Spindle Geometry at Lorena Frances blog

Spindle Geometry. The formation and geometry of the spindle are critical to allow it to correctly segregate the chromosomes. They are carefully calculated to match the needs of the machine and the work it will do. Architectural integrity of the mitotic spindle is required for efficient chromosome congression and accurate chromosome. On the basis of the data presented here, we propose that spatiotemporally controlled myosin flows in conjunction with spindle. The goal is to design a spindle that minimizes vibration and maximizes precision. The shape and size of a spindle are not random. A spindle’s geometry affects its balance, speed capabilities, and how much load it can handle. A prime suspect is spindle geometry since previous reports correlated spindle asymmetry and positioning with sibling cell size asymmetry 48,49,50.

164frontsuspensiongeometryrotated2d.jpg
from www.stangnet.com

On the basis of the data presented here, we propose that spatiotemporally controlled myosin flows in conjunction with spindle. A spindle’s geometry affects its balance, speed capabilities, and how much load it can handle. The formation and geometry of the spindle are critical to allow it to correctly segregate the chromosomes. A prime suspect is spindle geometry since previous reports correlated spindle asymmetry and positioning with sibling cell size asymmetry 48,49,50. The shape and size of a spindle are not random. They are carefully calculated to match the needs of the machine and the work it will do. The goal is to design a spindle that minimizes vibration and maximizes precision. Architectural integrity of the mitotic spindle is required for efficient chromosome congression and accurate chromosome.

164frontsuspensiongeometryrotated2d.jpg

Spindle Geometry The goal is to design a spindle that minimizes vibration and maximizes precision. The formation and geometry of the spindle are critical to allow it to correctly segregate the chromosomes. They are carefully calculated to match the needs of the machine and the work it will do. The goal is to design a spindle that minimizes vibration and maximizes precision. On the basis of the data presented here, we propose that spatiotemporally controlled myosin flows in conjunction with spindle. The shape and size of a spindle are not random. A spindle’s geometry affects its balance, speed capabilities, and how much load it can handle. A prime suspect is spindle geometry since previous reports correlated spindle asymmetry and positioning with sibling cell size asymmetry 48,49,50. Architectural integrity of the mitotic spindle is required for efficient chromosome congression and accurate chromosome.

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