degradation
type: PhysicalEntity
member physical entity: degradation
cellular location: cell

LEFT 0 conversion R8 CDX2 STOICHIOMETRY
type: Stoichiometry
physical entity: CDX2
stoichiometric coefficient: 1.0

RIGHT 0 conversion R10 degradation STOICHIOMETRY
type: Stoichiometry
physical entity: degradation
stoichiometric coefficient: 1.0

LEFT 0 conversion R1 OCT4 Gene STOICHIOMETRY
type: Stoichiometry
physical entity: OCT4_Gene
stoichiometric coefficient: 1.0

NANOG_Gene
type: Protein
xref: Q8N7R0
xref: ENSG00000176654

degradation
type: PhysicalEntity
member physical entity: degradation
cellular location: cell

GATA6_Gene
type: PhysicalEntity
member physical entity: GATA6_Gene
cellular location: cell

P04637
type: UnificationXref
id: P04637
db: UniProt Knowledgebase

p53
type: Protein
xref: P04637

OCT4
type: Protein
xref: Q01860

SOX2
type: Protein
xref: Q6ZRP7

RIGHT 0 conversion R1 OCT4 STOICHIOMETRY
type: Stoichiometry
physical entity: OCT4
stoichiometric coefficient: 1.0

ENSG00000141448
type: UnificationXref
id: ENSG00000141448
db: Ensembl

RIGHT 0 conversion R12 degradation STOICHIOMETRY
type: Stoichiometry
physical entity: degradation
stoichiometric coefficient: 1.0

SOX2_Gene
type: Protein
xref: Q6ZRP7
xref: ENSG00000165661

GO:0048863
type: UnificationXref
id: GO:0048863
db: Gene Ontology

NANOG
type: PhysicalEntity
member physical entity: NANOG
cellular location: cell

OCT4
type: PhysicalEntity
member physical entity: OCT4
cellular location: cell

degradation
type: PhysicalEntity
member physical entity: degradation
cellular location: cell

CDX2_Gene
type: PhysicalEntity
member physical entity: CDX2_Gene
cellular location: cell

GCNF
type: PhysicalEntity
member physical entity: GCNF
cellular location: cell

NANOG
type: PhysicalEntity
member physical entity: NANOG
cellular location: cell

ENSG00000165661
type: UnificationXref
id: ENSG00000165661
db: Ensembl

Q92908
type: UnificationXref
id: Q92908
db: UniProt Knowledgebase

RIGHT 0 conversion R2 degradation STOICHIOMETRY
type: Stoichiometry
physical entity: degradation
stoichiometric coefficient: 1.0

degradation
type: PhysicalEntity
member physical entity: degradation
cellular location: cell

SOX2
type: PhysicalEntity
member physical entity: SOX2
cellular location: cell

degradation
type: PhysicalEntity
member physical entity: degradation
cellular location: cell

http://identifiers.org/pubmed/18941526
type: PublicationXref
id: 18941526
db: PubMed

RIGHT 0 conversion R9 GCNF STOICHIOMETRY
type: Stoichiometry
physical entity: GCNF
stoichiometric coefficient: 1.0

A
type: PhysicalEntity
xref: GO:0042813

Q99626
type: UnificationXref
id: Q99626
db: UniProt Knowledgebase

RIGHT 0 conversion R3 SOX2 STOICHIOMETRY
type: Stoichiometry
physical entity: SOX2
stoichiometric coefficient: 1.0

GATA6
type: Protein
xref: Q92908

R11
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R11 GATA6 Gene STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R11 GATA6 STOICHIOMETRY
xref: GO:0010467
right: GATA6
left: GATA6_Gene

R10
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R10 degradation STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R10 GCNF STOICHIOMETRY
xref: GO:0030163
right: degradation
left: GCNF

R12
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R12 degradation STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R12 GATA6 STOICHIOMETRY
xref: GO:0030163
right: degradation
left: GATA6

cell
type: CellularLocationVocabulary
xref: GO:0005623

NANOG_Gene
type: PhysicalEntity
member physical entity: NANOG_Gene
cellular location: cell

