Q92574
type: unificationXref
ID: Q92574
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 20 PRAS40 T246
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 T246
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

MODEL1506230002
type: pathway
XREF: GO:2000479
XREF: BTO:0000165
XREF: http://identifiers.org/pubmed/22452783
XREF: MODEL1506230002
XREF: BTO:0000567
XREF: BIOMD0000000581
XREF: BIOMD0000000580
XREF: GO:0032869
PATHWAY-COMPONENTS: conversion reaction 19
PATHWAY-COMPONENTS: conversion reaction 17
PATHWAY-COMPONENTS: conversion reaction 1
PATHWAY-COMPONENTS: conversion reaction 18
PATHWAY-COMPONENTS: conversion reaction 6
PATHWAY-COMPONENTS: conversion reaction 7
PATHWAY-COMPONENTS: conversion reaction 8
PATHWAY-COMPONENTS: conversion reaction 9
PATHWAY-COMPONENTS: conversion reaction 2
PATHWAY-COMPONENTS: conversion reaction 3
PATHWAY-COMPONENTS: conversion reaction 4
PATHWAY-COMPONENTS: conversion reaction 5
PATHWAY-COMPONENTS: conversion reaction 11
PATHWAY-COMPONENTS: conversion reaction 12
PATHWAY-COMPONENTS: conversion reaction 10
PATHWAY-COMPONENTS: conversion reaction 15
PATHWAY-COMPONENTS: conversion reaction 16
PATHWAY-COMPONENTS: conversion reaction 13
PATHWAY-COMPONENTS: conversion reaction 14
PATHWAY-COMPONENTS: conversion reaction 22
PATHWAY-COMPONENTS: conversion reaction 23
PATHWAY-COMPONENTS: conversion reaction 20
PATHWAY-COMPONENTS: conversion reaction 21
PATHWAY-COMPONENTS: conversion reaction 26
PATHWAY-COMPONENTS: conversion reaction 24
PATHWAY-COMPONENTS: conversion reaction 25
COMMENT: This BioPAX Level2 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
COMMENT: The original model, 'MODEL1506230002', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
ORGANISM: biosource 2
DATA-SOURCE: datasource 2
DATA-SOURCE: datasource 1

RIGHT 0 conversion reaction 17 p70S6K
type: physicalEntityParticipant
PHYSICAL-ENTITY: p70S6K
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 26 PI3K variant
type: physicalEntityParticipant
PHYSICAL-ENTITY: PI3K variant
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 16 mTORC2 pS2481
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC2 pS2481
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 23 TSC1 TSC2 pT1462
type: physicalEntityParticipant
PHYSICAL-ENTITY: TSC1 TSC2 pT1462
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 7 AMPK pT172
type: physicalEntityParticipant
PHYSICAL-ENTITY: AMPK pT172
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 6 IRS1
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 22 PRAS40 pT246
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 pT246
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

Q96B36
type: unificationXref
ID: Q96B36
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 25 PI3K variant
type: physicalEntityParticipant
PHYSICAL-ENTITY: PI3K variant
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

P42336
type: unificationXref
ID: P42336
DB: UniProt Knowledgebase

LEFT 0 conversion reaction 9 Akt pT308
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt pT308
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 18 p70S6K
type: physicalEntityParticipant
PHYSICAL-ENTITY: p70S6K
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

P42345
type: unificationXref
ID: P42345
DB: UniProt Knowledgebase

LEFT 0 conversion reaction 19 PRAS40 pS183
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 pS183
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 21 PRAS40 S183
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 S183
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 5 IRS1 p
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1 p
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 16 mTORC2
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC2
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

BIOMD0000000581
type: unificationXref
ID: BIOMD0000000581
DB: BioModels Database

P06213
type: unificationXref
ID: P06213
DB: UniProt Knowledgebase

BIOMD0000000580
type: unificationXref
ID: BIOMD0000000580
DB: BioModels Database

RIGHT 0 conversion reaction 3 IR beta
type: physicalEntityParticipant
PHYSICAL-ENTITY: IR beta
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 24 TSC1 TSC2 pT1462
type: physicalEntityParticipant
PHYSICAL-ENTITY: TSC1 TSC2 pT1462
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 11 Akt S473
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt S473
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/taxonomy/10090
type: unificationXref
ID: 10090
DB: Taxonomy

P35568
type: unificationXref
ID: P35568
DB: UniProt Knowledgebase

LEFT 0 conversion reaction 24 TSC1 TSC2 pS1387
type: physicalEntityParticipant
PHYSICAL-ENTITY: TSC1 TSC2 pS1387
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 8 AMPK
type: physicalEntityParticipant
PHYSICAL-ENTITY: AMPK
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

