Bassoon Synapse at Cristina Andrew blog

Bassoon Synapse. Synapses are sophisticated cellular devices designed for the efficient and rapid communication between neurons via the. This study further reveals that a cdk5/pde4/camp axis controls neurotransmitter release. Use knockdown and knockout experiments of two major active zone proteins, bassoon and piccolo, to study their roles in synaptic proteostasis. We have investigated the role of the presynaptic cytomatrix protein bassoon, a major component of the photoreceptor ribbon, in a mouse retina deficient of functional bassoon protein. Synapses are sophisticated cellular devices designed for the efficient and rapid communication between neurons via the regulated release of neurotransmitter. The presynaptic proteins bassoon and piccolo interact with and inhibit the activity of the e3 ubiquitin ligase siah1 to regulate protein homeostasis and synaptic integrity. Photoreceptor ribbons lacking bassoon are not anchored to the presynaptic active zones. The presynaptic protein bassoon organizes synaptic vesicles into functional pools at glutamatergic synapses via regulation of presynaptic phosphorylation and camp homeostasis. A presynaptic active zone organizer protein bassoon orchestrates numerous important functions at the presynaptic active zone. They identify bassoon as a new regulator of presynaptic autophagy by its interaction with key autophagy protein atg5. These data reveal that bassoon organises sv pools in glutamatergic synapses via regulation of presynaptic phosphorylation and.

Bassoon Speeds Vesicle Reloading at a Central Excitatory Synapse Neuron
from www.cell.com

A presynaptic active zone organizer protein bassoon orchestrates numerous important functions at the presynaptic active zone. Synapses are sophisticated cellular devices designed for the efficient and rapid communication between neurons via the. Use knockdown and knockout experiments of two major active zone proteins, bassoon and piccolo, to study their roles in synaptic proteostasis. They identify bassoon as a new regulator of presynaptic autophagy by its interaction with key autophagy protein atg5. The presynaptic protein bassoon organizes synaptic vesicles into functional pools at glutamatergic synapses via regulation of presynaptic phosphorylation and camp homeostasis. Synapses are sophisticated cellular devices designed for the efficient and rapid communication between neurons via the regulated release of neurotransmitter. This study further reveals that a cdk5/pde4/camp axis controls neurotransmitter release. These data reveal that bassoon organises sv pools in glutamatergic synapses via regulation of presynaptic phosphorylation and. We have investigated the role of the presynaptic cytomatrix protein bassoon, a major component of the photoreceptor ribbon, in a mouse retina deficient of functional bassoon protein. The presynaptic proteins bassoon and piccolo interact with and inhibit the activity of the e3 ubiquitin ligase siah1 to regulate protein homeostasis and synaptic integrity.

Bassoon Speeds Vesicle Reloading at a Central Excitatory Synapse Neuron

Bassoon Synapse We have investigated the role of the presynaptic cytomatrix protein bassoon, a major component of the photoreceptor ribbon, in a mouse retina deficient of functional bassoon protein. A presynaptic active zone organizer protein bassoon orchestrates numerous important functions at the presynaptic active zone. The presynaptic protein bassoon organizes synaptic vesicles into functional pools at glutamatergic synapses via regulation of presynaptic phosphorylation and camp homeostasis. Photoreceptor ribbons lacking bassoon are not anchored to the presynaptic active zones. They identify bassoon as a new regulator of presynaptic autophagy by its interaction with key autophagy protein atg5. These data reveal that bassoon organises sv pools in glutamatergic synapses via regulation of presynaptic phosphorylation and. The presynaptic proteins bassoon and piccolo interact with and inhibit the activity of the e3 ubiquitin ligase siah1 to regulate protein homeostasis and synaptic integrity. Synapses are sophisticated cellular devices designed for the efficient and rapid communication between neurons via the. Use knockdown and knockout experiments of two major active zone proteins, bassoon and piccolo, to study their roles in synaptic proteostasis. We have investigated the role of the presynaptic cytomatrix protein bassoon, a major component of the photoreceptor ribbon, in a mouse retina deficient of functional bassoon protein. Synapses are sophisticated cellular devices designed for the efficient and rapid communication between neurons via the regulated release of neurotransmitter. This study further reveals that a cdk5/pde4/camp axis controls neurotransmitter release.

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