LEFT 1 conversion R00677 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/18547057
type: UnificationXref
id: 18547057
db: PubMed

M_5hoxnfkyn_c
type: PhysicalEntity
member physical entity: M_5HFKyn
cellular location: Cytosol

M_quln_c
type: PhysicalEntity
member physical entity: M_Quin
cellular location: Cytosol

R01960
type: UnificationXref
id: R01960
db: KEGG Reaction

M_Serotonin
type: SmallMolecule
xref: CHEBI:28790

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_atp_c
type: PhysicalEntity
member physical entity: M_ATP
cellular location: Cytosol

RIGHT 0 conversion R01959 M for c STOICHIOMETRY
type: Stoichiometry
physical entity: M_for_c
stoichiometric coefficient: 1.0

M_3HAA
type: SmallMolecule
xref: CHEBI:15793

http://identifiers.org/ec-code/4.1.1.28
type: UnificationXref
id: 4.1.1.28
db: Enzyme Nomenclature

LEFT 0 conversion R02665 M 3hanthrn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_3hanthrn_c
stoichiometric coefficient: 1.0

M_5hoxindact_c
type: PhysicalEntity
member physical entity: M_5HAc
cellular location: Cytosol

http://identifiers.org/ec-code/2.6.1.7
type: UnificationXref
id: 2.6.1.7
db: Enzyme Nomenclature

LEFT 1 conversion R02908 Maoa M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

M_dhbpt_c
type: PhysicalEntity
member physical entity: M_Dhbpt
cellular location: Cytosol

M_5htrp_c
type: PhysicalEntity
member physical entity: M_5HTrp
cellular location: Cytosol

LEFT 0 conversion R00685 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

M_cmusa_c
type: PhysicalEntity
member physical entity: M_Acms
cellular location: Cytosol

M_PPi
type: SmallMolecule
xref: CHEBI:18361

R02702
type: UnificationXref
id: R02702
db: KEGG Reaction

M_amp_c
type: PhysicalEntity
member physical entity: M_AMP
cellular location: Cytosol

LEFT 0 conversion R01956 Kat1 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

CHEBI:27897
type: UnificationXref
id: CHEBI:27897
db: ChEBI

M_ATP
type: SmallMolecule
xref: CHEBI:15422

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

M_akg_c
type: PhysicalEntity
member physical entity: M_Ketoglutarate
cellular location: Cytosol

R02701
type: UnificationXref
id: R02701
db: KEGG Reaction

CHEBI:15793
type: UnificationXref
id: CHEBI:15793
db: ChEBI

RIGHT 2 conversion R02911 M h c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h_c
stoichiometric coefficient: 1.0

TRP_ex
type: PhysicalEntity
member physical entity: Trp_ex
cellular location: Cytosol

RIGHT 1 conversion R02908 Maob M h2o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o2_c
stoichiometric coefficient: 1.0

M_coa_c
type: PhysicalEntity
member physical entity: M_CoA
cellular location: Cytosol

CHEBI:16765
type: UnificationXref
id: CHEBI:16765
db: ChEBI

RIGHT 0 conversion R02909 M f5hoxkyn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_f5hoxkyn_c
stoichiometric coefficient: 1.0

M_Xanth
type: SmallMolecule
xref: CHEBI:10072

M_H2O
type: SmallMolecule
xref: CHEBI:15377

TPH1
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R01814 Tph1 M trp DASH L c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R01814 Tph1 M dhbpt c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R01814 Tph1 M thbpt STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R01814 Tph1 M h2o c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R01814 Tph1 M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R01814 Tph1 M 5htrp c STOICHIOMETRY
xref: R01814
xref: http://identifiers.org/pubmed/15663479
xref: http://identifiers.org/ncbigene/7166
xref: http://identifiers.org/pubmed/19816759
xref: http://identifiers.org/ec-code/1.14.16.4
right: M_h2o_c
right: M_5htrp_c
right: M_dhbpt_c
left: M_trp_DASH_L_c
left: M_thbpt
left: M_o2_c

CHEBI:16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

M_CO2
type: SmallMolecule
xref: CHEBI:16526

LEFT 0 conversion R01814 Tph1 M thbpt STOICHIOMETRY
type: Stoichiometry
physical entity: M_thbpt
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/4135014
type: UnificationXref
id: 4135014
db: PubMed

http://identifiers.org/ncbigene/8942
type: UnificationXref
id: 8942
db: NCBI Gene

M_glu_DASH_L_c
type: PhysicalEntity
member physical entity: M_LGlu
cellular location: Cytosol

LEFT 1 conversion R04911 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

TPH2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R01814 Tph2 M trp DASH L c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R01814 Tph2 M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R01814 Tph2 M dhbpt c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R01814 Tph2 M 5htrp c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R01814 Tph2 M h2o c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R01814 Tph2 M thbpt STOICHIOMETRY
xref: R01814
xref: http://identifiers.org/pubmed/15663479
xref: http://identifiers.org/pubmed/19816759
xref: http://identifiers.org/ncbigene/121278
xref: http://identifiers.org/ec-code/1.14.16.4
right: M_dhbpt_c
right: M_5htrp_c
right: M_h2o_c
left: M_thbpt
left: M_trp_DASH_L_c
left: M_o2_c

CHEBI:29985
type: UnificationXref
id: CHEBI:29985
db: ChEBI

R02911
type: UnificationXref
id: R02911
db: KEGG Reaction

M_Kyna
type: SmallMolecule
xref: CHEBI:18344

http://identifiers.org/ncbigene/15
type: UnificationXref
id: 15
db: NCBI Gene

R02910
type: UnificationXref
id: R02910
db: KEGG Reaction

http://identifiers.org/ec-code/6.1.1.2
type: UnificationXref
id: 6.1.1.2
db: Enzyme Nomenclature

CHEBI:16675
type: UnificationXref
id: CHEBI:16675
db: ChEBI

http://identifiers.org/ec-code/4.1.1.45
type: UnificationXref
id: 4.1.1.45
db: Enzyme Nomenclature

M_glu_DASH_L_c
type: PhysicalEntity
member physical entity: M_LGlu
cellular location: Cytosol

M_H2O2
type: SmallMolecule
xref: CHEBI:16240

IDO_Serotonin
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R02909 M o2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02909 M srtn c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02909 M f5hoxkyn c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/3620
xref: http://identifiers.org/ec-code/1.13.11.52
xref: http://identifiers.org/pubmed/26687
xref: R02909
xref: http://identifiers.org/pubmed/19737010
right: M_f5hoxkyn_c
left: M_srtn_c
left: M_o2_c

RIGHT 0 conversion Lkynr trans Slc7a5 M Lkynr ex STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_ex
stoichiometric coefficient: 1.0

CHEBI:15346
type: UnificationXref
id: CHEBI:15346
db: ChEBI

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

RIGHT 1 conversion R04171 Kat2 M glu DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_glu_DASH_L_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R00988 M for c STOICHIOMETRY
type: Stoichiometry
physical entity: M_for_c
stoichiometric coefficient: 1.0

R02908
type: UnificationXref
id: R02908
db: KEGG Reaction

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

R02909
type: UnificationXref
id: R02909
db: KEGG Reaction

M_L_ALA
type: SmallMolecule
xref: CHEBI:16977

Quinolic Acid formation (spontaneous)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion quin form M cmusa c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion quin form M quln c STOICHIOMETRY
xref: http://identifiers.org/pubmed/15656614
right: M_quln_c
left: M_cmusa_c

http://identifiers.org/ncbigene/6999
type: UnificationXref
id: 6999
db: NCBI Gene

R00987
type: UnificationXref
id: R00987
db: KEGG Reaction

R01956
type: UnificationXref
id: R01956
db: KEGG Reaction

M_h2o2_c
type: PhysicalEntity
member physical entity: M_H2O2
cellular location: Cytosol

RIGHT 0 conversion Lkynr trans Slc7a8 M Lkynr ex STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_ex
stoichiometric coefficient: 1.0

