Dual GIP and GLP
Dual GIP and GLP-1 receptor agonist tirzepatide alleviates hepatic steatosis and modulates gut microbiota and bile acid metabolism in diabetic mice
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Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating GLP-1 levels through suppression of hepatic CYP8B1 expression and bile acid mediated inhibition of intestinal FXR signalling.
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Drugs that mimic the actions of GLP-1 or retard its degradation are effective treatments for diabetes, obesity, and their metabolic complications (e.g. non-alcoholic fatty liver disease). Altered gut and plasma levels of bile acids and GLP-1 are important for the clinical benefits of bariatric surgery.
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The aim of this study was to identify pathways important for GLP-1 release, and whether bile acids target their receptors on GLP-1 secreting L-cells from the apical or basolateral compartment.
Understanding Ozg Bile Acid Dynamics And Glp 1 Receptor Before the Gallery
Map of countries of dispatch of - 0c5d949b E868 42f0 Ae02 17e3bee62784. It gives the article a little more context before the image collection begins.
New Study Reveals How Hepatic Thyroid Hormone Signalling Modulates. This note connects the source idea with the visuals in a simple, reader-friendly way.
GLP-1 Receptor Agonists - ppt download. It works as a short bridge between the article summary and the gallery section.
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