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AETERNO Group AG · Zug, Switzerland · 2026

Oncology & Genetic
Intelligence

The most comprehensive early detection framework in preventive medicine

200+
Cancer Types Monitored
50+
Hereditary Syndromes
13
Oncology Signal Typologies
99%
Stage I Survival Rate
Explore
01 — Overview

Understanding Cancer

Cancer is a group of diseases characterised by the uncontrolled growth and spread of abnormal cells. In 2026, approximately 2.1 million new cancer cases are projected in the US alone. The 5-year survival rate has reached 70% — demonstrating the transformative impact of early detection.

80–90%
Carcinoma
Begins in epithelial cells — skin, organ linings, glands. Includes breast, lung, prostate, colorectal, pancreatic, thyroid cancers.
~1%
Sarcoma
Begins in connective tissues — bone, cartilage, fat, muscle, blood vessels. Includes osteosarcoma, liposarcoma, angiosarcoma.
~3%
Leukaemia
Cancer of blood-forming tissues — bone marrow and blood. Most common cancer in children. Types: ALL, CLL, AML, CML.
~5%
Lymphoma & Myeloma
Begins in immune system cells. Hodgkin and Non-Hodgkin lymphoma (60+ subtypes). Myeloma grows in plasma cells of bone marrow.
~2%
CNS Cancers
Central nervous system — brain and spinal cord. Glioblastoma, astrocytoma, meningioma. Often aggressive due to blood-brain barrier.
02 — Complete Reference

Cancer Types by Body System

A complete clinical reference across all major body systems — the foundation of AETERNO's 200+ cancer type monitoring framework.

Breast
  • Invasive Ductal Carcinoma (IDC) — most common
  • Invasive Lobular Carcinoma (ILC)
  • Ductal Carcinoma In Situ (DCIS)
  • Inflammatory Breast Cancer
  • Triple-Negative Breast Cancer
  • HER2-Positive Breast Cancer
  • Male Breast Cancer
Lung & Respiratory
  • Non-Small Cell Lung Cancer (NSCLC) — 85%
  • Small Cell Lung Cancer (SCLC)
  • Adenocarcinoma of the Lung
  • Squamous Cell Carcinoma of the Lung
  • Large Cell Carcinoma
  • Mesothelioma (lung lining)
  • Pleural Mesothelioma
Digestive System
  • Colorectal Cancer
  • Gastric (Stomach) Cancer
  • Pancreatic Cancer
  • Liver Cancer (Hepatocellular Carcinoma)
  • Esophageal Cancer
  • Gallbladder Cancer
  • Cholangiocarcinoma (bile duct)
  • Anal Cancer · Small Intestine Cancer
Reproductive — Female
  • Ovarian Cancer
  • Cervical Cancer
  • Uterine / Endometrial Cancer
  • Vaginal Cancer · Vulvar Cancer
  • Fallopian Tube Cancer
  • Gestational Trophoblastic Disease
Reproductive — Male
  • Prostate Cancer
  • Testicular Cancer
  • Penile Cancer
Urinary System
  • Bladder Cancer
  • Kidney Cancer (Renal Cell Carcinoma)
  • Renal Pelvis Cancer
  • Ureter Cancer · Urethral Cancer
Skin
  • Melanoma
  • Basal Cell Carcinoma (BCC)
  • Squamous Cell Carcinoma (SCC)
  • Merkel Cell Carcinoma
  • Dermatofibrosarcoma Protuberans
  • Cutaneous T-Cell Lymphoma
Head & Neck
  • Oral Cavity Cancer
  • Oropharyngeal Cancer (throat)
  • Nasopharyngeal Cancer
  • Laryngeal Cancer (voice box)
  • Thyroid Cancer · Parathyroid Cancer
  • Salivary Gland Cancer
Brain & Nervous System
  • Glioblastoma Multiforme (GBM)
  • Astrocytoma · Oligodendroglioma
  • Ependymoma · Meningioma
  • Medulloblastoma · Craniopharyngioma
  • Pituitary Adenoma
  • Spinal Cord Tumors · Neuroblastoma
Blood & Lymphatic
  • Acute Lymphoblastic Leukemia (ALL)
  • Chronic Lymphocytic Leukemia (CLL)
  • Acute Myelogenous Leukemia (AML)
  • Chronic Myelogenous Leukemia (CML)
  • Hodgkin Lymphoma
  • Non-Hodgkin Lymphoma (60+ subtypes)
  • Multiple Myeloma · Hairy Cell Leukemia
Bone & Soft Tissue
  • Osteosarcoma · Chondrosarcoma
  • Ewing Sarcoma · Liposarcoma
  • Leiomyosarcoma · Rhabdomyosarcoma
  • Synovial Sarcoma · Angiosarcoma
  • Gastrointestinal Stromal Tumor (GIST)
Endocrine & Rare Types
  • Adrenal Gland Cancer (Pheochromocytoma)
  • Pancreatic Neuroendocrine Tumors (pNET)
  • Carcinoid Tumors · Thymoma
  • Uveal Melanoma (eye) · Retinoblastoma
  • Neuroendocrine Tumors (NET)
  • Kaposi Sarcoma · Mesothelioma
03 — Treatment Framework

