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        <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Creative Commons CC0">CC0 Public Domain Dedication</a>
          for more information.      </p>
            <p>In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.</p>
            <br/>
            <p>To cite BioModels Database, please use:      <a href="http://www.ncbi.nlm.nih.gov/pubmed/20587024" target="_blank">Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.</a>
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        <annotation>
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            </species>
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        <annotation>
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        <annotation>
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        <annotation>
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        </annotation>
            </species>
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        </annotation>
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        <annotation>
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            </species>
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        <annotation>
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        <annotation>
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	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000548"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000582"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP2_R2C2" initialConcentration="0" metaid="metaid_0000164" name="cAMP2_R2C2">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000164">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000548"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000582"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP3_R2C2" initialConcentration="0" metaid="metaid_0000165" name="cAMP3_R2C2">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000165">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000548"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000582"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP4_R2C2" initialConcentration="0" metaid="metaid_0000166" name="cAMP4_R2C2">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000166">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000548"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000582"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP4_R2C" initialConcentration="0" metaid="metaid_0000174" name="cAMP4_R2C">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000174">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000548"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000582"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP4_R2" initialConcentration="0" metaid="metaid_0000177" name="cAMP4_R2">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000177">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000548"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP_PDE" initialConcentration="0" metaid="metaid_0000180" name="cAMP_PDE">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000180">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR000396"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="AMP" initialConcentration="0" metaid="metaid_0000183" name="AMP">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000183">
	<bqbiol:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16027"/>
	</rdf:Bag>
	</bqbiol:is>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="cAMP_PDEP" initialConcentration="0" metaid="metaid_0000185" name="cAMP_PDEP">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000185">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:17489"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR000396"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="PP2ACa" initialConcentration="0" metaid="metaid_0000191" name="PP2ACa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000191">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D34_75_PP2ACa" initialConcentration="0" metaid="metaid_0000192" name="D34:75_PP2ACa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000192">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D34_75_137_PP2ACa" initialConcentration="0" metaid="metaid_0000193" name="D34:75:137_PP2ACa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000193">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D75_PP2ACa" initialConcentration="0" metaid="metaid_0000200" name="D75_PP2ACa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000200">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D75_137_PP2ACa" initialConcentration="0" metaid="metaid_0000202" name="D75:137_PP2ACa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000202">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D34_75_PP2APCa" initialConcentration="0" metaid="metaid_0000208" name="D34:75_PP2APCa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000208">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="PP2APCa" initialConcentration="0" metaid="metaid_0000209" name="PP2APCa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000209">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D34_75_137_PP2APCa" initialConcentration="0" metaid="metaid_0000211" name="D34:75:137_PP2APCa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000211">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D75_PP2APCa" initialConcentration="0" metaid="metaid_0000217" name="D75_PP2APCa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000217">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="D75_137_PP2APCa" initialConcentration="0" metaid="metaid_0000219" name="D75:137_PP2APCa">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000219">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q9UD71"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species compartment="Spine" id="PP2ACa_PKA" initialConcentration="0" metaid="metaid_0000227" name="PP2ACa_PKA">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000227">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR006186"/>
	<rdf:li rdf:resource="http://identifiers.org/pirsf/PIRSF000582"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
          </rdf:RDF>
        </annotation>
            </species>
      <species boundaryCondition="true" compartment="Spine" constant="true" id="Empty" initialConcentration="0" metaid="metaid_0000232" name="Empty"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter constant="false" id="k57" metaid="metaid_0000236" name="ca_in" value="2.5E-8"/>
      <parameter id="cAMP_delay" metaid="metaid_0000261" name="cAMP_delay" value="400"/>
      <parameter id="cAMP_Ca_delay" metaid="metaid_0000262" name="cAMP_Ca_delay" value="50"/>
      <parameter id="kon_high" metaid="metaid_0000263" name="kon_high" value="6.6E-6"/>
      <parameter id="spike_duration" metaid="metaid_0000264" name="spike_duration" value="2"/>
      <parameter id="spike_interval" metaid="metaid_0000265" name="spike_interval" value="2"/>
      <parameter id="kon_low" metaid="metaid_0000266" name="kon_low" value="2.5E-8"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="von1" metaid="metaid_0000008" name="D_CDK5_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202336" species="D"/>
          <speciesReference metaid="_202348" species="CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202360" species="D_CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_202372">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> kon1 </ci>
              <ci> D </ci>
              <ci> CDK5 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon1" metaid="_202384" name="kon1" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff1" metaid="metaid_0000012" name="D_CDK5_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202396" species="D_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202408" species="D"/>
          <speciesReference metaid="_202420" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_202432">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D_CDK5 </ci>
              <ci> koff1 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff1" metaid="_202444" name="koff1" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat1" metaid="metaid_0000013" name="DPhospho_by_CDK5_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202456" species="D_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202468" species="D75"/>
          <speciesReference metaid="_202480" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_202492">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D_CDK5 </ci>
              <ci> kcat1 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat1" metaid="_202504" name="kcat1" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von2" metaid="metaid_0000011" name="DCDK1_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202516" species="D"/>
          <speciesReference metaid="_202528" species="CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202540" species="D_CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_202552">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D </ci>
              <ci> CK1 </ci>
              <ci> kon2 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon2" metaid="_202564" name="kon2" value="4400000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff2" metaid="metaid_0000017" name="D_CDK1_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202576" species="D_CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202588" species="D"/>
          <speciesReference metaid="_202600" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_202612">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> koff2 </ci>
              <ci> D_CK1 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff2" metaid="_202624" name="koff2" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat2" metaid="metaid_0000016" name="D_Phospho_by_CK1_on_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202636" species="D_CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202648" species="D137"/>
          <speciesReference metaid="_202660" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_202672">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> kcat2 </ci>
              <ci> D_CK1 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat2" metaid="_202684" name="kcat2" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von3" metaid="metaid_0000021" name="D_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202696" species="D"/>
          <speciesReference metaid="_202708" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202720" species="D_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_202732">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D </ci>
              <ci> PKA </ci>
              <ci> kon3 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon3" metaid="_202744" name="kon3" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff3" metaid="metaid_0000022" name="D_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202756" species="D_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202768" species="D"/>
          <speciesReference metaid="_202780" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_202792">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D_PKA </ci>
              <ci> koff3 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff3" metaid="_202804" name="koff3" value="10.8"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat3" metaid="metaid_0000024" name="D_Phospho_by_PKA_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202817" species="D_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202829" species="D34"/>
          <speciesReference metaid="_202841" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_202853">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D_PKA </ci>
              <ci> kcat3 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat3" metaid="_202865" name="kcat3" value="2.7"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von4" metaid="metaid_0000026" name="D34_CDK5_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202877" species="D34"/>
          <speciesReference metaid="_202889" species="CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202901" species="D34_CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_202913">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34 </ci>
