LEFT 0 conversion v4 lRIRII STOICHIOMETRY
type: Stoichiometry
physical entity: lRIRII
stoichiometric coefficient: 1.0

BIOMD0000000101
type: UnificationXref
id: BIOMD0000000101
db: BioModels Database

GO:0005768
type: UnificationXref
id: GO:0005768
db: Gene Ontology

RI
type: PhysicalEntity
member physical entity: Receptor 1
cellular location: Plasma membrane

RI
type: PhysicalEntity
member physical entity: Receptor 1
cellular location: Plasma membrane

http://identifiers.org/taxonomy/131567
type: UnificationXref
id: 131567
db: Taxonomy

GO:0006412
type: UnificationXref
id: GO:0006412
db: Gene Ontology

ligand receptor complex-endosome
type: Complex
xref: P01137
xref: P36897
xref: P37173

GO:0001881
type: UnificationXref
id: GO:0001881
db: Gene Ontology

RII
type: PhysicalEntity
member physical entity: Receptor 2
cellular location: Plasma membrane

GO:0005886
type: UnificationXref
id: GO:0005886
db: Gene Ontology

RII_endo
type: PhysicalEntity
member physical entity: Receptor 2 endosome
cellular location: Endosome

RII
type: PhysicalEntity
member physical entity: Receptor 2
cellular location: Plasma membrane

RIGHT 0 conversion v4 lRIRII endo STOICHIOMETRY
type: Stoichiometry
physical entity: lRIRII_endo
stoichiometric coefficient: 1.0

lRIRII_endo
type: PhysicalEntity
member physical entity: ligand receptor complex-endosome
cellular location: Endosome

RI_endo
type: PhysicalEntity
member physical entity: Receptor 1-endosome
cellular location: Endosome

RI
type: PhysicalEntity
member physical entity: Receptor 1
cellular location: Plasma membrane

RIGHT 0 conversion v1 lRIRII STOICHIOMETRY
type: Stoichiometry
physical entity: lRIRII
stoichiometric coefficient: 1.0

Endosome
type: CellularLocationVocabulary
xref: GO:0005768

RII
type: PhysicalEntity
member physical entity: Receptor 2
cellular location: Plasma membrane

RIGHT 0 conversion v10 RII STOICHIOMETRY
type: Stoichiometry
physical entity: RII
stoichiometric coefficient: 1.0

ligand receptor complex-plasma membrane
type: Complex
xref: P01137
xref: P36897
xref: P37173

RI
type: PhysicalEntity
member physical entity: Receptor 1
cellular location: Plasma membrane

LEFT 0 conversion v1 RII STOICHIOMETRY
type: Stoichiometry
physical entity: RII
stoichiometric coefficient: 1.0

P36897
type: UnificationXref
id: P36897
db: UniProt Knowledgebase

LEFT 0 conversion v9 lRIRII endo STOICHIOMETRY
type: Stoichiometry
physical entity: lRIRII_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion v7 RI endo STOICHIOMETRY
type: Stoichiometry
physical entity: RI_endo
stoichiometric coefficient: 1.0

LEFT 0 conversion v6 RI STOICHIOMETRY
type: Stoichiometry
physical entity: RI
stoichiometric coefficient: 1.0

RII
type: PhysicalEntity
member physical entity: Receptor 2
cellular location: Plasma membrane

lRIRII
type: PhysicalEntity
member physical entity: ligand receptor complex-plasma membrane
cellular location: Plasma membrane

lRIRII
type: PhysicalEntity
member physical entity: ligand receptor complex-plasma membrane
cellular location: Plasma membrane

P01137
type: UnificationXref
id: P01137
db: UniProt Knowledgebase

RIGHT 1 conversion v9 RII STOICHIOMETRY
type: Stoichiometry
physical entity: RII
stoichiometric coefficient: 1.0

Receptor 1
type: Protein
xref: P36897

LEFT 0 conversion v8 RI endo STOICHIOMETRY
type: Stoichiometry
physical entity: RI_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion v9 RI STOICHIOMETRY
type: Stoichiometry
physical entity: RI
stoichiometric coefficient: 1.0

LEFT 0 conversion v12 RII STOICHIOMETRY
type: Stoichiometry
physical entity: RII
stoichiometric coefficient: 1.0

RI_endo
type: PhysicalEntity
member physical entity: Receptor 1-endosome
cellular location: Endosome

GO:0030512
type: UnificationXref
id: GO:0030512
db: Gene Ontology

lRIRII_endo
type: PhysicalEntity
member physical entity: ligand receptor complex-endosome
cellular location: Endosome

GO:0030511
type: UnificationXref
id: GO:0030511
db: Gene Ontology

LEFT 1 conversion v1 RI STOICHIOMETRY
type: Stoichiometry
physical entity: RI
stoichiometric coefficient: 1.0

RIGHT 0 conversion v13 RII STOICHIOMETRY
type: Stoichiometry
physical entity: RII
stoichiometric coefficient: 1.0

REACT 6844.3
type: UnificationXref
id: REACT_6844.3
db: Reactome

GO:0050431
type: UnificationXref
id: GO:0050431
db: Gene Ontology

Ligand receptor complex formation
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion v1 RI STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v1 RII STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v1 lRIRII STOICHIOMETRY
xref: GO:0050431
xref: GO:0007181
right: lRIRII
spontaneous: true
left: RI
left: RII
conversion direction: LEFT_TO_RIGHT

Ligand receptor complex constitutive degradation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion v2 lRIRII STOICHIOMETRY
xref: GO:0030512
spontaneous: true
left: lRIRII
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion v5 RI STOICHIOMETRY
type: Stoichiometry
physical entity: RI
stoichiometric coefficient: 1.0

