The trillions of bacteria that constitutively colonize the human gut collectively generate thousands of unique small molecules. These microbial metabolites can accumulate both locally and systemically and potentially influence nearly all aspects of mammalian ... There is a growing appreciation that microbially produced metabolites have a mediating role in health and disease, as seen in type 2 diabetes (T2DM), inflammatory bowel diseases (IBDs), and metabolic-associated fatty liver disease. 3,4,5,6,7,8,9 Evidence of the influence of microbial-derived metabolites primarily comes from mechanistic studies, where they may promote health and disease states ... Microbial secondary metabolites not only have key roles in microbial processes and relationships but are also valued in various sectors of todays economy, especially in human health and ... What are microbial secondary metabolites? Provided by the Springer Nature SharedIt content-sharing initiative Microbial secondary metabolites not only have key roles in microbial processes and relationships but are also valued in various sectors of todays economy, especially in human health and agriculture. What is the microbial Metabolome Database (mimedb)? The Microbial Metabolome Database (MiMeDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human microbiome. It is intended to be used for applications in metabolomics, clinical chemistry, biomarker discovery and general education. Does microbial metabolite production play a role in fermented food? Indeed, the molecules produced during fermentation that dictate texture and flavor are likely to also play biological roles in many cases. Still, investigating the role of microbial metabolite production in a fermented food environment offers numerous intriguing yet understudied areas of research. Are microbially produced metabolites more important than bioactive compounds originating from oats? As observed in the short-term intervention study, microbially produced metabolites, especially phenolic compounds such as DHFA, may play a more relevant role in oat-induced metabolic improvements than bioactive compounds originating from oats.
Such details provide a deeper understanding and appreciation for A Microbially Generated Metabolite.
