LEFT 0 conversion r13 Smad P CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_CoSmad
stoichiometric coefficient: 1.0

TGFb_TGFbR_P
type: PhysicalEntity
member physical entity: TGFb_TGFbR_P
cellular location: cytoplasm

Smad
type: PhysicalEntity
member physical entity: Smad
cellular location: cytoplasm

RIGHT 0 conversion r18 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 1.0

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

RIGHT 0 conversion r25 I Smad mRNA1 STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad_mRNA1
stoichiometric coefficient: 1.0

GO:0070411
type: UnificationXref
id: GO:0070411
db: Gene Ontology

GO:0070410
type: UnificationXref
id: GO:0070410
db: Gene Ontology

Smad_P_Smad_P
type: Protein
xref: IPR008984

Smad_N
type: PhysicalEntity
member physical entity: Smad_N
cellular location: nucleus

GO:0005576
type: UnificationXref
id: GO:0005576
db: Gene Ontology

LEFT 0 conversion r20 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 1.0

CoSmad
type: Protein
xref: IPR008984

LEFT 0 conversion r3 TGFb TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR
stoichiometric coefficient: 1.0

Smad
type: Protein
xref: IPR008984

GO:0070412
type: UnificationXref
id: GO:0070412
db: Gene Ontology

MODEL1208280000
type: UnificationXref
id: MODEL1208280000
db: BioModels Database

TGFb_TGFbR
type: PhysicalEntity
member physical entity: TGFb_TGFbR
cellular location: cytoplasm

CoSmad_N
type: PhysicalEntity
member physical entity: CoSmad_N
cellular location: nucleus

I_Smad
type: PhysicalEntity
member physical entity: I_Smad
cellular location: cytoplasm

RIGHT 0 conversion r4 TGFb TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR
stoichiometric coefficient: 1.0

TGFb_TGFbR_P
type: Complex
xref: IPR016319
xref: IPR000333

TGFb_TGFbR
type: Complex
xref: IPR016319
xref: IPR000333

RIGHT 0 conversion r14 CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad_N
stoichiometric coefficient: 1.0

CoSmad
type: PhysicalEntity
member physical entity: CoSmad
cellular location: cytoplasm

RIGHT 0 conversion r17 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 1.0

CoSmad_N
type: PhysicalEntity
member physical entity: CoSmad_N
cellular location: nucleus

IPR016319
type: UnificationXref
id: IPR016319
db: InterPro

GO:0016311
type: UnificationXref
id: GO:0016311
db: Gene Ontology

Smad_P_Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_Smad_P_N
cellular location: nucleus

LEFT 0 conversion r22 Smad P Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_Smad_P_N
stoichiometric coefficient: 1.0

GO:0030617
type: UnificationXref
id: GO:0030617
db: Gene Ontology

LEFT 0 conversion r17 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 1.0

Smad_P_Smad_P_N
type: Protein
xref: IPR008984

cytoplasm
type: CellularLocationVocabulary
xref: GO:0005737

TGFb_TGFbR_P
type: PhysicalEntity
member physical entity: TGFb_TGFbR_P
cellular location: cytoplasm

LEFT 0 conversion r16 Smad P Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_Smad_P
stoichiometric coefficient: 1.0

r11
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r11 Smad P STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r11 Smad P Smad P STOICHIOMETRY
xref: GO:0043241
xref: IPR008984
right: Smad_P
left: Smad_P_Smad_P

GO:0006401
type: UnificationXref
id: GO:0006401
db: Gene Ontology

r10
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r10 Smad P STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r10 Smad P Smad P STOICHIOMETRY
xref: GO:0042803
xref: IPR008984
right: Smad_P_Smad_P
left: Smad_P

r13
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r13 Smad P CoSmad STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r13 Smad P STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r13 CoSmad STOICHIOMETRY
xref: GO:0043241
xref: IPR008984
right: CoSmad
right: Smad_P
left: Smad_P_CoSmad

