MODEL8609366518
type: Pathway
pathway component: PKA_P_PTP
pathway component: iso_binds_BAR_g
pathway component: PTP_PKA
pathway component: AC_activation
pathway component: PPase_mek
pathway component: iso_binds_BAR
pathway component: AC_basal
pathway component: G_binds_iso_BAR
pathway component: GRK
pathway component: PPase_Raf
pathway component: AC_active
pathway component: Raf_activates_MEK
pathway component: pp_ptp
pathway component: A1
pathway component: pde4_p
pathway component: A2
pathway component: bg_binds_GRK
pathway component: PTP
pathway component: GRK_bg
pathway component: highKM_PDE
pathway component: PDE4
pathway component: G_binds_BAR
pathway component: activate_Gs
pathway component: MEK_activates_MAPK
pathway component: PKA_activates_Raf
pathway component: pp2a_4
pathway component: B1
pathway component: B2
pathway component: trimer
pathway component: PPase_MAPK
pathway component: GTPase
pathway component: PKA_P_PDE
xref: GO:0000902
xref: BIOMD0000000182
xref: GO:0007190
xref: http://identifiers.org/pubmed/18485874
xref: GO:0000165
xref: rno04010
xref: MODEL8609366518
organism: biosource 1
comment: The original model, 'MODEL8609366518', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
data source: BioModels Database

LEFT 0 conversion PKA P PTP PTP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PTP_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion PPase mek MEK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MEK_cyto
stoichiometric coefficient: 1.0

iso_BAR_p_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_p_cyto_mem
cellular location: cyto_mem

LEFT 0 conversion bg binds GRK GRK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: GRK_cyto
stoichiometric coefficient: 1.0

iso_BAR_p_cyto_mem
type: Complex
xref: P18090

MEK_active_cyto
type: PhysicalEntity
member physical entity: MEK_active_cyto
cellular location: cyto

GO:0004115
type: UnificationXref
id: GO:0004115
db: Gene Ontology

http://identifiers.org/ec-code/3.1.3.48
type: UnificationXref
id: 3.1.3.48
db: Enzyme Nomenclature

G_binds_iso_BAR
type: Transport
participant stoichiometry: LEFT 1 conversion G binds iso BAR G protein cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion G binds iso BAR iso BAR G cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion G binds iso BAR iso BAR cyto mem STOICHIOMETRY
xref: GO:0032795
right: iso_BAR_G_cyto_mem
left: G_protein_cyto
left: iso_BAR_cyto_mem

http://identifiers.org/ec-code/3.1.4.17
type: UnificationXref
id: 3.1.4.17
db: Enzyme Nomenclature

PDE4_P_cyto
type: PhysicalEntity
member physical entity: PDE4_P_cyto
cellular location: cyto

pp_ptp
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion pp ptp PTP PKA cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion pp ptp PTP cyto STOICHIOMETRY
right: PTP_cyto
spontaneous: true
left: PTP_PKA_cyto
conversion direction: RIGHT_TO_LEFT

GO:0007190
type: UnificationXref
id: GO:0007190
db: Gene Ontology

R2C2_cyto
type: PhysicalEntity
member physical entity: R2C2_cyto
cellular location: cyto

MEK_active_cyto
type: Protein
xref: Q01986

http://identifiers.org/ec-code/2.7.12.2
type: UnificationXref
id: 2.7.12.2
db: Enzyme Nomenclature

LEFT 0 conversion pde4 p cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

bg_cyto
type: PhysicalEntity
member physical entity: bg_cyto
cellular location: cyto

RIGHT 0 conversion MEK activates MAPK MAPK active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_active_cyto
stoichiometric coefficient: 1.0

iso_extra
type: PhysicalEntity

GO:0005576
type: UnificationXref
id: GO:0005576
db: Gene Ontology

iso_BAR_G_cyto_mem
type: Complex
xref: GO:0005834
xref: P18090

PDE4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion PDE4 cAMP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion PDE4 AMP cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.4.17
xref: GO:0004115
right: AMP_cyto
left: cAMP_cyto

Q99MC6
type: UnificationXref
id: Q99MC6
db: UniProt Knowledgebase

RIGHT 0 conversion GTPase G GDP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_GDP_cyto
stoichiometric coefficient: 1.0

