There are two models described in the paper to simulate basal and receptor stimulated Ca2+ signaling. 1) No adaptive feedback (this model: MODEL1108050000) and 2) with three slow adaptive feedback loops (MODEL1108050001).

Figure 1B (which shows the simulation of cytosolic Calcium (CaI) at different levels of receptor activation) of the reference article has been reproduced here. The corresponding R value for 15%, 27%, 42% and 75% are 0.39286, 0.70714, 1.1 and 1.96428 respectively, the maximum R value being 2.61905.

The model has also been tested for a range of R values 0-100%, and the results were consistent with that of figure 1C (Control).  For the R range 1) between 0% and 22.5% there was no signal, 2) between 22.5% and 49% triggered Calicum oscillations and 3) between 49% and 100% induced the plateau phase.

The model was integrated and simulated using Copasi v4.7 (Build 34). Data were obtained from Copasi and plotted using Gnuplot.