R00988
type: UnificationXref
id: R00988
db: KEGG Reaction

M_glu_DASH_L_c
type: PhysicalEntity
member physical entity: M_LGlu
cellular location: Cytosol

R01959
type: UnificationXref
id: R01959
db: KEGG Reaction

M_srtn_c
type: PhysicalEntity
member physical entity: M_Serotonin
cellular location: Cytosol

http://identifiers.org/pubmed/15848762
type: UnificationXref
id: 15848762
db: PubMed

M_3HKyn
type: SmallMolecule
xref: CHEBI:36408

M_h2o2_c
type: PhysicalEntity
member physical entity: M_H2O2
cellular location: Cytosol

M_hLkynr_c
type: PhysicalEntity
member physical entity: M_3HKyn
cellular location: Cytosol

http://identifiers.org/pubmed/18620547
type: UnificationXref
id: 18620547
db: PubMed

M_trypta_c
type: PhysicalEntity
member physical entity: M_Trypta
cellular location: Cytosol

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

http://identifiers.org/pubmed/19143568
type: UnificationXref
id: 19143568
db: PubMed

M_for_c
type: PhysicalEntity
member physical entity: M_Formate
cellular location: Cytosol

RIGHT 0 conversion R02670 M Cinnavalininate c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Cinnavalininate_c
stoichiometric coefficient: 1.0

http://identifiers.org/ncbigene/23428
type: UnificationXref
id: 23428
db: NCBI Gene

CHEBI:28311
type: UnificationXref
id: CHEBI:28311
db: ChEBI

CHEBI:30754
type: UnificationXref
id: CHEBI:30754
db: ChEBI

R00678
type: UnificationXref
id: R00678
db: KEGG Reaction

LEFT 1 conversion R01956 Kat2 M akg c STOICHIOMETRY
type: Stoichiometry
physical entity: M_akg_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R03664 M ppi c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ppi_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/15663479
type: UnificationXref
id: 15663479
db: PubMed

M_nh4_c
type: PhysicalEntity
member physical entity: M_NH4
cellular location: Cytosol

M_id3acald_c
type: PhysicalEntity
member physical entity: M_IndolAc
cellular location: Cytosol

LEFT 2 conversion R02908 Maob M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

R04911
type: UnificationXref
id: R04911
db: KEGG Reaction

M_dnad_c
type: PhysicalEntity
member physical entity: M_NAAD
cellular location: Cytosol

R00677
type: UnificationXref
id: R00677
db: KEGG Reaction

M_nmtrpta_c
type: PhysicalEntity
member physical entity: M_MTrypta
cellular location: Cytosol

RIGHT 1 conversion R01814 Tph1 M dhbpt c STOICHIOMETRY
type: Stoichiometry
physical entity: M_dhbpt_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02911 M Nacsertn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Nacsertn_c
stoichiometric coefficient: 1.0

M_nicrnt_c
type: PhysicalEntity
member physical entity: M_NaMN
cellular location: Cytosol

M_thbpt
type: PhysicalEntity
member physical entity: M_Thbpt
cellular location: Cytosol

RIGHT 0 conversion R02173 Maob M id3acald c STOICHIOMETRY
type: Stoichiometry
physical entity: M_id3acald_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/17300176
type: UnificationXref
id: 17300176
db: PubMed

CHEBI:28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

M_Trp_tRNA
type: SmallMolecule
xref: CHEBI:29181

CHEBI:48294
type: UnificationXref
id: CHEBI:48294
db: ChEBI

M_5hoxindact_c
type: PhysicalEntity
member physical entity: M_5HAc
cellular location: Cytosol

LEFT 2 conversion R02173 Maob M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

M_Xanthurenate
type: PhysicalEntity
member physical entity: M_Xanth
cellular location: Cytosol

LEFT 1 conversion R00988 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R04323 M co2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_co2_c
stoichiometric coefficient: 1.0

M_glu_DASH_L_c
type: PhysicalEntity
member physical entity: M_LGlu
cellular location: Cytosol

M_CoA
type: SmallMolecule
xref: CHEBI:15346

M_nadp_c
type: PhysicalEntity
member physical entity: M_NADP
cellular location: Cytosol

RIGHT 2 conversion R02908 Maoa M nh4 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nh4_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R04171 Kat2 M kynate c STOICHIOMETRY
type: Stoichiometry
physical entity: M_kynate_c
stoichiometric coefficient: 1.0

M_ala_DASH_L_c
type: PhysicalEntity
member physical entity: M_L_ALA
cellular location: Cytosol

M_srtn_c
type: PhysicalEntity
member physical entity: M_Serotonin
cellular location: Cytosol

CHEBI:15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

R00685
type: UnificationXref
id: R00685
db: KEGG Reaction

CHEBI:16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_NADP
type: SmallMolecule
xref: CHEBI:18009

M_glu_DASH_L_c
type: PhysicalEntity
member physical entity: M_LGlu
cellular location: Cytosol

M_h_c
type: PhysicalEntity
member physical entity: M_H
cellular location: Cytosol

CHEBI:29750
type: UnificationXref
id: CHEBI:29750
db: ChEBI

RIGHT 1 conversion R04171 Kat3 M glu DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_glu_DASH_L_c
stoichiometric coefficient: 1.0

M_AA
type: SmallMolecule
xref: CHEBI:30754

LEFT 1 conversion R03936 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02701 M srtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_srtn_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02908 Maob M 5hoxindact c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5hoxindact_c
stoichiometric coefficient: 1.0

RIGHT 2 conversion R01814 Tph1 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

LEFT 1 conversion R02670 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 4.0

M_AMet
type: SmallMolecule
xref: CHEBI:15414

CHEBI:16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

M_Lfmkynr_c
type: PhysicalEntity
member physical entity: M_FKyn
cellular location: Cytosol

M_Lfmkynr_c
type: PhysicalEntity
member physical entity: M_FKyn
cellular location: Cytosol

LEFT 0 conversion R02174 metTrypta M amet c STOICHIOMETRY
type: Stoichiometry
physical entity: M_amet_c
stoichiometric coefficient: 1.0

M_Am6sa
type: SmallMolecule
xref: CHEBI:15745

LEFT 0 conversion R00987 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

CHEBI:3715
type: UnificationXref
id: CHEBI:3715
db: ChEBI

RIGHT 1 conversion R00987 M ala DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ala_DASH_L_c
stoichiometric coefficient: 1.0

R03936
type: UnificationXref
id: R03936
db: KEGG Reaction

LEFT 1 conversion R03005 M h c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h_c
stoichiometric coefficient: 1.0

M_h_c
type: PhysicalEntity
member physical entity: M_H
cellular location: Cytosol

M_3hanthrn_c
type: PhysicalEntity
member physical entity: M_3HAA
cellular location: Cytosol

MAOB_Serotonin
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R02908 Maob M h2o2 c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02908 Maob M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02908 Maob M 5hoxindact c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R02908 Maob M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R02908 Maob M nh4 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02908 Maob M srtn c STOICHIOMETRY
xref: http://identifiers.org/ec-code/1.4.3.4
xref: http://identifiers.org/pubmed/15848762
xref: R02908
xref: http://identifiers.org/ncbigene/4129
right: M_5hoxindact_c
right: M_nh4_c
right: M_h2o2_c
left: M_h2o_c
left: M_o2_c
left: M_srtn_c

LEFT 1 conversion R01959 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

CHEBI:15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

M_5HTrp
type: SmallMolecule
xref: CHEBI:28171

M_prpp_c
type: PhysicalEntity
member physical entity: M_PRPP
cellular location: Cytosol

LEFT 0 conversion R02174 M amet c STOICHIOMETRY
type: Stoichiometry
physical entity: M_amet_c
stoichiometric coefficient: 1.0

CHEBI:15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

M_hLkynr_c
type: PhysicalEntity
member physical entity: M_3HKyn
cellular location: Cytosol

M_for_c
type: PhysicalEntity
member physical entity: M_Formate
cellular location: Cytosol