              <ci> CDK5 </ci>
              <ci> kon4 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon4" metaid="_202925" name="kon4" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von5" metaid="metaid_0000027" name="D34_CK1_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202938" species="D34"/>
          <speciesReference metaid="_202950" species="CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_202963" species="D34_CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_202975">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34 </ci>
              <ci> CK1 </ci>
              <ci> kon5 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon5" metaid="_202987" name="kon5" value="4400000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von6" metaid="metaid_0000031" name="D34_PP2B_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_202999" species="D34"/>
          <speciesReference metaid="_203012" species="PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203025" species="D34_PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_203038">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34 </ci>
              <ci> PP2B </ci>
              <ci> kon6 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon6" metaid="_203051" name="kon6" value="10000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff4" metaid="metaid_0000032" name="D34_CDK5_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203064" species="D34_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203077" species="D34"/>
          <speciesReference metaid="_203090" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_203103">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_CDK5 </ci>
              <ci> koff4 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff4" metaid="_203116" name="koff4" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat4" metaid="metaid_0000033" name="D34_Phospho_by_CDK5_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203129" species="D34_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203141" species="D34_75"/>
          <speciesReference metaid="_203153" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_203165">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_CDK5 </ci>
              <ci> kcat4 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat4" metaid="_203177" name="kcat4" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff5" metaid="metaid_0000035" name="D34_CK1_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203189" species="D34_CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203201" species="D34"/>
          <speciesReference metaid="_203213" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_203225">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_CK1 </ci>
              <ci> koff5 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff5" metaid="_203237" name="koff5" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat5" metaid="metaid_0000036" name="D34_Phospho_by_CK1_on_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203249" species="D34_CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203261" species="D34_137"/>
          <speciesReference metaid="_203273" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_203285">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_CK1 </ci>
              <ci> kcat5 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat5" metaid="_203297" name="kcat5" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat6" metaid="metaid_0000038" name="D34_Dephospho_by_PP2B" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203309" species="D34_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203321" species="D"/>
          <speciesReference metaid="_203333" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_203345">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_PP2B </ci>
              <ci> kcat6 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat6" metaid="_203357" name="kcat6" value="4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff6" metaid="metaid_0000039" name="D34_PP2B_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203369" species="D34_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203381" species="D34"/>
          <speciesReference metaid="_203393" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_203405">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_PP2B </ci>
              <ci> koff6 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff6" metaid="_203417" name="koff6" value="16"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von7" metaid="metaid_0000040" name="D75_CK1_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203429" species="D75"/>
          <speciesReference metaid="_203441" species="CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203453" species="D75CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_203465">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75 </ci>
              <ci> CK1 </ci>
              <ci> kon7 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon7" metaid="_203477" name="kon7" value="4400000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von8" metaid="metaid_0000042" name="D75_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203489" species="D75"/>
          <speciesReference metaid="_203501" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203513" species="D75_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_203525">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75 </ci>
              <ci> PKA </ci>
              <ci> kon8 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon8" metaid="_203537" name="kon8" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von9" metaid="metaid_0000044" name="D75_PP2A_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203549" species="D75"/>
          <speciesReference metaid="_203561" species="PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203573" species="D75_PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_203585">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75 </ci>
              <ci> PP2A </ci>
              <ci> kon9 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon9" metaid="_203597" name="kon9" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von10" metaid="metaid_0000048" name="D75_PP2AP_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203609" species="D75"/>
          <speciesReference metaid="_203621" species="PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203633" species="D75_PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_203645">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75 </ci>
              <ci> PP2AP </ci>
              <ci> kon10 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon10" metaid="_203657" name="kon10" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff7" metaid="metaid_0000051" name="D75_CK1_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203669" species="D75CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203681" species="D75"/>
          <speciesReference metaid="_203693" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_203705">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75CK1 </ci>
              <ci> koff7 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff7" metaid="_203717" name="koff7" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat7" metaid="metaid_0000052" name="D75_Phospho_by_CK1_on_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203729" species="D75CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203741" species="CK1"/>
          <speciesReference metaid="_203753" species="D75_137"/>
        </listOfProducts>
        <kineticLaw metaid="_203766">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75CK1 </ci>
              <ci> kcat7 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat7" metaid="_203778" name="kcat7" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat8" metaid="metaid_0000054" name="D75_Phospho_by_PKA_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203791" species="D75_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203803" species="D34_75"/>
          <speciesReference metaid="_203815" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_203827">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PKA </ci>
              <ci> kcat8 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat8" metaid="_203839" name="kcat8" value="0"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff8" metaid="metaid_0000055" name="D75_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203851" species="D75_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203863" species="D75"/>
          <speciesReference metaid="_203875" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_203887">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PKA </ci>
              <ci> koff8 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff8" metaid="_203899" name="koff8" value="10.8"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat9" metaid="metaid_0000056" name="D75_dephospho_by_PP2A" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203911" species="D75_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203923" species="D"/>
          <speciesReference metaid="_203935" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_203947">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2A </ci>
              <ci> kcat9 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat9" metaid="_203959" name="kcat9" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff9" metaid="metaid_0000057" name="D75_PP2A_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_203971" species="D75_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_203983" species="D75"/>
          <speciesReference metaid="_203995" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_204007">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2A </ci>
              <ci> koff9 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff9" metaid="_204019" name="koff9" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat10" metaid="metaid_0000058" name="D75_dephospho_by_PP2AP" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204031" species="D75_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204043" species="D"/>
          <speciesReference metaid="_204055" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_204067">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2AP </ci>
              <ci> kcat10 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat10" metaid="_204079" name="kcat10" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff10" metaid="metaid_0000059" name="D75_PP2AP_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204091" species="D75_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204103" species="D75"/>
          <speciesReference metaid="_204115" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_204127">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2AP </ci>
              <ci> koff10 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff10" metaid="_204139" name="koff10" value="40"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von11" metaid="metaid_0000060" name="D137_CDK5_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204151" species="D137"/>
          <speciesReference metaid="_204163" species="CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204175" species="D137_CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_204187">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137 </ci>
              <ci> CDK5 </ci>
              <ci> kon11 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon11" metaid="_204199" name="kon11" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von12" metaid="metaid_0000062" name="D137_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204211" species="D137"/>
          <speciesReference metaid="_204223" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204235" species="D137_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_204247">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137 </ci>
              <ci> PKA </ci>
              <ci> kon12 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon12" metaid="_204259" name="kon12" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von13" metaid="metaid_0000064" name="D137_PP2C_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204271" species="D137"/>
