Hydroxyzine and Benadryl belong to the same class of medications called antihistamines, but they are not the same medication. Benadryl is the brand name for the generic medication diphenhydramine, which is typically used in animals to treat acute allergic reactions.
Hydroxyzine and Benadryl (diphenhydramine) are both older, sedating H1 antihistamines, but they are different drugs with different FDAapproved uses.Hydroxyzine is an antihistamine that may help treat allergies, anxiety, and motion sickness in dogs.
Non-Sedative: Unlike Hydroxyzine and Benadryl, Apoquel doesnt cause drowsiness, making it ideal for active dogs who need to stay alert. Long-Term Use: Its safe for extended use in dogs with chronic allergies or skin conditions, unlike Benadryl, which is more suitable for short-term use.

2. Tick bites on dogs. Ticks are another common external parasite that can bite dogs. They have an anesthetic enzyme in their saliva, so the dog may not feel the actual bite.
Species: Dogs, Cats, and Horses. Therapeutic Class: Antihistamine. Basic Information. Hydroxyzine HCl is an H1 receptor antihistamine. It competes with histamine for receptor sites on the target cells in the respiratory tract, intestines, blood vessels, and the skin.

Hydroxyzine Side Effects and Risks in Dogs. As with any medication, there are some associated side effects or risks. In most cases, your dog may just get a bit drowsy after administration.
Hydroxyzine for Dogs Hydroxyzine HCl for dogs (brand names: Atarax or Vistaril) is an antihistamine indicated for allergy treatment in dogs and cats.
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