MAOA_Serotonin
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R02908 Maoa M srtn c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R02908 Maoa M nh4 c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R02908 Maoa M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R02908 Maoa M h2o2 c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02908 Maoa M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02908 Maoa M 5hoxindact c STOICHIOMETRY
xref: http://identifiers.org/ec-code/1.4.3.4
xref: http://identifiers.org/pubmed/15848762
xref: R02908
xref: http://identifiers.org/ncbigene/4128
right: M_5hoxindact_c
right: M_h2o2_c
right: M_nh4_c
left: M_o2_c
left: M_h2o_c
left: M_srtn_c

LEFT 1 conversion R02911 M srtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_srtn_c
stoichiometric coefficient: 1.0

CHEBI:15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

M_tRNA
type: Rna
xref: CHEBI:17843

http://identifiers.org/pubmed/19737010
type: UnificationXref
id: 19737010
db: PubMed

C00268
type: UnificationXref
id: C00268
db: KEGG Compound

M_srtn_c
type: PhysicalEntity
member physical entity: M_Serotonin
cellular location: Cytosol

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

LEFT 1 conversion R01960 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R03936 M nformanth c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nformanth_c
stoichiometric coefficient: 1.0

M_LKyn_ex
type: SmallMolecule
xref: CHEBI:16946

LEFT 1 conversion R03664 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

LEFT 1 conversion R02908 Maob M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02173 Maoa M id3acald c STOICHIOMETRY
type: Stoichiometry
physical entity: M_id3acald_c
stoichiometric coefficient: 1.0

TRP_ex
type: PhysicalEntity
member physical entity: Trp_ex
cellular location: Cytosol

Stavrum2013 Tryptophan Metabolism in Liver
type: Pathway
pathway component: Tryptophan_Transport Slc7a5
pathway component: ACMSD
pathway component: Tryptophan_Transport Slc7a8
pathway component: HAAO
pathway component: KAT2_3HKyn
pathway component: DDC_Trypta
pathway component: KAT1_L-Kyn
pathway component: IDO_5HTrp
pathway component: KAT3_3HKyn
pathway component: KYNU_L-Kyn
pathway component: KYNU_3HKyn
pathway component: DDC_5HTrp
pathway component: AFMID_FAA
pathway component: AFMID_FKyn
pathway component: KYNU_FKyn
pathway component: IDO_Serotonin
pathway component: IDO
pathway component: Lkynr_Transporter_Slc7a5
pathway component: Quinolic Acid formation (spontaneous)
pathway component: Lkynr_Transporter_Slc7a8
pathway component: INMT_Trypta
pathway component: TDO
pathway component: INMT_MTrypta
pathway component: KAT2_L-Kyn
pathway component: KAT1_3HKyn
pathway component: Cinnavalinate formation
pathway component: KAT3_L-Kyn
pathway component: KMO
pathway component: QPRT
pathway component: MAOB_Serotonin
pathway component: WARS
pathway component: NMNAT1
pathway component: IL4I1
pathway component: AANAT_Serotonin
pathway component: AFMID_5HFKyn
pathway component: INMT_Serotonin
pathway component: MAOA_Trypta
pathway component: MAOA_Serotonin
pathway component: MAOB_Trypta
pathway component: TPH1
pathway component: AANAT_Trypta
pathway component: TPH2
xref: GO:0006587
xref: MODEL1310160000
xref: BIOMD0000000602
xref: http://identifiers.org/pubmed/24129579
xref: GO:0006568
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Stavrum2013___Tryptophan_Metabolism_in_Liver', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

M_nmsrtn_c
type: PhysicalEntity
member physical entity: M_NMSer
cellular location: Cytosol

LEFT 0 conversion R01814 Tph2 M thbpt STOICHIOMETRY
type: Stoichiometry
physical entity: M_thbpt
stoichiometric coefficient: 1.0

LEFT 0 conversion AANAT Trypta M accoa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_accoa_c
stoichiometric coefficient: 1.0

KYNU_FKyn
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R03936 M Lfmkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R03936 M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R03936 M nformanth c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R03936 M ala DASH L c STOICHIOMETRY
xref: R03936
xref: http://identifiers.org/pubmed/118164
xref: http://identifiers.org/ncbigene/8942
xref: http://identifiers.org/ec-code/3.7.1.3
right: M_ala_DASH_L_c
right: M_nformanth_c
left: M_Lfmkynr_c
left: M_h2o_c

CHEBI:16810
type: UnificationXref
id: CHEBI:16810
db: ChEBI

M_kynate_c
type: PhysicalEntity
member physical entity: M_Kyna
cellular location: Cytosol

http://identifiers.org/pubmed/15656614
type: UnificationXref
id: 15656614
db: PubMed

http://identifiers.org/ncbigene/23475
type: UnificationXref
id: 23475
db: NCBI Gene

LEFT 0 conversion R00678 Tdo M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

http://identifiers.org/ncbigene/125061
type: UnificationXref
id: 125061
db: NCBI Gene

RIGHT 0 conversion R01956 Kat1 M kynate c STOICHIOMETRY
type: Stoichiometry
physical entity: M_kynate_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R00678 Indo M Lfmkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lfmkynr_c
stoichiometric coefficient: 1.0

M_cmusa_c
type: PhysicalEntity
member physical entity: M_Acms
cellular location: Cytosol

http://identifiers.org/ncbigene/3620
type: UnificationXref
id: 3620
db: NCBI Gene

CHEBI:36408
type: UnificationXref
id: CHEBI:36408
db: ChEBI

M_nndmtrpta_c
type: PhysicalEntity
member physical entity: M_MMTrypta
cellular location: Cytosol

R02668
type: UnificationXref
id: R02668
db: KEGG Reaction

LEFT 0 conversion R02908 Maob M srtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_srtn_c
stoichiometric coefficient: 1.0

R02665
type: UnificationXref
id: R02665
db: KEGG Reaction

M_anth_c
type: PhysicalEntity
member physical entity: M_AA
cellular location: Cytosol

http://identifiers.org/pubmed/457635
type: UnificationXref
id: 457635
db: PubMed

M_nformanth_c
type: PhysicalEntity
member physical entity: M_FAA
cellular location: Cytosol

M_O2s
type: SmallMolecule
xref: CHEBI:18422

RIGHT 2 conversion R03348 M ppi c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ppi_c
stoichiometric coefficient: 1.0

M_NADPH
type: SmallMolecule
xref: CHEBI:16474

M_NH4
type: SmallMolecule
xref: CHEBI:28938

RIGHT 0 conversion R04911 M 5hxkyn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5hxkyn_c
stoichiometric coefficient: 1.0

LEFT 0 conversion R02173 Maoa M trypta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trypta_c
stoichiometric coefficient: 1.0

http://identifiers.org/ncbigene/56267
type: UnificationXref
id: 56267
db: NCBI Gene

M_accoa_c
type: PhysicalEntity
member physical entity: M_AcetylCoA
cellular location: Cytosol

http://identifiers.org/pubmed/24129579
type: PublicationXref
id: 24129579
db: PubMed

RIGHT 0 conversion R00987 M anth c STOICHIOMETRY
type: Stoichiometry
physical entity: M_anth_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/4190298
type: UnificationXref
id: 4190298
db: PubMed

http://identifiers.org/pubmed/2872885
type: UnificationXref
id: 2872885
db: PubMed

Tryptophan_Transport Slc7a5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion TRPtrans Slc7a5 TRP ex STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion TRPtrans Slc7a5 M trp DASH L c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/8140
xref: Q01650
xref: http://identifiers.org/pubmed/2872885
right: M_trp_DASH_L_c
left: TRP_ex

M_hLkynr_c
type: PhysicalEntity
member physical entity: M_3HKyn
cellular location: Cytosol

Tryptophan_Transport Slc7a8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion TRPtrans Slc7a8 TRP ex STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion TRPtrans Slc7a8 M trp DASH L c STOICHIOMETRY
xref: Q9UHI5
xref: http://identifiers.org/pubmed/2872885
xref: http://identifiers.org/ncbigene/23428
right: M_trp_DASH_L_c
left: TRP_ex

