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        Ipledge updates from november 30, 2023.  what is the ipledge ® rems (risk evaluation and mitigation strategy)? Because isotretinoin medications (like absorica, claravis, etc.) can cause severe birth defects when taken during pregnancy, the ipledge program was created to help reduce the number of babies born with birth defects caused by isotretinoin. Abstinence means that you commit to not having sex with. What do prescribers need to know now about the changes?  study with quizlet and memorize flashcards containing terms like most women who got pregnant during isotretinoin treatment.   abstinence means that you commit to not having sex or sexual contact with any male 24 hours a day, 7 days a.  answer your comprehension questions in the ipledge program system.   ipledge requirements for men and women. The ipledge rems is a safety program to.
    
    	
            
	
		 
         
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