LEFT 0 conversion activate Gs iso BAR G cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_G_cyto_mem
stoichiometric coefficient: 1.0

G_a_s_cyto
type: PhysicalEntity
member physical entity: G_a_s_cyto
cellular location: cyto

G_a_s_cyto
type: PhysicalEntity
member physical entity: G_a_s_cyto
cellular location: cyto

MODEL8609366518
type: UnificationXref
id: MODEL8609366518
db: BioModels Database

GTPase
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion GTPase G a s cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion GTPase G GDP cyto STOICHIOMETRY
xref: GO:0003924
right: G_GDP_cyto
spontaneous: true
left: G_a_s_cyto
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion G binds BAR BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: BAR_cyto_mem
stoichiometric coefficient: 1.0

iso_BAR_G_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_G_cyto_mem
cellular location: cyto_mem

AC_cyto_mem
type: PhysicalEntity
member physical entity: AC_cyto_mem
cellular location: cyto_mem

iso_extra
type: PhysicalEntity
member physical entity: iso_extra
cellular location: extra

LEFT 1 conversion B1 cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

GO:0003924
type: UnificationXref
id: GO:0003924
db: Gene Ontology

IPR001019
type: UnificationXref
id: IPR001019
db: InterPro

AC_basal
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AC basal ATP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AC basal cAMP cyto STOICHIOMETRY
xref: GO:0007190
right: cAMP_cyto
left: ATP_cyto

PDE4_P_cyto
type: PhysicalEntity
member physical entity: PDE4_P_cyto
cellular location: cyto

ATP_cyto
type: PhysicalEntity
member physical entity: ATP_cyto
cellular location: cyto

PKA_cyto
type: Protein
xref: A1L1M0

MEK_cyto
type: Protein
xref: Q01986

B_Raf_active_cyto
type: PhysicalEntity
member physical entity: B_Raf_active_cyto
cellular location: cyto

LEFT 0 conversion highKM PDE cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

iso_BAR_cyto_mem
type: Complex
xref: P18090

AC_cyto_mem
type: Complex
xref: P26769
xref: IPR001054

LEFT 0 conversion AC basal ATP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: ATP_cyto
stoichiometric coefficient: 1.0

MAPK_cyto
type: PhysicalEntity
member physical entity: MAPK_cyto
cellular location: cyto

ATP_cyto
type: SmallMolecule
xref: C00002
xref: CHEBI:15422

AC_active
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AC active ATP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AC active cAMP cyto STOICHIOMETRY
xref: GO:0006171
xref: http://identifiers.org/ec-code/4.6.1.1
right: cAMP_cyto
left: ATP_cyto

RIGHT 0 conversion PTP MAPK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_cyto
stoichiometric coefficient: 1.0

G_GDP_cyto
type: Complex
xref: C00035
xref: CHEBI:17552
xref: IPR001019

RIGHT 0 conversion PKA activates Raf B Raf active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: B_Raf_active_cyto
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.11.1
type: UnificationXref
id: 2.7.11.1
db: Enzyme Nomenclature

RIGHT 0 conversion pp ptp PTP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PTP_cyto
stoichiometric coefficient: 1.0

B_Raf_cyto
type: PhysicalEntity
member physical entity: B_Raf_cyto
cellular location: cyto

G_a_s_cyto
type: PhysicalEntity
member physical entity: G_a_s_cyto
cellular location: cyto

bg_cyto
type: PhysicalEntity

LEFT 0 conversion MEK activates MAPK MAPK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion A1 c3 R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: c3_R2C2_cyto
stoichiometric coefficient: 1.0

B_Raf_active_cyto
type: Protein
xref: Q99MC6

G_GDP_cyto
type: PhysicalEntity
member physical entity: G_GDP_cyto
cellular location: cyto

PP2A_cyto
type: Protein
xref: Q64623

c3_R2C2_cyto
type: PhysicalEntity
member physical entity: c3_R2C2_cyto
cellular location: cyto

LEFT 1 conversion G binds BAR G protein cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_protein_cyto
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/10116
type: UnificationXref
id: 10116
db: Taxonomy

G_protein_cyto
type: PhysicalEntity
member physical entity: G_protein_cyto
cellular location: cyto