RIGHT 1 conversion R02701 M co2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_co2_c
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/1.13.11.6
type: UnificationXref
id: 1.13.11.6
db: Enzyme Nomenclature

DDC_Trypta
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R00685 M trypta c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R00685 M co2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R00685 M trp DASH L c STOICHIOMETRY
xref: http://identifiers.org/ec-code/4.1.1.28
xref: http://identifiers.org/pubmed/4991409
xref: R00685
xref: http://identifiers.org/ncbigene/1644
right: M_trypta_c
right: M_co2_c
left: M_trp_DASH_L_c

CHEBI:28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

RIGHT 1 conversion R01960 M nadp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nadp_c
stoichiometric coefficient: 1.0

M_id3acald_c
type: PhysicalEntity
member physical entity: M_IndolAc
cellular location: Cytosol

LEFT 1 conversion R00987 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

M_trypta_c
type: PhysicalEntity
member physical entity: M_Trypta
cellular location: Cytosol

CHEBI:15740
type: UnificationXref
id: CHEBI:15740
db: ChEBI

http://identifiers.org/ncbigene/23498
type: UnificationXref
id: 23498
db: NCBI Gene

CHEBI:15745
type: UnificationXref
id: CHEBI:15745
db: ChEBI

M_kynate_c
type: PhysicalEntity
member physical entity: M_Kyna
cellular location: Cytosol

M_F5HKyn
type: SmallMolecule
xref: CHEBI:28736

LEFT 1 conversion R01814 Tph1 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/2723766
type: UnificationXref
id: 2723766
db: PubMed

RIGHT 1 conversion R02668 M ala DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ala_DASH_L_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R02908 Maoa M h2o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o2_c
stoichiometric coefficient: 1.0

M_MMTrypta
type: SmallMolecule
xref: CHEBI:28969

IL4I1
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R00677 M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R00677 M indpyr c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R00677 M nh4 c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R00677 M o2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R00677 M trp DASH L c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R00677 M h2o2 c STOICHIOMETRY
xref: http://identifiers.org/pubmed/15383589
xref: http://identifiers.org/ec-code/1.4.3.2
xref: R00677
xref: http://identifiers.org/ncbigene/259307
right: M_indpyr_c
right: M_h2o2_c
right: M_nh4_c
left: M_trp_DASH_L_c
left: M_h2o_c
left: M_o2_c

M_Thbpt
type: SmallMolecule
xref: CHEBI:15372

AFMID_5HFKyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R04911 M 5hxkyn c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R04911 M for c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R04911 M 5hoxnfkyn c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R04911 M h2o c STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.5.1.9
xref: http://identifiers.org/ncbigene/125061
xref: http://identifiers.org/pubmed/4135014
xref: R04911
right: M_5hxkyn_c
right: M_for_c
left: M_5hoxnfkyn_c
left: M_h2o_c

M_accoa_c
type: PhysicalEntity
member physical entity: M_AcetylCoA
cellular location: Cytosol

M_akg_c
type: PhysicalEntity
member physical entity: M_Ketoglutarate
cellular location: Cytosol

CHEBI:16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

http://identifiers.org/ec-code/1.13.11.52
type: UnificationXref
id: 1.13.11.52
db: Enzyme Nomenclature

M_Cin
type: SmallMolecule
xref: CHEBI:3715

LEFT 1 conversion R00678 Indo M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/15477086
type: UnificationXref
id: 15477086
db: PubMed

LEFT 1 conversion R03348 M prpp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_prpp_c
stoichiometric coefficient: 1.0

M_nh4_c
type: PhysicalEntity
member physical entity: M_NH4
cellular location: Cytosol

http://identifiers.org/pubmed/118164
type: UnificationXref
id: 118164
db: PubMed

RIGHT 0 conversion R03664 M amp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_amp_c
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.3.1.87
type: UnificationXref
id: 2.3.1.87
db: Enzyme Nomenclature

LEFT 2 conversion R02173 Maoa M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

M_o2s_c
type: PhysicalEntity
member physical entity: M_O2s
cellular location: Cytosol

R03664
type: UnificationXref
id: R03664
db: KEGG Reaction

RIGHT 1 conversion R03005 M ppi c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ppi_c
stoichiometric coefficient: 1.0

CHEBI:36575
type: UnificationXref
id: CHEBI:36575
db: ChEBI

RIGHT 2 conversion R00677 M h2o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o2_c
stoichiometric coefficient: 1.0

LEFT 2 conversion R03348 M quln c STOICHIOMETRY
type: Stoichiometry
physical entity: M_quln_c
stoichiometric coefficient: 1.0

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

RIGHT 1 conversion R01956 Kat1 M glu DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_glu_DASH_L_c
stoichiometric coefficient: 1.0

KYNU_L-Kyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R00987 M anth c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R00987 M Lkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R00987 M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R00987 M ala DASH L c STOICHIOMETRY
xref: R00987
xref: http://identifiers.org/pubmed/17300176
xref: http://identifiers.org/pubmed/19143568
xref: http://identifiers.org/ncbigene/8942
xref: http://identifiers.org/ec-code/3.7.1.3
xref: http://identifiers.org/pubmed/457635
right: M_anth_c
right: M_ala_DASH_L_c
left: M_h2o_c
left: M_Lkynr_c

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

RIGHT 1 conversion R01956 Kat3 M glu DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_glu_DASH_L_c
stoichiometric coefficient: 1.0

AFMID_FAA
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R00988 M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R00988 M anth c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R00988 M for c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R00988 M nformanth c STOICHIOMETRY
xref: R00988
xref: http://identifiers.org/ec-code/3.5.1.9
xref: http://identifiers.org/ncbigene/125061
xref: http://identifiers.org/pubmed/4190298
right: M_for_c
right: M_anth_c
left: M_h2o_c
left: M_nformanth_c

AFMID_FKyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R01959 M for c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R01959 M Lfmkynr c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R01959 M Lkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R01959 M h2o c STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.5.1.9
xref: R01959
xref: http://identifiers.org/ncbigene/125061
xref: http://identifiers.org/pubmed/4190298
right: M_for_c
right: M_Lkynr_c
left: M_Lfmkynr_c
left: M_h2o_c

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

CHEBI:15763
type: UnificationXref
id: CHEBI:15763
db: ChEBI

LEFT 2 conversion R03664 M trna trp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trna_trp_c
stoichiometric coefficient: 1.0

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

CHEBI:16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

LEFT 0 conversion R03664 M atp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_atp_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R01956 Kat2 M glu DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_glu_DASH_L_c
stoichiometric coefficient: 1.0

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

http://identifiers.org/ncbigene/1644
type: UnificationXref
id: 1644
db: NCBI Gene

http://identifiers.org/ncbigene/64802
type: UnificationXref
id: 64802
db: NCBI Gene

RIGHT 1 conversion R04171 Kat1 M glu DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_glu_DASH_L_c
stoichiometric coefficient: 1.0

LEFT 0 conversion R03936 M Lfmkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lfmkynr_c
stoichiometric coefficient: 1.0

M_3hanthrn_c
type: PhysicalEntity
member physical entity: M_3HAA
cellular location: Cytosol

LEFT 2 conversion R02908 Maoa M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

M_O2
type: SmallMolecule
xref: CHEBI:15379

LEFT 0 conversion R00677 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

RIGHT 2 conversion R02908 Maob M nh4 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nh4_c
stoichiometric coefficient: 1.0

AANAT_Serotonin
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R02911 M accoa c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R02911 M h c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02911 M srtn c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02911 M Nacsertn c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R02911 M coa c STOICHIOMETRY
xref: R02911
xref: http://identifiers.org/ec-code/2.3.1.87
xref: http://identifiers.org/pubmed/15477086
xref: http://identifiers.org/ncbigene/15
right: M_h_c
right: M_coa_c
right: M_Nacsertn_c
left: M_srtn_c
left: M_accoa_c

