Mitochondrial Dysfunction in CD4 T Effector Memory RA Cells
This study aims to assess mitochondrial dysfunction in CD4+ terminal effector memory T cells re-expressing CD45RA (TEMRA) cells and other CD4+ memory T cell subtypes, which are increased in number in the elderly population, with respect to how their metabolic responses to stimulation are altered compared to CD4+ naïve T cells .
In this study, we show that CD4+ TEMRA cells exhibit altered mitochondrial dynamics compared to CD4+ naïve cells and CD4+ central and effector memory cells , with a 25% reduction in OPA1 expression.
CD4+ TEMRA and memory cells show increased upregulation of Glucose transporter 1 following stimulation and higher levels of mitochondrial mass compared to CD4+ naïve T cells . Additionally, TEMRA cells exhibit a decrease in mitochondrial membrane potential compared to other CD4+ memory cell subsets by up to 50%.
This study aims to assess mitochondrial dysfunction in CD4+ terminal effector memory T cells re-expressing CD45RA (TEMRA) cells and other CD4+ memory T cell subtypes, which are increased in number in the elderly population, with respect to how their metabolic responses to stimulation are altered compared to CD4+ naïve T cells .
Mitochondrial Dysfunction in CD4 T Effector Memory RA Cells
Strickland, M.; Lee, S.; Neo, S.Y.; Balachander, A.; Low, I.; Mustafah, S.; Goh, W.I.; Wright, G.D.; Larbi, A.; Pender, S.L.F. Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells .
Mitochondrial Dysfunction in CD4 T Effector Memory RA Cells
Reducing mitochondrial function in human CD4+ T cells , through the addition of low‐dose rotenone, causes the generation of a CD 4+ T cell with a CD8+‐like phenotype, and it is proposed that it is the inherent metabolic stability that governs the susceptibility to an immunosenescent phenotype.
Such details provide a deeper understanding and appreciation for Mitochondrial Dysfunction In Cd4 Plus T Effector Memory Ra Plus Cells.
Arrows indicate an increase or decrease in the respective parameter. from publication: Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells | Human ageing is accompanied by poor responses ...
PDF Mitochondrial Dysfunction in CD4 T E ector Memory RA
This study aims to assess mitochondrial dysfunction in CD4+ terminal effector memory T cells re- expressing CD45RA (TEMRA) cells and other CD4+ memory T cell subtypes, which are increased in ...
Abstract Cellular metabolism modulates effector functions in human CD4 + T (Th) cells by providing energy and building blocks. Conversely, cellular metabolic responses are modulated by various influences, e.g., age. Thus, we hypothesized that metabolic reprogramming in human Th cells during aging modulates effector functions and contributes to "inflammaging", an aging-related, chronic ...
