AUTHOR
EIRINI MAROULI,
William Harvey Research Institute,
Barts and the London School of Medicine and Dentistry,
Queen Mary University London
Contact: e.marouli@qmul.ac.uk


#COVID19-hg GWAS meta-analyses round 3
#COVID19 PheWAS in the UK Biobank

Overview
PheWAS analysis in the UK Biobank using GP and Hospital Episode Statistics (HES) data. 

ANA_B2_V2
Download from:
COVID19_HGI_ANA_B2_V2_20200629.txt.gz.b37.txt.gz
i.	Genetic Score based on GWAS signals (p<1e-5). Significant outcome: Celiac Disease (p= 4.95E-07). Red line: Bonferroni significance level.
ii.	Genetic Score based on 31 COVID-19 associated SNPs (LD clump was performed at SNPs with pvalue <10-5, r2=0.1). No outcome passed Bonferroni correction. Blue line for p=0.05. 

ANA_C2_V2
Download from:
COVID19_HGI_ANA_C2_V2_20200629.txt.gz.b37.txt.gz
i.	Genetic Score based on GWAS signals (p<1e-5). Marginally significant outcome: Respiratory arrest (p= 9.57E-05). Red line: Bonferroni significance level.
ii.	Genetic Score based on 28 COVID -19 associated SNPs (LD clump was performed at SNPs with pvalue <10-5, r2=0.1). No outcome passed Bonferroni correction. Blue line for p=0.05. 


GWAS without UK Biobank
ANA_B2_V2
Download from: https://storage.googleapis.com/covid19-hg-public/20200619/results/leave_ukbb/build_37/COVID19_HGI_ANA_B2_V2_leave_UKBB_20200630.txt.gz.b37.txt.gz
- Genetic Score based on GWAS signals (p<1e-5). Significant outcome: Celiac Disease (p= 8.93E-07).

ANA_C2_V2
Download from: https://storage.googleapis.com/covid19-hg-public/20200619/results/leave_ukbb/build_37/COVID19_HGI_ANA_C2_V2_leave_UKBB_20200630.txt.gz.b37.txt.gz 
- Genetic Score based on GWAS signals (p<1e-5). No outcome passed Bonferroni correction

ANA_C1_V2
Download from: https://storage.googleapis.com/covid19-hg-public/20200619/results/leave_ukbb/build_37/COVID19_HGI_ANA_C1_V2_leave_UKBB_20200630.txt.gz.b37.txt.gz 
- Genetic Score based on GWAS signals (p<1e-5). No outcome passed Bonferroni correction


Contributors: Eirini Marouli, Areti Papadopoulou, Panos Deloukas