          <speciesReference metaid="_204283" species="PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204295" species="D137_PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_204307">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137 </ci>
              <ci> PP2C </ci>
              <ci> kon13 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon13" metaid="_204319" name="kon13" value="7500000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff11" metaid="metaid_0000067" name="D137_CDK5_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204331" species="D137_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204343" species="D137"/>
          <speciesReference metaid="_204355" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_204367">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137_CDK5 </ci>
              <ci> koff11 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff11" metaid="_204379" name="koff11" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat11" metaid="metaid_0000068" name="D137_Phospho_by_CDK5_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204391" species="D137_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204403" species="D75_137"/>
          <speciesReference metaid="_204415" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_204427">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137_CDK5 </ci>
              <ci> kcat11 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat11" metaid="_204439" name="kcat11" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff12" metaid="metaid_0000069" name="D137_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204451" species="D137_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204463" species="D137"/>
          <speciesReference metaid="_204475" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_204487">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137_PKA </ci>
              <ci> koff12 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff12" metaid="_204500" name="koff12" value="10.8"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat12" metaid="metaid_0000070" name="D137_phospho_by_PKA_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204512" species="D137_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204524" species="D34_137"/>
          <speciesReference metaid="_204536" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_204548">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137_PKA </ci>
              <ci> kcat12 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat12" metaid="_204560" name="kcat12" value="2.7"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat13" metaid="metaid_0000071" name="D137_dephospho_by_PP2C" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204572" species="D137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204584" species="D"/>
          <speciesReference metaid="_204596" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_204608">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137_PP2C </ci>
              <ci> kcat13 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat13" metaid="_204620" name="kcat13" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff13" metaid="metaid_0000072" name="D137_PP2C_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204632" species="D137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204644" species="D137"/>
          <speciesReference metaid="_204656" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_204668">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D137_PP2C </ci>
              <ci> koff13 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff13" metaid="_204680" name="koff13" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von14" metaid="metaid_0000073" name="D34:75_CK1_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204692" species="D34_75"/>
          <speciesReference metaid="_204704" species="CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204716" species="D34_75_CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_204729">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75 </ci>
              <ci> CK1 </ci>
              <ci> kon14 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon14" metaid="_204741" name="kon14" value="4400000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von18" metaid="metaid_0000075" name="D34:137_CDK5_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204753" species="D34_137"/>
          <speciesReference metaid="_204765" species="CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204777" species="D34_137_CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_204789">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137 </ci>
              <ci> CDK5 </ci>
              <ci> kon18 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon18" metaid="_204801" name="kon18" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff18" metaid="metaid_0000077" name="D34:137_CDK5_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204813" species="D34_137_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204825" species="D34_137"/>
          <speciesReference metaid="_204837" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_204849">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137_CDK5 </ci>
              <ci> koff18 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff18" metaid="_204861" name="koff18" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff14" metaid="metaid_0000078" name="D34:75_CK1_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204873" species="D34_75_CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204885" species="D34_75"/>
          <speciesReference metaid="_204897" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_204909">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_CK1 </ci>
              <ci> koff14 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff14" metaid="_204921" name="koff14" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat14" metaid="metaid_0000079" name="D34:75_phospho_by_CK1_on_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204933" species="D34_75_CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_204945" species="D34_75_137"/>
          <speciesReference metaid="_204957" species="CK1"/>
        </listOfProducts>
        <kineticLaw metaid="_204969">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_CK1 </ci>
              <ci> kcat14 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat14" metaid="_204981" name="kcat14" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat18" metaid="metaid_0000081" name="D34:137_phospho_by_CDK5_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_204993" species="D34_137_CDK5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205005" species="D34_75_137"/>
          <speciesReference metaid="_205018" species="CDK5"/>
        </listOfProducts>
        <kineticLaw metaid="_205029">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137_CDK5 </ci>
              <ci> kcat18 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat18" metaid="_205042" name="kcat18" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von21" metaid="metaid_0000082" name="D75:137_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205054" species="D75_137"/>
          <speciesReference metaid="_205066" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205078" species="D75_137_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_205090">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137 </ci>
              <ci> PKA </ci>
              <ci> kon21 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon21" metaid="_205102" name="kon21" value="5600000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat21" metaid="metaid_0000084" name="D75:137_phospho_by_PKA_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205114" species="D75_137_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205126" species="D34_75_137"/>
          <speciesReference metaid="_205138" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_205150">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PKA </ci>
              <ci> kcat21 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat21" metaid="_205162" name="kcat21" value="0"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff21" metaid="metaid_0000085" name="D75:137_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205174" species="D75_137_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205186" species="D75_137"/>
          <speciesReference metaid="_205198" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_205210">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PKA </ci>
              <ci> koff21 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff21" metaid="_205222" name="koff21" value="10.8"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von17" metaid="metaid_0000086" name="D34:75_PP2B_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205234" species="D34_75"/>
          <speciesReference metaid="_205246" species="PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205258" species="D34_75_PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205270">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75 </ci>
              <ci> PP2B </ci>
              <ci> kon17 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon17" metaid="_205282" name="kon17" value="10000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff17" metaid="metaid_0000088" name="D34:75_PP2B_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205294" species="D34_75_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205306" species="D34_75"/>
          <speciesReference metaid="_205318" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205330">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2B </ci>
              <ci> koff17 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff17" metaid="_205342" name="koff17" value="1600"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat17" metaid="metaid_0000089" name="D34:75_dephopsho_by_PP2B_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205354" species="D34_75_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205366" species="D75"/>
          <speciesReference metaid="_205378" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205390">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2B </ci>
              <ci> kcat17 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat17" metaid="_205402" name="kcat17" value="4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von19" metaid="metaid_0000090" name="D34:137_PP2B_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205414" species="D34_137"/>
          <speciesReference metaid="_205426" species="PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205438" species="D34_137_PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205450">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137 </ci>
              <ci> PP2B </ci>
              <ci> kon19 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon19" metaid="_205462" name="kon19" value="75000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat19" metaid="metaid_0000092" name="D34:137_dephospho_by_PP2B_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205474" species="D34_137_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205486" species="D137"/>
          <speciesReference metaid="_205498" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205510">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137_PP2B </ci>
              <ci> kcat19 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat19" metaid="_205522" name="kcat19" value="0.03"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff19" metaid="metaid_0000093" name="D34:137_PP2B_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205534" species="D34_137_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205546" species="D34_137"/>
          <speciesReference metaid="_205558" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205570">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137_PP2B </ci>
              <ci> koff19 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff19" metaid="_205582" name="koff19" value="0.12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von27" metaid="metaid_0000095" name="D34:75:137_PP2B_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205594" species="D34_75_137"/>
