Rab5-GDP
type: Complex
xref: CHEBI:17552
xref: GO:0031225
xref: P20339

GO:0045184
type: UnificationXref
id: GO:0045184
db: Gene Ontology

Rab7-GDP
type: Complex
xref: CHEBI:17552
xref: P51149
xref: GO:0031225

r7
type: PhysicalEntity
member physical entity: Rab7-GDP
cellular location: endosomal membrane

LEFT 0 conversion reaction 5 r7 STOICHIOMETRY
type: Stoichiometry
physical entity: r7
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 9 R7 STOICHIOMETRY
type: Stoichiometry
physical entity: R7
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 1 r5 STOICHIOMETRY
type: Stoichiometry
physical entity: r5
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 7 r7 STOICHIOMETRY
type: Stoichiometry
physical entity: r7
stoichiometric coefficient: 1.0

r7
type: PhysicalEntity
member physical entity: Rab7-GDP
cellular location: endosomal membrane

LEFT 0 conversion reaction 6 R5 STOICHIOMETRY
type: Stoichiometry
physical entity: R5
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

GO:0005097
type: UnificationXref
id: GO:0005097
db: Gene Ontology

LEFT 0 conversion reaction 4 r7 STOICHIOMETRY
type: Stoichiometry
physical entity: r7
stoichiometric coefficient: 1.0

MAMO_0000046
type: UnificationXref
id: MAMO_0000046
db: Mathematical Modelling Ontology

hydrolysis of Rab5 by Rab7
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 6 r5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 6 R5 STOICHIOMETRY
xref: GO:0003924
xref: GO:0005097
right: r5
left: R5

Model 1
type: Pathway
pathway component: hydrolysis of Rab5 by Rab7
pathway component: activation of Rab7 by GEF5
pathway component: hydrolysis of Rab5 (intr.)
pathway component: extraction of rab7
pathway component: hydrolysis of Rab7 (intr.)
pathway component: recruitment of Rab5
pathway component: extraction of Rab5
pathway component: activation of Rab5 (time)
pathway component: activation of Rab7 by GEF7
pathway component: recruitment of Rab7
xref: http://identifiers.org/pubmed/10591225
xref: BIOMD0000000174
xref: MODEL5937037510
xref: http://identifiers.org/pubmed/18628746
xref: GO:0032313
xref: MAMO_0000046
xref: http://identifiers.org/pubmed/16890441
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Model_1', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

activation of Rab7 by GEF5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 5 r7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 5 R7 STOICHIOMETRY
xref: GO:0032858
xref: GO:0017112
right: R7
left: r7

hydrolysis of Rab5 (intr.)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 8 R5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 8 r5 STOICHIOMETRY
xref: GO:0003924
right: r5
left: R5

Rab5-GTP
type: Complex
xref: CHEBI:15996
xref: GO:0031225
xref: P20339

RIGHT 0 conversion reaction 6 r5 STOICHIOMETRY
type: Stoichiometry
physical entity: r5
stoichiometric coefficient: 1.0

extraction of rab7
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 7 r7 STOICHIOMETRY
spontaneous: true
left: r7
conversion direction: RIGHT_TO_LEFT

GO:0032858
type: UnificationXref
id: GO:0032858
db: Gene Ontology

Rab7-GTP
type: Complex
xref: CHEBI:15996
xref: P51149
xref: GO:0031225

r5
type: PhysicalEntity
member physical entity: Rab5-GDP
cellular location: endosomal membrane

R5
type: PhysicalEntity
member physical entity: Rab5-GTP
cellular location: endosomal membrane

hydrolysis of Rab7 (intr.)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 9 R7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 9 r7 STOICHIOMETRY
xref: GO:0003924
right: r7
left: R7

r7
type: PhysicalEntity
member physical entity: Rab7-GDP
cellular location: endosomal membrane

recruitment of Rab5
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 0 r5 STOICHIOMETRY
xref: GO:0045184
right: r5
spontaneous: true
conversion direction: LEFT_TO_RIGHT

extraction of Rab5
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 2 r5 STOICHIOMETRY
spontaneous: true
left: r5
conversion direction: RIGHT_TO_LEFT