AC_active_cyto_mem
type: PhysicalEntity
member physical entity: AC_active_cyto_mem
cellular location: cyto_mem

GRK_bg_cyto
type: PhysicalEntity

AMP_cyto
type: SmallMolecule
xref: CHEBI:16027
xref: C00020

LEFT 1 conversion A2 cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

PDE4_cyto
type: PhysicalEntity
member physical entity: PDE4_cyto
cellular location: cyto

PTP_PKA
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PTP PKA MAPK cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PTP PKA MAPK active cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: MAPK_cyto
left: MAPK_active_cyto

GO:0004674
type: UnificationXref
id: GO:0004674
db: Gene Ontology

LEFT 0 conversion pp ptp PTP PKA cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PTP_PKA_cyto
stoichiometric coefficient: 1.0

PPase_mek
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PPase mek MEK cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PPase mek MEK active cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0000188
right: MEK_cyto
left: MEK_active_cyto

GO:0005886
type: UnificationXref
id: GO:0005886
db: Gene Ontology

c3_R2C2_cyto
type: PhysicalEntity
xref: GO:0005952

http://identifiers.org/ec-code/2.7.11.11
type: UnificationXref
id: 2.7.11.11
db: Enzyme Nomenclature

LEFT 0 conversion PTP MAPK active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_active_cyto
stoichiometric coefficient: 1.0

iso_BAR_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_cyto_mem
cellular location: cyto_mem

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

LEFT 0 conversion pp2a 4 PDE4 P cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PDE4_P_cyto
stoichiometric coefficient: 1.0

LEFT 1 conversion G binds iso BAR G protein cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_protein_cyto
stoichiometric coefficient: 1.0

BAR_G_cyto_mem
type: PhysicalEntity
member physical entity: BAR_G_cyto_mem
cellular location: cyto_mem

GRK_bg
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion GRK bg iso BAR cyto mem STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion GRK bg iso BAR p cyto mem STOICHIOMETRY
xref: GO:0004703
right: iso_BAR_p_cyto_mem
left: iso_BAR_cyto_mem

AMP_cyto
type: PhysicalEntity
member physical entity: AMP_cyto
cellular location: cyto

AC_active_cyto_mem
type: Complex
xref: P26769
xref: IPR001054

BAR_cyto_mem
type: PhysicalEntity
member physical entity: BAR_cyto_mem
cellular location: cyto_mem

LEFT 0 conversion PPase MAPK MAPK active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_active_cyto
stoichiometric coefficient: 1.0

G_GDP_cyto
type: PhysicalEntity
member physical entity: G_GDP_cyto
cellular location: cyto

RIGHT 0 conversion GRK bg iso BAR p cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_p_cyto_mem
stoichiometric coefficient: 1.0

GO:0034199
type: UnificationXref
id: GO:0034199
db: Gene Ontology

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

LEFT 0 conversion trimer bg cyto STOICHIOMETRY
type: Stoichiometry
physical entity: bg_cyto
stoichiometric coefficient: 1.0

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

c_R2C2_cyto
type: PhysicalEntity
member physical entity: c_R2C2_cyto
cellular location: cyto

PDE4_P_cyto
type: Protein
xref: P54748
xref: IPR003607

Q64623
type: UnificationXref
id: Q64623
db: UniProt Knowledgebase

PTP_PP_cyto
type: Complex
xref: P49445

LEFT 0 conversion B1 R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: R2C2_cyto
stoichiometric coefficient: 1.0

c3_R2C2_cyto
type: PhysicalEntity
member physical entity: c3_R2C2_cyto
cellular location: cyto

BAR_G_cyto_mem
type: PhysicalEntity
member physical entity: BAR_G_cyto_mem
cellular location: cyto_mem

GRK_cyto
type: PhysicalEntity
member physical entity: GRK_cyto
cellular location: cyto

RIGHT 0 conversion pp2a 4 PDE4 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PDE4_cyto
stoichiometric coefficient: 1.0

LEFT 0 conversion B2 c R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: c_R2C2_cyto
stoichiometric coefficient: 1.0

