REACT_22232
type: UnificationXref
id: REACT_22232
db: Reactome

RIGHT 0 conversion reaction 6 pJAK2 STOICHIOMETRY
type: Stoichiometry
physical entity: pJAK2
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 2 Rec i STOICHIOMETRY
type: Stoichiometry
physical entity: Rec_i
stoichiometric coefficient: 1.0

p_IL13_Rec
type: Complex
xref: GO:0016516
xref: P35225
xref: P24394
xref: P29597
xref: C00562
xref: P78552

P42229
type: UnificationXref
id: P42229
db: UniProt Knowledgebase

pSTAT5
type: PhysicalEntity
member physical entity: pSTAT5
cellular location: cell

LEFT 0 conversion reaction 3 Rec i STOICHIOMETRY
type: Stoichiometry
physical entity: Rec_i
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 11 STAT5 STOICHIOMETRY
type: Stoichiometry
physical entity: STAT5
stoichiometric coefficient: 1.0

IL13_DecoyR
type: PhysicalEntity
member physical entity: IL13_DecoyR
cellular location: cell

RIGHT 0 conversion reaction 9 JAK2 STOICHIOMETRY
type: Stoichiometry
physical entity: JAK2
stoichiometric coefficient: 1.0

p_IL13_Rec
type: PhysicalEntity
member physical entity: p_IL13_Rec
cellular location: cell

LEFT 0 conversion reaction 7 p IL13 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: p_IL13_Rec
stoichiometric coefficient: 1.0

DOID:0050743
type: UnificationXref
id: DOID:0050743
db: Human Disease Ontology

CD274mRNA
type: Protein
xref: C00046
xref: CHEBI:33699
xref: P20963

SOCS3
type: PhysicalEntity
member physical entity: SOCS3
cellular location: cell

reaction_6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 6 pJAK2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 6 JAK2 STOICHIOMETRY
right: pJAK2
left: JAK2

reaction_5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 5 JAK2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 5 pJAK2 STOICHIOMETRY
right: pJAK2
left: JAK2

reaction_8
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 8 p IL13 Rec i STOICHIOMETRY
spontaneous: true
left: p_IL13_Rec_i
conversion direction: RIGHT_TO_LEFT

reaction_7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 7 p IL13 Rec STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 7 p IL13 Rec i STOICHIOMETRY
right: p_IL13_Rec_i
left: p_IL13_Rec

reaction_9
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 9 JAK2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 9 pJAK2 STOICHIOMETRY
right: JAK2
left: pJAK2

pSTAT5
type: Protein
xref: P51692
xref: P42229
xref: C00562

LEFT 0 conversion reaction 9 pJAK2 STOICHIOMETRY
type: Stoichiometry
physical entity: pJAK2
stoichiometric coefficient: 1.0

JAK2
type: PhysicalEntity
member physical entity: JAK2
cellular location: cell

reaction_2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 2 Rec i STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 2 Rec STOICHIOMETRY
right: Rec_i
left: Rec

O60674
type: UnificationXref
id: O60674
db: UniProt Knowledgebase

reaction_1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 1 IL13 Rec STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 1 Rec STOICHIOMETRY
right: IL13_Rec
left: Rec

reaction_4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 4 IL13 Rec STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 4 p IL13 Rec STOICHIOMETRY
right: p_IL13_Rec
left: IL13_Rec

pJAK2
type: PhysicalEntity
member physical entity: pJAK2
cellular location: cell

reaction_3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 3 Rec i STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 3 Rec STOICHIOMETRY
right: Rec
left: Rec_i

O14543
type: UnificationXref
id: O14543
db: UniProt Knowledgebase

LEFT 0 conversion reaction 11 pSTAT5 STOICHIOMETRY
type: Stoichiometry
physical entity: pSTAT5
stoichiometric coefficient: 1.0

pSTAT5
type: PhysicalEntity
member physical entity: pSTAT5
cellular location: cell

GO:0019973
type: UnificationXref
id: GO:0019973
db: Gene Ontology

http://identifiers.org/pubmed/21127196
type: PublicationXref
id: 21127196
db: PubMed

BIOMD0000000313
type: UnificationXref
id: BIOMD0000000313
db: BioModels Database

JAK2
type: PhysicalEntity
member physical entity: JAK2
cellular location: cell

DecoyR
type: Protein
xref: Q14627

C00046
type: UnificationXref
id: C00046
db: KEGG Compound

LEFT 0 conversion reaction 10 STAT5 STOICHIOMETRY
type: Stoichiometry
physical entity: STAT5
stoichiometric coefficient: 1.0