CHEBI:10072
type: UnificationXref
id: CHEBI:10072
db: ChEBI

INMT_Serotonin
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R02910 M nmsrtn c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02910 M srtn c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02910 M amet c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02910 M ahcys c STOICHIOMETRY
xref: http://identifiers.org/pubmed/9852119
xref: http://identifiers.org/ncbigene/11185
xref: http://identifiers.org/ec-code/2.1.1.49
xref: R02910
right: M_ahcys_c
right: M_nmsrtn_c
left: M_srtn_c
left: M_amet_c

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

LEFT 1 conversion R02909 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

LEFT 0 conversion R02909 M srtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_srtn_c
stoichiometric coefficient: 1.0

LEFT 0 conversion R02670 M 3hanthrn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_3hanthrn_c
stoichiometric coefficient: 2.0

LEFT 1 conversion R02668 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

M_AcetylCoA
type: SmallMolecule
xref: CHEBI:15351

http://identifiers.org/pubmed/17402747
type: UnificationXref
id: 17402747
db: PubMed

RIGHT 2 conversion R02173 Maoa M h2o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o2_c
stoichiometric coefficient: 1.0

CHEBI:28736
type: UnificationXref
id: CHEBI:28736
db: ChEBI

http://identifiers.org/pubmed/26687
type: UnificationXref
id: 26687
db: PubMed

M_5htrp_c
type: PhysicalEntity
member physical entity: M_5HTrp
cellular location: Cytosol

LEFT 0 conversion R00988 M nformanth c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nformanth_c
stoichiometric coefficient: 1.0

M_h_c
type: PhysicalEntity
member physical entity: M_H
cellular location: Cytosol

IDO_5HTrp
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R02702 M 5hoxnfkyn c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02702 M o2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02702 M 5htrp c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/3620
xref: R02702
xref: http://identifiers.org/pubmed/26687
xref: http://identifiers.org/ec-code/1.13.11.52
xref: http://identifiers.org/pubmed/19737010
right: M_5hoxnfkyn_c
left: M_o2_c
left: M_5htrp_c

M_srtn_c
type: PhysicalEntity
member physical entity: M_Serotonin
cellular location: Cytosol

DDC_5HTrp
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R02701 M srtn c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R02701 M co2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02701 M 5htrp c STOICHIOMETRY
xref: http://identifiers.org/pubmed/18547057
xref: http://identifiers.org/ec-code/4.1.1.28
xref: R02701
xref: http://identifiers.org/ncbigene/1644
right: M_srtn_c
right: M_co2_c
left: M_5htrp_c

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

R02670
type: UnificationXref
id: R02670
db: KEGG Reaction

M_hLkynr_c
type: PhysicalEntity
member physical entity: M_3HKyn
cellular location: Cytosol

LEFT 1 conversion R02910 M srtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_srtn_c
stoichiometric coefficient: 1.0

CHEBI:17843
type: UnificationXref
id: CHEBI:17843
db: ChEBI

CHEBI:15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

RIGHT 3 conversion R02670 M h c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h_c
stoichiometric coefficient: 2.0

BioModels Database
type: Provenance
xref: BIOMD0000000602

RIGHT 2 conversion R03664 M trp L trna c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_L_trna_c
stoichiometric coefficient: 1.0

KAT2_L-Kyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R04171 Kat2 M kynate c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R04171 Kat2 M glu DASH L c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R04171 Kat2 M Lkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R04171 Kat2 M akg c STOICHIOMETRY
xref: R01956
xref: http://identifiers.org/pubmed/18620547
xref: http://identifiers.org/ncbigene/51166
xref: http://identifiers.org/ec-code/2.6.1.7
right: M_glu_DASH_L_c
right: M_kynate_c
left: M_Lkynr_c
left: M_akg_c

KAT1_3HKyn
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R04171 Kat1 M hLkynr c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R04171 Kat1 M glu DASH L c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R04171 Kat1 M Xanthurenate STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R04171 Kat1 M akg c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/883
xref: http://identifiers.org/pubmed/18620547
xref: R04171
xref: http://identifiers.org/ec-code/2.6.1.7
right: M_Xanthurenate
right: M_glu_DASH_L_c
left: M_hLkynr_c
left: M_akg_c

KAT3_L-Kyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R04171 Kat3 M glu DASH L c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R04171 Kat3 M kynate c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R04171 Kat3 M akg c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R04171 Kat3 M Lkynr c STOICHIOMETRY
xref: R01956
xref: http://identifiers.org/pubmed/18620547
xref: http://identifiers.org/ec-code/2.6.1.7
xref: http://identifiers.org/ncbigene/56267
right: M_kynate_c
right: M_glu_DASH_L_c
left: M_Lkynr_c
left: M_akg_c

KMO
type: BiochemicalReaction
participant stoichiometry: LEFT 3 conversion R01960 M h c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R01960 M nadph c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R01960 M Lkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R01960 M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R01960 M hLkynr c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R01960 M nadp c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R01960 M h2o c STOICHIOMETRY
xref: http://identifiers.org/pubmed/16973376
xref: http://identifiers.org/ncbigene/8564
xref: R01960
xref: http://identifiers.org/ec-code/1.14.13.9
right: M_h2o_c
right: M_nadp_c
right: M_hLkynr_c
left: M_o2_c
left: M_h_c
left: M_nadph_c
left: M_Lkynr_c

CHEBI:28969
type: UnificationXref
id: CHEBI:28969
db: ChEBI

LEFT 0 conversion R03348 M h c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h_c
stoichiometric coefficient: 1.0

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

BioModels Database
type: Provenance
xref: MODEL1310160000

RIGHT 1 conversion R02910 M nmsrtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nmsrtn_c
stoichiometric coefficient: 1.0

RIGHT 2 conversion R02670 M h2o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o2_c
stoichiometric coefficient: 2.0

CHEBI:15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

M_Lfmkynr_c
type: PhysicalEntity
member physical entity: M_FKyn
cellular location: Cytosol

http://identifiers.org/ec-code/1.13.11.11
type: UnificationXref
id: 1.13.11.11
db: Enzyme Nomenclature

LEFT 3 conversion R01960 M h c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h_c
stoichiometric coefficient: 1.0

LEFT 0 conversion R02908 Maoa M srtn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_srtn_c
stoichiometric coefficient: 1.0

M_3hanthrn_c
type: PhysicalEntity
member physical entity: M_3HAA
cellular location: Cytosol

LEFT 2 conversion R03005 M nicrnt c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nicrnt_c
stoichiometric coefficient: 1.0

M_NAAD
type: SmallMolecule
xref: CHEBI:18304

http://identifiers.org/ec-code/2.7.7.1
type: UnificationXref
id: 2.7.7.1
db: Enzyme Nomenclature

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

LEFT 0 conversion R02701 M 5htrp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5htrp_c
stoichiometric coefficient: 1.0

R03348
type: UnificationXref
id: R03348
db: KEGG Reaction

M_NMSer
type: SmallMolecule
xref: CHEBI:48294

http://identifiers.org/ncbigene/7166
type: UnificationXref
id: 7166
db: NCBI Gene

Q01650
type: UnificationXref
id: Q01650
db: UniProt Knowledgebase

http://identifiers.org/pubmed/17288562
type: UnificationXref
id: 17288562
db: PubMed

RIGHT 0 conversion R01814 Tph2 M 5htrp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5htrp_c
stoichiometric coefficient: 1.0

M_Nacsertn_c
type: PhysicalEntity
member physical entity: M_NAcSet
cellular location: Cytosol

CHEBI:55469
type: UnificationXref
id: CHEBI:55469
db: ChEBI

M_ala_DASH_L_c
type: PhysicalEntity
member physical entity: M_L_ALA
cellular location: Cytosol

Cinnavalinate formation
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion R02670 M h2o2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02670 M 3hanthrn c STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion R02670 M h c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02670 M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02670 M Cinnavalininate c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R02670 M o2s c STOICHIOMETRY
xref: http://identifiers.org/pubmed/2949752
xref: R02670
xref: http://identifiers.org/ec-code/1.11.1.6
right: M_h_c
right: M_h2o2_c
right: M_o2s_c
right: M_Cinnavalininate_c
left: M_3hanthrn_c
left: M_o2_c

