RIGHT 0 conversion r8a KPase P K STOICHIOMETRY
type: Stoichiometry
physical entity: KPase_P_K
stoichiometric coefficient: 1.0

P_K
type: PhysicalEntity
member physical entity: Erk2-P
cellular location: compartment

KPase
type: PhysicalEntity
member physical entity: MAPK-Pase
cellular location: compartment

KPase_P_K
type: PhysicalEntity
member physical entity: MAPK-Pase_P-Erk2
cellular location: compartment

P-Mos_Mek1
type: Complex
xref: P12965
xref: Q05116

http://identifiers.org/pubmed/8816754
type: PublicationXref
id: 8816754
db: PubMed

PP_KK_P_K
type: PhysicalEntity
member physical entity: PP-Mek1_P-Erk2
cellular location: compartment

REACT 143
type: UnificationXref
id: REACT_143
db: Reactome

LEFT 0 conversion r8b KPase P K STOICHIOMETRY
type: Stoichiometry
physical entity: KPase_P_K
stoichiometric coefficient: 1.0

PP_KK
type: PhysicalEntity
member physical entity: Mek1-PP
cellular location: compartment

compartment
type: CellularLocationVocabulary

RIGHT 1 conversion r2b KKK STOICHIOMETRY
type: Stoichiometry
physical entity: KKK
stoichiometric coefficient: 1.0

RIGHT 0 conversion r6b P KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KK
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.12.2
type: UnificationXref
id: 2.7.12.2
db: Enzyme Nomenclature

Erk2-P
type: Protein
xref: P26696

REACT 1780
type: UnificationXref
id: REACT_1780
db: Reactome

LEFT 0 conversion r7a K STOICHIOMETRY
type: Stoichiometry
physical entity: K
stoichiometric coefficient: 1.0

MAPK-Pase_PP-Erk2
type: Complex
xref: P26696
xref: Q90W58

RIGHT 0 conversion r10b P K STOICHIOMETRY
type: Stoichiometry
physical entity: P_K
stoichiometric coefficient: 1.0

E1_Mos
type: Complex
xref: IPR003577
xref: P12965

LEFT 0 conversion r6b KKPase PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase_PP_KK
stoichiometric coefficient: 1.0

K_PP_norm
type: PhysicalEntity

RIGHT 1 conversion r4b KKPase STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase
stoichiometric coefficient: 1.0

LEFT 1 conversion r8a KPase STOICHIOMETRY
type: Stoichiometry
physical entity: KPase
stoichiometric coefficient: 1.0

LEFT 1 conversion r4a KKPase STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase
stoichiometric coefficient: 1.0

P_K
type: PhysicalEntity
member physical entity: Erk2-P
cellular location: compartment

RIGHT 0 conversion r10a KPase PP K STOICHIOMETRY
type: Stoichiometry
physical entity: KPase_PP_K
stoichiometric coefficient: 1.0

PP_KK
type: PhysicalEntity
member physical entity: Mek1-PP
cellular location: compartment

P_KKK_P_KK
type: PhysicalEntity
member physical entity: P-Mos_P-Mek1
cellular location: compartment

Erk2
type: Protein
xref: P26696

RIGHT 0 conversion r8b K STOICHIOMETRY
type: Stoichiometry
physical entity: K
stoichiometric coefficient: 1.0

RIGHT 1 conversion r6b KKPase STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase
stoichiometric coefficient: 1.0

RIGHT 0 conversion r1a E1 KKK STOICHIOMETRY
type: Stoichiometry
physical entity: E1_KKK
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.11.1
type: UnificationXref
id: 2.7.11.1
db: Enzyme Nomenclature

RIGHT 0 conversion r5a P KKK P KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK_P_KK
stoichiometric coefficient: 1.0

LEFT 1 conversion r9a PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK
stoichiometric coefficient: 1.0

RIGHT 0 conversion r5b PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK
stoichiometric coefficient: 1.0

REACT 495
type: UnificationXref
id: REACT_495
db: Reactome

REACT 136
type: UnificationXref
id: REACT_136
db: Reactome

KPase
type: PhysicalEntity
member physical entity: MAPK-Pase
cellular location: compartment

GO:0051019
type: UnificationXref
id: GO:0051019
db: Gene Ontology

P_KK
type: PhysicalEntity
member physical entity: Mek1-P
cellular location: compartment

LEFT 0 conversion r4a P KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KK
stoichiometric coefficient: 1.0