AC_activation
type: Transport
participant stoichiometry: RIGHT 0 conversion AC activation AC active cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AC activation G a s cyto STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AC activation AC cyto mem STOICHIOMETRY
xref: GO:0007190
right: AC_active_cyto_mem
left: G_a_s_cyto
left: AC_cyto_mem

iso_BAR_G_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_G_cyto_mem
cellular location: cyto_mem

G_protein_cyto
type: PhysicalEntity
member physical entity: G_protein_cyto
cellular location: cyto

P26769
type: UnificationXref
id: P26769
db: UniProt Knowledgebase

P54748
type: UnificationXref
id: P54748
db: UniProt Knowledgebase

PTP_cyto
type: Protein
xref: P49445

LEFT 0 conversion iso binds BAR BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: BAR_cyto_mem
stoichiometric coefficient: 1.0

IPR001054
type: UnificationXref
id: IPR001054
db: InterPro

RIGHT 0 conversion AC basal cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

PPase_Raf
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PPase Raf B Raf cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PPase Raf B Raf active cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0004721
right: B_Raf_cyto
left: B_Raf_active_cyto

bg_cyto
type: PhysicalEntity
member physical entity: bg_cyto
cellular location: cyto

MAPK_active_cyto
type: Protein
xref: P63086

http://identifiers.org/ec-code/4.6.1.1
type: UnificationXref
id: 4.6.1.1
db: Enzyme Nomenclature

A1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion A1 c3 R2C2 cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion A1 c2 R2C2 cyto STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion A1 cAMP cyto STOICHIOMETRY
xref: GO:0034199
xref: GO:0030552
right: c3_R2C2_cyto
left: c2_R2C2_cyto
left: cAMP_cyto

A2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion A2 PKA cyto STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion A2 cAMP cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion A2 c3 R2C2 cyto STOICHIOMETRY
xref: GO:0034199
xref: GO:0030552
right: PKA_cyto
left: c3_R2C2_cyto
left: cAMP_cyto

LEFT 1 conversion bg binds GRK bg cyto STOICHIOMETRY
type: Stoichiometry
physical entity: bg_cyto
stoichiometric coefficient: 1.0

MEK_cyto
type: PhysicalEntity
member physical entity: MEK_cyto
cellular location: cyto

RIGHT 0 conversion PKA P PTP PTP PKA cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PTP_PKA_cyto
stoichiometric coefficient: 1.0

iso_BAR_p_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_p_cyto_mem
cellular location: cyto_mem

RIGHT 0 conversion GRK iso BAR p cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_p_cyto_mem
stoichiometric coefficient: 1.0

GO:0005515
type: UnificationXref
id: GO:0005515
db: Gene Ontology

highKM_PDE
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion highKM PDE cAMP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion highKM PDE AMP cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.4.17
xref: GO:0004115
right: AMP_cyto
left: cAMP_cyto

MAPK_active_cyto
type: PhysicalEntity
member physical entity: MAPK_active_cyto
cellular location: cyto

GO:0000188
type: UnificationXref
id: GO:0000188
db: Gene Ontology

c_R2C2_cyto
type: PhysicalEntity
xref: GO:0005952

GO:0006171
type: UnificationXref
id: GO:0006171
db: Gene Ontology

CHEBI:17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

activate_Gs
type: Transport
participant stoichiometry: LEFT 0 conversion activate Gs iso BAR G cyto mem STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion activate Gs bg cyto STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion activate Gs G a s cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion activate Gs iso BAR cyto mem STOICHIOMETRY
xref: GO:0004930
right: iso_BAR_cyto_mem
right: G_a_s_cyto
right: bg_cyto
left: iso_BAR_G_cyto_mem

LEFT 0 conversion PPase Raf B Raf active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: B_Raf_active_cyto
stoichiometric coefficient: 1.0

PKA_activates_Raf
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion PKA activates Raf B Raf cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion PKA activates Raf B Raf active cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.11.11
xref: GO:0004674
right: B_Raf_active_cyto
left: B_Raf_cyto

c2_R2C2_cyto
type: PhysicalEntity
member physical entity: c2_R2C2_cyto
cellular location: cyto

pp2a_4
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion pp2a 4 PDE4 cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion pp2a 4 PDE4 P cyto STOICHIOMETRY
xref: GO:0006470
right: PDE4_cyto
left: PDE4_P_cyto