LEFT 0 conversion R00678 Indo M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R04171 Kat3 M kynate c STOICHIOMETRY
type: Stoichiometry
physical entity: M_kynate_c
stoichiometric coefficient: 1.0

R04323
type: UnificationXref
id: R04323
db: KEGG Reaction

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_AHCys
type: SmallMolecule
xref: CHEBI:16680

M_co2_c
type: PhysicalEntity
member physical entity: M_CO2
cellular location: Cytosol

M_nformanth_c
type: PhysicalEntity
member physical entity: M_FAA
cellular location: Cytosol

RIGHT 0 conversion R01956 Kat2 M Xanthurenate STOICHIOMETRY
type: Stoichiometry
physical entity: M_Xanthurenate
stoichiometric coefficient: 1.0

LEFT 1 conversion R01814 Tph2 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

http://identifiers.org/ncbigene/8140
type: UnificationXref
id: 8140
db: NCBI Gene

http://identifiers.org/pubmed/18771288
type: UnificationXref
id: 18771288
db: PubMed

M_5htrp_c
type: PhysicalEntity
member physical entity: M_5HTrp
cellular location: Cytosol

RIGHT 0 conversion R04171 Kat1 M Xanthurenate STOICHIOMETRY
type: Stoichiometry
physical entity: M_Xanthurenate
stoichiometric coefficient: 1.0

M_am6sa_c
type: PhysicalEntity
member physical entity: M_Am6sa
cellular location: Cytosol

M_MTrypta
type: SmallMolecule
xref: CHEBI:28136

CHEBI:43120
type: UnificationXref
id: CHEBI:43120
db: ChEBI

RIGHT 0 conversion R03348 M co2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_co2_c
stoichiometric coefficient: 1.0

C00328
type: UnificationXref
id: C00328
db: KEGG Compound

http://identifiers.org/ncbigene/11185
type: UnificationXref
id: 11185
db: NCBI Gene

RIGHT 0 conversion R02665 M cmusa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_cmusa_c
stoichiometric coefficient: 1.0

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_trypta_c
type: PhysicalEntity
member physical entity: M_Trypta
cellular location: Cytosol

KAT2_3HKyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R01956 Kat2 M Xanthurenate STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R01956 Kat2 M akg c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R01956 Kat2 M hLkynr c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R01956 Kat2 M glu DASH L c STOICHIOMETRY
xref: http://identifiers.org/pubmed/18620547
xref: R04171
xref: http://identifiers.org/ncbigene/51166
xref: http://identifiers.org/ec-code/2.6.1.7
right: M_Xanthurenate
right: M_glu_DASH_L_c
left: M_hLkynr_c
left: M_akg_c

M_akg_c
type: PhysicalEntity
member physical entity: M_Ketoglutarate
cellular location: Cytosol

KAT1_L-Kyn
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R01956 Kat1 M Lkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R01956 Kat1 M akg c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R01956 Kat1 M kynate c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R01956 Kat1 M glu DASH L c STOICHIOMETRY
xref: R01956
xref: http://identifiers.org/ncbigene/883
xref: http://identifiers.org/pubmed/18620547
xref: http://identifiers.org/ec-code/2.6.1.7
right: M_kynate_c
right: M_glu_DASH_L_c
left: M_akg_c
left: M_Lkynr_c

KAT3_3HKyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R01956 Kat3 M glu DASH L c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R01956 Kat3 M hLkynr c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R01956 Kat3 M Xanthurenate STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R01956 Kat3 M akg c STOICHIOMETRY
xref: http://identifiers.org/pubmed/18620547
xref: R04171
xref: http://identifiers.org/ec-code/2.6.1.7
xref: http://identifiers.org/ncbigene/56267
right: M_Xanthurenate
right: M_glu_DASH_L_c
left: M_hLkynr_c
left: M_akg_c

http://identifiers.org/pubmed/2949752
type: UnificationXref
id: 2949752
db: PubMed

M_kynate_c
type: PhysicalEntity
member physical entity: M_Kyna
cellular location: Cytosol

M_NaMN
type: SmallMolecule
xref: CHEBI:15763

http://identifiers.org/pubmed/11754741
type: UnificationXref
id: 11754741
db: PubMed

M_h_c
type: PhysicalEntity
member physical entity: M_H
cellular location: Cytosol

CHEBI:29181
type: UnificationXref
id: CHEBI:29181
db: ChEBI

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

RIGHT 1 conversion R04911 M for c STOICHIOMETRY
type: Stoichiometry
physical entity: M_for_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02174 M ahcys c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ahcys_c
stoichiometric coefficient: 1.0

Lkynr_Transporter_Slc7a5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Lkynr trans Slc7a5 M Lkynr ex STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Lkynr trans Slc7a5 M Lkynr c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/8140
xref: http://identifiers.org/pubmed/2723766
xref: Q01650
xref: http://identifiers.org/pubmed/2872885
right: M_Lkynr_ex
left: M_Lkynr_c

RIGHT 2 conversion R01814 Tph2 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

Lkynr_Transporter_Slc7a8
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Lkynr trans Slc7a8 M Lkynr ex STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Lkynr trans Slc7a8 M Lkynr c STOICHIOMETRY
xref: http://identifiers.org/pubmed/2723766
xref: Q9UHI5
xref: http://identifiers.org/ncbigene/23428
xref: http://identifiers.org/pubmed/2872885
right: M_Lkynr_ex
left: M_Lkynr_c

M_Acms
type: SmallMolecule
xref: CHEBI:995

M_trypta_c
type: PhysicalEntity
member physical entity: M_Trypta
cellular location: Cytosol

RIGHT 0 conversion R00677 M indpyr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_indpyr_c
stoichiometric coefficient: 1.0

M_ppi_c
type: PhysicalEntity
member physical entity: M_PPi
cellular location: Cytosol

LEFT 0 conversion R04171 Kat2 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

WARS
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion R03664 M trp L trna c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R03664 M amp c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R03664 M ppi c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R03664 M trna trp c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R03664 M trp DASH L c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R03664 M atp c STOICHIOMETRY
xref: http://identifiers.org/ec-code/6.1.1.2
xref: http://identifiers.org/pubmed/11676605
xref: http://identifiers.org/ncbigene/7453
xref: R03664
right: M_trp_L_trna_c
right: M_amp_c
right: M_ppi_c
left: M_trna_trp_c
left: M_trp_DASH_L_c
left: M_atp_c

M_trypta_c
type: PhysicalEntity
member physical entity: M_Trypta
cellular location: Cytosol

http://identifiers.org/ec-code/3.7.1.3
type: UnificationXref
id: 3.7.1.3
db: Enzyme Nomenclature

http://identifiers.org/ncbigene/259307
type: UnificationXref
id: 259307
db: NCBI Gene

LEFT 0 conversion R02911 M accoa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_accoa_c
stoichiometric coefficient: 1.0

M_dhbpt_c
type: PhysicalEntity
member physical entity: M_Dhbpt
cellular location: Cytosol

M_Dhbpt
type: SmallMolecule
xref: C00268
xref: CHEBI:43120

http://identifiers.org/ncbigene/130013
type: UnificationXref
id: 130013
db: NCBI Gene

RIGHT 0 conversion R02668 M 3hanthrn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_3hanthrn_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion AANAT Trypta M Nactrypta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Nactrypta_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02174 metTrypta M ahcys c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ahcys_c
stoichiometric coefficient: 1.0

Trp_ex
type: SmallMolecule
xref: CHEBI:27897

LEFT 1 conversion AANAT Trypta M trypta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trypta_c
stoichiometric coefficient: 1.0

M_L-Kyn
type: SmallMolecule
xref: C00328
xref: CHEBI:16946

RIGHT 1 conversion R00988 M anth c STOICHIOMETRY
type: Stoichiometry
physical entity: M_anth_c
stoichiometric coefficient: 1.0

M_anth_c
type: PhysicalEntity
member physical entity: M_AA
cellular location: Cytosol

LEFT 0 conversion R03005 M atp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_atp_c
stoichiometric coefficient: 1.0

