It is, therefore, stressed that IgL restriction itself should be characterized as monotypic, but never as monoclonal, in order not to overlook oligoclonal B-cell proliferation. Similarly, polytypic staining of IgL should not be characterized as polyclonal because possibilities of such a process to be oligoclonal or monoclonal exist. Footnotes
This analysis detected all types of variable (V) segments with a gaussian distribution of CDR3 in lymph nodes. In contrast, a restricted heterogeneity was found in atherosclerotic lesions, with expansion of a limited set of V and V segments and a monotypic or oligotypic CDR3 spectrum in each lesion.
As we can see from the illustration, Monotypic And Oligoclonal Expansion has many fascinating aspects to explore.
More permanent deficits in interconnectivity result in oligoclonal expansions of T lymphocytes, as seen in Omenns syndrome and in the experimental transplantation of a suboptimal diversity of syngeneic T cells to immunodeficient hosts, which also have pathogenic consequences.
Furthermore, the oligoclonal expansion frequencies of TRDV5 and TRDV6 in patients with relapse were significantly higher than those in non-recurrent cases.Oligoclonal expansion frequencies of the TRDV subfamilies in T cells from AML patients (using the Fishers exact test).
Intratumoral oligoclonal expansion of TIL-B was demonstrated by a preponderance (45-68%) of clonal B cells. In contrast, only 7% of tumor-draining lymph node and 0% of healthy donor PBL IgG H chains were clonal, consistent with the larger repertoires of node and peripheral...
