AbDim
type: PhysicalEntity
member physical entity: AbetaDimer
cellular location: cell

Abeta
type: PhysicalEntity
member physical entity: AbetaMonomer
cellular location: cell

P08473
type: UnificationXref
id: P08473
db: UniProt Knowledgebase

BIOMD0000000462
type: UnificationXref
id: BIOMD0000000462
db: BioModels Database

AbetaDimerisation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AbetaDimerisation AbDim STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AbetaDimerisation Abeta STOICHIOMETRY
right: AbDim
left: Abeta

AbetaDedimerisation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AbetaDedimerisation AbDim STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AbetaDedimerisation Abeta STOICHIOMETRY
right: Abeta
left: AbDim

Nep
type: PhysicalEntity
member physical entity: Neprilysin
cellular location: cell

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: cell

LEFT 1 conversion AbetaDegradation Nep STOICHIOMETRY
type: Stoichiometry
physical entity: Nep
stoichiometric coefficient: 1.0

MODEL1202290000
type: UnificationXref
id: MODEL1202290000
db: BioModels Database

Sink
type: PhysicalEntity

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

Abeta
type: PhysicalEntity
member physical entity: AbetaMonomer
cellular location: cell

AbetaDegradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AbetaDegradation Abeta STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AbetaDegradation Sink STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AbetaDegradation Nep STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AbetaDegradation Nep STOICHIOMETRY
right: Nep
right: Sink
left: Nep
left: Abeta

RIGHT 0 conversion Abetaproduction Abeta STOICHIOMETRY
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

LEFT 0 conversion AbetaDedimerisation AbDim STOICHIOMETRY
type: Stoichiometry
physical entity: AbDim
stoichiometric coefficient: 1.0

RIGHT 0 conversion AbetaDegradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

AbetaPlaque
type: SmallMolecule
xref: BTO:0002774
xref: CHEBI:64645

AbDim
type: PhysicalEntity
member physical entity: AbetaDimer
cellular location: cell

RIGHT 0 conversion AbetaPlaqueFormation AbP STOICHIOMETRY
type: Stoichiometry
physical entity: AbP
stoichiometric coefficient: 4.0

BTO:0002774
type: UnificationXref
id: BTO:0002774

LEFT 0 conversion Abetaproduction Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

Abeta
type: PhysicalEntity
member physical entity: AbetaMonomer
cellular location: cell

Nep
type: PhysicalEntity
member physical entity: Neprilysin
cellular location: cell

CHEBI:64645
type: UnificationXref
id: CHEBI:64645
db: ChEBI

RIGHT 0 conversion AbetaDedimerisation Abeta STOICHIOMETRY
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/22748062
type: PublicationXref
id: 22748062
db: PubMed

AbP
type: PhysicalEntity
member physical entity: AbetaPlaque
cellular location: cell

LEFT 0 conversion AbetaDegradation Abeta STOICHIOMETRY
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

AbetaDimer
type: SmallMolecule
xref: CHEBI:64645
xref: GO:0043234

Abeta
type: PhysicalEntity
member physical entity: AbetaMonomer
cellular location: cell

LEFT 0 conversion AbetaDisaggregation AbP STOICHIOMETRY
type: Stoichiometry
physical entity: AbP
stoichiometric coefficient: 1.0

AbetaPlaqueGrowth
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AbetaPlaqueGrowth Abeta STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AbetaPlaqueGrowth AbP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AbetaPlaqueGrowth AbP STOICHIOMETRY
right: AbP
left: AbP
left: Abeta

AbP
type: PhysicalEntity
member physical entity: AbetaPlaque
cellular location: cell

cell
type: CellularLocationVocabulary

GO:0097242
type: UnificationXref
id: GO:0097242
db: Gene Ontology

Abetaproduction
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Abetaproduction Source STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Abetaproduction Abeta STOICHIOMETRY
right: Abeta
left: Source

RIGHT 0 conversion NepDegradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Source
type: PhysicalEntity

RIGHT 1 conversion AbetaDegradation Nep STOICHIOMETRY
type: Stoichiometry
physical entity: Nep
stoichiometric coefficient: 1.0

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cell

RIGHT 0 conversion AbetaPlaqueGrowth AbP STOICHIOMETRY
type: Stoichiometry
physical entity: AbP
stoichiometric coefficient: 2.0

Nep
type: PhysicalEntity
member physical entity: Neprilysin
cellular location: cell

GO:0070841
type: UnificationXref
id: GO:0070841
db: Gene Ontology

RIGHT 0 conversion AbetaDisaggregation Abeta STOICHIOMETRY
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

NepDegradation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion NepDegradation Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion NepDegradation Nep STOICHIOMETRY
right: Sink
left: Nep

AbP
type: PhysicalEntity
member physical entity: AbetaPlaque
cellular location: cell

AbetaDisaggregation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AbetaDisaggregation AbP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AbetaDisaggregation Abeta STOICHIOMETRY
right: Abeta
left: AbP

LEFT 0 conversion NepDegradation Nep STOICHIOMETRY
type: Stoichiometry
physical entity: Nep
stoichiometric coefficient: 1.0

Abeta
type: PhysicalEntity
member physical entity: AbetaMonomer
cellular location: cell

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: cell

BioModels Database
type: Provenance
xref: BIOMD0000000462

LEFT 0 conversion AbetaPlaqueGrowth Abeta STOICHIOMETRY
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

RIGHT 0 conversion AbetaDimerisation AbDim STOICHIOMETRY
type: Stoichiometry
physical entity: AbDim
stoichiometric coefficient: 1.0

AbP
type: PhysicalEntity
member physical entity: AbetaPlaque
cellular location: cell

DOID:10652
type: UnificationXref
id: DOID:10652
db: Human Disease Ontology

GO:0043234
type: UnificationXref
id: GO:0043234
db: Gene Ontology

LEFT 0 conversion AbetaDimerisation Abeta STOICHIOMETRY
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 2.0

Abeta
type: PhysicalEntity
member physical entity: AbetaMonomer
cellular location: cell

BioModels Database
type: Provenance
xref: MODEL1202290000

BIOMD0000000462
type: Pathway
pathway component: AbetaPlaqueFormation
pathway component: AbetaDimerisation
pathway component: AbetaDegradation
pathway component: AbetaDedimerisation
pathway component: AbetaPlaqueGrowth
pathway component: NepDegradation
pathway component: Abetaproduction
pathway component: AbetaDisaggregation
xref: MODEL1202290000
xref: BIOMD0000000462
xref: http://identifiers.org/pubmed/22748062
xref: DOID:10652
xref: GO:0070841
xref: GO:0097242
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'BIOMD0000000462', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

AbetaPlaqueFormation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AbetaPlaqueFormation AbDim STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AbetaPlaqueFormation AbP STOICHIOMETRY
right: AbP
left: AbDim

AbetaMonomer
type: SmallMolecule
xref: CHEBI:64645

Neprilysin
type: Protein
xref: P08473

AbDim
type: PhysicalEntity
member physical entity: AbetaDimer
cellular location: cell

LEFT 0 conversion AbetaPlaqueFormation AbDim STOICHIOMETRY
type: Stoichiometry
physical entity: AbDim
stoichiometric coefficient: 2.0

LEFT 1 conversion AbetaPlaqueGrowth AbP STOICHIOMETRY
type: Stoichiometry
physical entity: AbP
stoichiometric coefficient: 1.0