LEFT 1 conversion AC activation AC cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: AC_cyto_mem
stoichiometric coefficient: 1.0

B1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion B1 R2C2 cyto STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion B1 cAMP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion B1 c R2C2 cyto STOICHIOMETRY
xref: GO:0034199
xref: GO:0030552
right: c_R2C2_cyto
left: cAMP_cyto
left: R2C2_cyto

B2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion B2 cAMP cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion B2 c R2C2 cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion B2 c2 R2C2 cyto STOICHIOMETRY
xref: GO:0034199
xref: GO:0030552
right: c2_R2C2_cyto
left: c_R2C2_cyto
left: cAMP_cyto

RIGHT 0 conversion AC active cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

RIGHT 2 conversion activate Gs G a s cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_a_s_cyto
stoichiometric coefficient: 1.0

GRK_bg_cyto
type: PhysicalEntity
member physical entity: GRK_bg_cyto
cellular location: cyto

RIGHT 0 conversion bg binds GRK GRK bg cyto STOICHIOMETRY
type: Stoichiometry
physical entity: GRK_bg_cyto
stoichiometric coefficient: 1.0

GO:0032795
type: UnificationXref
id: GO:0032795
db: Gene Ontology

A1L1M0
type: UnificationXref
id: A1L1M0
db: UniProt Knowledgebase

PP_PDE_cyto
type: Protein
xref: P54748
xref: IPR003607

LEFT 0 conversion iso binds BAR g iso extra STOICHIOMETRY
type: Stoichiometry
physical entity: iso_extra
stoichiometric coefficient: 1.0

PTP_PKA_cyto
type: PhysicalEntity
member physical entity: PTP_PKA_cyto
cellular location: cyto

LEFT 0 conversion AC activation G a s cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_a_s_cyto
stoichiometric coefficient: 1.0

GRK_cyto
type: PhysicalEntity

LEFT 1 conversion A1 cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

RIGHT 1 conversion activate Gs bg cyto STOICHIOMETRY
type: Stoichiometry
physical entity: bg_cyto
stoichiometric coefficient: 1.0

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

iso_binds_BAR
type: Transport
participant stoichiometry: RIGHT 0 conversion iso binds BAR iso BAR cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion iso binds BAR BAR cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion iso binds BAR iso extra STOICHIOMETRY
xref: GO:0031697
right: iso_BAR_cyto_mem
left: BAR_cyto_mem
left: iso_extra

LEFT 0 conversion Raf activates MEK MEK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MEK_cyto
stoichiometric coefficient: 1.0

bg_cyto
type: PhysicalEntity
member physical entity: bg_cyto
cellular location: cyto

RIGHT 0 conversion G binds iso BAR iso BAR G cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_G_cyto_mem
stoichiometric coefficient: 1.0

GRK
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion GRK iso BAR p cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion GRK iso BAR cyto mem STOICHIOMETRY
xref: GO:0004703
right: iso_BAR_p_cyto_mem
left: iso_BAR_cyto_mem

B_Raf_cyto
type: PhysicalEntity
member physical entity: B_Raf_cyto
cellular location: cyto

GO:0031697
type: UnificationXref
id: GO:0031697
db: Gene Ontology

pde4_p
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion pde4 p cAMP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion pde4 p AMP cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.4.17
xref: GO:0004115
right: AMP_cyto
left: cAMP_cyto

iso_extra
type: PhysicalEntity
member physical entity: iso_extra
cellular location: extra

GO:0005737
type: UnificationXref
id: GO:0005737
db: Gene Ontology

ATP_cyto
type: PhysicalEntity
member physical entity: ATP_cyto
cellular location: cyto

RIGHT 0 conversion G binds BAR BAR G cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: BAR_G_cyto_mem
stoichiometric coefficient: 1.0

bg_binds_GRK
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion bg binds GRK GRK cyto STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion bg binds GRK bg cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion bg binds GRK GRK bg cyto STOICHIOMETRY
xref: GO:0005515
right: GRK_bg_cyto
left: bg_cyto
left: GRK_cyto

