239039.omex
title: Locational influence of dendritic PIC on input-output properties of spinal motoneurons (Kim 2017)
abstract: How does the dendritic location of calcium persistent inward current (Ca-PIC) influence dendritic excitability and firing behavior across the spinal motoneuron pool? This issue was investigated developing a model motoneuron pool where model parameters were analytically determined to reflect key motoneuron type-specific properties experimentally identified. The simulation results point out the negative relationship between the distance of Ca-PIC source from the soma and cell recruitment threshold as a basis underlying the systematic variation in input-output properties of motoneurons over the motoneuron pool.
description: Readme for the simulations associated with: Hojeong Kim, Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study, J App Physiol 123(5):1166-1187, 2017. The goal of this study is to investigate how the dendritic Ca-PIC location influences nonlinear input-output properties and depends on the type of motoneurons across the motoneuron pool. A model motoneuron pool consisting of 10 motoneurons was constructed using a recently developed two-compartment modeling approach that reflected key cell type-associated properties experimentally identified. The dendritic excitability and firing output depended systematically on both the PIC location and the motoneuron type. The PIC onset and offset in the current-voltage (I-V) relationship tended to occur at more hyperpolarized voltages as the path length to the PIC channels from the soma increased and as the cell type shifted from high- to low-threshold motoneurons. At the same time, the firing acceleration and frequency hysteresis in the frequency-current (F-I) relationship became faster and larger, respectively. However, the PIC onset-offset hysteresis increased as the path length and the recruitment threshold increased. Furthermore, the gain of frequency-current function before full PIC activation was larger for PIC channels located over distal dendritic regions in low- compared with high-threshold motoneurons. When compared with previously published experimental observations, the modeling concurred when Ca-PIC channels were placed closer to the soma in high- than low-threshold motoneurons in the model motoneuron pool. All of these results suggest that the negative relationship of Ca-PIC location and cell recruitment threshold may underlie the systematic variation in I-V and F-I transformation across the motoneuron pool. The direct comparison between the anatomical and reduced motoneuron model has been made for FR-type alpha-motoneu…
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is described by: local:00014
created: 2018-03-08
modified: 2018-03-08

Neuron or other electrically excitable cell
identifier: http://modeldb.science/ModelList

Spinal cord lumbar motor neuron alpha ACh cell
identifier: http://modeldb.science/ModelList

I Calcium
identifier: http://modeldb.science/ModelList

I Potassium
identifier: http://modeldb.science/ModelList

I Sodium
identifier: http://modeldb.science/ModelList

I_AHP
identifier: http://modeldb.science/ModelList

Active Dendrites
identifier: http://modeldb.science/ModelList

Hojeong Kim

Hojeong Kim

Sense Lab at Yale University
identifier: https://senselab.med.yale.edu/
account name: https://senselab.med.yale.edu/

Jonathan R. Karr
identifier: http://identifiers.org/orcid:0000-0002-2605-5080
account name: https://orcid.org/0000-0002-2605-5080

modeldb:239039
identifier: https://identifiers.org/modeldb:239039

00013
identifier: http://identifiers.org/doi:10.1152/japplphysiol.00034.2017
label: Hojeong Kim. Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study. Journal of Applied Physiology 123, 5: 1166-1187 (2017).

00014
identifier: http://identifiers.org/doi:10.1371/journal.pone.0095454
label: Hojeong Kim, Kelvin E. Jones & C. J. Heckman. Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons. PLoS ONE 9, 8: e95454 (2014).