RII
type: PhysicalEntity
member physical entity: Receptor 2
cellular location: Plasma membrane

Ligand independent complex degradation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion v3 lRIRII STOICHIOMETRY
xref: GO:0030512
spontaneous: true
left: lRIRII
conversion direction: RIGHT_TO_LEFT

Receptor 1-endosome
type: Protein
xref: P36897

RI
type: PhysicalEntity
member physical entity: Receptor 1
cellular location: Plasma membrane

Ligand receptor complex internalization
type: Transport
participant stoichiometry: LEFT 0 conversion v4 lRIRII STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v4 lRIRII endo STOICHIOMETRY
xref: GO:0030511
right: lRIRII_endo
left: lRIRII

lRIRII
type: PhysicalEntity
member physical entity: ligand receptor complex-plasma membrane
cellular location: Plasma membrane

RI synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v5 RI STOICHIOMETRY
xref: GO:0006412
right: RI

RI constitutive degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v6 RI STOICHIOMETRY
xref: GO:0032801
left: RI

RI internalization
type: Transport
participant stoichiometry: LEFT 0 conversion v7 RI STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v7 RI endo STOICHIOMETRY
xref: GO:0031623
right: RI_endo
left: RI

RI recycling
type: Transport
participant stoichiometry: LEFT 0 conversion v8 RI endo STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v8 RI STOICHIOMETRY
xref: GO:0001881
right: RI
left: RI_endo

Ligand Receptor complex recycling
type: Transport
participant stoichiometry: RIGHT 1 conversion v9 RII STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v9 lRIRII endo STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v9 RI STOICHIOMETRY
xref: GO:0001881
right: RI
right: RII
left: lRIRII_endo

MODEL4023382414
type: UnificationXref
id: MODEL4023382414
db: BioModels Database

P37173
type: UnificationXref
id: P37173
db: UniProt Knowledgebase

LEFT 0 conversion v2 lRIRII STOICHIOMETRY
type: Stoichiometry
physical entity: lRIRII
stoichiometric coefficient: 1.0

LEFT 0 conversion v13 RII endo STOICHIOMETRY
type: Stoichiometry
physical entity: RII_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion v12 RII endo STOICHIOMETRY
type: Stoichiometry
physical entity: RII_endo
stoichiometric coefficient: 1.0

LEFT 0 conversion v11 RII STOICHIOMETRY
type: Stoichiometry
physical entity: RII
stoichiometric coefficient: 1.0

GO:0032801
type: UnificationXref
id: GO:0032801
db: Gene Ontology

RII
type: PhysicalEntity
member physical entity: Receptor 2
cellular location: Plasma membrane

BioModels Database
type: Provenance
xref: BIOMD0000000101

http://identifiers.org/pubmed/16446785
type: PublicationXref
id: 16446785
db: PubMed

LEFT 0 conversion v7 RI STOICHIOMETRY
type: Stoichiometry
physical entity: RI
stoichiometric coefficient: 1.0

hsa04350
type: UnificationXref
id: hsa04350
db: KEGG Pathway

Receptor 2 endosome
type: Protein
xref: P37173

RI
type: PhysicalEntity
member physical entity: Receptor 1
cellular location: Plasma membrane

RII_endo
type: PhysicalEntity
member physical entity: Receptor 2 endosome
cellular location: Endosome

LEFT 0 conversion v3 lRIRII STOICHIOMETRY
type: Stoichiometry
physical entity: lRIRII
stoichiometric coefficient: 1.0

RIGHT 0 conversion v8 RI STOICHIOMETRY
type: Stoichiometry
physical entity: RI
stoichiometric coefficient: 1.0

GO:0007179
type: UnificationXref
id: GO:0007179
db: Gene Ontology

RII constitutive degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v11 RII STOICHIOMETRY
xref: GO:0032801
left: RII

lRIRII
type: PhysicalEntity
member physical entity: ligand receptor complex-plasma membrane
cellular location: Plasma membrane

RII synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v10 RII STOICHIOMETRY
xref: GO:0006412
right: RII

RII recycling
type: Transport
participant stoichiometry: RIGHT 0 conversion v13 RII STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v13 RII endo STOICHIOMETRY
xref: GO:0001881
right: RII
left: RII_endo

BioModels Database
type: Provenance
xref: MODEL4023382414

RII internalization
type: Transport
participant stoichiometry: RIGHT 0 conversion v12 RII endo STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v12 RII STOICHIOMETRY
xref: GO:0031623
right: RII_endo
left: RII

Receptor 2
type: Protein
xref: P37173

Vilar2006 TGFbeta
type: Pathway
pathway component: Ligand receptor complex formation
pathway component: Ligand receptor complex constitutive degradation
pathway component: Ligand independent complex degradation
pathway component: Ligand receptor complex internalization
pathway component: RI synthesis
pathway component: RI constitutive degradation
pathway component: RI internalization
pathway component: RI recycling
pathway component: Ligand Receptor complex recycling
pathway component: RII constitutive degradation
pathway component: RII synthesis
pathway component: RII recycling
pathway component: RII internalization
xref: http://identifiers.org/pubmed/16446785
xref: BIOMD0000000101
xref: hsa04350
xref: REACT 6844.3
xref: GO:0007179
xref: MODEL4023382414
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Vilar2006_TGFbeta', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

GO:0007181
type: UnificationXref
id: GO:0007181
db: Gene Ontology

Plasma membrane
type: CellularLocationVocabulary
xref: GO:0005886

GO:0031623
type: UnificationXref
id: GO:0031623
db: Gene Ontology