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

LEFT 1 conversion R04171 Kat1 M akg c STOICHIOMETRY
type: Stoichiometry
physical entity: M_akg_c
stoichiometric coefficient: 1.0

M_amet_c
type: PhysicalEntity
member physical entity: M_AMet
cellular location: Cytosol

M_nh4_c
type: PhysicalEntity
member physical entity: M_NH4
cellular location: Cytosol

LEFT 0 conversion R04171 Kat1 M hLkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_hLkynr_c
stoichiometric coefficient: 1.0

M_Xanthurenate
type: PhysicalEntity
member physical entity: M_Xanth
cellular location: Cytosol

M_Nactrypta_c
type: PhysicalEntity
member physical entity: M_Nactrypta
cellular location: Cytosol

M_srtn_c
type: PhysicalEntity
member physical entity: M_Serotonin
cellular location: Cytosol

R02173
type: UnificationXref
id: R02173
db: KEGG Reaction

IDO
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R00678 Indo M trp DASH L c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R00678 Indo M o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R00678 Indo M Lfmkynr c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/3620
xref: R00678
xref: http://identifiers.org/pubmed/26687
xref: http://identifiers.org/ec-code/1.13.11.52
xref: http://identifiers.org/pubmed/19737010
right: M_Lfmkynr_c
left: M_trp_DASH_L_c
left: M_o2_c

R02174
type: UnificationXref
id: R02174
db: KEGG Reaction

M_Quin
type: SmallMolecule
xref: CHEBI:16675

LEFT 0 conversion R04323 M cmusa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_cmusa_c
stoichiometric coefficient: 1.0

M_atp_c
type: PhysicalEntity
member physical entity: M_ATP
cellular location: Cytosol

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_ahcys_c
type: PhysicalEntity
member physical entity: M_AHCys
cellular location: Cytosol

http://identifiers.org/pubmed/4991409
type: UnificationXref
id: 4991409
db: PubMed

RIGHT 2 conversion R02173 Maob M h2o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o2_c
stoichiometric coefficient: 1.0

M_5HFKyn
type: SmallMolecule
xref: CHEBI:2065

M_IndolP
type: SmallMolecule
xref: CHEBI:29750

M_LGlu
type: SmallMolecule
xref: CHEBI:29985

LEFT 0 conversion TRPtrans Slc7a5 TRP ex STOICHIOMETRY
type: Stoichiometry
physical entity: TRP_ex
stoichiometric coefficient: 1.0

RIGHT 1 conversion AANAT Trypta M coa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_coa_c
stoichiometric coefficient: 1.0

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

LEFT 1 conversion R01956 Kat1 M akg c STOICHIOMETRY
type: Stoichiometry
physical entity: M_akg_c
stoichiometric coefficient: 1.0

M_co2_c
type: PhysicalEntity
member physical entity: M_CO2
cellular location: Cytosol

M_Trypta
type: SmallMolecule
xref: CHEBI:16765

M_amet_c
type: PhysicalEntity
member physical entity: M_AMet
cellular location: Cytosol

M_ppi_c
type: PhysicalEntity
member physical entity: M_PPi
cellular location: Cytosol

HAAO
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R02665 M 3hanthrn c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02665 M cmusa c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02665 M o2 c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/23498
xref: http://identifiers.org/ec-code/1.13.11.6
xref: http://identifiers.org/pubmed/12672479
xref: R02665
right: M_cmusa_c
left: M_o2_c
left: M_3hanthrn_c

http://identifiers.org/ec-code/1.4.3.4
type: UnificationXref
id: 1.4.3.4
db: Enzyme Nomenclature

R03005
type: UnificationXref
id: R03005
db: KEGG Reaction

http://identifiers.org/ec-code/1.4.3.2
type: UnificationXref
id: 1.4.3.2
db: Enzyme Nomenclature

LEFT 1 conversion R02665 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

M_for_c
type: PhysicalEntity
member physical entity: M_Formate
cellular location: Cytosol

KYNU_3HKyn
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R02668 M ala DASH L c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02668 M hLkynr c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02668 M 3hanthrn c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02668 M h2o c STOICHIOMETRY
xref: http://identifiers.org/pubmed/19143568
xref: http://identifiers.org/ncbigene/8942
xref: R02668
xref: http://identifiers.org/ec-code/3.7.1.3
right: M_3hanthrn_c
right: M_ala_DASH_L_c
left: M_hLkynr_c
left: M_h2o_c

M_AMP
type: SmallMolecule
xref: CHEBI:16027

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

LEFT 0 conversion R02668 M hLkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_hLkynr_c
stoichiometric coefficient: 1.0

M_Formate
type: SmallMolecule
xref: CHEBI:15740

http://identifiers.org/ec-code/2.1.1.49
type: UnificationXref
id: 2.1.1.49
db: Enzyme Nomenclature

M_PRPP
type: SmallMolecule
xref: CHEBI:17111

LEFT 0 conversion R01956 Kat2 M hLkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_hLkynr_c
stoichiometric coefficient: 1.0

CHEBI:2065
type: UnificationXref
id: CHEBI:2065
db: ChEBI

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

LEFT 2 conversion R01960 M nadph c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nadph_c
stoichiometric coefficient: 1.0

LEFT 2 conversion R01814 Tph2 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R02173 Maoa M nh4 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nh4_c
stoichiometric coefficient: 1.0

M_5HKyn
type: SmallMolecule
xref: CHEBI:36408

http://identifiers.org/pubmed/15383589
type: UnificationXref
id: 15383589
db: PubMed

RIGHT 0 conversion quin form M quln c STOICHIOMETRY
type: Stoichiometry
physical entity: M_quln_c
stoichiometric coefficient: 1.0

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

http://identifiers.org/ncbigene/8564
type: UnificationXref
id: 8564
db: NCBI Gene

M_FKyn
type: SmallMolecule
xref: CHEBI:18377

RIGHT 0 conversion R02702 M 5hoxnfkyn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5hoxnfkyn_c
stoichiometric coefficient: 1.0

LEFT 0 conversion TRPtrans Slc7a8 TRP ex STOICHIOMETRY
type: Stoichiometry
physical entity: TRP_ex
stoichiometric coefficient: 1.0

RIGHT 0 conversion R01956 Kat3 M Xanthurenate STOICHIOMETRY
type: Stoichiometry
physical entity: M_Xanthurenate
stoichiometric coefficient: 1.0

RIGHT 1 conversion R02174 metTrypta M nndmtrpta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nndmtrpta_c
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary

M_h2o2_c
type: PhysicalEntity
member physical entity: M_H2O2
cellular location: Cytosol

RIGHT 1 conversion R02670 M o2s c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2s_c
stoichiometric coefficient: 2.0

M_cmusa_c
type: PhysicalEntity
member physical entity: M_Acms
cellular location: Cytosol

LEFT 0 conversion R01959 M Lfmkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lfmkynr_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R00685 M co2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_co2_c
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.4.2.19
type: UnificationXref
id: 2.4.2.19
db: Enzyme Nomenclature

RIGHT 0 conversion R03005 M dnad c STOICHIOMETRY
type: Stoichiometry
physical entity: M_dnad_c
stoichiometric coefficient: 1.0

M_Nactrypta
type: SmallMolecule
xref: CHEBI:55469

M_nmtrpta_c
type: PhysicalEntity
member physical entity: M_MTrypta
cellular location: Cytosol

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_thbpt
type: PhysicalEntity
member physical entity: M_Thbpt
cellular location: Cytosol

LEFT 0 conversion R01960 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

LEFT 0 conversion quin form M cmusa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_cmusa_c
stoichiometric coefficient: 1.0

M_h_c
type: PhysicalEntity
member physical entity: M_H
cellular location: Cytosol

NMNAT1
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R03005 M h c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R03005 M nicrnt c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R03005 M dnad c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R03005 M atp c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R03005 M ppi c STOICHIOMETRY
xref: http://identifiers.org/ncbigene/64802
xref: http://identifiers.org/pubmed/17402747
xref: R03005
xref: http://identifiers.org/ec-code/2.7.7.1
right: M_ppi_c
right: M_dnad_c
left: M_nicrnt_c
left: M_h_c
left: M_atp_c