GO:0051389
type: UnificationXref
id: GO:0051389
db: Gene Ontology

P_KKK
type: PhysicalEntity
member physical entity: Mos-P
cellular location: compartment

E2_P_KKK
type: PhysicalEntity
member physical entity: E2_Mos-P
cellular location: compartment

MAPKKK activator (Ras)
type: Protein
xref: IPR003577

RIGHT 0 conversion r7b P K STOICHIOMETRY
type: Stoichiometry
physical entity: P_K
stoichiometric coefficient: 1.0

MODEL6615048798
type: UnificationXref
id: MODEL6615048798
db: BioModels Database

MAPKKK inactivator
type: PhysicalEntity

LEFT 0 conversion r9a P K STOICHIOMETRY
type: Stoichiometry
physical entity: P_K
stoichiometric coefficient: 1.0

P_K
type: PhysicalEntity
member physical entity: Erk2-P
cellular location: compartment

KKPase_P_KK
type: PhysicalEntity
member physical entity: MAPKK-Pase_P-Mek1
cellular location: compartment

RIGHT 1 conversion r9b PP K STOICHIOMETRY
type: Stoichiometry
physical entity: PP_K
stoichiometric coefficient: 1.0

binding of MAPKKK activator
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion r1a E1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r1a E1 KKK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r1a KKK STOICHIOMETRY
xref: REACT 996
xref: GO:0031435
right: E1_KKK
spontaneous: true
left: KKK
left: E1
conversion direction: LEFT_TO_RIGHT

MAPKKK activation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r1b E1 KKK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r1b E1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r1b P KKK STOICHIOMETRY
xref: GO:0008349
xref: REACT 525
xref: GO:0000185
xref: http://identifiers.org/ec-code/2.7.11.1
right: E1
right: P_KKK
spontaneous: true
left: E1_KKK
conversion direction: RIGHT_TO_LEFT

P_KKK
type: PhysicalEntity
member physical entity: Mos-P
cellular location: compartment

RIGHT 0 conversion r1b E1 STOICHIOMETRY
type: Stoichiometry
physical entity: E1
stoichiometric coefficient: 1.0

PP-Mek1_P-Erk2
type: Complex
xref: P26696
xref: Q05116

LEFT 0 conversion r2b E2 P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: E2_P_KKK
stoichiometric coefficient: 1.0

MAPK-Pase
type: Protein
xref: Q90W58

P_KKK_KK
type: PhysicalEntity
member physical entity: P-Mos_Mek1
cellular location: compartment

LEFT 0 conversion r4b KKPase P KK STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase_P_KK
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/8355
type: UnificationXref
id: 8355
db: Taxonomy

GO:0051390
type: UnificationXref
id: GO:0051390
db: Gene Ontology

KPase
type: PhysicalEntity
member physical entity: MAPK-Pase
cellular location: compartment

P_KKK
type: PhysicalEntity
member physical entity: Mos-P
cellular location: compartment

LEFT 0 conversion r5a P KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KK
stoichiometric coefficient: 1.0

KK_PP_norm
type: PhysicalEntity

MAPKKK inactivation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r2b E2 P KKK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r2b E2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r2b KKK STOICHIOMETRY
xref: GO:0006470
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0051390
right: KKK
right: E2
spontaneous: true
left: E2_P_KKK
conversion direction: RIGHT_TO_LEFT

KKK
type: PhysicalEntity
member physical entity: Mos
cellular location: compartment

binding of MAPKKK inactivator
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r2a P KKK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r2a E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r2a E2 P KKK STOICHIOMETRY
xref: GO:0031435
right: E2_P_KKK
spontaneous: true
left: P_KKK
left: E2
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion r2a E2 P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: E2_P_KKK
stoichiometric coefficient: 1.0

LEFT 1 conversion r3a P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK
stoichiometric coefficient: 1.0

KKPase_PP_KK
type: PhysicalEntity
member physical entity: MAPKK-Pase_PP-Mek1
cellular location: compartment

RIGHT 1 conversion r3b P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK
stoichiometric coefficient: 1.0

LEFT 0 conversion r2a P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK
stoichiometric coefficient: 1.0

LEFT 0 conversion r7b PP KK K STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK_K
stoichiometric coefficient: 1.0