LEFT 0 conversion r11 Smad P Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_Smad_P
stoichiometric coefficient: 1.0

r12
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r12 Smad P STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r12 Smad P CoSmad STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r12 CoSmad STOICHIOMETRY
xref: GO:0042803
xref: GO:0070410
xref: IPR008984
xref: GO:0070412
right: Smad_P_CoSmad
left: CoSmad
left: Smad_P

GO:0007179
type: UnificationXref
id: GO:0007179
db: Gene Ontology

r15
type: Transport
participant stoichiometry: LEFT 0 conversion r15 CoSmad N STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r15 CoSmad STOICHIOMETRY
xref: GO:0051168
xref: IPR008984
right: CoSmad
left: CoSmad_N

r14
type: Transport
participant stoichiometry: LEFT 0 conversion r14 CoSmad STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r14 CoSmad N STOICHIOMETRY
xref: GO:0007184
xref: IPR008984
right: CoSmad_N
left: CoSmad

nucleus
type: CellularLocationVocabulary
xref: GO:0005634

r17
type: Transport
participant stoichiometry: LEFT 0 conversion r17 Smad P STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r17 Smad P N STOICHIOMETRY
xref: GO:0007184
xref: cr.2008.325
xref: IPR008984
right: Smad_P_N
left: Smad_P

r16
type: Transport
participant stoichiometry: RIGHT 0 conversion r16 Smad P Smad P N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r16 Smad P Smad P STOICHIOMETRY
xref: http://identifiers.org/pubmed/12809600
xref: GO:0007184
xref: cr.2008.325
xref: IPR008984
right: Smad_P_Smad_P_N
left: Smad_P_Smad_P

LEFT 0 conversion r27 I Smad mRNA2 STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad_mRNA2
stoichiometric coefficient: 1.0

r19
type: Transport
participant stoichiometry: RIGHT 0 conversion r19 Smad P CoSmad N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r19 Smad P CoSmad STOICHIOMETRY
xref: GO:0007184
xref: cr.2008.325
xref: IPR008984
right: Smad_P_CoSmad_N
left: Smad_P_CoSmad

RIGHT 0 conversion r16 Smad P Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_Smad_P_N
stoichiometric coefficient: 1.0

r18
type: Transport
participant stoichiometry: RIGHT 0 conversion r18 Smad P STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r18 Smad P N STOICHIOMETRY
xref: GO:0051168
xref: cr.2008.325
xref: IPR008984
right: Smad_P
left: Smad_P_N

RIGHT 0 conversion r23 Smad P CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_CoSmad_N
stoichiometric coefficient: 1.0

GO:0007183
type: UnificationXref
id: GO:0007183
db: Gene Ontology

GO:0007184
type: UnificationXref
id: GO:0007184
db: Gene Ontology

CoSmad
type: PhysicalEntity
member physical entity: CoSmad
cellular location: cytoplasm

LEFT 1 conversion r2 TGFb STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb
stoichiometric coefficient: 1.0

LEFT 0 conversion r5 TGFb TGFbR P STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR_P
stoichiometric coefficient: 1.0

RIGHT 0 conversion r5 I Smad TGFb TGFbR P STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad_TGFb_TGFbR_P
stoichiometric coefficient: 1.0

LEFT 0 conversion r18 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 1.0

LEFT 0 conversion r1 TGFb TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR
stoichiometric coefficient: 1.0

CoSmad_N
type: PhysicalEntity
member physical entity: CoSmad_N
cellular location: nucleus

r20
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r20 Smad N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r20 Smad P N STOICHIOMETRY
xref: GO:0006470
xref: IPR008984
xref: 978-1-60761-738-9 7
right: Smad_N
left: Smad_P_N

r22
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r22 Smad P N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r22 Smad P Smad P N STOICHIOMETRY
xref: GO:0043241
xref: IPR008984
xref: GO:0010862
right: Smad_P_N
left: Smad_P_Smad_P_N

