SBML creators: Armando Reyes-Palomares * , Carlos Rodríguez-Caso +, Raul Montañez * , Marta Cascante $, Francisca Sánchez-Jiménez * , Miguel A. Medina *

* ProCel Group, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Malaga and CIBER de Enfermedades Raras (CIBER-ER). + Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB). $ Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona.

http://asp.uma.es

Metabolic modeling of polyamine metabolism in mammals.
Rodríguez-Caso,C et al.: J Biol Chem 2006 : 281:21799-812.
The model reproduces the dynamical behavior of the polyamine metabolism in mammals. In this model there are some additions and corrections to the publication. All perturbations and analysis have produced results very close to the published experiments. The model was successfully tested on CoPaSi v.4.4 (build 26).

Parameters not included in the publication:

1. Parameters for SSAT kinetic constants:

KmAcCoA = 1.5 µM

KmCoA = 40 µM

2. Parameters for equation MAT (table 1):

Vmax_MAT = 0.45 µM/min

Km_MAT = 41 µM

Ki_MET_MAT = 50 µM

3. Erratum.: The corrected ODE for time-dependent variable Antz is:

KsANTZ*(1-1/(1+Keq*0.01*([D]+[S])))-KdANTZ*[Antz]

According to these modifications the new steady-state analysis results are:

Metabolites:

[P]= 104.681 µM

[D]= 76.7492 µM

[S]= 58.0135 µM

[SAM]= 52.327 µM

[A]= 0.0101962 µM

[aS]= 0.0245375 µM

[aD]= 0.832236 µM

Time-dependent global parameters:

[Antz] = 0.574038 µM

Vmaxodc = 1.28315 µM/min

Vmaxssat = 0.673814 µM/min

Vmaxsamdc = 0.36829 µM/min

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.