Three Pillars of Cancer Treatment

AETERNO's position is clear: true healing is integrative. The best outcomes combine the precision of biological medicine, the power of conventional oncology when necessary, and the restorative support of natural approaches. Early detection through AETERNO enables all three to work optimally.

Frontier Oncology
Immunotherapy

The most revolutionary development in oncology in 30 years. Activates or enhances the immune system to recognise and destroy cancer cells.

  • Checkpoint Inhibitors (PD-1/PD-L1): pembrolizumab, nivolumab — remove 'brakes' on immune cells
  • CAR-T Cell Therapy: patient's T-cells reprogrammed to attack cancer — highly effective in blood cancers
  • Cancer Vaccines: therapeutic vaccines stimulate immune response to specific tumour antigens
  • Cytokine Therapy: interleukins and interferons boost immune activity
  • Monoclonal Antibodies: lab-made antibodies target specific cancer cell proteins
Precision Medicine
Targeted Therapy

Drugs designed to target specific genetic mutations or proteins that drive cancer growth — more precise than chemotherapy.

  • Tyrosine Kinase Inhibitors: imatinib (CML), erlotinib (NSCLC), lapatinib (breast)
  • HER2 Inhibitors: trastuzumab (Herceptin) for HER2+ breast cancer
  • VEGF Inhibitors: bevacizumab — cuts off tumour blood supply
  • PARP Inhibitors: olaparib — for BRCA-mutated breast and ovarian cancers
  • BRAF/MEK Inhibitors: vemurafenib, dabrafenib — for BRAF-mutated melanoma
Hormonal Regulation
Hormone Therapy
  • Antiestrogens: tamoxifen, fulvestrant — breast cancer
  • Aromatase Inhibitors: anastrozole, letrozole — post-menopausal breast cancer
  • LHRH Agonists: goserelin, leuprolide — prostate and breast cancer
  • Antiandrogens: enzalutamide, bicalutamide — prostate cancer
Cellular Regeneration
Bone Marrow / Stem Cell Transplant
  • Autologous transplant: patient's own stem cells harvested, then reinfused post-chemotherapy
  • Allogeneic transplant: donor stem cells (matched sibling or unrelated donor)
  • Used in: leukemia, lymphoma, multiple myeloma, aplastic anemia
Systemic Treatment
Chemotherapy

Systemic drugs that kill rapidly dividing cells. AETERNO's early detection maximises effectiveness by enabling Stage I-II intervention.

  • Alkylating agents: cyclophosphamide, cisplatin, carboplatin
  • Antimetabolites: methotrexate, 5-fluorouracil, gemcitabine
  • Anthracyclines: doxorubicin, epirubicin
  • Taxanes: paclitaxel, docetaxel — prevent cell division
  • Vinca Alkaloids: vincristine, vinblastine — plant-derived
Energy Targeting
Radiation Therapy
  • External Beam Radiation (EBRT): standard radiation
  • IMRT: intensity-modulated, precisely shaped beams
  • Stereotactic Radiosurgery: Gamma Knife, CyberKnife — extreme precision
  • Proton Beam Therapy: less damage to surrounding tissue
  • Brachytherapy: radioactive seeds placed inside tumour
  • Radiopharmaceuticals: Lutetium PSMA for prostate cancer
Physical Intervention
Surgery
  • Curative surgery: complete tumour removal with clear margins
  • Debulking surgery: reduces tumour burden
  • Preventive surgery: prophylactic mastectomy in BRCA carriers
  • Minimally invasive: laparoscopic, robotic-assisted (da Vinci)
  • Mohs surgery: layer-by-layer removal for skin cancers
Light-Activated
Photodynamic Therapy (PDT)

Light-activated drug produces reactive oxygen selectively toxic to cancer cells.