GO:0004674
type: UnificationXref
id: GO:0004674
db: Gene Ontology

r21
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r21 Smad P Smad P N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r21 Smad P N STOICHIOMETRY
xref: GO:0007183
xref: j.bbrc.2008.08.143
xref: IPR008984
right: Smad_P_Smad_P_N
left: Smad_P_N

r24
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r24 Smad P N STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r24 CoSmad N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r24 Smad P CoSmad N STOICHIOMETRY
xref: Q13485
xref: GO:0070410
xref: GO:0043241
xref: IPR008984
xref: GO:0010862
right: CoSmad_N
right: Smad_P_N
left: Smad_P_CoSmad_N

r23
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r23 Smad P CoSmad N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r23 Smad P N STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r23 CoSmad N STOICHIOMETRY
xref: Q13485
xref: GO:0070410
xref: IPR008984
xref: GO:0070412
xref: GO:0010862
right: Smad_P_CoSmad_N
left: CoSmad_N
left: Smad_P_N

r26
type: Transport
participant stoichiometry: RIGHT 0 conversion r26 I Smad mRNA2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r26 I Smad mRNA1 STOICHIOMETRY
xref: GO:0051168
xref: IPR008984
right: I_Smad_mRNA2
left: I_Smad_mRNA1

r25
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r25 I Smad mRNA1 STOICHIOMETRY
xref: IPR008984
right: I_Smad_mRNA1

r28
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r28 I Smad STOICHIOMETRY
xref: IPR008984
right: I_Smad

r27
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r27 I Smad mRNA2 STOICHIOMETRY
xref: GO:0006401
xref: IPR008984
left: I_Smad_mRNA2

RIGHT 0 conversion r19 Smad P CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_CoSmad_N
stoichiometric coefficient: 1.0

r29
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r29 I Smad STOICHIOMETRY
xref: GO:0030163
xref: IPR008984
left: I_Smad

TGFb_TGFbR
type: PhysicalEntity
member physical entity: TGFb_TGFbR
cellular location: cytoplasm

LEFT 1 conversion r5 I Smad STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad
stoichiometric coefficient: 1.0

I_Smad_mRNA1
type: PhysicalEntity
member physical entity: I_Smad_mRNA1
cellular location: nucleus

GO:0030163
type: UnificationXref
id: GO:0030163
db: Gene Ontology

LEFT 0 conversion r12 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 1.0

CoSmad
type: PhysicalEntity
member physical entity: CoSmad
cellular location: cytoplasm

P36897
type: UnificationXref
id: P36897
db: UniProt Knowledgebase

TGFb
type: Protein
xref: P36897

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

LEFT 0 conversion r4 TGFb TGFbR P STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR_P
stoichiometric coefficient: 1.0

Smad_N
type: PhysicalEntity
member physical entity: Smad_N
cellular location: nucleus

http://identifiers.org/pubmed/12809600
type: UnificationXref
id: 12809600
db: PubMed

RIGHT 0 conversion r2 TGFb TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR
stoichiometric coefficient: 1.0

Smad
type: PhysicalEntity
member physical entity: Smad
cellular location: cytoplasm

j.bbrc.2008.08.143
type: UnificationXref
id: 10.1016/j.bbrc.2008.08.143
db: DOI

TGFb_TGFbR
type: PhysicalEntity
member physical entity: TGFb_TGFbR
cellular location: cytoplasm

LEFT 0 conversion r26 I Smad mRNA1 STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad_mRNA1
stoichiometric coefficient: 1.0

TGFb
type: PhysicalEntity
member physical entity: TGFb
cellular location: extracellular

GO:0051168
type: UnificationXref
id: GO:0051168
db: Gene Ontology

RIGHT 0 conversion r21 Smad P Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_Smad_P_N
stoichiometric coefficient: 1.0

r1
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion r1 TGFb TGFbR STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r1 TGFbR STOICHIOMETRY
xref: GO:0043241
xref: IPR016319
xref: IPR000333
right: TGFbR
spontaneous: true
left: TGFb_TGFbR
conversion direction: RIGHT_TO_LEFT

r2
type: Transport
participant stoichiometry: RIGHT 0 conversion r2 TGFb TGFbR STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion r2 TGFb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r2 TGFbR STOICHIOMETRY
xref: GO:0005160
xref: http://identifiers.org/pubmed/12729750
xref: IPR016319
xref: IPR000333
right: TGFb_TGFbR
left: TGFb
left: TGFbR

