RIGHT 0 conversion reaction 0000034 internalization STOICHIOMETRY
type: Stoichiometry
physical entity: internalization
stoichiometric coefficient: 1.0

RHRG2
type: Complex
xref: IPR002154
xref: GO:0043235

GS
type: PhysicalEntity
member physical entity: GS
cellular location: cell

IPR008350
type: UnificationXref
id: IPR008350
db: InterPro

ShGS
type: PhysicalEntity

LEFT 0 conversion reaction 0000026 PI3Kstar STOICHIOMETRY
type: Stoichiometry
physical entity: PI3Kstar
stoichiometric coefficient: 1.0

Akt
type: PhysicalEntity
member physical entity: Akt
cellular location: cell

AktPIP
type: PhysicalEntity
member physical entity: AktPIP
cellular location: cell

IPR000980
type: UnificationXref
id: IPR000980
db: InterPro

GO:0038127
type: UnificationXref
id: GO:0038127
db: Gene Ontology

GS
type: PhysicalEntity
member physical entity: GS
cellular location: cell

PI3K
type: PhysicalEntity
xref: GO:0005942

LEFT 0 conversion reaction 0000034 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

P_I
type: SmallMolecule
xref: CHEBI:26034

LEFT 0 conversion reaction 0000008 RShGS STOICHIOMETRY
type: Stoichiometry
physical entity: RShGS
stoichiometric coefficient: 1.0

GO:0032147
type: UnificationXref
id: GO:0032147
db: Gene Ontology

MKP3
type: Protein
xref: Q9DBB1

RHRG
type: PhysicalEntity
member physical entity: RHRG
cellular location: cell

LEFT 0 conversion reaction 0000009 ShGS STOICHIOMETRY
type: Stoichiometry
physical entity: ShGS
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000003 RHRG2 STOICHIOMETRY
type: Stoichiometry
physical entity: RHRG2
stoichiometric coefficient: 1.0

PI3Kstar
type: PhysicalEntity
member physical entity: PI3Kstar
cellular location: cell

LEFT 1 conversion reaction 0000023 PI3K STOICHIOMETRY
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000025 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

RShc
type: PhysicalEntity
member physical entity: RShc
cellular location: cell

internalization
type: PhysicalEntity

RHRG2
type: PhysicalEntity
member physical entity: RHRG2
cellular location: cell

RP
type: PhysicalEntity
xref: GO:0043235

LEFT 0 conversion reaction 0000029 PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

E
type: PhysicalEntity

model_0000001
type: Pathway
pathway component: reaction_0000031
pathway component: reaction_0000030
pathway component: reaction_0000011
pathway component: reaction_0000033
pathway component: reaction_0000010
pathway component: reaction_0000032
pathway component: reaction_0000013
pathway component: reaction_0000012
pathway component: reaction_0000034
pathway component: reaction_0000015
pathway component: reaction_0000014
pathway component: reaction_0000017
pathway component: reaction_0000016
pathway component: reaction_0000019
pathway component: reaction_0000018
pathway component: reaction_0000020
pathway component: reaction_0000022
pathway component: reaction_0000021
pathway component: reaction_0000002
pathway component: reaction_0000024
pathway component: reaction_0000001
pathway component: reaction_0000023
pathway component: reaction_0000004
pathway component: reaction_0000026
pathway component: reaction_0000003
pathway component: reaction_0000025
pathway component: reaction_0000006
pathway component: reaction_0000028
pathway component: reaction_0000005
pathway component: reaction_0000027
pathway component: reaction_0000008
pathway component: reaction_0000007
pathway component: reaction_0000029
pathway component: reaction_0000009
xref: BIOMD0000000048
xref: http://identifiers.org/pubmed/11772030
xref: BIOMD0000000146
xref: GO:0038127
xref: BIOMD0000000010
xref: MODEL8256371999
xref: http://identifiers.org/pubmed/12691603
xref: BIOMD0000000019
xref: GO:0043405
xref: GO:0051896
xref: MAMO_0000046
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'model_0000001', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