  • Photosensitising agent accumulates in cancer cells
  • Specific wavelength activates drug, destroying cells
  • Used for: skin, esophageal, lung, bladder cancer
Nature's Pharmacy
Plant-Derived Anti-Cancer Compounds

Many chemotherapy drugs are themselves derived from natural sources — refined over millions of years of evolution.

  • Taxol (Paclitaxel): Pacific Yew tree — breast, ovarian, lung cancer standard
  • Artemisinin: Sweet Wormwood — potent activity, especially leukemia
  • Curcumin: Turmeric — anti-inflammatory, anti-proliferative — 3,000+ studies
  • Resveratrol: Grape skin — inhibits tumour initiation and progression
  • EGCG: Green Tea — induces apoptosis in cancer cells
Immune Modulation
Mushroom & Fungal Immunotherapy
  • Reishi: immune modulation, apoptosis induction, anti-angiogenic
  • Turkey Tail (PSK): approved in Japan for gastric, colorectal cancer
  • Chaga: anti-tumour, high antioxidant ORAC value
  • Lion's Mane: nerve growth factor, anti-tumour
  • Maitake: D-Fraction — clinical studies in breast cancer
Metabolic Therapy
IV Vitamin C & Ketogenic Protocol
  • IV Vitamin C (25-100g): pro-oxidant, selectively toxic to cancer cells
  • Ketogenic Diet: starves cancer cells of glucose (Warburg effect)
  • Fasting-Mimicking Diet: reduces IGF-1 and glucose
  • HBOT: oxygen-rich environment hostile to anaerobic cancer cells
  • DCA: reverses Warburg effect, reactivates mitochondrial apoptosis
Integrative Medicine
Mistletoe (Iscador / Helixor)

Most extensively researched natural cancer therapy in Europe. Standard integrative therapy in Germany, Switzerland, Austria — covered by insurance.

  • Viscum album extracts: direct cytotoxic, immune-stimulating
  • Clinical evidence: improved survival in breast, lung, colorectal, pancreatic
  • Anthroposophic medicine — developed by Rudolf Steiner, refined 100+ years
  • Mind-Body: meditation, HRV — documented immune enhancement
04 — Genetic Intelligence

DNA & Hereditary Cancer Risk

Cancer is, fundamentally, a disease of the genome. Approximately 5-10% of all cancers are hereditary. Identifying genetic predisposition enables enhanced surveillance, preventive interventions, and personalised AETERNO monitoring protocols.

The Human Genome at a Glance

Every cell contains 2 metres of DNA carrying all instructions for life — and when it goes wrong, it drives cancer.

3.2B
DNA Base Pairs
25,000
Human Genes
~10%
Cancers Are Hereditary
50+
Hereditary Cancer Genes
Brakes — Loss of Function
Tumour Suppressor Genes
Act as brakes on cell division. When both copies are mutated ('two-hit hypothesis'), the brake is lost and uncontrolled growth begins.
BRCA1BRCA2TP53APCPTENRB1VHLCDH1
Accelerators — Gain of Function
Proto-Oncogenes / Oncogenes
Normally promote healthy cell growth. When mutated or overexpressed, they become stuck accelerators. Only ONE copy needs to be mutated.
KRASBRAFMYCEGFRHER2ALKBCR-ABL
Genome Guardians
DNA Repair Genes
Maintain integrity of the genome by correcting errors in DNA replication. When they fail, mutations accumulate at accelerated rate.
MLH1MSH2MSH6ATMCHEK2PALB2POLE