RIGHT 0 conversion R6 degradation STOICHIOMETRY
type: Stoichiometry
physical entity: degradation
stoichiometric coefficient: 1.0

GO:0042813
type: UnificationXref
id: GO:0042813
db: Gene Ontology

RIGHT 0 conversion R4 degradation STOICHIOMETRY
type: Stoichiometry
physical entity: degradation
stoichiometric coefficient: 1.0

SG
type: PhysicalEntity

LEFT 0 conversion R3 SOX2 Gene STOICHIOMETRY
type: Stoichiometry
physical entity: SOX2_Gene
stoichiometric coefficient: 1.0

Q6ZRP7
type: UnificationXref
id: Q6ZRP7
db: UniProt Knowledgebase

MODEL8390025091
type: Pathway
pathway component: R9
pathway component: R1
pathway component: R11
pathway component: R2
pathway component: R10
pathway component: R3
pathway component: R4
pathway component: R12
pathway component: R5
pathway component: R6
pathway component: R7
pathway component: R8
xref: GO:0048863
xref: GO:0001830
xref: MODEL8390025091
xref: BIOMD0000000209
xref: GO:0042663
xref: http://identifiers.org/pubmed/18941526
xref: BIOMD0000000204
xref: BIOMD0000000203
organism: biosource 1
comment: The original model, 'MODEL8390025091', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
data source: BioModels Database

SN
type: PhysicalEntity

GATA6
type: PhysicalEntity
member physical entity: GATA6
cellular location: cell

degradation
type: PhysicalEntity
member physical entity: degradation
cellular location: cell

LEFT 0 conversion R9 GCNF Gene STOICHIOMETRY
type: Stoichiometry
physical entity: GCNF_Gene
stoichiometric coefficient: 1.0

Q15406
type: UnificationXref
id: Q15406
db: UniProt Knowledgebase

CDX2
type: PhysicalEntity
member physical entity: CDX2
cellular location: cell

GO:0042663
type: UnificationXref
id: GO:0042663
db: Gene Ontology

OCT4
type: PhysicalEntity
member physical entity: OCT4
cellular location: cell

CDX2_Gene
type: Protein
xref: Q99626
xref: ENSG00000165556

SOX2
type: PhysicalEntity
member physical entity: SOX2
cellular location: cell

ENSG00000176654
type: UnificationXref
id: ENSG00000176654
db: Ensembl

NANOG
type: Protein
xref: Q8N7R0

GO:0010467
type: UnificationXref
id: GO:0010467
db: Gene Ontology

LEFT 0 conversion R12 GATA6 STOICHIOMETRY
type: Stoichiometry
physical entity: GATA6
stoichiometric coefficient: 1.0

degradation
type: PhysicalEntity

GCNF_Gene
type: PhysicalEntity
member physical entity: GCNF_Gene
cellular location: cell

ENSG00000148200
type: UnificationXref
id: ENSG00000148200
db: Ensembl

LEFT 0 conversion R5 NANOG Gene STOICHIOMETRY
type: Stoichiometry
physical entity: NANOG_Gene
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

GO:0030163
type: UnificationXref
id: GO:0030163
db: Gene Ontology

RIGHT 0 conversion R11 GATA6 STOICHIOMETRY
type: Stoichiometry
physical entity: GATA6
stoichiometric coefficient: 1.0

LEFT 0 conversion R7 CDX2 Gene STOICHIOMETRY
type: Stoichiometry
physical entity: CDX2_Gene
stoichiometric coefficient: 1.0

GATA6
type: PhysicalEntity
member physical entity: GATA6
cellular location: cell

Q8N7R0
type: UnificationXref
id: Q8N7R0
db: UniProt Knowledgebase

RIGHT 0 conversion R7 CDX2 STOICHIOMETRY
type: Stoichiometry
physical entity: CDX2
stoichiometric coefficient: 1.0

CDX2
type: PhysicalEntity
member physical entity: CDX2
cellular location: cell

SOX2_Gene
type: PhysicalEntity
member physical entity: SOX2_Gene
cellular location: cell