ERKPP
type: Complex
xref: IPR008350
xref: CHEBI:18361
xref: IPR008349

LEFT 0 conversion reaction 0000007 RShP STOICHIOMETRY
type: Stoichiometry
physical entity: RShP
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000001 R STOICHIOMETRY
type: Stoichiometry
physical entity: R
stoichiometric coefficient: 1.0

MEKP
type: PhysicalEntity
member physical entity: MEKP
cellular location: cell

R
type: Protein
xref: GO:0043235
xref: Q15303

GO:0007171
type: UnificationXref
id: GO:0007171
db: Gene Ontology

ShGS
type: PhysicalEntity
member physical entity: ShGS
cellular location: cell

RShP
type: PhysicalEntity
member physical entity: RShP
cellular location: cell

AktPIP3
type: PhysicalEntity
member physical entity: AktPIP3
cellular location: cell

ERKP
type: PhysicalEntity
member physical entity: ERKP
cellular location: cell

RIGHT 0 conversion reaction 0000022 ERKP STOICHIOMETRY
type: Stoichiometry
physical entity: ERKP
stoichiometric coefficient: 1.0

GO:0016311
type: UnificationXref
id: GO:0016311
db: Gene Ontology

LEFT 0 conversion reaction 0000004 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000012 RasGTP STOICHIOMETRY
type: Stoichiometry
physical entity: RasGTP
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000008 ShGS STOICHIOMETRY
type: Stoichiometry
physical entity: ShGS
stoichiometric coefficient: 1.0

Rafstar
type: PhysicalEntity
member physical entity: Rafstar
cellular location: cell

IPR015592
type: UnificationXref
id: IPR015592
db: InterPro

PP2A
type: PhysicalEntity
xref: GO:0000159

HRG
type: PhysicalEntity
member physical entity: HRG
cellular location: cell

LEFT 0 conversion reaction 0000014 Rafstar STOICHIOMETRY
type: Stoichiometry
physical entity: Rafstar
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000011 RasGTP STOICHIOMETRY
type: Stoichiometry
physical entity: RasGTP
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000029 AktPIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP3
stoichiometric coefficient: 1.0

ShP
type: PhysicalEntity

HRG
type: Protein
xref: IPR002154

ERKP
type: PhysicalEntity
member physical entity: ERKP
cellular location: cell

RIGHT 0 conversion reaction 0000023 RPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: RPI3K
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000006 RShc STOICHIOMETRY
type: Stoichiometry
physical entity: RShc
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 0000025 PI3Kstar STOICHIOMETRY
type: Stoichiometry
physical entity: PI3Kstar
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 0000001 HRG STOICHIOMETRY
type: Stoichiometry
physical entity: HRG
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 0000007 GS STOICHIOMETRY
type: Stoichiometry
physical entity: GS
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000033 AktPIP STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP
stoichiometric coefficient: 1.0

GO:0004672
type: UnificationXref
id: GO:0004672
db: Gene Ontology

GO:0043405
type: UnificationXref
id: GO:0043405
db: Gene Ontology

Shc
type: Protein
xref: IPR001452
xref: IPR000980

RPI3Kstar
type: PhysicalEntity
member physical entity: RPI3Kstar
cellular location: cell

MODEL8256371999
type: UnificationXref
id: MODEL8256371999
db: BioModels Database

Shc
type: PhysicalEntity
member physical entity: Shc
cellular location: cell

RasGTP
type: PhysicalEntity
member physical entity: RasGTP
cellular location: cell

RIGHT 0 conversion reaction 0000028 P I STOICHIOMETRY
type: Stoichiometry
physical entity: P_I
stoichiometric coefficient: 1.0

MAMO_0000046
type: UnificationXref
id: MAMO_0000046
db: Mathematical Modelling Ontology

LEFT 0 conversion reaction 0000018 MEKPP STOICHIOMETRY
type: Stoichiometry
physical entity: MEKPP
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000004 RHRG2 STOICHIOMETRY
type: Stoichiometry
physical entity: RHRG2
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000016 MEKP STOICHIOMETRY
type: Stoichiometry
physical entity: MEKP
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000017 MEKP STOICHIOMETRY
type: Stoichiometry
physical entity: MEKP
stoichiometric coefficient: 1.0

