152292.omex
title: PreBotzinger Complex inspiratory neuron with NaP and CAN currents (Park and Rubin 2013)
abstract: We have built on earlier models to develop a single-compartment Hodgkin-Huxley type model incorporating NaP and CAN currents, both of which can play important roles in bursting of inspiratory neurons in the PreBotzinger Complex of the mammalian respiratory brain stem. The model tracks the evolution of membrane potential, related (in)activation variables, calcium concentration, and available fraction of IP3 channels. The model can produce several types of bursting, presented and analyzed from a dynamical systems perspective in our paper.
description: This is the readme for the model associated with the paper Park C, Rubin JE (2013) Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Botzinger complex neurons. J Comput Neurosci 34:345-66 This model written in XPP was implemented by Jon Rubin and Choongseok Park. XPP is freely available at <http://www.math.pitt.edu/~bard/xpp/xpp.html> To run the model in it's default setting start with a command like (depends on your platform): xppaut OneCellTwoOsc.ode Once XPP starts select Initalconds -> (G)o to see an figure like this: ![screenshot]([binary]) Inside XPP, use File -> Read set with the included set files to get certain dynamics from the paper: OneCellTwoOsc.ode.setsb the paper's Fig. 2a, ![fig 2a]([binary]) OneCellTwoOsc.ode.setdb the paper's Fig. 2b, ![fig 2b]([binary]) OneCellTwoOsc.ode.setsdb the paper's Fig. 2c ![fig 2c]([binary])
encodes: local:00001
encodes: local:00002
encodes: local:00003
encodes: local:00004
encodes: local:00005
encodes: local:00006
encodes: local:00007
encodes: local:00008
encodes: local:00009
encodes: local:00010
creator: local:00011
creator: local:00012
contributor: local:00013
contributor: local:00014
is: local:00015
is described by: local:00016
created: 2014-01-31
modified: 2017-09-13

Neuron or other electrically excitable cell
identifier: http://modeldb.science/ModelList

Respiratory column neuron
identifier: http://modeldb.science/ModelList

PreBotzinger complex neuron
identifier: http://modeldb.science/ModelList

I Na,p
identifier: http://modeldb.science/ModelList

I K
identifier: http://modeldb.science/ModelList

I CAN
identifier: http://modeldb.science/ModelList

I Sodium
identifier: http://modeldb.science/ModelList

AMPA
identifier: http://modeldb.science/ModelList

IP3
identifier: http://modeldb.science/ModelList

Bursting
identifier: http://modeldb.science/ModelList

Jonathan E Rubin

Choongseok Park

Sense Lab at Yale University
identifier: https://senselab.med.yale.edu/
account name: https://senselab.med.yale.edu/

Jonathan R. Karr
identifier: http://identifiers.org/orcid:0000-0002-2605-5080
account name: https://orcid.org/0000-0002-2605-5080

modeldb:152292
identifier: https://identifiers.org/modeldb:152292

00016
identifier: http://identifiers.org/doi:10.1007/s10827-012-0425-5
label: Choongseok Park & Jonathan E. Rubin. Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Bötzinger complex neurons. Journal of Computational Neuroscience 34, 2: 345-366 (2013).