          <speciesReference metaid="_205606" species="PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205618" species="D34_75_137_PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205630">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137 </ci>
              <ci> PP2B </ci>
              <ci> kon27 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon27" metaid="_205642" name="kon27" value="75000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff27" metaid="metaid_0000096" name="D34:75:137_PP2B_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205655" species="D34_75_137_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205667" species="D34_75_137"/>
          <speciesReference metaid="_205679" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205691">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2B </ci>
              <ci> koff27 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff27" metaid="_205703" name="koff27" value="120"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat27" metaid="metaid_0000097" name="D34:75:137_dephospho_by_PP2B_on_34" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205715" species="D34_75_137_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205727" species="D75_137"/>
          <speciesReference metaid="_205739" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_205751">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2B </ci>
              <ci> kcat27 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat27" metaid="_205763" name="kcat27" value="0.03"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von15" metaid="metaid_0000099" name="D34:75_PP2A_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205775" species="D34_75"/>
          <speciesReference metaid="_205787" species="PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205800" species="D34_75_PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_205812">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75 </ci>
              <ci> PP2A </ci>
              <ci> kon15 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon15" metaid="_205824" name="kon15" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat15" metaid="metaid_0000100" name="D34:75_dephospho_by_PP2A_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205836" species="D34_75_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205848" species="D34"/>
          <speciesReference metaid="_205860" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_205872">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2A </ci>
              <ci> kcat15 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat15" metaid="_205884" name="kcat15" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff15" metaid="metaid_0000101" name="D34:75_PP2A_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205896" species="D34_75_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205908" species="D34_75"/>
          <speciesReference metaid="_205920" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_205932">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2A </ci>
              <ci> koff15 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff15" metaid="_205944" name="koff15" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von22" metaid="metaid_0000102" name="D75:137_PP2A_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_205956" species="D75_137"/>
          <speciesReference metaid="_205968" species="PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_205980" species="D75_137_PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_205992">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137 </ci>
              <ci> PP2A </ci>
              <ci> kon22 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon22" metaid="_206004" name="kon22" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat22" metaid="metaid_0000104" name="D75:137_dephospho_by_PP2A_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206016" species="D75_137_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206029" species="D137"/>
          <speciesReference metaid="_206041" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_206053">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2A </ci>
              <ci> kcat22 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat22" metaid="_206065" name="kcat22" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff22" metaid="metaid_0000105" name="D75:137_PP2A_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206077" species="D75_137_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206089" species="D75_137"/>
          <speciesReference metaid="_206101" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_206113">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2A </ci>
              <ci> koff22 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff22" metaid="_206125" name="koff22" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von25" metaid="metaid_0000106" name="D34:75:137_PP2A_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206137" species="D34_75_137"/>
          <speciesReference metaid="_206149" species="PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206162" species="D34_75_137_PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_206174">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137 </ci>
              <ci> PP2A </ci>
              <ci> kon25 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon25" metaid="_206186" name="kon25" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat25" metaid="metaid_0000108" name="D34:75:137_dephospho_by_PP2A_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206198" species="D34_75_137_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206210" species="D34_137"/>
          <speciesReference metaid="_206223" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_206235">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2A </ci>
              <ci> kcat25 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat25" metaid="_206247" name="kcat25" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff25" metaid="metaid_0000109" name="D34:75:137_PP2A_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206259" species="D34_75_137_PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206271" species="D34_75_137"/>
          <speciesReference metaid="_206283" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_206295">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2A </ci>
              <ci> koff25 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff25" metaid="_206307" name="koff25" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von16" metaid="metaid_0000110" name="D34:75_PP2AP_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206319" species="D34_75"/>
          <speciesReference metaid="_206331" species="PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206343" species="D34_75_PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206355">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75 </ci>
              <ci> PP2AP </ci>
              <ci> kon16 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon16" metaid="_206367" name="kon16" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat16" metaid="metaid_0000112" name="D34:75_dephospho_by_PP2AP_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206379" species="D34_75_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206391" species="D34"/>
          <speciesReference metaid="_206403" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206415">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2AP </ci>
              <ci> kcat16 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat16" metaid="_206427" name="kcat16" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff16" metaid="metaid_0000113" name="D34:75_PP2AP_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206439" species="D34_75_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206451" species="D34_75"/>
          <speciesReference metaid="_206463" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206475">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2AP </ci>
              <ci> koff16 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff16" metaid="_206487" name="koff16" value="40"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von23" metaid="metaid_0000114" name="D75:137_PP2AP_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206499" species="D75_137"/>
          <speciesReference metaid="_206511" species="PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206523" species="D75_137_PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206535">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137 </ci>
              <ci> PP2AP </ci>
              <ci> kon23 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon23" metaid="_206547" name="kon23" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat23" metaid="metaid_0000116" name="D75:137_dephospho_by_PP2AP_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206559" species="D75_137_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206571" species="D137"/>
          <speciesReference metaid="_206583" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206595">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2AP </ci>
              <ci> kcat23 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat23" metaid="_206607" name="kcat23" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff23" metaid="metaid_0000117" name="D75:137_PP2AP_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206619" species="D75_137_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206631" species="D75_137"/>
          <speciesReference metaid="_206643" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206655">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2AP </ci>
              <ci> koff23 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff23" metaid="_206667" name="koff23" value="40"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat26" metaid="metaid_0000118" name="D34:75:137_dephospho_by_PP2AP_on 75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206679" species="D34_75_137_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206691" species="D34_137"/>
          <speciesReference metaid="_206703" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206715">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2AP </ci>
              <ci> kcat26 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat26" metaid="_206727" name="kcat26" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von26" metaid="metaid_0000120" name="D34:75:137_PP2AP_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206739" species="D34_75_137"/>
          <speciesReference metaid="_206751" species="PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206763" species="D34_75_137_PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206776">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137 </ci>
              <ci> PP2AP </ci>
              <ci> kon26 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon26" metaid="_206788" name="kon26" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff26" metaid="metaid_0000121" name="D34:75:137_PP2AP_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206800" species="D34_75_137_PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206812" species="D34_75_137"/>
          <speciesReference metaid="_206824" species="PP2AP"/>
        </listOfProducts>
        <kineticLaw metaid="_206836">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2AP </ci>
              <ci> koff26 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff26" metaid="_206848" name="koff26" value="40"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von20" metaid="metaid_0000122" name="D34:137_PP2C_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206861" species="D34_137"/>
          <speciesReference metaid="_206873" species="PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206885" species="D34_137_PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_206897">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137 </ci>
              <ci> PP2C </ci>