Hereditary Cancer Syndromes

Syndrome Gene(s) Key Cancer Risks Risk Level
Hereditary Breast & Ovarian Cancer (HBOC) BRCA1, BRCA2 Breast (50-72%), Ovarian (44%), Pancreatic, Prostate HIGH
Lynch Syndrome (HNPCC) MLH1, MSH2, MSH6, PMS2 Colorectal (70-80%), Endometrial (40-60%), Ovarian (10-12%) HIGH
Familial Adenomatous Polyposis (FAP) APC Colorectal near 100% by age 40, Duodenal, Thyroid VERY HIGH
Li-Fraumeni Syndrome TP53 Lifetime cancer risk 90%+: Breast, Sarcomas, Brain, Leukemia VERY HIGH
Cowden Syndrome PTEN Breast (25-50%), Thyroid (10%), Endometrial (28%) HIGH
Von Hippel-Lindau (VHL) VHL Kidney (70%), Haemangioblastomas, Phaeochromocytoma HIGH
Multiple Endocrine Neoplasia 1 (MEN1) MEN1 Parathyroid (95%), Pancreatic NET (30-70%), Pituitary (15-50%) HIGH
Hereditary Diffuse Gastric Cancer CDH1 Gastric (56-83%), Breast lobular (42%). Prophylactic gastrectomy HIGH
Peutz-Jeghers Syndrome STK11 Colorectal (40%), Pancreatic (11-36%), Breast (50%) HIGH
Hereditary Melanoma (FAMMM) CDKN2A Melanoma (70%), Pancreatic (20-34%) HIGH
Neurofibromatosis Type 1 (NF1) NF1 MPNST, Glioma, Breast, GIST, Leukemia HIGH
Gorlin Syndrome (Basal Cell Naevus) PTCH1 Multiple BCC (often hundreds by age 20), Medulloblastoma HIGH
Retinoblastoma (Hereditary) RB1 Bilateral retinoblastoma (90%), Osteosarcoma, Melanoma VERY HIGH
MUTYH-Associated Polyposis (MAP) MUTYH Colorectal (80% lifetime), Duodenal, Ovarian HIGH (biallelic)
05 — AETERNO Intelligence

The Signal Before the Storm

AETERNO's Oncology Signal module integrates thermal intelligence and blood biomarker analysis to detect early oncological signals across 13 cancer typologies — weeks or months before clinical symptoms appear.

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Inflammatory Cascade
Blood Intelligence
  • CRP C-Reactive Protein — trending elevation above personal baseline signals colorectal, lung, breast, lymphoma risk
  • IL-6 Interleukin-6 — persistent elevation activates STAT3 signalling directly implicated in tumour survival
  • NLR Neutrophil-to-Lymphocyte Ratio — NLR >3.5 associated with elevated cancer risk across multiple types
  • Fibrinogen Elevated in chronic inflammation — associated with colorectal, lung and gastric cancer risk
  • Ferritin Iron storage protein — marker of occult malignancy in trend analysis
🌡️
Thermal Intelligence
InfiRay · 0.05°C Sensitivity
  • Breast Asymmetric heat patterns and angiogenic signals detectable weeks before mass formation
  • Thyroid Temperature differentials consistent with nodular activity and early inflammatory change
  • Lymph Nodes Axillary and cervical thermal asymmetries — early lymphatic involvement signals
  • Abdominal Hepatic, pancreatic and colorectal region thermal variance analysis
  • Pulmonary Respiratory thermal patterns consistent with early malignant or inflammatory activity
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HRV Intelligence
Autonomic Nervous System
  • Trend HRV declines significantly in weeks preceding clinically symptomatic illness — trend beats single measurement
  • Immune Sustained HRV depression correlates with elevated inflammatory markers and immune dysregulation
  • Fusion HRV integrated with inflammatory and thermal data to create composite autonomic-oncological signal
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Tumour Marker Panel
Cancer-Specific Biomarkers
  • PSAProstate cancer — trend analysis vs population threshold
  • CA-125Ovarian cancer early signal monitoring
  • CEAColorectal cancer — trend deviation from baseline
  • CA 19-9Pancreatic cancer — one of the earliest signals available
  • CA 15-3Breast cancer longitudinal monitoring
  • AFPLiver cancer — hepatocellular carcinoma marker
Multi-Signal Fusion — The AETERNO AI Layer

No single biomarker is sufficient. The power of AETERNO's approach lies in the simultaneous analysis of multiple signal streams. The AI layer identifies pattern combinations that carry significantly higher predictive value than any individual marker.