RHRG
type: PhysicalEntity
member physical entity: RHRG
cellular location: cell

P15056
type: UnificationXref
id: P15056
db: UniProt Knowledgebase

P_I
type: PhysicalEntity
member physical entity: P_I
cellular location: cell

MEKPP
type: Complex
xref: IPR003527
xref: CHEBI:35782

IPR002154
type: UnificationXref
id: IPR002154
db: InterPro

RIGHT 0 conversion reaction 0000016 MEK STOICHIOMETRY
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000017 MEKPP STOICHIOMETRY
type: Stoichiometry
physical entity: MEKPP
stoichiometric coefficient: 1.0

GO:0016303
type: UnificationXref
id: GO:0016303
db: Gene Ontology

AktPIP
type: PhysicalEntity
member physical entity: AktPIP
cellular location: cell

CHEBI:26034
type: UnificationXref
id: CHEBI:26034
db: ChEBI

RIGHT 0 conversion reaction 0000030 AktPIP STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP
stoichiometric coefficient: 1.0

AktPIP
type: Complex
xref: CHEBI:26034
xref: IPR015744

LEFT 0 conversion reaction 0000019 ERK STOICHIOMETRY
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000024 RPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: RPI3K
stoichiometric coefficient: 1.0

GO:0005623
type: UnificationXref
id: GO:0005623
db: Gene Ontology

CHEBI:35782
type: UnificationXref
id: CHEBI:35782
db: ChEBI

RHRG
type: Complex
xref: IPR002154
xref: GO:0043235

RPI3K
type: PhysicalEntity
member physical entity: RPI3K
cellular location: cell

RShP
type: PhysicalEntity

ShP
type: PhysicalEntity
member physical entity: ShP
cellular location: cell

GO:0032320
type: UnificationXref
id: GO:0032320
db: Gene Ontology

RIGHT 0 conversion reaction 0000021 ERKPP STOICHIOMETRY
type: Stoichiometry
physical entity: ERKPP
stoichiometric coefficient: 1.0

MEKP
type: Complex
xref: CHEBI:18367
xref: IPR003527

RShc
type: PhysicalEntity

http://identifiers.org/pubmed/12691603
type: PublicationXref
id: 12691603
db: PubMed

RIGHT 0 conversion reaction 0000013 Rafstar STOICHIOMETRY
type: Stoichiometry
physical entity: Rafstar
stoichiometric coefficient: 1.0

GO:0005515
type: UnificationXref
id: GO:0005515
db: Gene Ontology

AktPIPP
type: PhysicalEntity
member physical entity: AktPIPP
cellular location: cell

IPR008349
type: UnificationXref
id: IPR008349
db: InterPro

GS
type: PhysicalEntity

Raf
type: PhysicalEntity
member physical entity: Raf
cellular location: cell

ERKP
type: Complex
xref: CHEBI:18367
xref: IPR008350
xref: IPR008349

CHEBI:17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

RPI3K
type: PhysicalEntity
member physical entity: RPI3K
cellular location: cell

GO:0000159
type: UnificationXref
id: GO:0000159
db: Gene Ontology

BIOMD0000000146
type: UnificationXref
id: BIOMD0000000146
db: BioModels Database

RIGHT 0 conversion reaction 0000007 RShGS STOICHIOMETRY
type: Stoichiometry
physical entity: RShGS
stoichiometric coefficient: 1.0

AktPIP
type: PhysicalEntity
member physical entity: AktPIP
cellular location: cell

LEFT 0 conversion reaction 0000028 PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

RasGTP
type: Complex
xref: CHEBI:15996
xref: IPR015592
xref: IPR013753

RHRG2
type: PhysicalEntity
member physical entity: RHRG2
cellular location: cell

GO:0004872
type: UnificationXref
id: GO:0004872
db: Gene Ontology

ShP
type: PhysicalEntity
member physical entity: ShP
cellular location: cell

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: cell

LEFT 0 conversion reaction 0000011 RasGDP STOICHIOMETRY
type: Stoichiometry
physical entity: RasGDP
stoichiometric coefficient: 1.0