              <ci> kon20 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon20" metaid="_206909" name="kon20" value="7500000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat20" metaid="metaid_0000124" name="D34:137_dephospho_by_PP2C_on_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206921" species="D34_137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206933" species="D34"/>
          <speciesReference metaid="_206945" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_206957">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137_PP2C </ci>
              <ci> kcat20 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat20" metaid="_206969" name="kcat20" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff20" metaid="metaid_0000125" name="D34:137_PP2C_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_206981" species="D34_137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_206993" species="D34_137"/>
          <speciesReference metaid="_207005" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207017">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_137_PP2C </ci>
              <ci> koff20 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff20" metaid="_207029" name="koff20" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von24" metaid="metaid_0000129" name="D75:137_PP2C_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207041" species="D75_137"/>
          <speciesReference metaid="_207053" species="PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207065" species="D75_137_PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207077">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137 </ci>
              <ci> PP2C </ci>
              <ci> kon24 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon24" metaid="_207089" name="kon24" value="7500000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat24" metaid="metaid_0000130" name="D75:137_dephospho_by_PP2C_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207101" species="D75_137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207113" species="D75"/>
          <speciesReference metaid="_207125" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207137">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2C </ci>
              <ci> kcat24 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat24" metaid="_207149" name="kcat24" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff24" metaid="metaid_0000131" name="D75:137_PP2C_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207161" species="D75_137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207173" species="D75_137"/>
          <speciesReference metaid="_207185" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207198">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2C </ci>
              <ci> koff24 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff24" metaid="_207210" name="koff24" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von28" metaid="metaid_0000132" name="D34:75:137_PP2C_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207222" species="D34_75_137"/>
          <speciesReference metaid="_207234" species="PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207247" species="D34_75_137_PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207259">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137 </ci>
              <ci> PP2C </ci>
              <ci> kon28 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon28" metaid="_207271" name="kon28" value="7500000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat28" metaid="metaid_0000300" name="D34:75:137_dephospho_by_PP2C_on_137" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207283" species="D34_75_137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207295" species="D34_75"/>
          <speciesReference metaid="_207307" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207319">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2C </ci>
              <ci> kcat28 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat28" metaid="_207331" name="kcat28" value="3"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff28" metaid="metaid_0000135" name="D34:75:137_PP2C_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207343" species="D34_75_137_PP2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207355" species="D34_75_137"/>
          <speciesReference metaid="_207367" species="PP2C"/>
        </listOfProducts>
        <kineticLaw metaid="_207379">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2C </ci>
              <ci> koff28 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff28" metaid="_207392" name="koff28" value="12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von29" metaid="metaid_0000136" name="CK1P_PP2B_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207405" species="CK1P"/>
          <speciesReference metaid="_207418" species="PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207431" species="CK1P_PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_207444">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> CK1P </ci>
              <ci> PP2B </ci>
              <ci> kon29 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon29" metaid="_207457" name="kon29" value="30000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff29" metaid="metaid_0000139" name="CK1P_PP2B_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207470" species="CK1P_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207484" species="CK1P"/>
          <speciesReference metaid="_207497" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_207510">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> CK1P_PP2B </ci>
              <ci> koff29 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff29" metaid="_207523" name="koff29" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat29" metaid="metaid_0000140" name="CK1P_dephospho_by_PP2B" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207535" species="CK1P_PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207548" species="CK1"/>
          <speciesReference metaid="_207560" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_207572">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> CK1P_PP2B </ci>
              <ci> kcat29 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat29" metaid="_207584" name="kcat29" value="6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat30" metaid="metaid_0000141" name="CK1_phosphorylation" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207596" species="CK1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207608" species="CK1P"/>
        </listOfProducts>
        <kineticLaw metaid="_207620">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> CK1 </ci>
              <ci> kcat30 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat30" metaid="_207632" name="kcat30" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von31" metaid="metaid_0000142" name="PDE_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207644" species="PDE"/>
          <speciesReference metaid="_207656" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207668" species="PDE_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_207680">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PDE </ci>
              <ci> PKA </ci>
              <ci> kon31 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon31" metaid="_207692" name="kon31" value="6000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat31" metaid="metaid_0000144" name="PDE_phospho_by_PKA" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207704" species="PDE_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207716" species="PDEP"/>
          <speciesReference metaid="_207728" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_207740">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PDE_PKA </ci>
              <ci> kcat31 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat31" metaid="_207752" name="kcat31" value="9"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff31" metaid="metaid_0000146" name="PDE_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207765" species="PDE_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207777" species="PDE"/>
          <speciesReference metaid="_207789" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_207801">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PDE_PKA </ci>
              <ci> koff31 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff31" metaid="_207813" name="koff31" value="36"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat32" metaid="metaid_0000147" name="PDEP_dephospho" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207825" species="PDEP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207837" species="PDE"/>
        </listOfProducts>
        <kineticLaw metaid="_207849">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PDEP </ci>
              <ci> kcat32 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat32" metaid="_207861" name="kcat32" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von33" metaid="metaid_0000148" name="PP2A_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207873" species="PP2A"/>
          <speciesReference metaid="_207885" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207897" species="PP2A_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_207909">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2A </ci>
              <ci> PKA </ci>
              <ci> kon33 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon33" metaid="_207921" name="kon33" value="10000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff33" metaid="metaid_0000150" name="PP2A_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207933" species="PP2A_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_207945" species="PP2A"/>
          <speciesReference metaid="_207957" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_207969">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2A_PKA </ci>
              <ci> koff33 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff33" metaid="_207981" name="koff33" value="16"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat33" metaid="metaid_0000151" name="PP2A_phospho_by_PKA" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_207993" species="PP2A_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208005" species="PP2AP"/>
          <speciesReference metaid="_208017" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_208029">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2A_PKA </ci>
              <ci> kcat33 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat33" metaid="_208041" name="kcat33" value="4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat34" metaid="metaid_0000152" name="PP2AP_dephospho" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208053" species="PP2AP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208065" species="PP2A"/>
        </listOfProducts>
        <kineticLaw metaid="_208077">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2AP </ci>
              <ci> kcat34 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat34" metaid="_208089" name="kcat34" value="5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von35" metaid="metaid_0000153" name="PP2Binactive_Ca_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208101" species="PP2Binactive"/>
          <speciesReference metaid="_208113" species="Ca" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208125" species="PP2BinactiveCa2"/>
        </listOfProducts>
        <kineticLaw metaid="_208137">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2Binactive </ci>
              <ci> Ca </ci>
              <ci> Ca </ci>
              <ci> kon35 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon35" metaid="_208149" name="kon35" value="1E15"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von36" metaid="metaid_0000156" name="PP2B_activation" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208161" species="PP2BinactiveCa2"/>
          <speciesReference metaid="_208173" species="Ca" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208186" species="PP2B"/>
        </listOfProducts>
        <kineticLaw metaid="_208198">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2BinactiveCa2 </ci>
              <ci> Ca </ci>
              <ci> Ca </ci>
