PreBotzinger Complex inspiratory neuron with NaP and CAN currents (Park and Rubin 2013)
We have built on earlier models to develop a single-compartment Hodgkin-Huxley type model incorporating NaP and CAN currents, both of which can play important roles in bursting of inspiratory neurons in the PreBotzinger Complex of the mammalian respiratory brain stem. The model tracks the evolution of membrane potential, related (in)activation variables, calcium concentration, and available fraction of IP3 channels. The model can produce several types of bursting, presented and analyzed from a dynamical systems perspective in our paper.
This is the readme for the model associated with the paper Park C, Rubin JE (2013) Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Botzinger complex neurons. J Comput Neurosci 34:345-66 This model written in XPP was implemented by Jon Rubin and Choongseok Park. XPP is freely available at <http://www.math.pitt.edu/~bard/xpp/xpp.html> To run the model in it's default setting start with a command like (depends on your platform): xppaut OneCellTwoOsc.ode Once XPP starts select Initalconds -> (G)o to see an figure like this: ![screenshot]([binary]) Inside XPP, use File -> Read set with the included set files to get certain dynamics from the paper: OneCellTwoOsc.ode.setsb the paper's Fig. 2a, ![fig 2a]([binary]) OneCellTwoOsc.ode.setdb the paper's Fig. 2b, ![fig 2b]([binary]) OneCellTwoOsc.ode.setsdb the paper's Fig. 2c ![fig 2c]([binary])
Neuron or other electrically excitable cell
Choongseok Park & Jonathan E. Rubin. Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Bötzinger complex neurons. Journal of Computational Neuroscience 34, 2: 345-366 (2013).