r3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r3 TGFb TGFbR STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r3 TGFb TGFbR P STOICHIOMETRY
xref: GO:0004674
xref: IPR016319
xref: IPR000333
right: TGFb_TGFbR_P
left: TGFb_TGFbR

r4
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r4 TGFb TGFbR STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r4 TGFb TGFbR P STOICHIOMETRY
xref: IPR016319
xref: GO:0016311
xref: IPR000333
right: TGFb_TGFbR
left: TGFb_TGFbR_P

r5
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion r5 I Smad STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r5 TGFb TGFbR P STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r5 I Smad TGFb TGFbR P STOICHIOMETRY
xref: GO:0030617
xref: GO:0070411
xref: IPR008984
xref: IPR016319
xref: GO:0016311
xref: IPR000333
right: I_Smad_TGFb_TGFbR_P
left: TGFb_TGFbR_P
left: I_Smad

r6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion r6 TGFb TGFbR STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion r6 I Smad STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r6 I Smad TGFb TGFbR P STOICHIOMETRY
xref: GO:0043241
xref: IPR008984
xref: IPR016319
xref: IPR000333
right: TGFb_TGFbR
right: I_Smad
left: I_Smad_TGFb_TGFbR_P

r7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion r7 Smad STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion r7 Smad P STOICHIOMETRY
xref: GO:0060389
xref: IPR008984
xref: IPR016319
xref: IPR000333
right: Smad_P
left: Smad

r8
type: Transport
participant stoichiometry: RIGHT 0 conversion r8 Smad N STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r8 Smad STOICHIOMETRY
xref: GO:0007184
xref: IPR008984
right: Smad_N
left: Smad

r9
type: Transport
participant stoichiometry: RIGHT 0 conversion r9 Smad STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion r9 Smad N STOICHIOMETRY
xref: GO:0051168
xref: IPR008984
right: Smad
left: Smad_N

TGFb_TGFbR_P
type: PhysicalEntity
member physical entity: TGFb_TGFbR_P
cellular location: cytoplasm

Smad_P_Smad_P
type: PhysicalEntity
member physical entity: Smad_P_Smad_P
cellular location: cytoplasm

I_Smad
type: PhysicalEntity
member physical entity: I_Smad
cellular location: cytoplasm

Smad_P_CoSmad_N
type: PhysicalEntity
member physical entity: Smad_P_CoSmad_N
cellular location: nucleus

LEFT 0 conversion r9 Smad N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_N
stoichiometric coefficient: 1.0

RIGHT 0 conversion r28 I Smad STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad
stoichiometric coefficient: 1.0

IPR017855
type: UnificationXref
id: IPR017855
db: InterPro

Celli re2011 Plasticity of TGF Signalling
type: Pathway
pathway component: r20
pathway component: r1
pathway component: r22
pathway component: r2
pathway component: r21
pathway component: r3
pathway component: r24
pathway component: r4
pathway component: r23
pathway component: r5
pathway component: r26
pathway component: r6
pathway component: r25
pathway component: r7
pathway component: r28
pathway component: r8
pathway component: r27
pathway component: r9
pathway component: r29
pathway component: r11
pathway component: r10
pathway component: r13
pathway component: r12
pathway component: r15
pathway component: r14
pathway component: r17
pathway component: r16
pathway component: r19
pathway component: r18
xref: MODEL1208280000
xref: http://identifiers.org/pubmed/22051045
xref: GO:0007179
xref: BIOMD0000000600
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Celli_re2011___Plasticity_of_TGF___Signalling', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

GO:0005634
type: UnificationXref
id: GO:0005634
db: Gene Ontology

LEFT 0 conversion r8 Smad STOICHIOMETRY
type: Stoichiometry
physical entity: Smad
stoichiometric coefficient: 1.0

LEFT 0 conversion r24 Smad P CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_CoSmad_N
stoichiometric coefficient: 1.0

LEFT 0 conversion r7 Smad STOICHIOMETRY
type: Stoichiometry
physical entity: Smad
stoichiometric coefficient: 1.0

RIGHT 0 conversion r15 CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad
stoichiometric coefficient: 1.0

