Paracetamol Overdose Glutathione at Patricia Peralta blog

Paracetamol Overdose Glutathione. As a result, napqi accumulates, causing hepatocellular necrosis and possibly damage to other organs (eg, kidneys, pancreas). Paracetamol overdose is a common reason for admission to hospital for emergency treatment. 1g four times daily, max 4g/day. Paracetamol poisoning can cause severe hepatotoxicity owing to a minor but highly reactive metabolite produced by cytochrome p450 enzymes. An acute overdose depletes glutathione stores in the liver. 95% metabolised via glucuronidation, 5% via cytochrome p450 to toxic napqi, detoxified by glutathione. The mechanism of toxicity is well. The antidotes for paracetamol are based on the concept that toxicity of the drug is caused by metabolic conversion to a reactive.

Management of paracetamol overdose Paediatrics and Child Health
from www.paediatricsandchildhealthjournal.co.uk

An acute overdose depletes glutathione stores in the liver. Paracetamol poisoning can cause severe hepatotoxicity owing to a minor but highly reactive metabolite produced by cytochrome p450 enzymes. 1g four times daily, max 4g/day. The antidotes for paracetamol are based on the concept that toxicity of the drug is caused by metabolic conversion to a reactive. 95% metabolised via glucuronidation, 5% via cytochrome p450 to toxic napqi, detoxified by glutathione. As a result, napqi accumulates, causing hepatocellular necrosis and possibly damage to other organs (eg, kidneys, pancreas). Paracetamol overdose is a common reason for admission to hospital for emergency treatment. The mechanism of toxicity is well.

Management of paracetamol overdose Paediatrics and Child Health

Paracetamol Overdose Glutathione The antidotes for paracetamol are based on the concept that toxicity of the drug is caused by metabolic conversion to a reactive. Paracetamol poisoning can cause severe hepatotoxicity owing to a minor but highly reactive metabolite produced by cytochrome p450 enzymes. The mechanism of toxicity is well. As a result, napqi accumulates, causing hepatocellular necrosis and possibly damage to other organs (eg, kidneys, pancreas). 95% metabolised via glucuronidation, 5% via cytochrome p450 to toxic napqi, detoxified by glutathione. 1g four times daily, max 4g/day. The antidotes for paracetamol are based on the concept that toxicity of the drug is caused by metabolic conversion to a reactive. Paracetamol overdose is a common reason for admission to hospital for emergency treatment. An acute overdose depletes glutathione stores in the liver.

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