              <ci> kon36 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon36" metaid="_208210" name="kon36" value="3E15"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff35" metaid="metaid_0000157" name="PP2BinactiveCa2_Ca_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208222" species="PP2BinactiveCa2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208234" species="PP2Binactive"/>
          <speciesReference metaid="_208246" species="Ca" stoichiometry="2"/>
        </listOfProducts>
        <kineticLaw metaid="_208258">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2BinactiveCa2 </ci>
              <ci> koff35 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff35" metaid="_208270" name="koff35" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff36" metaid="metaid_0000158" name="PP2B_inactivation" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208282" species="PP2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208294" species="PP2BinactiveCa2"/>
          <speciesReference metaid="_208306" species="Ca" stoichiometry="2"/>
        </listOfProducts>
        <kineticLaw metaid="_208318">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2B </ci>
              <ci> koff36 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff36" metaid="_208330" name="koff36" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von37" metaid="metaid_0000159" name="R2C2_cAMP_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208342" species="R2C2"/>
          <speciesReference metaid="_208354" species="cAMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208366" species="cAMP_R2C2"/>
        </listOfProducts>
        <kineticLaw metaid="_208378">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> R2C2 </ci>
              <ci> cAMP </ci>
              <ci> kon37 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon37" metaid="_208390" name="kon37" value="54000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von38" metaid="metaid_0000163" name="cAMP_R2C2_binding_by_cAMP" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208402" species="cAMP_R2C2"/>
          <speciesReference metaid="_208414" species="cAMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208426" species="cAMP2_R2C2"/>
        </listOfProducts>
        <kineticLaw metaid="_208438">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP_R2C2 </ci>
              <ci> cAMP </ci>
              <ci> kon38 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon38" metaid="_208450" name="kon38" value="54000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von39" metaid="metaid_0000167" name="cAMP2_R2C2_binding_by_cAMP" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208462" species="cAMP2_R2C2"/>
          <speciesReference metaid="_208474" species="cAMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208486" species="cAMP3_R2C2"/>
        </listOfProducts>
        <kineticLaw metaid="_208498">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP2_R2C2 </ci>
              <ci> cAMP </ci>
              <ci> kon39 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon39" metaid="_208510" name="kon39" value="75000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von40" metaid="metaid_0000168" name="cAMP3_R2C2_binding_by_cAMP" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208522" species="cAMP3_R2C2"/>
          <speciesReference metaid="_208534" species="cAMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208546" species="cAMP4_R2C2"/>
        </listOfProducts>
        <kineticLaw metaid="_208558">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP3_R2C2 </ci>
              <ci> cAMP </ci>
              <ci> kon40 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon40" metaid="_208571" name="kon40" value="75000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff37" metaid="metaid_0000169" name="cAMP_R2C2_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208584" species="cAMP_R2C2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208596" species="R2C2"/>
          <speciesReference metaid="_208608" species="cAMP"/>
        </listOfProducts>
        <kineticLaw metaid="_208620">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP_R2C2 </ci>
              <ci> koff37 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff37" metaid="_208632" name="koff37" value="33"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff38" metaid="metaid_0000170" name="cAMP2_R2C2_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208644" species="cAMP2_R2C2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208656" species="cAMP_R2C2"/>
          <speciesReference metaid="_208668" species="cAMP"/>
        </listOfProducts>
        <kineticLaw metaid="_208680">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP2_R2C2 </ci>
              <ci> koff38 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff38" metaid="_208692" name="koff38" value="33"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff39" metaid="metaid_0000171" name="cAMP3_R2C2_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208704" species="cAMP3_R2C2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208716" species="cAMP2_R2C2"/>
          <speciesReference metaid="_208728" species="cAMP"/>
        </listOfProducts>
        <kineticLaw metaid="_208740">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP3_R2C2 </ci>
              <ci> koff39 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff39" metaid="_208752" name="koff39" value="110"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff40" metaid="metaid_0000172" name="cAMP4_R2C2_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208764" species="cAMP4_R2C2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208776" species="cAMP3_R2C2"/>
          <speciesReference metaid="_208788" species="cAMP"/>
        </listOfProducts>
        <kineticLaw metaid="_208800">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP4_R2C2 </ci>
              <ci> koff40 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff40" metaid="_208812" name="koff40" value="32.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von41" metaid="metaid_0000173" name="cAMP4_R2C_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208824" species="cAMP4_R2C"/>
          <speciesReference metaid="_208836" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208848" species="cAMP4_R2C2"/>
        </listOfProducts>
        <kineticLaw metaid="_208860">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP4_R2C </ci>
              <ci> PKA </ci>
              <ci> kon41 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon41" metaid="_208872" name="kon41" value="18000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff41" metaid="metaid_0000175" name="cAMP4_R2C2_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208884" species="cAMP4_R2C2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208896" species="cAMP4_R2C"/>
          <speciesReference metaid="_208908" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_208921">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP4_R2C2 </ci>
              <ci> koff41 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff41" metaid="_208933" name="koff41" value="60"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von42" metaid="metaid_0000176" name="cAMP4_R2_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_208945" species="cAMP4_R2"/>
          <speciesReference metaid="_208957" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_208969" species="cAMP4_R2C"/>
        </listOfProducts>
        <kineticLaw metaid="_208981">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP4_R2 </ci>
              <ci> PKA </ci>
              <ci> kon42 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon42" metaid="_208993" name="kon42" value="18000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von43" metaid="metaid_0000178" name="cAMP4_R2C_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209005" species="cAMP4_R2C"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209017" species="cAMP4_R2"/>
          <speciesReference metaid="_209029" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_209041">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP4_R2C </ci>
              <ci> kon43 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon43" metaid="_209053" name="kon43" value="60"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von44" metaid="metaid_0000179" name="cAMP_PDE_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209065" species="cAMP"/>
          <speciesReference metaid="_209077" species="PDE"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209089" species="cAMP_PDE"/>
        </listOfProducts>
        <kineticLaw metaid="_209101">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP </ci>
              <ci> PDE </ci>
              <ci> kon44 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon44" metaid="_209113" name="kon44" value="2520000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff44" metaid="metaid_0000181" name="cAMP_PDE_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209125" species="cAMP_PDE"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209137" species="cAMP"/>
          <speciesReference metaid="_209150" species="PDE"/>
        </listOfProducts>
        <kineticLaw metaid="_209162">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP_PDE </ci>
              <ci> koff44 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff44" metaid="_209175" name="koff44" value="40"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat44" metaid="metaid_0000182" name="cAMP_PDE_degradation" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209187" species="cAMP_PDE"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209199" species="AMP"/>
          <speciesReference metaid="_209211" species="PDE"/>
        </listOfProducts>
        <kineticLaw metaid="_209223">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP_PDE </ci>
              <ci> kcat44 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat44" metaid="_209235" name="kcat44" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von45" metaid="metaid_0000184" name="cAMP_PDEP_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209247" species="cAMP"/>
          <speciesReference metaid="_209259" species="PDEP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209271" species="cAMP_PDEP"/>
        </listOfProducts>
        <kineticLaw metaid="_209283">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP </ci>
              <ci> PDEP </ci>
              <ci> kon45 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon45" metaid="_209295" name="kon45" value="5040000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff45" metaid="metaid_0000186" name="cAMP_PDEP_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209307" species="cAMP_PDEP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209319" species="cAMP"/>
          <speciesReference metaid="_209331" species="PDEP"/>
        </listOfProducts>
        <kineticLaw metaid="_209343">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP_PDEP </ci>
              <ci> koff45 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff45" metaid="_209355" name="koff45" value="80"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat45" metaid="metaid_0000187" name="cAMP_PDEP_degradation" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209367" species="cAMP_PDEP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209379" species="AMP"/>
          <speciesReference metaid="_209391" species="PDEP"/>
        </listOfProducts>
        <kineticLaw metaid="_209403">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> cAMP_PDEP </ci>
              <ci> kcat45 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat45" metaid="_209415" name="kcat45" value="20"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="v57" metaid="metaid_0000188" name="Ca_in" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209427" species="Empty"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209439" species="Ca"/>
        </listOfProducts>
        <kineticLaw metaid="_209451">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> k57 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="v58" metaid="metaid_0000189" name="Ca_destroy" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209463" species="Ca"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209475" species="Empty"/>
