Flt3L enhances clonal diversification and selective expansion of ...
Chun et al. characterize the transition of tumor-infiltrating CD8+ T cell populations that are distinguished by asialo-ganglio-N-tetraosylceramide (asGM1) expression. They show that, while both in situ Flt3L expression and PD-1 inhibition promote the transition with acquisition of effector functions via IL-12, the former induces TCR repertoire diversification .
Together, these results indicate that Flt3L diversifies the TCR repertoire and promotes clonal selection and expansion of CD8+ T cells harboring specific CDR3 amino acid sequences during their differentiation into effector-like cells.
Flt3L enhances clonal diversification and selective expansion of ...
Moving forward, it's essential to keep these visual contexts in mind when discussing Flt3L Enhances Clonal Diversification And Selective Expansion.
Flt3L enhances clonal diversity and selective expansion of intratumoral CD8+T cells We next sought to determine whether Flt3L also influences the size and dynamics of the T cell receptor (TCR) repertoire.
Both therapies selectively expanded intratumoral CD8+ T cells, increased expression of Tpex and Teffector-like genes, and promoted the selective expansion and differentiation of asGM1neg into asGM1pos CD8+ T cells via cDC1-derived IL-12. However, only FLT3L enhanced clonal diversification and broadened the T cell repertoire.
Flt3L enhances clonal diversification and selective expansion of ...
Such details provide a deeper understanding and appreciation for Flt3L Enhances Clonal Diversification And Selective Expansion.
Both interventions selectively expand CD8+ T cells, but only Flt3L expression broadens their T cell receptor (TCR) repertoire. These data indicate the distinct role of Flt3L in diversifying the TCR repertoire, offering potential solutions for immune checkpoint blockade-resistant cancers.
Request PDF | On Dec 1, 2024, Dongmin Chun and others published Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like ...
Flt3L enhances clonal diversification and selective expansion of intratumoral CD8 T cells while differentiating into effector-like cells. / Chun, Dongmin; Park, Jiyeon; Lee, Seulgi et al.
As we can see from the illustration, Flt3L Enhances Clonal Diversification And Selective Expansion has many fascinating aspects to explore.
Flt3L expression or PD-1 inhibition induced differentiation of asGM1neg into asGM1pos CD8+ T cells via interleukin-12 (IL-12). These interventions enhanced Tpex and effector-like T cell gene expression and effector functions, selectively expanding CD8+ T cells. Flt3L expression uniquely broadened the TCR repertoire, unlike PD-1 inhibition.
Vol 43, Issue 12, 24 December 2024
Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells Dongmin Chun, Jiyeon Park, Seulgi Lee, Hyo Jae Kim, ... Suk-Jo Kang
Chun, Dongmin, et al. " Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells."