GO:0005144
type: UnificationXref
id: GO:0005144
db: Gene Ontology

cell
type: CellularLocationVocabulary
xref: BTO:0001518
xref: GO:0005623

SOCS3
type: Protein
xref: O14543

RIGHT 0 conversion reaction 1 IL13 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: IL13_Rec
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 8 p IL13 Rec i STOICHIOMETRY
type: Stoichiometry
physical entity: p_IL13_Rec_i
stoichiometric coefficient: 1.0

Rec
type: PhysicalEntity
member physical entity: Rec
cellular location: cell

RIGHT 0 conversion reaction 16 CD274mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: CD274mRNA
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 1 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Rec
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 10 pSTAT5 STOICHIOMETRY
type: Stoichiometry
physical entity: pSTAT5
stoichiometric coefficient: 1.0

pJAK2
type: PhysicalEntity
member physical entity: pJAK2
cellular location: cell

SOCS3mRNA
type: PhysicalEntity
member physical entity: SOCS3mRNA
cellular location: cell

p_IL13_Rec
type: PhysicalEntity
member physical entity: p_IL13_Rec
cellular location: cell

RIGHT 0 conversion reaction 14 SOCS3 STOICHIOMETRY
type: Stoichiometry
physical entity: SOCS3
stoichiometric coefficient: 1.0

pJAK2
type: Protein
xref: O60674
xref: C00562

p_IL13_Rec_i
type: PhysicalEntity
member physical entity: p_IL13_Rec_i
cellular location: cell

CD274mRNA
type: PhysicalEntity
member physical entity: CD274mRNA
cellular location: cell

P51692
type: UnificationXref
id: P51692
db: UniProt Knowledgebase

P20963
type: UnificationXref
id: P20963
db: UniProt Knowledgebase

DecoyR
type: PhysicalEntity
member physical entity: DecoyR
cellular location: cell

RIGHT 0 conversion reaction 5 pJAK2 STOICHIOMETRY
type: Stoichiometry
physical entity: pJAK2
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 12 DecoyR STOICHIOMETRY
type: Stoichiometry
physical entity: DecoyR
stoichiometric coefficient: 1.0

Rec
type: Complex
xref: GO:0016516
xref: P24394
xref: P29597
xref: GO:0019973
xref: P78552

pJAK2
type: PhysicalEntity
member physical entity: pJAK2
cellular location: cell

IL13_Rec
type: PhysicalEntity
member physical entity: IL13_Rec
cellular location: cell

C00562
type: UnificationXref
id: C00562
db: KEGG Compound

LEFT 0 conversion reaction 4 IL13 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: IL13_Rec
stoichiometric coefficient: 1.0

Raia2010 IL13 MedB1
type: Pathway
pathway component: reaction_6
pathway component: reaction_5
pathway component: reaction_8
pathway component: reaction_7
pathway component: reaction_9
pathway component: reaction_16
pathway component: reaction_15
pathway component: reaction_14
pathway component: reaction_2
pathway component: reaction_1
pathway component: reaction_4
pathway component: reaction_3
pathway component: reaction_13
pathway component: reaction_12
pathway component: reaction_11
pathway component: reaction_10
xref: REACT_22232
xref: BTO:0001518
xref: MODEL1102020001
xref: http://identifiers.org/pubmed/21127196
xref: DOID:0050743
xref: GO:0046425
xref: BIOMD0000000313
xref: hsa04630
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Raia2010_IL13_MedB1', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

BTO:0001518
type: UnificationXref
id: BTO:0001518
db: Brenda Tissue Ontology

reaction_16
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 16 CD274mRNA STOICHIOMETRY
right: CD274mRNA

reaction_15
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 15 SOCS3 STOICHIOMETRY
left: SOCS3

RIGHT 0 conversion reaction 7 p IL13 Rec i STOICHIOMETRY
type: Stoichiometry
physical entity: p_IL13_Rec_i
stoichiometric coefficient: 1.0

reaction_14
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 14 SOCS3 STOICHIOMETRY
right: SOCS3

p_IL13_Rec_i
type: PhysicalEntity
member physical entity: p_IL13_Rec_i
cellular location: cell

IL13_Rec
type: Complex
xref: GO:0016516
xref: P35225
xref: P24394
xref: P29597
xref: P78552

reaction_13
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 13 SOCS3mRNA STOICHIOMETRY
right: SOCS3mRNA