BIOMD0000000009
type: Pathway
pathway component: dephosphorylation of PP-MAPK
pathway component: binding MAPK-Pase and PP-MAPK
pathway component: binding PP-MAPKK and P-MAPK
pathway component: binding MAPK and PP-MAPKK
pathway component: dephosphorylation of P-MAPK
pathway component: binding MAPK-Pase and P-MAPK
pathway component: phosphorylation of P-MAPK
pathway component: binding P-MAPKKK and P-MAPKK
pathway component: dephosphorylation of PP-MAPKK
pathway component: binding MAPKK-Pase and PP-MAPKK
pathway component: phosphorylation of MAPK
pathway component: binding P-MAPKKK and MAPKK
pathway component: dephosphorylation of P-MAPKK
pathway component: binding MAPKK-Pase and P-MAPKK
pathway component: phosphorylation of P-MAPKK
pathway component: binding of MAPKKK activator
pathway component: MAPKKK inactivation
pathway component: binding of MAPKKK inactivator
pathway component: phosphorylation of MAPKK
pathway component: MAPKKK activation
xref: REACT 634
xref: BIOMD0000000009
xref: MODEL6615048798
xref: GO:0000165
xref: http://identifiers.org/pubmed/8816754
organism: biosource 1
comment: The original model, 'BIOMD0000000009', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
data source: BioModels Database

relative maximal K_PP
type: PhysicalEntity

dephosphorylation of PP-MAPK
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion r10b P K STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r10b KPase STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r10b KPase PP K STOICHIOMETRY
xref: GO:0006470
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0000188
right: P_K
right: KPase
spontaneous: true
left: KPase_PP_K
conversion direction: RIGHT_TO_LEFT

binding MAPK-Pase and PP-MAPK
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion r10a KPase STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r10a PP K STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r10a KPase PP K STOICHIOMETRY
xref: GO:0051019
right: KPase_PP_K
spontaneous: true
left: KPase
left: PP_K
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion r8a P K STOICHIOMETRY
type: Stoichiometry
physical entity: P_K
stoichiometric coefficient: 1.0

MAPKK-Pase_PP-Mek1
type: Complex
xref: Q05116

PP_KK_K
type: PhysicalEntity
member physical entity: PP-Mek1_Erk2
cellular location: compartment

PP_KK
type: PhysicalEntity
member physical entity: Mek1-PP
cellular location: compartment

RIGHT 0 conversion r3b P KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KK
stoichiometric coefficient: 1.0

LEFT 1 conversion r10a KPase STOICHIOMETRY
type: Stoichiometry
physical entity: KPase
stoichiometric coefficient: 1.0

MAPK-Pase_P-Erk2
type: Complex
xref: P26696
xref: Q90W58

binding P-MAPKKK and MAPKK
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion r3a P KKK KK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r3a KK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r3a P KKK STOICHIOMETRY
xref: REACT 143
xref: GO:0031434
xref: GO:0031435
right: P_KKK_KK
spontaneous: true
left: KK
left: P_KKK
conversion direction: LEFT_TO_RIGHT

phosphorylation of MAPKK
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion r3b P KKK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r3b P KK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r3b P KKK KK STOICHIOMETRY
xref: REACT 614
xref: http://identifiers.org/ec-code/2.7.11.25
xref: GO:0004709
xref: GO:0006468
right: P_KK
right: P_KKK
spontaneous: true
left: P_KKK_KK
conversion direction: RIGHT_TO_LEFT

KKPase_P_KK
type: PhysicalEntity
member physical entity: MAPKK-Pase_P-Mek1
cellular location: compartment

Q05116
type: UnificationXref
id: Q05116
db: UniProt Knowledgebase

KKPase_PP_KK
type: PhysicalEntity
member physical entity: MAPKK-Pase_PP-Mek1
cellular location: compartment

PP_KK
type: PhysicalEntity
member physical entity: Mek1-PP
cellular location: compartment

PP_K
type: PhysicalEntity
member physical entity: Erk2-PP
cellular location: compartment

GO:0008349
type: UnificationXref
id: GO:0008349
db: Gene Ontology

E1
type: PhysicalEntity
member physical entity: MAPKKK activator (Ras)
cellular location: compartment

P_K
type: PhysicalEntity
member physical entity: Erk2-P
cellular location: compartment

