LEFT 0 conversion R25 Smads Complex Dissociation Smads Complex n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smads Complex n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/taxonomy/131567
type: unificationXref
ID: 131567
DB: Taxonomy

RIGHT 0 conversion R8 T1R EE formation T1R EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

conversion R25 Smads Complex Dissociation
type: complexAssembly
LEFT: LEFT 0 conversion R25 Smads Complex Dissociation Smads Complex n
SPONTANEOUS: R_L
RIGHT: RIGHT 1 conversion R25 Smads Complex Dissociation Smad2n
RIGHT: RIGHT 0 conversion R25 Smads Complex Dissociation Smad4n

LEFT 0 conversion R19 LRC Cave recycling LRC Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R24 Smads Complex import Smads Complex n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smads Complex n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R4 Smad4 export Smad4c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad4c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0005737
type: unificationXref
ID: GO:0005737
DB: Gene Ontology

Q13485
type: unificationXref
ID: Q13485
DB: UniProt Knowledgebase

LEFT 0 conversion R1 Smad2 import Smad2c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad2c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/pubmed/17895977
type: publicationXref
ID: 17895977
DB: PubMed

GO:0005576
type: unificationXref
ID: GO:0005576
DB: Gene Ontology

LEFT 0 conversion R18 LRC Cave formation LRC Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R13 T2R Cave recycling T2R Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

P01137
type: unificationXref
ID: P01137
DB: UniProt Knowledgebase

LEFT 0 conversion R9 T1R EE recycling T1R EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R7 T1R Cave recycling T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

Q8NER5
type: unificationXref
ID: Q8NER5
DB: UniProt Knowledgebase

RIGHT 0 conversion R17 LRC formation LRC Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R12 T2R Cave formation T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R1 Smad2 import Smad2n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad2n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

Zi2007 TGFbeta signaling
type: pathway
XREF: MODEL3388742457
XREF: GO:0017015
XREF: http://identifiers.org/pubmed/17895977
XREF: hsa04350
XREF: BIOMD0000000163
PATHWAY-COMPONENTS: conversion R8 T1R EE formation
PATHWAY-COMPONENTS: conversion R5 T1R production
PATHWAY-COMPONENTS: conversion R18 LRC Cave formation
PATHWAY-COMPONENTS: conversion R10 T1R EE degradation
PATHWAY-COMPONENTS: conversion R13 T2R Cave recycling
PATHWAY-COMPONENTS: conversion R6 T1R Cave formation
PATHWAY-COMPONENTS: conversion R26 LRC Cave degradation
PATHWAY-COMPONENTS: conversion R23 Smads Complex formation
PATHWAY-COMPONENTS: conversion R1 Smad2 import
PATHWAY-COMPONENTS: conversion R15 T2R EE recycling
PATHWAY-COMPONENTS: conversion R19 LRC Cave recycling
PATHWAY-COMPONENTS: conversion R9 T1R EE recycling
PATHWAY-COMPONENTS: conversion R3 Smad4 import
PATHWAY-COMPONENTS: conversion R14 T2R EE formation
PATHWAY-COMPONENTS: conversion R7 T1R Cave recycling
PATHWAY-COMPONENTS: conversion R20 LRC EE formation
PATHWAY-COMPONENTS: conversion R11 T2R production
PATHWAY-COMPONENTS: conversion R12 T2R Cave formation
PATHWAY-COMPONENTS: conversion R25 Smads Complex Dissociation
PATHWAY-COMPONENTS: conversion R4 Smad4 export
PATHWAY-COMPONENTS: conversion R2 Smad2 export
PATHWAY-COMPONENTS: conversion R17 LRC formation
PATHWAY-COMPONENTS: conversion R22 LRC EE degradation
PATHWAY-COMPONENTS: conversion R21 LRC EE recycling
PATHWAY-COMPONENTS: conversion R24 Smads Complex import
PATHWAY-COMPONENTS: conversion R16 T2R EE degradation
COMMENT: The original model, 'Zi2007_TGFbeta_signaling', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
COMMENT: This BioPAX Level2 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
ORGANISM: biosource 1
DATA-SOURCE: datasource 2
DATA-SOURCE: datasource 1

RIGHT 0 conversion R23 Smads Complex formation Smads Complex c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smads Complex c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

P37173
type: unificationXref
ID: P37173
DB: UniProt Knowledgebase

LEFT 0 conversion R2 Smad2 export Smad2n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad2n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R3 Smad4 import Smad4c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad4c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R6 T1R Cave formation T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R10 T1R EE degradation T1R EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R18 LRC Cave formation LRC Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R7 T1R Cave recycling T1R Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

conversion R23 Smads Complex formation
type: complexAssembly
XREF: GO:0007184
LEFT: LEFT 1 conversion R23 Smads Complex formation Smad4c
LEFT: LEFT 0 conversion R23 Smads Complex formation Smad2c
SPONTANEOUS: L_R
RIGHT: RIGHT 0 conversion R23 Smads Complex formation Smads Complex c

