Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from tissue-specific posttranslational processing of the proglucagon peptide.
The data shown here extend the spectrum of antiapoptotic GLP-1 actions to ER stress-induced cell death, linking GLP-1R activation to cell survival via a cAMP and PKA-dependent pathway.
Data obtained in insulin receptor down-regulated cells strongly reinforce those in cells overexpressing ENPP1 and altogether demonstrate that insulin receptor signaling is critical for the protective GLP-1 effect on beta-cell function and survival.
Such details provide a deeper understanding and appreciation for Glp-1 Receptor Activation And Beta Cell Survival.
However, the long-term effects of prolonged activation of GLP-1 receptors by long-acting GLP-1RAs on beta cell exhaustion remain uncertain, as it is unclear whether sustained stimulation might lead to adaptive changes that could impair beta cell functionality or contribute to eventual cellular exhaustion.
Perturbation of endoplasmic reticulum (ER) homeostasis impairs insulin biosynthesis, beta cell survival, and glucose homeostasis. We show that a murine model of diabetes is associated with the development of ER stress in beta cells and that treatment with the GLP-1R agonist exendin-4 significantly ...
GLP-1 receptor agonists have emerged as key pharmacological tools in the treatment of type 2 diabetes and obesity. While their anorexigenic effects are well characterized, the mechanisms by which GLP-1 modulates pancreatic -cell function remain only partially understood.
Glucagon-like peptide-1 (GLP-1) plays a crucial role in pancreatic -cells; GLP-1 binds to the GLP-1 receptor (GLP-1R) in the -cell membrane and thereby enhances insulin secretion, suppresses apoptotic cell death and increase proliferation of -cells.
GLP-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice.Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.