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

reaction_12
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 12 IL13 DecoyR STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 12 DecoyR STOICHIOMETRY
right: IL13_DecoyR
spontaneous: true
left: DecoyR
conversion direction: LEFT_TO_RIGHT

reaction_11
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 11 STAT5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 11 pSTAT5 STOICHIOMETRY
right: STAT5
left: pSTAT5

reaction_10
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 10 STAT5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 10 pSTAT5 STOICHIOMETRY
right: pSTAT5
left: STAT5

IL13_Rec
type: PhysicalEntity
member physical entity: IL13_Rec
cellular location: cell

JAK2
type: Protein
xref: O60674

STAT5
type: PhysicalEntity
member physical entity: STAT5
cellular location: cell

CHEBI:33699
type: UnificationXref
id: CHEBI:33699
db: ChEBI

IL13
type: Protein
xref: P35225
xref: GO:0005144

Rec
type: PhysicalEntity
member physical entity: Rec
cellular location: cell

Rec_i
type: PhysicalEntity
member physical entity: Rec_i
cellular location: cell

IL13_DecoyR
type: Complex
xref: Q14627
xref: P35225

SOCS3
type: PhysicalEntity
member physical entity: SOCS3
cellular location: cell

P24394
type: UnificationXref
id: P24394
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 3 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Rec
stoichiometric coefficient: 1.0

JAK2
type: PhysicalEntity
member physical entity: JAK2
cellular location: cell

STAT5
type: PhysicalEntity
member physical entity: STAT5
cellular location: cell

RIGHT 0 conversion reaction 13 SOCS3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: SOCS3mRNA
stoichiometric coefficient: 1.0

GO:0005623
type: UnificationXref
id: GO:0005623
db: Gene Ontology

SOCS3mRNA
type: Protein
xref: O14543
xref: C00046
xref: CHEBI:33699

LEFT 0 conversion reaction 2 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Rec
stoichiometric coefficient: 1.0

GO:0016516
type: UnificationXref
id: GO:0016516
db: Gene Ontology

p_IL13_Rec_i
type: Complex
xref: GO:0016516
xref: P35225
xref: P24394
xref: P29597
xref: GO:0031623
xref: P78552

SHP1
type: Protein
xref: P29350

STAT5
type: Protein
xref: P51692
xref: P42229

P29597
type: UnificationXref
id: P29597
db: UniProt Knowledgebase

Rec_i
type: PhysicalEntity
member physical entity: Rec_i
cellular location: cell

RIGHT 0 conversion reaction 12 IL13 DecoyR STOICHIOMETRY
type: Stoichiometry
physical entity: IL13_DecoyR
stoichiometric coefficient: 1.0

P29350
type: UnificationXref
id: P29350
db: UniProt Knowledgebase

BioModels Database
type: Provenance
xref: BIOMD0000000313

LEFT 0 conversion reaction 15 SOCS3 STOICHIOMETRY
type: Stoichiometry
physical entity: SOCS3
stoichiometric coefficient: 1.0

Rec
type: PhysicalEntity
member physical entity: Rec
cellular location: cell

MODEL1102020001
type: UnificationXref
id: MODEL1102020001
db: BioModels Database

P35225
type: UnificationXref
id: P35225
db: UniProt Knowledgebase

Rec_i
type: Complex
xref: GO:0016516
xref: P24394
xref: P29597
xref: GO:0031623
xref: P78552

GO:0046425
type: UnificationXref
id: GO:0046425
db: Gene Ontology

BioModels Database
type: Provenance
xref: MODEL1102020001

P78552
type: UnificationXref
id: P78552
db: UniProt Knowledgebase

Q14627
type: UnificationXref
id: Q14627
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 4 p IL13 Rec STOICHIOMETRY
type: Stoichiometry
physical entity: p_IL13_Rec
stoichiometric coefficient: 1.0

GO:0031623
type: UnificationXref
id: GO:0031623
db: Gene Ontology

LEFT 0 conversion reaction 5 JAK2 STOICHIOMETRY
type: Stoichiometry
physical entity: JAK2
stoichiometric coefficient: 1.0

hsa04630
type: UnificationXref
id: hsa04630
db: KEGG Pathway

LEFT 0 conversion reaction 6 JAK2 STOICHIOMETRY
type: Stoichiometry
physical entity: JAK2
stoichiometric coefficient: 1.0