MEKP
type: PhysicalEntity
member physical entity: MEKP
cellular location: cell

ERKPP
type: PhysicalEntity
member physical entity: ERKPP
cellular location: cell

RIGHT 0 conversion reaction 0000020 ERK STOICHIOMETRY
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

cell
type: CellularLocationVocabulary
xref: GO:0005623

RIGHT 0 conversion reaction 0000026 PI3K STOICHIOMETRY
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

RPI3Kstar
type: Complex
xref: GO:0043235
xref: GO:0005942

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

RIGHT 0 conversion reaction 0000010 Shc STOICHIOMETRY
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

reaction_0000002
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000002 RHRG2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000002 RHRG STOICHIOMETRY
xref: GO:0007171
right: RHRG2
left: RHRG

reaction_0000001
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 0000001 HRG STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000001 RHRG STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000001 R STOICHIOMETRY
xref: GO:0005515
xref: GO:0005102
right: RHRG
spontaneous: true
left: HRG
left: R
conversion direction: LEFT_TO_RIGHT

reaction_0000004
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 0000004 RHRG2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000004 RP STOICHIOMETRY
xref: GO:0016311
right: RHRG2
spontaneous: true
left: RP
conversion direction: LEFT_TO_RIGHT

reaction_0000003
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 0000003 RP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000003 RHRG2 STOICHIOMETRY
xref: GO:0004672
right: RP
spontaneous: true
left: RHRG2
conversion direction: RIGHT_TO_LEFT

reaction_0000006
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000006 RShc STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000006 RShP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: RShP
left: RShc

reaction_0000005
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 0000005 Shc STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000005 RP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000005 RShc STOICHIOMETRY
xref: GO:0005515
xref: GO:0004872
right: RShc
left: Shc
left: RP

RIGHT 0 conversion reaction 0000001 RHRG STOICHIOMETRY
type: Stoichiometry
physical entity: RHRG
stoichiometric coefficient: 1.0

reaction_0000008
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000008 RShGS STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 0000008 RP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000008 ShGS STOICHIOMETRY
xref: GO:0043241
right: RP
right: ShGS
left: RShGS

RPI3K
type: Complex
xref: GO:0043235
xref: GO:0005942

reaction_0000007
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000007 RShGS STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 0000007 GS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000007 RShP STOICHIOMETRY
xref: GO:0005515
right: RShGS
left: GS
left: RShP

reaction_0000009
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000009 GS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000009 ShGS STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 0000009 ShP STOICHIOMETRY
xref: GO:0043241
right: ShP
right: GS
left: ShGS

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

Q15303
type: UnificationXref
id: Q15303
db: UniProt Knowledgebase

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

LEFT 0 conversion reaction 0000027 P I STOICHIOMETRY
type: Stoichiometry
physical entity: P_I
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000002 RHRG STOICHIOMETRY
type: Stoichiometry
physical entity: RHRG
stoichiometric coefficient: 2.0

RIGHT 0 conversion reaction 0000027 PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000015 MEK STOICHIOMETRY
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

ERK
type: Protein
xref: IPR003527
xref: IPR008350
xref: IPR008349

ERK
type: PhysicalEntity
member physical entity: ERK
cellular location: cell

reaction_0000011
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000011 RasGTP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000011 RasGDP STOICHIOMETRY
xref: GO:0032320
right: RasGTP
left: RasGDP

reaction_0000010
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000010 Shc STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000010 ShP STOICHIOMETRY
xref: GO:0016311
right: Shc
left: ShP

LEFT 0 conversion reaction 0000022 ERKPP STOICHIOMETRY
type: Stoichiometry
physical entity: ERKPP
stoichiometric coefficient: 1.0

reaction_0000013
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000013 Raf STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000013 Rafstar STOICHIOMETRY
xref: GO:0032147
right: Rafstar
left: Raf