Mos
type: Protein
xref: P12965

GO:0000186
type: UnificationXref
id: GO:0000186
db: Gene Ontology

GO:0000185
type: UnificationXref
id: GO:0000185
db: Gene Ontology

GO:0000188
type: UnificationXref
id: GO:0000188
db: Gene Ontology

LEFT 0 conversion r1b E1 KKK STOICHIOMETRY
type: Stoichiometry
physical entity: E1_KKK
stoichiometric coefficient: 1.0

KKPase
type: PhysicalEntity
member physical entity: MAPKK-Pase
cellular location: compartment

RIGHT 0 conversion r9a PP KK P K STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK_P_K
stoichiometric coefficient: 1.0

GO:0000187
type: UnificationXref
id: GO:0000187
db: Gene Ontology

Mos-P
type: Protein
xref: P12965

IPR003577
type: UnificationXref
id: IPR003577
db: InterPro

dephosphorylation of P-MAPKK
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion r4b KK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r4b KKPase STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r4b KKPase P KK STOICHIOMETRY
xref: GO:0006470
xref: http://identifiers.org/ec-code/3.1.3.16
right: KK
right: KKPase
spontaneous: true
left: KKPase_P_KK
conversion direction: RIGHT_TO_LEFT

binding MAPKK-Pase and P-MAPKK
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r4a P KK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r4a KKPase STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r4a KKPase P KK STOICHIOMETRY
xref: GO:0031434
right: KKPase_P_KK
spontaneous: true
left: P_KK
left: KKPase
conversion direction: LEFT_TO_RIGHT

LEFT 1 conversion r5a P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.11.25
type: UnificationXref
id: 2.7.11.25
db: Enzyme Nomenclature

LEFT 0 conversion r1a KKK STOICHIOMETRY
type: Stoichiometry
physical entity: KKK
stoichiometric coefficient: 1.0

RIGHT 0 conversion r4b KK STOICHIOMETRY
type: Stoichiometry
physical entity: KK
stoichiometric coefficient: 1.0

PP_KK
type: PhysicalEntity
member physical entity: Mek1-PP
cellular location: compartment

PP_KK_K
type: PhysicalEntity
member physical entity: PP-Mek1_Erk2
cellular location: compartment

LEFT 0 conversion r10a PP K STOICHIOMETRY
type: Stoichiometry
physical entity: PP_K
stoichiometric coefficient: 1.0

K
type: PhysicalEntity
member physical entity: Erk2
cellular location: compartment

E2_Mos-P
type: Complex
xref: P12965

RIGHT 1 conversion r5b P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK
stoichiometric coefficient: 1.0

KPase_PP_K
type: PhysicalEntity
member physical entity: MAPK-Pase_PP-Erk2
cellular location: compartment

binding P-MAPKKK and P-MAPKK
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r5a P KK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r5a P KKK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r5a P KKK P KK STOICHIOMETRY
xref: REACT 143
xref: GO:0031434
xref: GO:0031435
right: P_KKK_P_KK
spontaneous: true
left: P_KK
left: P_KKK
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion r2b E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

phosphorylation of P-MAPKK
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion r5b P KKK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r5b P KKK P KK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r5b PP KK STOICHIOMETRY
xref: REACT 614
xref: http://identifiers.org/ec-code/2.7.11.25
xref: GO:0004709
xref: GO:0000186
xref: GO:0006468
right: PP_KK
right: P_KKK
spontaneous: true
left: P_KKK_P_KK
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion r10b KPase PP K STOICHIOMETRY
type: Stoichiometry
physical entity: KPase_PP_K
stoichiometric coefficient: 1.0

LEFT 1 conversion r2a E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

LEFT 0 conversion r9b PP KK P K STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK_P_K
stoichiometric coefficient: 1.0

P_KK
type: PhysicalEntity
member physical entity: Mek1-P
cellular location: compartment

GO:0000165
type: UnificationXref
id: GO:0000165
db: Gene Ontology

REACT 2247
type: UnificationXref
id: REACT_2247
db: Reactome

dephosphorylation of PP-MAPKK
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r6b KKPase PP KK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r6b P KK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r6b KKPase STOICHIOMETRY
xref: GO:0006470
xref: GO:0051389
xref: http://identifiers.org/ec-code/3.1.3.16
right: KKPase
right: P_KK
spontaneous: true
left: KKPase_PP_KK
conversion direction: RIGHT_TO_LEFT

binding MAPKK-Pase and PP-MAPKK
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r6a PP KK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r6a KKPase STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r6a KKPase PP KK STOICHIOMETRY
xref: GO:0031434
right: KKPase_PP_KK
spontaneous: true
left: PP_KK
left: KKPase
conversion direction: LEFT_TO_RIGHT

