRay P2 Pro.
✓ Validated in peer-reviewed studies · 2021–2025
🔥
Gingival Inflammation Pattern
Periodontitis Signal · Now Available
Persistent inflammatory heat across gum tissue. AI-assisted analysis distinguishes healthy gingival thermal pattern from inflamed tissue. Systematic review (2025) confirms infrared thermography as valid non-ionising diagnostic tool for periodontal inflammation.
✓ AI-assisted gingival assessment — published 2025
💉
Systemic Inflammatory Cascade
Blood Intelligence · Cross-Reference
CRP and IL-6 elevation in the absence of other identified cause — combined with facial thermal asymmetry — creates a composite signal pointing to oral inflammatory source. This cross-signal correlation is unique to AETERNO's multi-signal fusion approach.
✓ Multi-signal fusion: thermal + blood = dental signal
🦷
Post-Surgical Monitoring
Recovery Surveillance · Now Available
Continuous thermal monitoring after dental surgery — bridge placement, root canal treatment, implants. Any unexpected temperature elevation or asymmetry in post-surgical period triggers alert for clinical re-evaluation. Exactly what was missing in our real case.
✓ Weekly monitoring post-procedure — automated comparison

Blood Markers That Reveal Dental Disease

CRP
C-Reactive Protein
Elevated in active periapical infection and periodontitis — often the first sign before tooth pain begins
IL-6
Interleukin-6
Oral bacteria trigger IL-6 production — drives systemic inflammation and cardiovascular risk
Fibrinogen
Fibrinogen
Elevated in chronic dental infection — associated with blood clot risk and cardiovascular complications
WBC / NLR
White Blood Cells
Leukocytosis signals active systemic bacterial seeding — can originate from silent periapical abscess
Dental Intelligence · Clinical Partnership

The tooth that hurts
is rarely the only problem.

AETERNO monitors the thermal and inflammatory signatures of dental pathology continuously.
No radiation. No contact. No waiting for pain to appear.

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