Protein
type: PhysicalEntity

RIGHT 0 conversion R8 degradation STOICHIOMETRY
type: Stoichiometry
physical entity: degradation
stoichiometric coefficient: 1.0

GCNF
type: Protein
xref: Q15406

LEFT 0 conversion R4 SOX2 STOICHIOMETRY
type: Stoichiometry
physical entity: SOX2
stoichiometric coefficient: 1.0

Q01860
type: UnificationXref
id: Q01860
db: UniProt Knowledgebase

GATA6_Gene
type: Protein
xref: Q92908
xref: ENSG00000141448

targetGene
type: PhysicalEntity

LEFT 0 conversion R6 NANOG STOICHIOMETRY
type: Stoichiometry
physical entity: NANOG
stoichiometric coefficient: 1.0

ENSG00000165556
type: UnificationXref
id: ENSG00000165556
db: Ensembl

GO:0005623
type: UnificationXref
id: GO:0005623
db: Gene Ontology

OCT4_Gene
type: Protein
xref: ENSG00000204531
xref: Q01860

OCT4_Gene
type: PhysicalEntity
member physical entity: OCT4_Gene
cellular location: cell

RIGHT 0 conversion R5 NANOG STOICHIOMETRY
type: Stoichiometry
physical entity: NANOG
stoichiometric coefficient: 1.0

ENSG00000204531
type: UnificationXref
id: ENSG00000204531
db: Ensembl

MODEL8390025091
type: UnificationXref
id: MODEL8390025091
db: BioModels Database

OCT4_SOX2
type: Complex
xref: Q6ZRP7
xref: Q01860

BIOMD0000000209
type: UnificationXref
id: BIOMD0000000209
db: BioModels Database

BIOMD0000000204
type: UnificationXref
id: BIOMD0000000204
db: BioModels Database

BIOMD0000000203
type: UnificationXref
id: BIOMD0000000203
db: BioModels Database

GCNF_Gene
type: Protein
xref: Q15406
xref: ENSG00000148200

BioModels Database
type: Provenance
xref: BIOMD0000000209

GO:0001830
type: UnificationXref
id: GO:0001830
db: Gene Ontology

LEFT 0 conversion R11 GATA6 Gene STOICHIOMETRY
type: Stoichiometry
physical entity: GATA6_Gene
stoichiometric coefficient: 1.0

CDX2
type: Protein
xref: Q99626

R1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R1 OCT4 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R1 OCT4 Gene STOICHIOMETRY
xref: GO:0010467
right: OCT4
left: OCT4_Gene

R2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R2 degradation STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R2 OCT4 STOICHIOMETRY
xref: GO:0030163
right: degradation
left: OCT4

R3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R3 SOX2 Gene STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R3 SOX2 STOICHIOMETRY
xref: GO:0010467
right: SOX2
left: SOX2_Gene

LEFT 0 conversion R10 GCNF STOICHIOMETRY
type: Stoichiometry
physical entity: GCNF
stoichiometric coefficient: 1.0

R4
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R4 degradation STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R4 SOX2 STOICHIOMETRY
xref: GO:0030163
right: degradation
left: SOX2

LEFT 0 conversion R2 OCT4 STOICHIOMETRY
type: Stoichiometry
physical entity: OCT4
stoichiometric coefficient: 1.0

R5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R5 NANOG STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R5 NANOG Gene STOICHIOMETRY
xref: GO:0010467
right: NANOG
left: NANOG_Gene

R6
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R6 NANOG STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R6 degradation STOICHIOMETRY
xref: GO:0030163
right: degradation
left: NANOG

R7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R7 CDX2 Gene STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R7 CDX2 STOICHIOMETRY
xref: GO:0010467
right: CDX2
left: CDX2_Gene

BioModels Database
type: Provenance
xref: MODEL8390025091

R8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R8 CDX2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R8 degradation STOICHIOMETRY
xref: GO:0030163
right: degradation
left: CDX2

R9
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R9 GCNF Gene STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R9 GCNF STOICHIOMETRY
xref: GO:0010467
right: GCNF
left: GCNF_Gene

GCNF
type: PhysicalEntity
member physical entity: GCNF
cellular location: cell