REACT 525
type: UnificationXref
id: REACT_525
db: Reactome

RIGHT 0 conversion r4a KKPase P KK STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase_P_KK
stoichiometric coefficient: 1.0

KKPase
type: PhysicalEntity
member physical entity: MAPKK-Pase
cellular location: compartment

binding MAPK and PP-MAPKK
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion r7a PP KK K STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r7a PP KK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r7a K STOICHIOMETRY
xref: REACT 495
xref: GO:0031434
xref: REACT 1780
xref: GO:0051019
right: PP_KK_K
spontaneous: true
left: PP_KK
left: K
conversion direction: LEFT_TO_RIGHT

phosphorylation of MAPK
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r7b PP KK K STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r7b PP KK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r7b P K STOICHIOMETRY
xref: REACT 2247
xref: REACT 136
xref: GO:0004708
xref: http://identifiers.org/ec-code/2.7.12.2
xref: GO:0006468
right: P_K
right: PP_KK
spontaneous: true
left: PP_KK_K
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion r7b PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK
stoichiometric coefficient: 1.0

GO:0031434
type: UnificationXref
id: GO:0031434
db: Gene Ontology

LEFT 0 conversion r3b P KKK KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK_KK
stoichiometric coefficient: 1.0

BIOMD0000000009
type: UnificationXref
id: BIOMD0000000009
db: BioModels Database

K
type: PhysicalEntity
member physical entity: Erk2
cellular location: compartment

GO:0031435
type: UnificationXref
id: GO:0031435
db: Gene Ontology

Mek1
type: Protein
xref: Q05116

Mek1-PP
type: Protein
xref: Q05116

P_KKK_P_KK
type: PhysicalEntity
member physical entity: P-Mos_P-Mek1
cellular location: compartment

dephosphorylation of P-MAPK
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r8b KPase P K STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r8b K STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r8b KPase STOICHIOMETRY
xref: GO:0006470
xref: http://identifiers.org/ec-code/3.1.3.16
right: K
right: KPase
spontaneous: true
left: KPase_P_K
conversion direction: RIGHT_TO_LEFT

binding MAPK-Pase and P-MAPK
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion r8a KPase P K STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r8a KPase STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r8a P K STOICHIOMETRY
xref: GO:0051019
right: KPase_P_K
spontaneous: true
left: P_K
left: KPase
conversion direction: LEFT_TO_RIGHT

KK
type: PhysicalEntity
member physical entity: Mek1
cellular location: compartment

RIGHT 0 conversion r3a P KKK KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK_KK
stoichiometric coefficient: 1.0

LEFT 0 conversion r6a PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: MAPKKK inactivator
cellular location: compartment

KKPase
type: PhysicalEntity
member physical entity: MAPKK-Pase
cellular location: compartment

RIGHT 0 conversion r6a KKPase PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase_PP_KK
stoichiometric coefficient: 1.0

RIGHT 1 conversion r1b P KKK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK
stoichiometric coefficient: 1.0

P_KK
type: PhysicalEntity
member physical entity: Mek1-P
cellular location: compartment

Mek1-P
type: Protein
xref: Q05116

binding PP-MAPKK and P-MAPK
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion r9a PP KK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r9a PP KK P K STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r9a P K STOICHIOMETRY
xref: REACT 495
xref: GO:0031434
xref: REACT 1780
xref: GO:0051019
right: PP_KK_P_K
spontaneous: true
left: PP_KK
left: P_K
conversion direction: LEFT_TO_RIGHT

phosphorylation of P-MAPK
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion r9b PP KK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r9b PP K STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r9b PP KK P K STOICHIOMETRY
xref: REACT 2247
xref: GO:0004708
xref: REACT 136
xref: http://identifiers.org/ec-code/2.7.12.2
xref: GO:0000187
xref: GO:0006468
right: PP_KK
right: PP_K
spontaneous: true
left: PP_KK_P_K
conversion direction: RIGHT_TO_LEFT

KPase_PP_K
type: PhysicalEntity
member physical entity: MAPK-Pase_PP-Erk2
cellular location: compartment

P_KK
type: PhysicalEntity
member physical entity: Mek1-P
cellular location: compartment

RIGHT 1 conversion r10b KPase STOICHIOMETRY
type: Stoichiometry
physical entity: KPase
stoichiometric coefficient: 1.0