        </listOfProducts>
        <kineticLaw metaid="_209487">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> Ca </ci>
              <ci> k58 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k58" metaid="_209499" name="k58" value="1.7"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von46" metaid="metaid_0000190" name="D34:75_PP2ACa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209511" species="D34_75"/>
          <speciesReference metaid="_209523" species="PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209536" species="D34_75_PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209548">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75 </ci>
              <ci> PP2ACa </ci>
              <ci> kon46 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon46" metaid="_209560" name="kon46" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von47" metaid="metaid_0000194" name="D34:75:137_PP2ACa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209572" species="D34_75_137"/>
          <speciesReference metaid="_209584" species="PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209596" species="D34_75_137_PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209608">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137 </ci>
              <ci> PP2ACa </ci>
              <ci> kon47 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon47" metaid="_209620" name="kon47" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat47" metaid="metaid_0000195" name="D34:75:137_dephospho_by_PP2ACa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209632" species="D34_75_137_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209644" species="D34_137"/>
          <speciesReference metaid="_209656" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209668">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2ACa </ci>
              <ci> kcat47 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat47" metaid="_209680" name="kcat47" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff47" metaid="metaid_0000196" name="D34:75:137_PP2ACa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209692" species="D34_75_137_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209704" species="D34_75_137"/>
          <speciesReference metaid="_209716" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209728">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2ACa </ci>
              <ci> koff47 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff47" metaid="_209740" name="koff47" value="6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat46" metaid="metaid_0000197" name="D34:75_dephospho_by_PP2ACa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209752" species="D34_75_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209764" species="D34"/>
          <speciesReference metaid="_209776" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209788">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2ACa </ci>
              <ci> kcat46 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat46" metaid="_209800" name="kcat46" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff46" metaid="metaid_0000198" name="D34:75_PP2ACa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209812" species="D34_75_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209824" species="D34_75"/>
          <speciesReference metaid="_209836" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209848">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2ACa </ci>
              <ci> koff46 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff46" metaid="_209860" name="koff46" value="6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von48" metaid="metaid_0000199" name="D75_PP2ACa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209872" species="D75"/>
          <speciesReference metaid="_209884" species="PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209896" species="D75_PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209908">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75 </ci>
              <ci> PP2ACa </ci>
              <ci> kon48 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon48" metaid="_209920" name="kon48" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von49" metaid="metaid_0000201" name="D75:137_PP2ACa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209932" species="D75_137"/>
          <speciesReference metaid="_209944" species="PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_209956" species="D75_137_PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_209969">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137 </ci>
              <ci> PP2ACa </ci>
              <ci> kon49 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon49" metaid="_209981" name="kon49" value="3800000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat49" metaid="metaid_0000203" name="D75:137_dephospho_by_PP2ACa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_209993" species="D75_137_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210005" species="D137"/>
          <speciesReference metaid="_210017" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_210029">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2ACa </ci>
              <ci> kcat49 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat49" metaid="_210041" name="kcat49" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff49" metaid="metaid_0000204" name="D75:137_PP2ACa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210053" species="D75_137_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210065" species="D75_137"/>
          <speciesReference metaid="_210077" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_210089">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2ACa </ci>
              <ci> koff49 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff49" metaid="_210101" name="koff49" value="6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat48" metaid="metaid_0000205" name="D75_dephospho_by_PP2ACa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210113" species="D75_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210125" species="D"/>
          <speciesReference metaid="_210137" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_210150">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2ACa </ci>
              <ci> kcat48 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat48" metaid="_210162" name="kcat48" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff48" metaid="metaid_0000206" name="D75_PP2ACa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210174" species="D75_PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210186" species="D75"/>
          <speciesReference metaid="_210198" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_210210">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2ACa </ci>
              <ci> koff48 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff48" metaid="_210222" name="koff48" value="6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von50" metaid="metaid_0000207" name="D34:75_PP2APCa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210234" species="D34_75"/>
          <speciesReference metaid="_210246" species="PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210258" species="D34_75_PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210272">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75 </ci>
              <ci> PP2APCa </ci>
              <ci> kon50 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon50" metaid="_210284" name="kon50" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von51" metaid="metaid_0000210" name="D34:75:137_PP2APCa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210296" species="D34_75_137"/>
          <speciesReference metaid="_210308" species="PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210321" species="D34_75_137_PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210333">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137 </ci>
              <ci> PP2APCa </ci>
              <ci> kon51 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon51" metaid="_210345" name="kon51" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat51" metaid="metaid_0000212" name="D34:75:137_dephospho_by_PP2APCa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210357" species="D34_75_137_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210369" species="PP2APCa"/>
          <speciesReference metaid="_210381" species="D34_137"/>
        </listOfProducts>
        <kineticLaw metaid="_210393">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2APCa </ci>
              <ci> kcat51 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat51" metaid="_210405" name="kcat51" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff51" metaid="metaid_0000213" name="D34:75:137_PP2APCa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210417" species="D34_75_137_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210429" species="D34_75_137"/>
          <speciesReference metaid="_210441" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210453">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_137_PP2APCa </ci>
              <ci> koff51 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff51" metaid="_210465" name="koff51" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat50" metaid="metaid_0000214" name="D34:75_dephospho_by_PP2APCa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210477" species="D34_75_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210489" species="D34"/>
          <speciesReference metaid="_210501" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210513">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2APCa </ci>
              <ci> kcat50 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat50" metaid="_210525" name="kcat50" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff50" metaid="metaid_0000215" name="D34:75_PP2APCa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210537" species="D34_75_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210549" species="D34_75"/>
          <speciesReference metaid="_210561" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210573">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D34_75_PP2APCa </ci>
              <ci> koff50 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff50" metaid="_210585" name="koff50" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von52" metaid="metaid_0000216" name="D75_PP2APCa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210597" species="D75"/>
          <speciesReference metaid="_210609" species="PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210621" species="D75_PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210633">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75 </ci>
              <ci> PP2APCa </ci>
              <ci> kon52 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon52" metaid="_210645" name="kon52" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von53" metaid="metaid_0000218" name="D75:137_PP2APCa_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210657" species="D75_137"/>
          <speciesReference metaid="_210669" species="PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210681" species="D75_137_PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210693">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137 </ci>
              <ci> PP2APCa </ci>
              <ci> kon53 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon53" metaid="_210705" name="kon53" value="17000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat53" metaid="metaid_0000220" name="D75:137_dephospho_by_PP2APCa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210717" species="D75_137_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210729" species="D137"/>
          <speciesReference metaid="_210741" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210753">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2APCa </ci>
              <ci> kcat53 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat53" metaid="_210765" name="kcat53" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff53" metaid="metaid_0000221" name="D75:137_PP2APCa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210777" species="D75_137_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210789" species="D75_137"/>