PTP
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion PTP MAPK active cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion PTP MAPK cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: MAPK_cyto
left: MAPK_active_cyto

iso_BAR_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_cyto_mem
cellular location: cyto_mem

cyto_mem
type: CellularLocationVocabulary
xref: GO:0005886

GO:0000165
type: UnificationXref
id: GO:0000165
db: Gene Ontology

Q8CGK7
type: UnificationXref
id: Q8CGK7
db: UniProt Knowledgebase

LEFT 1 conversion iso binds BAR g BAR G cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: BAR_G_cyto_mem
stoichiometric coefficient: 1.0

MAPK_cyto
type: Protein
xref: P63086

BAR_cyto_mem
type: Protein
xref: P18090

MAPK_cyto
type: PhysicalEntity
member physical entity: MAPK_cyto
cellular location: cyto

GO:0031684
type: UnificationXref
id: GO:0031684
db: Gene Ontology

C00020
type: UnificationXref
id: C00020
db: KEGG Compound

B_Raf_cyto
type: Protein
xref: Q99MC6

LEFT 0 conversion PKA P PDE PDE4 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PDE4_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion PTP PKA MAPK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_cyto
stoichiometric coefficient: 1.0

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

LEFT 0 conversion PDE4 cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion B2 c2 R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: c2_R2C2_cyto
stoichiometric coefficient: 1.0

MAPK_cyto
type: PhysicalEntity
member physical entity: MAPK_cyto
cellular location: cyto

LEFT 0 conversion A1 c2 R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: c2_R2C2_cyto
stoichiometric coefficient: 1.0

iso_BAR_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_cyto_mem
cellular location: cyto_mem

CHEBI:17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

G_protein_cyto
type: PhysicalEntity
xref: GO:0005834

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

RIGHT 0 conversion B1 c R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: c_R2C2_cyto
stoichiometric coefficient: 1.0

cyto
type: CellularLocationVocabulary
xref: GO:0005737

cAMP_cyto
type: SmallMolecule
xref: CHEBI:17489
xref: C00575

C00035
type: UnificationXref
id: C00035
db: KEGG Compound

G_protein_cyto
type: PhysicalEntity
member physical entity: G_protein_cyto
cellular location: cyto

GO:0005834
type: UnificationXref
id: GO:0005834
db: Gene Ontology

P18090
type: UnificationXref
id: P18090
db: UniProt Knowledgebase

PTP_cyto
type: PhysicalEntity
member physical entity: PTP_cyto
cellular location: cyto

AC_PKA_cyto_mem
type: Complex
xref: A1L1M0
xref: P26769
xref: IPR001054

LEFT 0 conversion G binds iso BAR iso BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_cyto_mem
stoichiometric coefficient: 1.0

rno04010
type: UnificationXref
id: rno04010
db: KEGG Pathway

GO:0005952
type: UnificationXref
id: GO:0005952
db: Gene Ontology

RIGHT 0 conversion activate Gs iso BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_cyto_mem
stoichiometric coefficient: 1.0

RIGHT 0 conversion AC activation AC active cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: AC_active_cyto_mem
stoichiometric coefficient: 1.0

PTP_PKA_cyto
type: Complex
xref: A1L1M0
xref: P49445

LEFT 1 conversion B2 cAMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: cAMP_cyto
stoichiometric coefficient: 1.0

CHEBI:16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

G_a_s_cyto
type: Protein
xref: Q8CGK7

LEFT 0 conversion GRK iso BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_cyto_mem
stoichiometric coefficient: 1.0

AMP_cyto
type: PhysicalEntity
member physical entity: AMP_cyto
cellular location: cyto

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

PKA_P_PTP
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion PKA P PTP PTP PKA cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PKA P PTP PTP cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.11.11
xref: GO:0004674
right: PTP_PKA_cyto
spontaneous: true
left: PTP_cyto
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion highKM PDE AMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: AMP_cyto
stoichiometric coefficient: 1.0

iso_binds_BAR_g
type: Transport
participant stoichiometry: LEFT 0 conversion iso binds BAR g iso extra STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion iso binds BAR g iso BAR G cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion iso binds BAR g BAR G cyto mem STOICHIOMETRY
xref: GO:0031697
right: iso_BAR_G_cyto_mem
left: BAR_G_cyto_mem
left: iso_extra

