Ciliberto-J-Cell-Biol-2003-morphogenesis-checkpoint-continuous.omex
title: Morphogenesis checkpoint in budding yeast (continuous) (Ciliberto et al., J Cell Biol, 2003)
abstract: Continuous kinetic model of the molecular network that controls Swe1 and the regulation of cyclin-dependent kinase.
keyword: cell cycle
keyword: cell division
keyword: cyclin-dependent kinase
keyword: morphogenesis
keyword: signal transduction
description: Set of ordinary differential equations that model the molecular network that controls Swe1 and the regulation of cyclin-dependent kinase. The model is based on published observations of budding yeast and analogous control signals in fission yeast. Simulations of the model accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.
has taxon: Schizosaccharomyces pombe
  identifier: http://identifiers.org/taxonomy/4896
encodes: cell cycle
  identifier: kegg.pathway:ko04111
encodes: anatomical structure morphogenesis
  identifier: GO:0009653
encodes: mitotic morphogenesis checkpoint signaling
  identifier: GO:0044879
is derived from: John J. Tyson & Bela Novak. Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. Journal of Theoretical Biology 210 (2001): 249-263.
  identifier: jtbi.2001.2293
is derived from:
  identifier: mbc.11.1.369
  label: Katherine C. Chen, Attila Csikasz-Nagy, Bela Gyorffy, John Val, Bela Novak & John J. Tyson. Kinetic analysis of a molecular model of the budding yeast cell cycle. Mololecular Biology of the Cell 11 (2000): 369-391.
is: biomodels.db:BIOMD0000000297
  identifier: biomodels.db:BIOMD0000000297
creator: Andrea Ciliberto
creator: Bela Novak
  account name: https://orcid.org/0000-0002-6961-1366
  identifier: orcid:0000-0002-6961-1366
creator: John J. Tyson
  account name: https://orcid.org/0000-0001-7560-6013
  identifier: orcid:0000-0001-7560-6013
contributor: Harish Dharuri
contributor: Jonathan Karr
  account name: https://orcid.org/0000-0002-2605-5080
  identifier: orcid:0000-0002-2605-5080
is described by: Andrea Ciliberto, Bela Novak & John J. Tyson. Cell Biology 163, 3 (2003): 1243-1254.
  identifier: jcb.200306139
license: CC0-1.0
  identifier: spdx:CC0-1.0
created:
  W3 CDTF: 2003-12-22
modified: 2021-06-26

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  identifier: jcb.200306139

Figure 3a
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  identifier: jcb.200306139