          <speciesReference metaid="_210801" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210813">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_137_PP2APCa </ci>
              <ci> koff53 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff53" metaid="_210825" name="koff53" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat52" metaid="metaid_0000222" name="D75_dephospho_by_PP2APCa_on_75" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210837" species="D75_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210849" species="D"/>
          <speciesReference metaid="_210861" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210873">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2APCa </ci>
              <ci> kcat52 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat52" metaid="_210885" name="kcat52" value="24"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff52" metaid="metaid_0000223" name="D75_PP2APCa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210897" species="D75_PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210909" species="D75"/>
          <speciesReference metaid="_210921" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_210933">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> D75_PP2APCa </ci>
              <ci> koff52 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff52" metaid="_210945" name="koff52" value="10"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von54" metaid="metaid_0000224" name="PP2A_Ca_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_210957" species="Ca"/>
          <speciesReference metaid="_210969" species="PP2A"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_210981" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_210993">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2A </ci>
              <ci> Ca </ci>
              <ci> kon54 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon54" metaid="_211006" name="kon54" value="200000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff54" metaid="metaid_0000225" name="PP2A_Ca_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211018" species="PP2ACa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211030" species="PP2A"/>
          <speciesReference metaid="_211042" species="Ca"/>
        </listOfProducts>
        <kineticLaw metaid="_211054">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2ACa </ci>
              <ci> koff54 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff54" metaid="_211066" name="koff54" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von55" metaid="metaid_0000226" name="PP2ACa_PKA_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211078" species="PP2ACa"/>
          <speciesReference metaid="_211090" species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211102" species="PP2ACa_PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_211114">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PKA </ci>
              <ci> PP2ACa </ci>
              <ci> kon55 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon55" metaid="_211127" name="kon55" value="10000000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat55" metaid="metaid_0000228" name="PP2ACa_phospho_by_PKA" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211139" species="PP2ACa_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211151" species="PP2APCa"/>
          <speciesReference metaid="_211164" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_211176">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2ACa_PKA </ci>
              <ci> kcat55 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat55" metaid="_211188" name="kcat55" value="4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="von56" metaid="metaid_0000229" name="PP2AP_Ca_binding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211200" species="PP2AP"/>
          <speciesReference metaid="_211212" species="Ca"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211224" species="PP2APCa"/>
        </listOfProducts>
        <kineticLaw metaid="_211236">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2AP </ci>
              <ci> Ca </ci>
              <ci> kon56 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kon56" metaid="_211248" name="kon56" value="200000"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff56" metaid="metaid_0000230" name="PP2APCa_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211260" species="PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211272" species="PP2AP"/>
          <speciesReference metaid="_211284" species="Ca"/>
        </listOfProducts>
        <kineticLaw metaid="_211296">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2APCa </ci>
              <ci> koff56 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff56" metaid="_211308" name="koff56" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="vcat56" metaid="metaid_0000231" name="PP2APCa_dephospho" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211320" species="PP2APCa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211332" species="PP2ACa"/>
        </listOfProducts>
        <kineticLaw metaid="_211344">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2APCa </ci>
              <ci> kcat56 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="kcat56" metaid="_211356" name="kcat56" value="5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="voff55" metaid="metaid_0000233" name="PP2ACa_PKA_unbinding" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_211368" species="PP2ACa_PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_211380" species="PP2ACa"/>
          <speciesReference metaid="_211392" species="PKA"/>
        </listOfProducts>
        <kineticLaw metaid="_211404">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Spine </ci>
              <ci> PP2ACa_PKA </ci>
              <ci> koff55 </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="koff55" metaid="_211416" name="koff55" value="16"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
    <listOfEvents>
      <event id="cAMP_pulse" metaid="metaid_0000240" name="cAMP_pulse">
        <trigger metaid="_211429">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <ci> cAMP_delay </ci>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211441" variable="cAMP">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <cn type="e-notation">6.6 <sep/> -6 </cn>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on1" metaid="metaid_0000241" name="ca_on1">
        <trigger metaid="_211453">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211465" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on2" metaid="metaid_0000242" name="ca_on2">
        <trigger metaid="_211477">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 1 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211490" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off1" metaid="metaid_0000251" name="ca_off">
        <trigger metaid="_211503">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211516" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="Ca_on3" metaid="metaid_0000243" name="Ca_on3">
        <trigger metaid="_211529">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 2 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211542" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on4" metaid="metaid_0000244" name="ca_on4">
        <trigger metaid="_211555">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 3 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211568" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on5" metaid="metaid_0000245" name="ca_on5">
        <trigger metaid="_211581">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 4 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211594" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on6" metaid="metaid_0000246" name="ca_on6">
        <trigger metaid="_211606">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 5 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211618" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on7" metaid="metaid_0000247" name="ca_on7">
        <trigger metaid="_211630">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 6 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211642" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on8" metaid="metaid_0000248" name="ca_on8">
        <trigger metaid="_211654">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 7 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211666" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on9" metaid="metaid_0000249" name="ca_on9">
        <trigger metaid="_211678">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 8 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211690" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_on10" metaid="metaid_0000250" name="ca_on10">
        <trigger metaid="_211703">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <apply>
                  <times/>
                  <cn> 9 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_duration </ci>
                    <ci> spike_interval </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211716" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_high </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off2" metaid="metaid_0000252" name="ca_off2">
        <trigger metaid="_211728">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 1 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211740" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off3" metaid="metaid_0000253" name="ca_off3">
        <trigger metaid="_211752">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 2 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211764" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off4" metaid="metaid_0000254" name="ca_off4">
        <trigger metaid="_211776">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 3 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211789" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off5" metaid="metaid_0000255" name="ca_off5">
        <trigger metaid="_211801">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 4 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211813" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off6" metaid="metaid_0000256" name="ca_off6">
        <trigger metaid="_211825">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 5 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211837" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off7" metaid="metaid_0000257" name="ca_off7">
        <trigger metaid="_211849">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 6 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211861" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off8" metaid="metaid_0000258" name="ca_off8">
        <trigger metaid="_211873">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 7 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211885" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off9" metaid="metaid_0000259" name="ca_off9">
        <trigger metaid="_211897">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 8 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211909" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="ca_off10" metaid="metaid_0000260" name="ca_off10">
        <trigger metaid="_211921">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <geq/>
              <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
              <apply>
                <plus/>
                <ci> cAMP_delay </ci>
                <ci> cAMP_Ca_delay </ci>
                <ci> spike_duration </ci>
                <apply>
                  <times/>
                  <cn> 9 </cn>
                  <apply>
                    <plus/>
                    <ci> spike_interval </ci>
                    <ci> spike_duration </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </trigger>
        <listOfEventAssignments>
          <eventAssignment metaid="_211933" variable="k57">
            <math xmlns="http://www.w3.org/1998/Math/MathML">            
              <ci> kon_low </ci>
            </math>
                    </eventAssignment>
        </listOfEventAssignments>
      </event>
    </listOfEvents>
  </model>
</sbml>