LEFT 0 conversion PPase mek MEK active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MEK_active_cyto
stoichiometric coefficient: 1.0

BIOMD0000000182
type: UnificationXref
id: BIOMD0000000182
db: BioModels Database

LEFT 0 conversion PTP PKA MAPK active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_active_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion pde4 p AMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: AMP_cyto
stoichiometric coefficient: 1.0

c_R2C2_cyto
type: PhysicalEntity
member physical entity: c_R2C2_cyto
cellular location: cyto

c2_R2C2_cyto
type: PhysicalEntity
member physical entity: c2_R2C2_cyto
cellular location: cyto

B_Raf_active_cyto
type: PhysicalEntity
member physical entity: B_Raf_active_cyto
cellular location: cyto

iso_BAR_G_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_G_cyto_mem
cellular location: cyto_mem

Raf_activates_MEK
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Raf activates MEK MEK active cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Raf activates MEK MEK cyto STOICHIOMETRY
xref: GO:0004674
xref: http://identifiers.org/ec-code/2.7.11.1
right: MEK_active_cyto
left: MEK_cyto

RIGHT 0 conversion trimer G protein cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_protein_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion PKA P PDE PDE4 P cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PDE4_P_cyto
stoichiometric coefficient: 1.0

AMP_cyto
type: PhysicalEntity
member physical entity: AMP_cyto
cellular location: cyto

GO:0004725
type: UnificationXref
id: GO:0004725
db: Gene Ontology

R2C2_cyto
type: PhysicalEntity
xref: GO:0005952

MAPK_active_cyto
type: PhysicalEntity
member physical entity: MAPK_active_cyto
cellular location: cyto

C00575
type: UnificationXref
id: C00575
db: KEGG Compound

RIGHT 0 conversion A2 PKA cyto STOICHIOMETRY
type: Stoichiometry
physical entity: PKA_cyto
stoichiometric coefficient: 1.0

LEFT 0 conversion PKA activates Raf B Raf cyto STOICHIOMETRY
type: Stoichiometry
physical entity: B_Raf_cyto
stoichiometric coefficient: 1.0

MAPK_cyto
type: PhysicalEntity
member physical entity: MAPK_cyto
cellular location: cyto

RIGHT 0 conversion PPase MAPK MAPK cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MAPK_cyto
stoichiometric coefficient: 1.0

PTP_cyto
type: PhysicalEntity
member physical entity: PTP_cyto
cellular location: cyto

http://identifiers.org/pubmed/18485874
type: PublicationXref
id: 18485874
db: PubMed

GO:0004721
type: UnificationXref
id: GO:0004721
db: Gene Ontology

RIGHT 0 conversion iso binds BAR g iso BAR G cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_G_cyto_mem
stoichiometric coefficient: 1.0

GO:0006470
type: UnificationXref
id: GO:0006470
db: Gene Ontology

c2_R2C2_cyto
type: PhysicalEntity
xref: GO:0005952

LEFT 1 conversion iso binds BAR iso extra STOICHIOMETRY
type: Stoichiometry
physical entity: iso_extra
stoichiometric coefficient: 1.0

Q01986
type: UnificationXref
id: Q01986
db: UniProt Knowledgebase

iso_BAR_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_cyto_mem
cellular location: cyto_mem

GO:0030552
type: UnificationXref
id: GO:0030552
db: Gene Ontology

PPase_MAPK
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PPase MAPK MAPK cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PPase MAPK MAPK active cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0000188
right: MAPK_cyto
left: MAPK_active_cyto

P63086
type: UnificationXref
id: P63086
db: UniProt Knowledgebase

RIGHT 0 conversion PDE4 AMP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: AMP_cyto
stoichiometric coefficient: 1.0

PKA_P_PDE
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PKA P PDE PDE4 P cyto STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PKA P PDE PDE4 cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.11.11
xref: GO:0004674
right: PDE4_P_cyto
left: PDE4_cyto

C00002
type: UnificationXref
id: C00002
db: KEGG Compound

RIGHT 0 conversion Raf activates MEK MEK active cyto STOICHIOMETRY
type: Stoichiometry
physical entity: MEK_active_cyto
stoichiometric coefficient: 1.0