📈 Rising CRP trend + 📉 Declining HRV + 🌡️ Thermal asymmetry
→ HIGH PRIORITY ONCOLOGICAL SIGNAL
📈 Stable CRP + 📉 Declining HRV alone
→ Autonomic stress signal — lower oncological specificity
🌡️ Thermal asymmetry alone (no blood deviation)
→ Anatomical signal — clinical correlation recommended
90%+
5-Year Survival at Stage I
vs. 15-30% at Stage IV — the survival advantage of early detection
Daily
Continuous Monitoring
AETERNO watches biomarker trends daily, not once every 6-12 months
Personal
Baseline Comparison
Compares you to yourself — not population averages. Dramatically improves specificity.
06 — Clinical Evidence

The Diagnostic Gap — Illustrated

A 52-year-old female, non-smoker, no family history. Standard annual check-up: all blood values within population reference ranges. No symptoms. Discharged as 'healthy' for another 12 months. What AETERNO detected — 8 weeks earlier.

Without AETERNO — Standard Care
Annual Check-Up
All blood values within population reference ranges. No symptoms reported. Physician assessment: healthy. Discharge.
Months 1-12
No monitoring. Biological signals present and escalating — completely unobserved. The diagnostic blind spot.
!
Month 12-24
Patient notices lump. Presents to GP. Imaging ordered. Stage II-III diagnosis. Treatment: mastectomy + chemotherapy + radiation.
Probable Stage at Detection
Stage II–III
5-Year Survival: 57–86%
With AETERNO — Pre-Diagnostic Intelligence
W3
Week 3 of Monitoring
CRP trending 1.2 → 2.4 mg/L vs. personal baseline of 0.8-1.5. AETERNO flags inflammatory trend.
W5
Week 5 of Monitoring
HRV declining 42ms → 29ms — sustained 5-week decline unexplained by lifestyle. Autonomic stress signal confirmed.
W7
Week 7 — Thermal Scan
Right breast thermal asymmetry: +0.6°C vs. baseline — present over 3 consecutive weekly assessments. Angiogenic pattern detected.
W8
Week 8 — AETERNO Alert
"Composite inflammatory-thermal signal deviation. Clinical breast investigation recommended." Patient referred immediately.
Actual Stage at Detection
Stage IA
5-Year Survival: >99%

8mm hypoechoic lesion confirmed on subsequent mammography. Core biopsy: Grade 1 invasive ductal carcinoma. Treatment: lumpectomy + radiotherapy. Without AETERNO: next scheduled mammography in 2 years — probable Stage II-III detection.

"Your body has always been speaking.
AETERNO Life is listening."
— AETERNO Group AG · Zug, Switzerland · 2026

This framework is dedicated to the memory of those whose cancers were detected too late — not because early signals did not exist, but because no infrastructure existed to detect and act upon them.

The biological signals of cancer precede clinical diagnosis. The mandate of modern preventive medicine is to build the infrastructure that closes this gap.

AETERNO Life is that infrastructure.

07 — Compliance

Regulatory Framework

AETERNO Life is designed and positioned as a health signal monitoring and early warning platform — explicitly not a medical diagnostic device. This positioning is deliberate, evidence-based, and clinically meaningful.

EU MDR 2017/745
Medical Device Regulation
✓ Compliant — Non-Device Classification
Health signal monitoring platform — not a medical device. Operates outside Class I-III classification. Does not diagnose, prescribe, or treat. Generates reasons for clinical investigation.
EU AI Act 2024/1689
Artificial Intelligence Act
✓ Limited-Risk AI System
Aligned as limited-risk AI system. Transparency obligations fully met — users informed of AI involvement at every interaction. Not classified as high-risk medical AI.
GDPR 2016/679
Data Protection
✓ Full EU Compliance
All biometric and health data processed within EU jurisdiction (Frankfurt, Germany). AES-256 encryption. Zero third-party data sharing. Sovereign data architecture.
AETERNO Signal Language Protocol

All AETERNO outputs use signal language: "Deviation from baseline detected" · "Pattern consistent with elevated inflammatory load" · "Clinical correlation recommended."

Never: "You have cancer" or "This is a diagnosis." Clinical diagnosis remains exclusively within the physician's domain.

For Clinicians & Institutions

Join the Pilot Programme

10 European clinical institutions · 200 high-risk patients · 12 months
Prospective monitoring alongside standard clinical surveillance.

hello@aeternolife.ai · aeternolife.ai · aeterno-group.ai

Interactive Tool
Try the Signal Analyzer
Enter your tumour marker values and thermal zones — get your personal Oncology Signal Score.
⚡ Open Signal Analyzer