<?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" metaid="metaid_0000001" version="1" xmlns:html="http://www.w3.org/1999/xhtml" xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell" xmlns:math="http://www.w3.org/1998/Math/MathML" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:sbml="http://www.sbml.org/sbml/level2">
  <model id="Obeyesekere1999_CellCycle" metaid="metaid_0000002" name="Obeyesekere1999_CellCycle">
    <notes>
      <body xmlns="http://www.w3.org/1999/xhtml">
        <p>The model reproduces the time profiles of the different species depicted in Fig 3a of the paper. Model successfully reproduced using MathSBML.</p>
            <br/>
            <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Creative Commons CC0">CC0 Public Domain Dedication</a>
          for more information.      </p>
            <p>In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.</p>
            <br/>
            <p>To cite BioModels Database, please use:      <a href="http://www.ncbi.nlm.nih.gov/pubmed/20587024" target="_blank">Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.</a>
                </p>
            </body>
      
    </notes>
    <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
        <rdf:Description rdf:about="#metaid_0000002">
	<dc:creator>
	<rdf:Bag>
	<rdf:li rdf:parseType="Resource">
	<vCard:N rdf:parseType="Resource">
	<vCard:Family>Dharuri</vCard:Family>
	<vCard:Given>Harish</vCard:Given>
	</vCard:N>
	<vCard:EMAIL>hdharuri@cds.caltech.edu</vCard:EMAIL>
	<vCard:ORG rdf:parseType="Resource">
	<vCard:Orgname>California Institute of Technology</vCard:Orgname>
	</vCard:ORG>
	</rdf:li>
	</rdf:Bag>
	</dc:creator>
	<dcterms:created rdf:parseType="Resource">
	<dcterms:W3CDTF>2008-03-16T19:31:22Z</dcterms:W3CDTF>
	</dcterms:created>
	<dcterms:modified rdf:parseType="Resource">
	<dcterms:W3CDTF>2014-05-27T22:24:11Z</dcterms:W3CDTF>
	</dcterms:modified>
	<bqmodel:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/biomodels.db/MODEL3896909694"/>
	</rdf:Bag>
	</bqmodel:is>
	<bqmodel:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/biomodels.db/BIOMD0000000168"/>
	</rdf:Bag>
	</bqmodel:is>
	<bqmodel:isDescribedBy>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/pubmed/17886749"/>
	</rdf:Bag>
	</bqmodel:isDescribedBy>
	<bqmodel:isDerivedFrom>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/pubmed/9375029"/>
	</rdf:Bag>
	</bqmodel:isDerivedFrom>
	<bqbiol:isPartOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/kegg.pathway/hsa04110"/>
	</rdf:Bag>
	</bqbiol:isPartOf>
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0000278"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	<bqbiol:hasTaxon>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/taxonomy/2759"/>
	</rdf:Bag>
	</bqbiol:hasTaxon>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
      <listOfCompartments>
      <compartment id="cell_1" metaid="metaid_0000023" name="cell" size="1">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000023">
	<bqbiol:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0005623"/>
	</rdf:Bag>
	</bqbiol:is>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </compartment>
    </listOfCompartments>
    <listOfSpecies>
      <species compartment="cell_1" id="D_1" initialAmount="0.1" metaid="metaid_0000024" name="D">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000024">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P24385"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell_1" id="E_1" initialAmount="0.6" metaid="metaid_0000025" name="E">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000025">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P24864"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell_1" id="RS_1" initialAmount="1" metaid="metaid_0000026" name="RS">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000026">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q01094"/>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P06400"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell_1" id="R_1" initialAmount="0.5" metaid="metaid_0000027" name="R">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000027">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P06400"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell_1" id="X_1" initialAmount="0.7" metaid="metaid_0000028" name="X"/>
      <species compartment="cell_1" id="E2F_1" metaid="metaid_0000029" name="E2F">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000029">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q01094"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell_1" id="RP_1" metaid="metaid_0000030" name="RP">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000030">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P06400"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
            </species>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="aD_1" metaid="metaid_0000003" name="aD" value="0.4"/>
      <parameter id="k_1" metaid="metaid_0000004" name="k" value="0.05"/>
      <parameter id="GF_1" metaid="metaid_0000005" name="GF" value="6.3"/>
      <parameter id="dD_1" metaid="metaid_0000006" name="dD" value="0.4"/>
      <parameter id="aE_1" metaid="metaid_0000007" name="aE" value="0.16"/>