Q9DBB1
type: UnificationXref
id: Q9DBB1
db: UniProt Knowledgebase

reaction_0000012
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000012 RasGDP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000012 RasGTP STOICHIOMETRY
xref: GO:0016311
right: RasGDP
left: RasGTP

reaction_0000015
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 0000015 MEK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000015 MEKP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: MEKP
spontaneous: true
left: MEK
conversion direction: LEFT_TO_RIGHT

reaction_0000014
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000014 Rafstar STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000014 Raf STOICHIOMETRY
xref: GO:0006469
right: Raf
left: Rafstar

reaction_0000017
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000017 MEKP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000017 MEKPP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: MEKPP
left: MEKP

reaction_0000016
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 0000016 MEKP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000016 MEK STOICHIOMETRY
xref: GO:0016311
right: MEK
spontaneous: true
left: MEKP
conversion direction: RIGHT_TO_LEFT

reaction_0000019
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 0000019 ERK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000019 ERKP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: ERKP
spontaneous: true
left: ERK
conversion direction: LEFT_TO_RIGHT

reaction_0000018
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000018 MEKPP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000018 MEKP STOICHIOMETRY
xref: GO:0016311
right: MEKP
left: MEKPP

GO:0005942
type: UnificationXref
id: GO:0005942
db: Gene Ontology

CHEBI:16152
type: UnificationXref
id: CHEBI:16152
db: ChEBI

RIGHT 0 conversion reaction 0000002 RHRG2 STOICHIOMETRY
type: Stoichiometry
physical entity: RHRG2
stoichiometric coefficient: 1.0

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

Rafstar
type: PhysicalEntity
member physical entity: Rafstar
cellular location: cell

IPR003527
type: UnificationXref
id: IPR003527
db: InterPro

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

ERK
type: PhysicalEntity
member physical entity: ERK
cellular location: cell

AktPIP3
type: PhysicalEntity
member physical entity: AktPIP3
cellular location: cell

RasGDP
type: PhysicalEntity
member physical entity: RasGDP
cellular location: cell

RIGHT 0 conversion reaction 0000014 Raf STOICHIOMETRY
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000015 MEKP STOICHIOMETRY
type: Stoichiometry
physical entity: MEKP
stoichiometric coefficient: 1.0

PI3Kstar
type: PhysicalEntity
member physical entity: PI3Kstar
cellular location: cell

LEFT 0 conversion reaction 0000010 ShP STOICHIOMETRY
type: Stoichiometry
physical entity: ShP
stoichiometric coefficient: 1.0

IPR015744
type: UnificationXref
id: IPR015744
db: InterPro

Raf
type: PhysicalEntity
member physical entity: Raf
cellular location: cell

reaction_0000020
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 0000020 ERK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000020 ERKP STOICHIOMETRY
xref: GO:0016311
right: ERK
spontaneous: true
left: ERKP
conversion direction: RIGHT_TO_LEFT

PI3Kstar
type: PhysicalEntity
xref: GO:0005942

RIGHT 0 conversion reaction 0000012 RasGDP STOICHIOMETRY
type: Stoichiometry
physical entity: RasGDP
stoichiometric coefficient: 1.0

reaction_0000022
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000022 ERKPP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000022 ERKP STOICHIOMETRY
xref: GO:0016311
right: ERKP
left: ERKPP

reaction_0000021
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000021 ERKPP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000021 ERKP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: ERKPP
left: ERKP

reaction_0000024
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000024 RPI3Kstar STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000024 RPI3K STOICHIOMETRY
xref: GO:0032147
right: RPI3Kstar
left: RPI3K

BIOMD0000000010
type: UnificationXref
id: BIOMD0000000010
db: BioModels Database

reaction_0000023
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 0000023 PI3K STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000023 RP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000023 RPI3K STOICHIOMETRY
xref: GO:0005515
xref: GO:0004872
right: RPI3K
spontaneous: true
left: PI3K
left: RP
conversion direction: LEFT_TO_RIGHT

reaction_0000026
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000026 PI3Kstar STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000026 PI3K STOICHIOMETRY
xref: GO:0006469
right: PI3K
left: PI3Kstar

internalization
type: PhysicalEntity
member physical entity: internalization
cellular location: cell

