Acute lymphoblastic leukemia. Animal model
Herpeslike virus isolated from spontaneously degenerated tissue culture derived from leukemia -susceptible guinea pigs . J Virol. 1969 Mar;3(3):355-357.[PMC free article] [PubMed] [Google Scholar] Rhim JS, Vernon ML, Green I. In vitro studies on L2C leukemia : isolation of guinea pig herpes virus from mink cells after cocultivation with leukemic ...
2 guinea pigs with large emulsified in complete Freund's adjuvant and injected in the foot pads protects almost all animals against subsequent lethal leukemic challenge. Animals similarly immunized with normal strain 2 lymphocytes or a chemically-induced syngeneic hepatoma were not protected. Thus, the L2C leukemia possesses a tumor-specific transplantation antigen. When specifically immunized ...
L2C Guinea Pig Lymphatic Leukemia
The B or T cell origin of the lymphocytes of human or animal leukemia has received little attention. In the present study, we have examined the functional and morphologic properties of a guinea pig lymphatic leukemia L 2 C. L 2 C cells secrete immunoglobulin and also bear this immunoglobulin on their surface.
Immune Response in Strain 2 Guinea Pigs to the Syngeneic L2C Leukemia
The L2C leukemia is a transplantable acute B lymphoblastic leukemia that arose spontaneously in a female strain 2 guinea pig (1). The presence of immunoglobulin (Ig) and complement receptors on the surface of L2C tumor cells has established the B lymphocyte lineage...
Additional Notes on Guinea Pig Leukemia Transmission Animal Vector
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