227577.omex
title: Pallidostriatal projections promote beta oscillations (Corbit, Whalen, et al 2016)
abstract: This model consists of an inhibitory loop combining the projections from GPe neurons back to the striatum (shown experimentally to predominantly affect fast spiking interneurons, FSIs), together with the coupling from FSIs to medium spiny neurons (MSNs) in the striatum, along with the projections from MSNs to GPe. All models are in the Hodgkin-Huxley formalism, adapted from previously published models for each cell type. The connected circuit produces irregular activity under control conditions, but increasing FSI-to-MSN connectivity as observed experimentally under dopamine depletion yields exaggerated beta oscillations and synchrony. Additional mechanistic aspects are also explored.
description: This is the readme for the XPP model associated with the paper: Corbit VL, Whalen TC, Zitelli KT, Crilly SY, Rubin JE, Gittis AH (2016) Pallidostriatal Projections Promote ß Oscillations in a Dopamine-Depleted Biophysical Network Model. J Neurosci 36:5556-71 This model was contributed by Jon Rubin. Sample run in its default settings: start xpp with the ode file, for example on a mac os x unix installation type: xppaut Corbit2016\_basic\_PS.ode then from the gui select InitalConds -> Go which produces this graph: ![screenshot]([binary]) For the file to run, the included txt files must be in the same directory. These specify the connectivity pattern among the model neurons. Please see the comments at the top of the ode file for instructions on how to run in control and dopamine-depleted (DD) cases and for instructions on how to simulate this model in silent mode, which will save output (time points and voltages of all model neurons at those time points) in a data file as it is generated.
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is described by: local:00023
created: 2017-05-05
modified: 2017-05-12

Neuron or other electrically excitable cell
identifier: http://modeldb.science/ModelList

Realistic Network
identifier: http://modeldb.science/ModelList

Neuronal circuit

Basal ganglia
identifier: http://modeldb.science/ModelList

Globus pallidus neuron
identifier: http://modeldb.science/ModelList

Hodgkin-Huxley neuron
identifier: http://modeldb.science/ModelList

Neostriatum fast spiking interneuron
identifier: http://modeldb.science/ModelList

Neostriatum spiny neuron
identifier: http://modeldb.science/ModelList

Striatal FSIs, striatal MSNs

Gaba
identifier: http://modeldb.science/ModelList

Glutamate
identifier: http://modeldb.science/ModelList

GabaA
identifier: http://modeldb.science/ModelList

Glutamate
identifier: http://modeldb.science/ModelList

Oscillations
identifier: http://modeldb.science/ModelList

Synchronization
identifier: http://modeldb.science/ModelList

Jonathan E Rubin

Timothy C Whalen

Victoria L Corbit

Jonathan Rubin

Sense Lab at Yale University
identifier: https://senselab.med.yale.edu/
account name: https://senselab.med.yale.edu/

Jonathan R. Karr
identifier: http://identifiers.org/orcid:0000-0002-2605-5080
account name: https://orcid.org/0000-0002-2605-5080

modeldb:227577
identifier: https://identifiers.org/modeldb:227577

00023
identifier: http://identifiers.org/doi:10.1523/JNEUROSCI.0339-16.2016
label: V. L. Corbit, T. C. Whalen, K. T. Zitelli, S. Y. Crilly, J. E. Rubin & A. H. Gittis. Pallidostriatal Projections Promote β Oscillations in a Dopamine-Depleted Biophysical Network Model. Journal of Neuroscience 36, 20: 5556-5571 (2016).