RIGHT 0 conversion R14 T2R EE formation T2R EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R14 T2R EE formation T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R16 T2R EE degradation T2R EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 1 conversion R23 Smads Complex formation Smad4c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad4c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R23 Smads Complex formation Smad2c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad2c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R2 Smad2 export Smad2c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad2c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R3 Smad4 import Smad4n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad4n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R21 LRC EE recycling T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0006886
type: unificationXref
ID: GO:0006886
DB: Gene Ontology

GO:0005160
type: unificationXref
ID: GO:0005160
DB: Gene Ontology

RIGHT 1 conversion R25 Smads Complex Dissociation Smad2n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad2n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0007184
type: unificationXref
ID: GO:0007184
DB: Gene Ontology

GO:0017015
type: unificationXref
ID: GO:0017015
DB: Gene Ontology

RIGHT 0 conversion R19 LRC Cave recycling T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0032906
type: unificationXref
ID: GO:0032906
DB: Gene Ontology

RIGHT 0 conversion R13 T2R Cave recycling T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

conversion R26 LRC Cave degradation
type: complexAssembly
XREF: GO:0030163
LEFT: LEFT 0 conversion R26 LRC Cave degradation LRC Cave
SPONTANEOUS: R_L

GO:0032905
type: unificationXref
ID: GO:0032905
DB: Gene Ontology

RIGHT 1 conversion R15 T2R EE recycling TGF beta
type: physicalEntityParticipant
PHYSICAL-ENTITY: TGF beta
CELLULAR-LOCATION: V medium
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 2 conversion R17 LRC formation T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R17 LRC formation TGF beta
type: physicalEntityParticipant
PHYSICAL-ENTITY: TGF beta
CELLULAR-LOCATION: V medium
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0030163
type: unificationXref
ID: GO:0030163
DB: Gene Ontology

RIGHT 0 conversion R12 T2R Cave formation T2R Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R26 LRC Cave degradation LRC Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 1 conversion R21 LRC EE recycling T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R20 LRC EE formation LRC Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 2 conversion R21 LRC EE recycling TGF beta
type: physicalEntityParticipant
PHYSICAL-ENTITY: TGF beta
CELLULAR-LOCATION: V medium
STOICHIOMETRIC-COEFFICIENT: 1.0

V medium
type: openControlledVocabulary
XREF: GO:0005576
TERM: Medium

LEFT 0 conversion R8 T1R EE formation T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

V cyt
type: openControlledVocabulary
XREF: GO:0005737
TERM: Cytoplasm

RIGHT 2 conversion R19 LRC Cave recycling T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

MODEL3388742457
type: unificationXref
ID: MODEL3388742457
DB: BioModels Database

RIGHT 1 conversion R19 LRC Cave recycling TGF beta
type: physicalEntityParticipant
PHYSICAL-ENTITY: TGF beta
CELLULAR-LOCATION: V medium
STOICHIOMETRIC-COEFFICIENT: 1.0

BIOMD0000000163
type: unificationXref
ID: BIOMD0000000163
DB: BioModels Database

LEFT 0 conversion R21 LRC EE recycling LRC EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R9 T1R EE recycling T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

Q15796
type: unificationXref
ID: Q15796
DB: UniProt Knowledgebase

LEFT 0 conversion R22 LRC EE degradation LRC EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R6 T1R Cave formation T1R Cave
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Cave
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R15 T2R EE recycling T2R EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion R24 Smads Complex import Smads Complex c
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smads Complex c
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R5 T1R production T1R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T1R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R15 T2R EE recycling T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

datasource 2
type: dataSource
XREF: BIOMD0000000163
NAME: BioModels Database

hsa04350
type: unificationXref
ID: hsa04350
DB: KEGG Pathway

LEFT 0 conversion R4 Smad4 export Smad4n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad4n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R11 T2R production T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0005634
type: unificationXref
ID: GO:0005634
DB: Gene Ontology

LEFT 1 conversion R17 LRC formation T2R Surf
type: physicalEntityParticipant
PHYSICAL-ENTITY: T2R Surf
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

conversion R22 LRC EE degradation
type: complexAssembly
XREF: GO:0017015
LEFT: LEFT 0 conversion R22 LRC EE degradation LRC EE
SPONTANEOUS: R_L

datasource 1
type: dataSource
XREF: MODEL3388742457
NAME: BioModels Database

GO:0002090
type: unificationXref
ID: GO:0002090
DB: Gene Ontology

RIGHT 0 conversion R20 LRC EE formation LRC EE
type: physicalEntityParticipant
PHYSICAL-ENTITY: LRC EE
CELLULAR-LOCATION: V cyt
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion R25 Smads Complex Dissociation Smad4n
type: physicalEntityParticipant
PHYSICAL-ENTITY: Smad4n
CELLULAR-LOCATION: V nuc
STOICHIOMETRIC-COEFFICIENT: 1.0

V nuc
type: openControlledVocabulary
XREF: GO:0005634
TERM: Nucleus

GO:0031623
type: unificationXref
ID: GO:0031623
DB: Gene Ontology