PTP_PKA_cyto
type: PhysicalEntity
member physical entity: PTP_PKA_cyto
cellular location: cyto

PDE4_cyto
type: Protein
xref: P54748
xref: IPR003607

PDE4_cyto
type: PhysicalEntity
member physical entity: PDE4_cyto
cellular location: cyto

GO:0004930
type: UnificationXref
id: GO:0004930
db: Gene Ontology

iso_BAR_cyto_mem
type: PhysicalEntity
member physical entity: iso_BAR_cyto_mem
cellular location: cyto_mem

P49445
type: UnificationXref
id: P49445
db: UniProt Knowledgebase

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

MEK_active_cyto
type: PhysicalEntity
member physical entity: MEK_active_cyto
cellular location: cyto

CHEBI:15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

BAR_G_cyto_mem
type: Protein
xref: P18090

extra
type: CellularLocationVocabulary
xref: GO:0005576

LEFT 0 conversion AC active ATP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: ATP_cyto
stoichiometric coefficient: 1.0

LEFT 1 conversion trimer G GDP cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_GDP_cyto
stoichiometric coefficient: 1.0

IPR003607
type: UnificationXref
id: IPR003607
db: InterPro

LEFT 0 conversion GTPase G a s cyto STOICHIOMETRY
type: Stoichiometry
physical entity: G_a_s_cyto
stoichiometric coefficient: 1.0

BAR_cyto_mem
type: PhysicalEntity
member physical entity: BAR_cyto_mem
cellular location: cyto_mem

BioModels Database
type: Provenance
xref: BIOMD0000000182

GO:0004703
type: UnificationXref
id: GO:0004703
db: Gene Ontology

LEFT 0 conversion GRK bg iso BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_cyto_mem
stoichiometric coefficient: 1.0

GO:0000902
type: UnificationXref
id: GO:0000902
db: Gene Ontology

MEK_cyto
type: PhysicalEntity
member physical entity: MEK_cyto
cellular location: cyto

LEFT 0 conversion A2 c3 R2C2 cyto STOICHIOMETRY
type: Stoichiometry
physical entity: c3_R2C2_cyto
stoichiometric coefficient: 1.0

G_binds_BAR
type: Transport
participant stoichiometry: RIGHT 0 conversion G binds BAR BAR G cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion G binds BAR BAR cyto mem STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion G binds BAR G protein cyto STOICHIOMETRY
xref: GO:0032795
right: BAR_G_cyto_mem
left: BAR_cyto_mem
left: G_protein_cyto

BioModels Database
type: Provenance
xref: MODEL8609366518

cAMP_cyto
type: PhysicalEntity
member physical entity: cAMP_cyto
cellular location: cyto

RIGHT 0 conversion PPase Raf B Raf cyto STOICHIOMETRY
type: Stoichiometry
physical entity: B_Raf_cyto
stoichiometric coefficient: 1.0

RIGHT 0 conversion iso binds BAR iso BAR cyto mem STOICHIOMETRY
type: Stoichiometry
physical entity: iso_BAR_cyto_mem
stoichiometric coefficient: 1.0

PDE_high_km_cyto
type: PhysicalEntity

MEK_activates_MAPK
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MEK activates MAPK MAPK cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MEK activates MAPK MAPK active cyto STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.12.2
xref: GO:0004709
right: MAPK_active_cyto
left: MAPK_cyto

http://identifiers.org/ec-code/3.1.3.16
type: UnificationXref
id: 3.1.3.16
db: Enzyme Nomenclature

MAPK_active_cyto
type: PhysicalEntity
member physical entity: MAPK_active_cyto
cellular location: cyto

PKA_cyto
type: PhysicalEntity
member physical entity: PKA_cyto
cellular location: cyto

GO:0004709
type: UnificationXref
id: GO:0004709
db: Gene Ontology

trimer
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion trimer bg cyto STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion trimer G GDP cyto STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion trimer G protein cyto STOICHIOMETRY
xref: GO:0031684
right: G_protein_cyto
spontaneous: true
left: bg_cyto
left: G_GDP_cyto
conversion direction: RIGHT_TO_LEFT

MAPK_active_cyto
type: PhysicalEntity
member physical entity: MAPK_active_cyto
cellular location: cyto