RIGHT 0 conversion reaction 0000018 MEKP STOICHIOMETRY
type: Stoichiometry
physical entity: MEKP
stoichiometric coefficient: 1.0

reaction_0000025
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 0000025 RP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 0000025 PI3Kstar STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000025 RPI3Kstar STOICHIOMETRY
xref: GO:0043241
right: RP
right: PI3Kstar
spontaneous: true
left: RPI3Kstar
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 0000013 Raf STOICHIOMETRY
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

reaction_0000028
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 0000028 PIP3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000028 P I STOICHIOMETRY
xref: GO:0016311
right: P_I
left: PIP3

reaction_0000027
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000027 PIP3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000027 P I STOICHIOMETRY
xref: GO:0016303
right: PIP3
left: P_I

Akt
type: Protein
xref: IPR015744

GO:0043235
type: UnificationXref
id: GO:0043235
db: Gene Ontology

ERKP
type: PhysicalEntity
member physical entity: ERKP
cellular location: cell

reaction_0000029
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 0000029 PIP3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 0000029 AktPIP3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 0000029 Akt STOICHIOMETRY
xref: GO:0005515
right: AktPIP3
spontaneous: true
left: PIP3
left: Akt
conversion direction: LEFT_TO_RIGHT

LEFT 1 conversion reaction 0000029 Akt STOICHIOMETRY
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

MEKP
type: PhysicalEntity
member physical entity: MEKP
cellular location: cell

RIGHT 0 conversion reaction 0000019 ERKP STOICHIOMETRY
type: Stoichiometry
physical entity: ERKP
stoichiometric coefficient: 1.0

MEK
type: PhysicalEntity
member physical entity: MEK
cellular location: cell

LEFT 1 conversion reaction 0000005 Shc STOICHIOMETRY
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000032 AktPIPP STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIPP
stoichiometric coefficient: 1.0

RShP
type: PhysicalEntity
member physical entity: RShP
cellular location: cell

LEFT 0 conversion reaction 0000032 AktPIP STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP
stoichiometric coefficient: 1.0

R
type: PhysicalEntity
member physical entity: R
cellular location: cell

RIGHT 0 conversion reaction 0000003 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

BIOMD0000000019
type: UnificationXref
id: BIOMD0000000019
db: BioModels Database

GO:0051896
type: UnificationXref
id: GO:0051896
db: Gene Ontology

reaction_0000031
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000031 AktPIP3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000031 AktPIP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: AktPIP3
left: AktPIP

reaction_0000030
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000030 AktPIP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000030 AktPIP3 STOICHIOMETRY
xref: GO:0016311
right: AktPIP
left: AktPIP3

reaction_0000033
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000033 AktPIP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000033 AktPIPP STOICHIOMETRY
xref: GO:0016311
right: AktPIP
left: AktPIPP

reaction_0000032
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000032 AktPIPP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000032 AktPIP STOICHIOMETRY
xref: GO:0004672
xref: GO:0006468
right: AktPIPP
left: AktPIP

reaction_0000034
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0000034 internalization STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0000034 RP STOICHIOMETRY
xref: GO:0031623
right: internalization
left: RP

GO:0043241
type: UnificationXref
id: GO:0043241
db: Gene Ontology

RasGDP
type: PhysicalEntity
member physical entity: RasGDP
cellular location: cell

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: cell

RP
type: PhysicalEntity
member physical entity: RP
cellular location: cell

RIGHT 1 conversion reaction 0000008 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

RHRG2
type: PhysicalEntity
member physical entity: RHRG2
cellular location: cell

http://identifiers.org/pubmed/11772030
type: PublicationXref
id: 11772030
db: PubMed

MEK
type: PhysicalEntity
member physical entity: MEK
cellular location: cell

AktPIP3
type: Complex
xref: CHEBI:16618
xref: IPR015744

AktPIPP
type: PhysicalEntity
member physical entity: AktPIPP
cellular location: cell

Shc
type: PhysicalEntity
member physical entity: Shc
cellular location: cell

PI3K
type: PhysicalEntity
member physical entity: PI3K
cellular location: cell

RShGS
type: PhysicalEntity
member physical entity: RShGS
cellular location: cell

CHEBI:16618
type: UnificationXref
id: CHEBI:16618
db: ChEBI

LEFT 0 conversion reaction 0000031 AktPIP STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000005 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

RPI3Kstar
type: PhysicalEntity
member physical entity: RPI3Kstar
cellular location: cell