      <parameter id="af_1" metaid="metaid_0000008" name="af" value="0.9"/>
      <parameter id="theta_1" metaid="metaid_0000009" name="theta" value="1.5"/>
      <parameter id="dE_1" metaid="metaid_0000010" name="dE" value="0.2"/>
      <parameter id="pX_1" metaid="metaid_0000011" name="pX" value="0.48"/>
      <parameter id="RT_1" metaid="metaid_0000012" name="RT" value="2.5"/>
      <parameter id="pS_1" metaid="metaid_0000013" name="pS" value="0.6"/>
      <parameter id="pD_1" metaid="metaid_0000014" name="pD" value="0.48"/>
      <parameter id="qD_1" metaid="metaid_0000015" name="qD" value="0.6"/>
      <parameter id="pE_1" metaid="metaid_0000016" name="pE" value="0.096"/>
      <parameter id="qE_1" metaid="metaid_0000017" name="qE" value="0.6"/>
      <parameter id="aX_1" metaid="metaid_0000018" name="aX" value="0.08"/>
      <parameter id="f_1" metaid="metaid_0000019" name="f" value="0.2"/>
      <parameter id="g_1" metaid="metaid_0000020" name="g" value="0.528"/>
      <parameter id="dX_1" metaid="metaid_0000021" name="dX" value="1.04"/>
      <parameter id="qX_1" metaid="metaid_0000022" name="qX" value="0.8"/>
      <parameter constant="false" id="unpho_RB" metaid="metaid_0000043" value="0"/>
    </listOfParameters>
    <listOfRules>
      <assignmentRule metaid="metaid_0000031" variable="E2F_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <apply>
            <minus/>
            <ci> theta_1 </ci>
            <ci> RS_1 </ci>
          </apply>
        </math>
            </assignmentRule>
      <assignmentRule metaid="metaid_0000032" variable="RP_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <apply>
            <minus/>
            <apply>
              <minus/>
              <ci> RT_1 </ci>
              <ci> RS_1 </ci>
            </apply>
            <ci> R_1 </ci>
          </apply>
        </math>
            </assignmentRule>
      <assignmentRule metaid="metaid_0000044" variable="unpho_RB">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <apply>
            <plus/>
            <ci> R_1 </ci>
            <ci> RS_1 </ci>
          </apply>
        </math>
            </assignmentRule>
    </listOfRules>
    <listOfReactions>
      <reaction id="_1" metaid="metaid_0000033" name="cycD/CDK4 synthesis" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000033">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0006412"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfProducts>
          <speciesReference metaid="_077317" species="D_1"/>
        </listOfProducts>
        <kineticLaw metaid="_077330">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> aD_1 </ci>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <ci> k_1 </ci>
                  <ci> GF_1 </ci>
                </apply>
                <apply>
                  <plus/>
                  <cn> 1 </cn>
                  <apply>
                    <times/>
                    <ci> k_1 </ci>
                    <ci> GF_1 </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="cyclinCDK4degradation_1" metaid="metaid_0000034" name="cycD/CDK4 degradation" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000034">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0008054"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfReactants>
          <speciesReference metaid="_077342" species="D_1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077354" species="D_1"/>
          <modifierSpeciesReference metaid="_077366" species="E_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077378">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> dD_1 </ci>
              <ci> E_1 </ci>
              <ci> D_1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="cyclin_1" metaid="metaid_0000035" name="cycE/CDK2 synthesis" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000035">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0006412"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfProducts>
          <speciesReference metaid="_077390" species="E_1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077402" species="E2F_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077414">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> aE_1 </ci>
              <apply>
                <plus/>
                <cn> 1 </cn>
                <apply>
                  <times/>
                  <ci> af_1 </ci>
                  <ci> E2F_1 </ci>
                </apply>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="cycECDK2degradation_1" metaid="metaid_0000036" name="cycE/CDK2 degradation" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000036">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0008054"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfReactants>
          <speciesReference metaid="_077426" species="E_1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077438" species="E_1"/>
          <modifierSpeciesReference metaid="_077450" species="X_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077462">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> dE_1 </ci>
              <ci> X_1 </ci>
