Everything You Should Know About The Pyrroloquinoline Quinone Disodium Salt (PQQ)
What is Pyrroloquinoline Quinone disodium salt (PQQ)?
Pyrroloquinoline Quinone disodium salt (PQQ) also known as methoxatin is a vitamin-like cofactor compound present in many plant foods. PQQ is known to influence multiple cellular pathways, including the production of
Pyrroloquinoline Quinone disodium salt or PQQ is a compound that exists in plants as well as many bacteria and single-cell eukaryotes, such as yeast. PQQ occurs naturally in human breast milk as well as in the mammalian tissues. PQQ also exists naturally in human breast milk as well as fermented soybeans, kiwi, papaya, spinach, parsley, oolong, green pepper and green tea. Research done on animals has linked insufficient PQQ or PQQ shortage with a compromised immune response, growth impairment, abnormal reproductive performance and reduced metabolic flexibility.
The Pyrroloquinoline quinone (PQQ) mechanisms of action
Pyrroloquinoline quinone (PQQ) exhibits numerous health benefits through different mechanisms such as regulation of cellular signaling pathways, getting rid of free radicals and redox activity.
The pqq mechanisms of action include:
Affects the way genes work
Pyrroloquinoline quinone can affect the way various genes are expressed and especially the genes involved in mitochondria activity. Its antioxidant activity is said to be 100 times that of vitamin C.
PQQ supplementation has been shown to activate the CREB and PGC-1a signaling pathways that are directly involved in mitochondria biogenesis.
Acts as an antioxidant
Pyrroloquinoline quinone (pqq) anti-oxidative activity is mainly due to its ability to be reduced to PQQH2 through the reaction with reducing agents such as cysteine, glutathione or nicotinamide adenine dinucleotide phosphate (NADPH).
Inhibits enzymes
Pyrroloquinoline quinone also hinders the enzyme thioredoxin reductase 1 (TrxR1), which in turn triggers the Nuclear factor erythroid 2-related factor 2 (Nrf2) activities that promotes antioxidant production.
PQQ has also been known to inhibit the development of quinoproteins (damaging proteins) that leads to Parkinson’s disorder.
Pyrroloquinoline Quinone disodium salt (PQQ) Uses
Pyrroloquinoline Quinone disodium salt (PQQ) was initially thought to be a vitamin. However, further research established it as a non-vitamin compound that occurs in both the diet as well as mammalian tissue. However, it is important to highlight that though no research has verified its mammalian synthesis, about 100-400 nanograms of PQQ is formed in the human body every day. Unfortunately, this amount is not enough to support the various functions that PQQ has been proven to perform. Thus, human beings are often advised to consume PQQ in the form of dietary supplements.
Pyrroloquinoline Quinone disodium salt (PQQ) is intended for use in energy, sport, and electrolyte drinks and enhanced and fortified water beverages at a maximum use levels of up to 5 and 20 mg/serving respectively in these product types.
Why Take Pyrroloquinoline Quinone disodium salt（PQQ）?
Good For Body
A diet lacking in PQQ not only leads to reduced growth but also reduced sexual function. Similarly, several studies have linked PQQ with growth factor and mitochondrial biogenesis. In simple words, the human body can benefit from PQQ as it promotes the number and work of mitochondria, thereby leading to better energy levels. PQQ is also known to be an excellent REDOX agent and prevents self-oxidation and polymerization.
Highly Absorbable
PQQ products use a patented natural fermentation process that results in a highly absorbable PQQ disodium salt. Not only is this a natural process opposed to synthetic PQQ but also the type of PQQ used in successful human clinical trials.
Safty
Adverse Pyrroloquinoline Quinone disodium salt side effects are quite sporadic especially if you stick to the standard 20-40mg daily dose with short-term use. Humans ought not to exceed one year of consistent usage.
Pyrroloquinoline Quinone disodium salt (PQQ) Dosage
So far no upper or lower limit has been established on
Pyrroloquinoline Quinone disodium salt (PQQ) dosage. However, results inferred from animal studies reveal that this compound becomes bioactive when taken in doses as low as 2 mg. However, most dietary supplements these days are available in the range of 20 mg to 40 mg, which is considered to be a safe range. The dose hinges on whatever condition you are managing. For instance, when increasing the mitochondria count, you may only need less than a milligram of Pyrroloquinoline Quinone disodium salt per day. However, the dose escalates up to 20mg when treating inflammation.
PQQ is mostly available in the form of capsules, which people are advised to take on an empty stomach. However, users are advised to not go beyond 80 mg dosage per day.
Although there are no known grave
Pyrroloquinoline Quinone disodium salt side effects, you must stick to the above dosage. You should not exceed 80mg in a single day lest you fall out with the PQQ dangers.
Where you can buy Pyrroloquinoline Quinone disodium salt (PQQ) in Bulk?
With people becoming more and more aware of the benefits of pyrroloquinoline quinone disodium salt (PQQ) , the demand for Pyrroloquinoline Quinone disodium salt (PQQ) supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the Pyrroloquinoline Quinone disodium salt (PQQ) supplements market, you must ensure that you are getting the highest-quality Pyrroloquinoline Quinone disodium salt (PQQ) powder. Sourcing good-quality material is the first step in ensuring the success of any business.
If you are looking for a place to buy Pyrroloquinoline Quinone disodium salt (PQQ) powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The Pyrroloquinoline Quinone disodium salt (PQQ) produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy Pyrroloquinoline Quinone disodium salt (PQQ) in bulk, the only place to shop is cofttek.com.
Pyrroloquinoline quinone (PQQ) is reduced to pyrroloquinoline quinol (PQQH2) by vitamin C, and PQQH2 produced is recycled to PQQ by air oxidation in buffer solution at pH 7.4. Mukai K, Ouchi A, Nagaoka S, Nakano M, Ikemoto K.Biosci Biotechnol Biochem. 2016;80(1):178-87. doi: 10.1080/09168451.2015.1072462. Epub 2015 Aug 11.PMID: 26264520
Crystal structure and characterization of pyrroloquinoline quinone disodium trihydrate. Ikemoto K, Sakamoto H, Nakano M.Chem Cent J. 2012 Jun 19;6(1):57. doi: 10.1186/1752-153X-6-57.PMID: 22713213
Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution. Miyauchi K, Urakami T, Abeta H, Shi H, Noguchi N, Niki E.Antioxid Redox Signal. 1999 Winter;1(4):547-54. doi: 10.1089/ars.1999. 1.4-547. PMID: 11233151
Structural requirements of pyrroloquinoline quinone dependent enzymatic reactions. Oubrie A, Dijkstra BW.Protein Sci. 2000 Jul;9(7):1265-73. doi: 10.1110/ps.9.7.1265.PMID: 10933491
Transcriptome analysis of the effect of pyrroloquinoline quinone disodium (PQQ·Na2) on reproductive performance in sows during gestation and lactation. Zhang B, Wang C, Yang W, Zhang H, Meng Q, Shi B, Shan A.J Anim Sci Biotechnol. 2019 Aug 7;10:62. doi: 10.1186/s40104-019-0369-y. eCollection 2019.PMID: 31406573