However, taking ibuprofen, aspirin, and other types of nonsteroidal anti-inflammatory drugs (NSAIDs) in the second half of pregnancy can lead to oligohydramnios (low amniotic fluid) or kidney problems in the baby.
Ibuprofen Pregnancy Warnings. Contraindicated last trimester of pregnancy NSAIDs should be avoided at 20 weeks gestation and later.Through 2017, the FDA has received 35 reports of low amniotic fluid levels or kidney problems in mothers who took NSAIDs while pregnant.

Acetaminophen and ibuprofen are pain-relief medicines that work differently. Ibuprofen has the added benefit of reducing inflammation.Signs of kidney problems such as a decreased amount of pee or swelling in your ankles, feet, or hands.

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The kidney and amniotic fluid problems the FDA flagged typically develop after days to weeks of treatment, and the ductus arteriosus risk applies mainly to later pregnancy. If you took ibuprofen very early on, before a positive test, the exposure is unlikely to have caused the specific...

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Because ibuprofen can also cause problems with amniotic fluid and the fetuss kidneys, ibuprofen use is discouraged between weeks 20 and 29 of a pregnancy. Acetaminophen is the preferred pain relief medication and fever reducer for pregnant women.
Avoid using ibuprofen after 20 weeks of pregnancy, as it may cause rare but serious kidney problems in an unborn baby. This can lead to low levels of amniotic fluid surrounding the baby and possible complications.
The risks of taking ibuprofen are highest after 20 weeks of pregnancy because it can reduce the babys kidney function and cause low amniotic fluid levels. For this reason, it should be avoided unless a healthcare professional specifically advises otherwise.