              <ci> E_1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="pRBpdephosphorylation_1" metaid="metaid_0000037" name="pRB-p dephosphorilation" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000037">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0016311"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfProducts>
          <speciesReference metaid="_077474" species="R_1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077486" species="RP_1"/>
          <modifierSpeciesReference metaid="_077498" species="X_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077534">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> pX_1 </ci>
                <ci> RP_1 </ci>
                <ci> X_1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> qX_1 </ci>
                <ci> RP_1 </ci>
                <ci> X_1 </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="pRBE2Fcomplexassociation_1" metaid="metaid_0000038" name="pRB/E2F complex association" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000038">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0006461"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfReactants>
          <speciesReference metaid="_077546" species="R_1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_077558" species="RS_1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077570" species="RS_1"/>
          <modifierSpeciesReference metaid="_077582" species="R_1"/>
          <modifierSpeciesReference metaid="_077594" species="E2F_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077606">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> pS_1 </ci>
              <ci> E2F_1 </ci>
              <ci> R_1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="pRBE2FcomplexdeassociationviacycDCDK4_1" metaid="metaid_0000039" name="pRB/E2F complex deassociation via cycD/CDK4" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000039">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0043624"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfReactants>
          <speciesReference metaid="_077618" species="RS_1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077630" species="RS_1"/>
          <modifierSpeciesReference metaid="_077642" species="D_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077678">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> pD_1 </ci>
                <ci> RS_1 </ci>
                <ci> D_1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> qD_1 </ci>
                <ci> RS_1 </ci>
                <ci> D_1 </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="_7" metaid="metaid_0000040" name="pRB/E2F complex deassociation via cycE/CDK2" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000040">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0043624"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfReactants>
          <speciesReference metaid="_077690" species="RS_1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077702" species="RS_1"/>
          <modifierSpeciesReference metaid="_077714" species="E_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077750">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> pE_1 </ci>
                <ci> RS_1 </ci>
                <ci> E_1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> qE_1 </ci>
                <ci> RS_1 </ci>
                <ci> E_1 </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="cycleprogression_1" metaid="metaid_0000041" name="cycle progression" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000041">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0051726"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfProducts>
          <speciesReference metaid="_077762" species="X_1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077774" species="E_1"/>
          <modifierSpeciesReference metaid="_077786" species="E2F_1"/>
          <modifierSpeciesReference metaid="_077798" species="X_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077823">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> aX_1 </ci>
                <ci> E_1 </ci>
              </apply>
              <apply>
                <times/>
                <ci> f_1 </ci>
                <ci> E2F_1 </ci>
              </apply>
              <apply>
                <times/>
                <ci> g_1 </ci>
                <apply>
                  <power/>
                  <ci> X_1 </ci>
                  <cn> 2 </cn>
                </apply>
                <ci> E_1 </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="cyclebreak_1" metaid="metaid_0000042" name="cycle break" reversible="false">
        <annotation xmlns:jigcell="http://www.sbml.org/2001/ns/jigcell">
<jigcell:ratelaw jigcell:name="Local"/>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000042">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0051726"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	</rdf:RDF>
	</annotation>
              <listOfReactants>
          <speciesReference metaid="_077835" species="X_1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_077847" species="X_1"/>
        </listOfModifiers>
        <kineticLaw metaid="_077859">
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> dX_1 </ci>
              <ci> X_1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>