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

Smad_P_CoSmad
type: PhysicalEntity
member physical entity: Smad_P_CoSmad
cellular location: cytoplasm

TGFbR
type: PhysicalEntity
member physical entity: TGFbR
cellular location: cytoplasm

RIGHT 0 conversion r7 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 1.0

TGFb_TGFbR
type: PhysicalEntity
member physical entity: TGFb_TGFbR
cellular location: cytoplasm

Smad_P_CoSmad_N
type: PhysicalEntity
member physical entity: Smad_P_CoSmad_N
cellular location: nucleus

LEFT 0 conversion r21 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 2.0

RIGHT 0 conversion r26 I Smad mRNA2 STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad_mRNA2
stoichiometric coefficient: 1.0

Smad_P_CoSmad
type: Protein
xref: Q13485
xref: IPR008984

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

I_Smad_mRNA1
type: PhysicalEntity
member physical entity: I_Smad_mRNA1
cellular location: nucleus

GO:0005737
type: UnificationXref
id: GO:0005737
db: Gene Ontology

RIGHT 0 conversion r3 TGFb TGFbR P STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR_P
stoichiometric coefficient: 1.0

Q13485
type: UnificationXref
id: Q13485
db: UniProt Knowledgebase

I_Smad_TGFb_TGFbR_P
type: PhysicalEntity
member physical entity: I_Smad_TGFb_TGFbR_P
cellular location: cytoplasm

cr.2008.325
type: UnificationXref
id: 10.1038/cr.2008.325
db: DOI

Smad_P_CoSmad_N
type: PhysicalEntity
member physical entity: Smad_P_CoSmad_N
cellular location: nucleus

I_Smad_mRNA2
type: PhysicalEntity
member physical entity: I_Smad_mRNA2
cellular location: cytoplasm

IPR000333
type: UnificationXref
id: IPR000333
db: InterPro

GO:0042803
type: UnificationXref
id: GO:0042803
db: Gene Ontology

LEFT 0 conversion r19 Smad P CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_CoSmad
stoichiometric coefficient: 1.0

Smad_P_CoSmad
type: PhysicalEntity
member physical entity: Smad_P_CoSmad
cellular location: cytoplasm

I_Smad_TGFb_TGFbR_P
type: PhysicalEntity
member physical entity: I_Smad_TGFb_TGFbR_P
cellular location: cytoplasm

RIGHT 0 conversion r6 TGFb TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_TGFbR
stoichiometric coefficient: 1.0

CoSmad_N
type: PhysicalEntity
member physical entity: CoSmad_N
cellular location: nucleus

LEFT 0 conversion r23 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 1.0

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

CoSmad
type: PhysicalEntity
member physical entity: CoSmad
cellular location: cytoplasm

LEFT 0 conversion r14 CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad
stoichiometric coefficient: 1.0

RIGHT 0 conversion r22 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 2.0

Smad_P_Smad_P
type: PhysicalEntity
member physical entity: Smad_P_Smad_P
cellular location: cytoplasm

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

Smad_P
type: Protein
xref: IPR008984

TGFbR
type: Protein
xref: IPR000333

Smad_N
type: Protein
xref: IPR008984

TGFb_TGFbR
type: PhysicalEntity
member physical entity: TGFb_TGFbR
cellular location: cytoplasm

LEFT 0 conversion r6 I Smad TGFb TGFbR P STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad_TGFb_TGFbR_P
stoichiometric coefficient: 1.0

RIGHT 0 conversion r13 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 1.0

LEFT 0 conversion r10 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 2.0

GO:0005160
type: UnificationXref
id: GO:0005160
db: Gene Ontology

RIGHT 0 conversion r9 Smad STOICHIOMETRY
type: Stoichiometry
physical entity: Smad
stoichiometric coefficient: 1.0

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

GO:0010862
type: UnificationXref
id: GO:0010862
db: Gene Ontology

GO:0043241
type: UnificationXref
id: GO:0043241
db: Gene Ontology

LEFT 1 conversion r12 CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad
stoichiometric coefficient: 1.0

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

LEFT 0 conversion r2 TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbR
stoichiometric coefficient: 1.0