P_KKK
type: PhysicalEntity
member physical entity: Mos-P
cellular location: compartment

E2_P_KKK
type: PhysicalEntity
member physical entity: E2_Mos-P
cellular location: compartment

P12965
type: UnificationXref
id: P12965
db: UniProt Knowledgebase

RIGHT 0 conversion r7a PP KK K STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK_K
stoichiometric coefficient: 1.0

LEFT 1 conversion r7a PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK
stoichiometric coefficient: 1.0

PP_KK_P_K
type: PhysicalEntity
member physical entity: PP-Mek1_P-Erk2
cellular location: compartment

Q90W58
type: UnificationXref
id: Q90W58
db: UniProt Knowledgebase

LEFT 1 conversion r1a E1 STOICHIOMETRY
type: Stoichiometry
physical entity: E1
stoichiometric coefficient: 1.0

KPase
type: PhysicalEntity
member physical entity: MAPK-Pase
cellular location: compartment

REACT 634
type: UnificationXref
id: REACT_634
db: Reactome

REACT 996
type: UnificationXref
id: REACT_996
db: Reactome

KPase_P_K
type: PhysicalEntity
member physical entity: MAPK-Pase_P-Erk2
cellular location: compartment

E1_KKK
type: PhysicalEntity
member physical entity: E1_Mos
cellular location: compartment

P_KKK_KK
type: PhysicalEntity
member physical entity: P-Mos_Mek1
cellular location: compartment

GO:0006468
type: UnificationXref
id: GO:0006468
db: Gene Ontology

GO:0006470
type: UnificationXref
id: GO:0006470
db: Gene Ontology

P-Mos_P-Mek1
type: Complex
xref: P12965
xref: Q05116

MAPKK-Pase_P-Mek1
type: Complex
xref: Q05116

P26696
type: UnificationXref
id: P26696
db: UniProt Knowledgebase

KKK
type: PhysicalEntity
member physical entity: Mos
cellular location: compartment

P_KKK
type: PhysicalEntity
member physical entity: Mos-P
cellular location: compartment

RIGHT 1 conversion r8b KPase STOICHIOMETRY
type: Stoichiometry
physical entity: KPase
stoichiometric coefficient: 1.0

P_KKK
type: PhysicalEntity
member physical entity: Mos-P
cellular location: compartment

KK
type: PhysicalEntity
member physical entity: Mek1
cellular location: compartment

MAPKK-Pase
type: PhysicalEntity

E1
type: PhysicalEntity
member physical entity: MAPKKK activator (Ras)
cellular location: compartment

RIGHT 0 conversion r9b PP KK STOICHIOMETRY
type: Stoichiometry
physical entity: PP_KK
stoichiometric coefficient: 1.0

LEFT 0 conversion r3a KK STOICHIOMETRY
type: Stoichiometry
physical entity: KK
stoichiometric coefficient: 1.0

LEFT 1 conversion r6a KKPase STOICHIOMETRY
type: Stoichiometry
physical entity: KKPase
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: MAPKKK inactivator
cellular location: compartment

LEFT 0 conversion r5b P KKK P KK STOICHIOMETRY
type: Stoichiometry
physical entity: P_KKK_P_KK
stoichiometric coefficient: 1.0

PP_KK
type: PhysicalEntity
member physical entity: Mek1-PP
cellular location: compartment

PP-Mek1_Erk2
type: Complex
xref: P26696
xref: Q05116

KKPase
type: PhysicalEntity
member physical entity: MAPKK-Pase
cellular location: compartment

BioModels Database
type: Provenance
xref: BIOMD0000000009

GO:0004708
type: UnificationXref
id: GO:0004708
db: Gene Ontology

PP_K
type: PhysicalEntity
member physical entity: Erk2-PP
cellular location: compartment

REACT 614
type: UnificationXref
id: REACT_614
db: Reactome

Erk2-PP
type: Protein
xref: P26696

BioModels Database
type: Provenance
xref: MODEL6615048798

KKK_P_norm
type: PhysicalEntity

http://identifiers.org/ec-code/3.1.3.16
type: UnificationXref
id: 3.1.3.16
db: Enzyme Nomenclature

GO:0004709
type: UnificationXref
id: GO:0004709
db: Gene Ontology

E1_KKK
type: PhysicalEntity
member physical entity: E1_Mos
cellular location: compartment