activation of Rab5 (time)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 1 R5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 1 r5 STOICHIOMETRY
xref: GO:0032858
right: R5
left: r5

activation of Rab7 by GEF7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 4 r7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 4 R7 STOICHIOMETRY
xref: GO:0032858
xref: GO:0017112
right: R7
left: r7

recruitment of Rab7
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 3 r7 STOICHIOMETRY
xref: GO:0045184
right: r7
spontaneous: true
conversion direction: LEFT_TO_RIGHT

r5
type: PhysicalEntity
member physical entity: Rab5-GDP
cellular location: endosomal membrane

http://identifiers.org/pubmed/10591225
type: PublicationXref
id: 10591225
db: PubMed

CHEBI:15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

P51149
type: UnificationXref
id: P51149
db: UniProt Knowledgebase

R7
type: PhysicalEntity
member physical entity: Rab7-GTP
cellular location: endosomal membrane

GO:0010008
type: UnificationXref
id: GO:0010008
db: Gene Ontology

GO:0017112
type: UnificationXref
id: GO:0017112
db: Gene Ontology

R5
type: PhysicalEntity
member physical entity: Rab5-GTP
cellular location: endosomal membrane

r7
type: PhysicalEntity
member physical entity: Rab7-GDP
cellular location: endosomal membrane

r5
type: PhysicalEntity
member physical entity: Rab5-GDP
cellular location: endosomal membrane

R5
type: PhysicalEntity
member physical entity: Rab5-GTP
cellular location: endosomal membrane

RIGHT 0 conversion reaction 3 r7 STOICHIOMETRY
type: Stoichiometry
physical entity: r7
stoichiometric coefficient: 1.0

r7
type: PhysicalEntity
member physical entity: Rab7-GDP
cellular location: endosomal membrane

GO:0003924
type: UnificationXref
id: GO:0003924
db: Gene Ontology

MODEL5937037510
type: UnificationXref
id: MODEL5937037510
db: BioModels Database

RIGHT 0 conversion reaction 8 r5 STOICHIOMETRY
type: Stoichiometry
physical entity: r5
stoichiometric coefficient: 1.0

P20339
type: UnificationXref
id: P20339
db: UniProt Knowledgebase

endosomal membrane
type: CellularLocationVocabulary
xref: GO:0010008

R7
type: PhysicalEntity
member physical entity: Rab7-GTP
cellular location: endosomal membrane

R7
type: PhysicalEntity
member physical entity: Rab7-GTP
cellular location: endosomal membrane

RIGHT 0 conversion reaction 1 R5 STOICHIOMETRY
type: Stoichiometry
physical entity: R5
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 5 R7 STOICHIOMETRY
type: Stoichiometry
physical entity: R7
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: BIOMD0000000174

BIOMD0000000174
type: UnificationXref
id: BIOMD0000000174
db: BioModels Database

r5
type: PhysicalEntity
member physical entity: Rab5-GDP
cellular location: endosomal membrane

BioModels Database
type: Provenance
xref: MODEL5937037510

RIGHT 0 conversion reaction 4 R7 STOICHIOMETRY
type: Stoichiometry
physical entity: R7
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 0 r5 STOICHIOMETRY
type: Stoichiometry
physical entity: r5
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 8 R5 STOICHIOMETRY
type: Stoichiometry
physical entity: R5
stoichiometric coefficient: 1.0

CHEBI:17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

GO:0031225
type: UnificationXref
id: GO:0031225
db: Gene Ontology

LEFT 0 conversion reaction 2 r5 STOICHIOMETRY
type: Stoichiometry
physical entity: r5
stoichiometric coefficient: 1.0

r5
type: PhysicalEntity
member physical entity: Rab5-GDP
cellular location: endosomal membrane

http://identifiers.org/pubmed/18628746
type: PublicationXref
id: 18628746
db: PubMed

GO:0032313
type: UnificationXref
id: GO:0032313
db: Gene Ontology

http://identifiers.org/pubmed/16890441
type: PublicationXref
id: 16890441
db: PubMed

RIGHT 0 conversion reaction 9 r7 STOICHIOMETRY
type: Stoichiometry
physical entity: r7
stoichiometric coefficient: 1.0