Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from tissue-specific posttranslational processing of the proglucagon peptide.
In summary, through its direct central actions, coordination of gut-liver-brain signals, modulation of microbial metabolites, and interaction with bile acid pathways, GLP-1 acts as a central integrator within the brain-gut-taste axis.
Here we provide a targeted synthesis of recent developments in the field of GLP-1 neurobiology, highlighting studies which have advanced our understanding of how GLP-1 signaling modulates eating, and identify open questions and future challenges we believe still need to be addressed to aid the prevention and/or treatment of obesity.
GLP-1 is an incretin hormone and neuromodulator produced by gut enterocytes and CNS neurons. Brierley et al. find that GLP-1 from peripheral and central sources acts independently through distinct ...
Pharmacology studies from 20 years ago had suggested a possible inhibitory effect of the sympathetic neurotransmitter norepinephrine on gut GLP-1 secretion. 6 In this issue, Ren et al. 1 have now elegantly pinpointed the role of sympathetic nerves in the modulation of intestinal GLP-1 release and consequent changes in GLP-1 glucoregulatory action.
Furthermore, visual representations like the one above help us fully grasp the concept of Glp-1 And Gut-Sensory System Modulation.
In this review, we highlight the latest experimental data supporting the role of the gut-brain and brain-periphery axes in the control of glucose homeostasis. We also focus our attention on the relevance of -cell and brain cell targeting by gut GLP-1 for the regulation of glucose homeostasis.
Science says eating just one meal per day can improve your health.Learn more at https://highintensityhealth.com/OMAD-----Dr. Edwin Lee explains how the gut ...
A systems-level view of how four distinct mechanisms connect digestion to cognition, disease, and drug response The Assumption When most scientists hear "gut-brain axis," they think of the microbiome. It has become the default frame.