GO:0006469
type: UnificationXref
id: GO:0006469
db: Gene Ontology

RIGHT 0 conversion reaction 0000031 AktPIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP3
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000033 AktPIPP STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIPP
stoichiometric coefficient: 1.0

GO:0006468
type: UnificationXref
id: GO:0006468
db: Gene Ontology

AktPIPP
type: Complex
xref: IPR015744
xref: CHEBI:16152

MEK
type: Protein
xref: IPR003527

ERKPP
type: PhysicalEntity
member physical entity: ERKPP
cellular location: cell

CHEBI:15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

LEFT 0 conversion reaction 0000023 RP STOICHIOMETRY
type: Stoichiometry
physical entity: RP
stoichiometric coefficient: 1.0

PIP3
type: SmallMolecule
xref: CHEBI:16618

MEKP
type: PhysicalEntity
member physical entity: MEKP
cellular location: cell

P_I
type: PhysicalEntity
member physical entity: P_I
cellular location: cell

RIGHT 1 conversion reaction 0000009 ShP STOICHIOMETRY
type: Stoichiometry
physical entity: ShP
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0000030 AktPIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AktPIP3
stoichiometric coefficient: 1.0

IPR013753
type: UnificationXref
id: IPR013753
db: InterPro

ERKP
type: PhysicalEntity
member physical entity: ERKP
cellular location: cell

BIOMD0000000048
type: UnificationXref
id: BIOMD0000000048
db: BioModels Database

RIGHT 0 conversion reaction 0000024 RPI3Kstar STOICHIOMETRY
type: Stoichiometry
physical entity: RPI3Kstar
stoichiometric coefficient: 1.0

ShGS
type: PhysicalEntity
member physical entity: ShGS
cellular location: cell

GO:0005102
type: UnificationXref
id: GO:0005102
db: Gene Ontology

RasGTP
type: PhysicalEntity
member physical entity: RasGTP
cellular location: cell

Rafstar
type: Protein
xref: P15056

IPR001452
type: UnificationXref
id: IPR001452
db: InterPro

http://identifiers.org/taxonomy/10026
type: UnificationXref
id: 10026
db: Taxonomy

RShGS
type: PhysicalEntity

RIGHT 0 conversion reaction 0000009 GS STOICHIOMETRY
type: Stoichiometry
physical entity: GS
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0000006 RShP STOICHIOMETRY
type: Stoichiometry
physical entity: RShP
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: BIOMD0000000146

AktPIP
type: PhysicalEntity
member physical entity: AktPIP
cellular location: cell

MEKPP
type: PhysicalEntity
member physical entity: MEKPP
cellular location: cell

RShc
type: PhysicalEntity
member physical entity: RShc
cellular location: cell

CHEBI:18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

LEFT 0 conversion reaction 0000021 ERKP STOICHIOMETRY
type: Stoichiometry
physical entity: ERKP
stoichiometric coefficient: 1.0

PI3K
type: PhysicalEntity
member physical entity: PI3K
cellular location: cell

AktPIP3
type: PhysicalEntity
member physical entity: AktPIP3
cellular location: cell

BioModels Database
type: Provenance
xref: MODEL8256371999

MEKPP
type: PhysicalEntity
member physical entity: MEKPP
cellular location: cell

LEFT 0 conversion reaction 0000020 ERKP STOICHIOMETRY
type: Stoichiometry
physical entity: ERKP
stoichiometric coefficient: 1.0

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: cell

CHEBI:18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

RShGS
type: PhysicalEntity
member physical entity: RShGS
cellular location: cell

Raf
type: Protein
xref: P15056

RasGDP
type: Complex
xref: CHEBI:17552
xref: IPR015592
xref: IPR013753

RIGHT 0 conversion reaction 0000005 RShc STOICHIOMETRY
type: Stoichiometry
physical entity: RShc
stoichiometric coefficient: 1.0

GO:0031623
type: UnificationXref
id: GO:0031623
db: Gene Ontology

LEFT 0 conversion reaction 0000025 RPI3Kstar STOICHIOMETRY
type: Stoichiometry
physical entity: RPI3Kstar
stoichiometric coefficient: 1.0