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

RIGHT 1 conversion r13 CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad
stoichiometric coefficient: 1.0

RIGHT 0 conversion r24 Smad P N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_N
stoichiometric coefficient: 1.0

I_Smad
type: PhysicalEntity
member physical entity: I_Smad
cellular location: cytoplasm

978-1-60761-738-9 7
type: UnificationXref
id: 10.1007/978-1-60761-738-9_7
db: DOI

I_Smad
type: Protein
xref: IPR008984

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

http://identifiers.org/pubmed/22051045
type: PublicationXref
id: 22051045
db: PubMed

RIGHT 1 conversion r24 CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad_N
stoichiometric coefficient: 1.0

CoSmad_N
type: Protein
xref: IPR008984

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

LEFT 0 conversion r29 I Smad STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad
stoichiometric coefficient: 1.0

I_Smad_mRNA1
type: Protein
xref: IPR008984

GO:0006470
type: UnificationXref
id: GO:0006470
db: Gene Ontology

Smad_P_Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_Smad_P_N
cellular location: nucleus

I_Smad_mRNA2
type: Protein
xref: IPR008984

RIGHT 0 conversion r1 TGFbR STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbR
stoichiometric coefficient: 1.0

GO:0060389
type: UnificationXref
id: GO:0060389
db: Gene Ontology

RIGHT 0 conversion r20 Smad N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_N
stoichiometric coefficient: 1.0

LEFT 0 conversion r15 CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad_N
stoichiometric coefficient: 1.0

Smad_P_N
type: Protein
xref: Q13485
xref: IPR008984

RIGHT 0 conversion r12 Smad P CoSmad STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_CoSmad
stoichiometric coefficient: 1.0

RIGHT 0 conversion r11 Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P
stoichiometric coefficient: 2.0

I_Smad
type: PhysicalEntity
member physical entity: I_Smad
cellular location: cytoplasm

Smad_P_CoSmad_N
type: Protein
xref: Q13485
xref: IPR008984

Smad_P_CoSmad
type: PhysicalEntity
member physical entity: Smad_P_CoSmad
cellular location: cytoplasm

I_Smad_mRNA2
type: PhysicalEntity
member physical entity: I_Smad_mRNA2
cellular location: cytoplasm

http://identifiers.org/pubmed/12729750
type: UnificationXref
id: 12729750
db: PubMed

TGFbR
type: PhysicalEntity
member physical entity: TGFbR
cellular location: cytoplasm

BIOMD0000000600
type: UnificationXref
id: BIOMD0000000600
db: BioModels Database

BioModels Database
type: Provenance
xref: BIOMD0000000600

RIGHT 0 conversion r10 Smad P Smad P STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_P_Smad_P
stoichiometric coefficient: 1.0

extracellular
type: CellularLocationVocabulary
xref: GO:0005576

Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_N
cellular location: nucleus

Smad
type: PhysicalEntity
member physical entity: Smad
cellular location: cytoplasm

I_Smad_TGFb_TGFbR_P
type: Complex
xref: IPR017855
xref: IPR016319
xref: IPR000333

IPR008984
type: UnificationXref
id: IPR008984
db: InterPro

RIGHT 0 conversion r8 Smad N STOICHIOMETRY
type: Stoichiometry
physical entity: Smad_N
stoichiometric coefficient: 1.0

LEFT 1 conversion r23 CoSmad N STOICHIOMETRY
type: Stoichiometry
physical entity: CoSmad_N
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: MODEL1208280000

Smad_P
type: PhysicalEntity
member physical entity: Smad_P
cellular location: cytoplasm

Smad_N
type: PhysicalEntity
member physical entity: Smad_N
cellular location: nucleus

Smad_P_Smad_P
type: PhysicalEntity
member physical entity: Smad_P_Smad_P
cellular location: cytoplasm

RIGHT 1 conversion r6 I Smad STOICHIOMETRY
type: Stoichiometry
physical entity: I_Smad
stoichiometric coefficient: 1.0

Smad_P_Smad_P_N
type: PhysicalEntity
member physical entity: Smad_P_Smad_P_N
cellular location: nucleus