BTO:0000567
type: unificationXref
ID: BTO:0000567
DB: Brenda Tissue Ontology

RIGHT 0 conversion reaction 21 PRAS40 pS183
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 pS183
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 10 Akt S473
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt S473
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 9 Akt T308
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt T308
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 20 PRAS40 pT246
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 pT246
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 15 mTORC2 pS2481
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC2 pS2481
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 5 IRS1 pS636
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1 pS636
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

MODEL1506230002
type: unificationXref
ID: MODEL1506230002
DB: BioModels Database

RIGHT 0 conversion reaction 12 Akt pT308
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt pT308
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

P49815
type: unificationXref
ID: P49815
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 23 TSC1 TSC2 pS1387
type: physicalEntityParticipant
PHYSICAL-ENTITY: TSC1 TSC2 pS1387
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 25 PI3K variant p
type: physicalEntityParticipant
PHYSICAL-ENTITY: PI3K variant p
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 18 p70S6K pT389
type: physicalEntityParticipant
PHYSICAL-ENTITY: p70S6K pT389
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 13 mTORC1 pS2448
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC1 pS2448
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 1 IR beta
type: physicalEntityParticipant
PHYSICAL-ENTITY: IR beta
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 3 IR beta refractory
type: physicalEntityParticipant
PHYSICAL-ENTITY: IR beta refractory
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 17 p70S6K pT389
type: physicalEntityParticipant
PHYSICAL-ENTITY: p70S6K pT389
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

P54619
type: unificationXref
ID: P54619
DB: UniProt Knowledgebase

LEFT 0 conversion reaction 4 IRS1
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 12 Akt T308
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt T308
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:2000479
type: unificationXref
ID: GO:2000479
DB: Gene Ontology

RIGHT 0 conversion reaction 1 IR beta pY1146
type: physicalEntityParticipant
PHYSICAL-ENTITY: IR beta pY1146
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

P31749
type: unificationXref
ID: P31749
DB: UniProt Knowledgebase

LEFT 0 conversion reaction 2 IR beta pY1146
type: physicalEntityParticipant
PHYSICAL-ENTITY: IR beta pY1146
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 11 Akt pS473
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt pS473
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 6 IRS1 pS636
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1 pS636
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 10 Akt pS473
type: physicalEntityParticipant
PHYSICAL-ENTITY: Akt pS473
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

P01308
type: unificationXref
ID: P01308
DB: UniProt Knowledgebase

P23443
type: unificationXref
ID: P23443
DB: UniProt Knowledgebase

LEFT 0 conversion reaction 7 AMPK
type: physicalEntityParticipant
PHYSICAL-ENTITY: AMPK
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0032869
type: unificationXref
ID: GO:0032869
DB: Gene Ontology

RIGHT 0 conversion reaction 15 mTORC2
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC2
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 2 IR beta refractory
type: physicalEntityParticipant
PHYSICAL-ENTITY: IR beta refractory
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/taxonomy/9606
type: unificationXref
ID: 9606
DB: Taxonomy

RIGHT 0 conversion reaction 19 PRAS40 S183
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 S183
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 13 mTORC1
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC1
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

Cell
type: openControlledVocabulary
XREF: BTO:0000567
TERM: Cell

LEFT 0 conversion reaction 22 PRAS40 T246
type: physicalEntityParticipant
PHYSICAL-ENTITY: PRAS40 T246
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

Q9Y478
type: unificationXref
ID: Q9Y478
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 26 PI3K variant p
type: physicalEntityParticipant
PHYSICAL-ENTITY: PI3K variant p
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

Q13131
type: unificationXref
ID: Q13131
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 14 mTORC1 pS2448
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC1 pS2448
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

BTO:0000165
type: unificationXref
ID: BTO:0000165
DB: Brenda Tissue Ontology

RIGHT 0 conversion reaction 4 IRS1 p
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1 p
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 8 AMPK pT172
type: physicalEntityParticipant
PHYSICAL-ENTITY: AMPK pT172
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/pubmed/22452783
type: publicationXref
ID: 22452783
DB: PubMed

datasource 2
type: dataSource
XREF: BIOMD0000000580
NAME: BioModels Database

datasource 1
type: dataSource
XREF: MODEL1506230002
NAME: BioModels Database

LEFT 0 conversion reaction 14 mTORC1
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC1
CELLULAR-LOCATION: Cell
STOICHIOMETRIC-COEFFICIENT: 1.0