M_5hoxnfkyn_c
type: PhysicalEntity
member physical entity: M_5HFKyn
cellular location: Cytosol

RIGHT 1 conversion R02174 M nmtrpta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nmtrpta_c
stoichiometric coefficient: 1.0

CHEBI:16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

RIGHT 0 conversion R04323 M am6sa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_am6sa_c
stoichiometric coefficient: 1.0

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

CHEBI:18422
type: UnificationXref
id: CHEBI:18422
db: ChEBI

M_H
type: SmallMolecule
xref: CHEBI:29235

M_Xanthurenate
type: PhysicalEntity
member physical entity: M_Xanth
cellular location: Cytosol

RIGHT 1 conversion R00677 M nh4 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nh4_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R00685 M trypta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trypta_c
stoichiometric coefficient: 1.0

CHEBI:18304
type: UnificationXref
id: CHEBI:18304
db: ChEBI

M_akg_c
type: PhysicalEntity
member physical entity: M_Ketoglutarate
cellular location: Cytosol

http://identifiers.org/ncbigene/7453
type: UnificationXref
id: 7453
db: NCBI Gene

M_quln_c
type: PhysicalEntity
member physical entity: M_Quin
cellular location: Cytosol

RIGHT 0 conversion TRPtrans Slc7a8 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/1.11.1.6
type: UnificationXref
id: 1.11.1.6
db: Enzyme Nomenclature

M_Cinnavalininate_c
type: PhysicalEntity
member physical entity: M_Cin
cellular location: Cytosol

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_h_c
type: PhysicalEntity
member physical entity: M_H
cellular location: Cytosol

M_5HAc
type: SmallMolecule
xref: CHEBI:50157

CHEBI:28136
type: UnificationXref
id: CHEBI:28136
db: ChEBI

M_h2o2_c
type: PhysicalEntity
member physical entity: M_H2O2
cellular location: Cytosol

LEFT 0 conversion Lkynr trans Slc7a8 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

M_Lkynr_ex
type: PhysicalEntity
member physical entity: M_LKyn_ex
cellular location: Cytosol

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

M_Ketoglutarate
type: SmallMolecule
xref: CHEBI:16810

RIGHT 0 conversion R00678 Tdo M Lfmkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lfmkynr_c
stoichiometric coefficient: 1.0

http://identifiers.org/ncbigene/121278
type: UnificationXref
id: 121278
db: NCBI Gene

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_co2_c
type: PhysicalEntity
member physical entity: M_CO2
cellular location: Cytosol

RIGHT 0 conversion R01814 Tph1 M 5htrp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5htrp_c
stoichiometric coefficient: 1.0

M_trp_L_trna_c
type: PhysicalEntity
member physical entity: M_Trp_tRNA
cellular location: Cytosol

http://identifiers.org/ncbigene/51166
type: UnificationXref
id: 51166
db: NCBI Gene

http://identifiers.org/pubmed/19816759
type: UnificationXref
id: 19816759
db: PubMed

MODEL1310160000
type: UnificationXref
id: MODEL1310160000
db: BioModels Database

M_Lfmkynr_c
type: PhysicalEntity
member physical entity: M_FKyn
cellular location: Cytosol

http://identifiers.org/ec-code/1.14.13.9
type: UnificationXref
id: 1.14.13.9
db: Enzyme Nomenclature

LEFT 0 conversion R02702 M 5htrp c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5htrp_c
stoichiometric coefficient: 1.0

LEFT 0 conversion R04171 Kat3 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

M_nicrnt_c
type: PhysicalEntity
member physical entity: M_NaMN
cellular location: Cytosol

INMT_Trypta
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R02174 M amet c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02174 M ahcys c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02174 M trypta c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R02174 M nmtrpta c STOICHIOMETRY
xref: http://identifiers.org/pubmed/3949799
xref: http://identifiers.org/pubmed/9852119
xref: http://identifiers.org/ncbigene/11185
xref: http://identifiers.org/ec-code/2.1.1.49
xref: R02174
right: M_ahcys_c
right: M_nmtrpta_c
left: M_trypta_c
left: M_amet_c

TDO
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R00678 Tdo M trp DASH L c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R00678 Tdo M Lfmkynr c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R00678 Tdo M o2 c STOICHIOMETRY
xref: R00678
xref: http://identifiers.org/ec-code/1.13.11.11
xref: http://identifiers.org/pubmed/18370401
xref: http://identifiers.org/ncbigene/6999
right: M_Lfmkynr_c
left: M_o2_c
left: M_trp_DASH_L_c

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_FAA
type: SmallMolecule
xref: CHEBI:36575

CHEBI:50157
type: UnificationXref
id: CHEBI:50157
db: ChEBI

M_trna_trp_c
type: PhysicalEntity
member physical entity: M_tRNA
cellular location: Cytosol

http://identifiers.org/pubmed/17868694
type: UnificationXref
id: 17868694
db: PubMed

RIGHT 0 conversion R01960 M hLkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_hLkynr_c
stoichiometric coefficient: 1.0

RIGHT 2 conversion AANAT Trypta M h c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h_c
stoichiometric coefficient: 1.0

CHEBI:17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

M_h2o2_c
type: PhysicalEntity
member physical entity: M_H2O2
cellular location: Cytosol

RIGHT 1 conversion R03936 M ala DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ala_DASH_L_c
stoichiometric coefficient: 1.0

MAOA_Trypta
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R02173 Maoa M nh4 c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R02173 Maoa M o2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02173 Maoa M trypta c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02173 Maoa M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R02173 Maoa M h2o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02173 Maoa M id3acald c STOICHIOMETRY
xref: http://identifiers.org/pubmed/11754741
xref: R02173
xref: http://identifiers.org/ec-code/1.4.3.4
xref: http://identifiers.org/ncbigene/4128
right: M_nh4_c
right: M_id3acald_c
right: M_h2o2_c
left: M_trypta_c
left: M_h2o_c
left: M_o2_c

M_ppi_c
type: PhysicalEntity
member physical entity: M_PPi
cellular location: Cytosol

M_NAcSet
type: SmallMolecule
xref: CHEBI:28136

CHEBI:16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

http://identifiers.org/ec-code/3.5.1.9
type: UnificationXref
id: 3.5.1.9
db: Enzyme Nomenclature

LEFT 2 conversion R00677 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

MAOB_Trypta
type: BiochemicalReaction
participant stoichiometry: LEFT 2 conversion R02173 Maob M o2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02173 Maob M trypta c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02173 Maob M h2o c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02173 Maob M id3acald c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R02173 Maob M h2o2 c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R02173 Maob M nh4 c STOICHIOMETRY
xref: http://identifiers.org/pubmed/11754741
xref: R02173
xref: http://identifiers.org/ec-code/1.4.3.4
xref: http://identifiers.org/ncbigene/4129
right: M_nh4_c
right: M_h2o2_c
right: M_id3acald_c
left: M_trypta_c
left: M_o2_c
left: M_h2o_c

M_indpyr_c
type: PhysicalEntity
member physical entity: M_IndolP
cellular location: Cytosol

LEFT 0 conversion R04911 M 5hoxnfkyn c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5hoxnfkyn_c
stoichiometric coefficient: 1.0

LEFT 1 conversion R02173 Maob M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

RIGHT 0 conversion R02908 Maoa M 5hoxindact c STOICHIOMETRY
type: Stoichiometry
physical entity: M_5hoxindact_c
stoichiometric coefficient: 1.0

LEFT 1 conversion R04171 Kat2 M akg c STOICHIOMETRY
type: Stoichiometry
physical entity: M_akg_c
stoichiometric coefficient: 1.0

RIGHT 1 conversion R02173 Maob M nh4 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nh4_c
stoichiometric coefficient: 1.0

M_h2o2_c
type: PhysicalEntity
member physical entity: M_H2O2
cellular location: Cytosol

M_5hxkyn_c
type: PhysicalEntity
member physical entity: M_5HKyn
cellular location: Cytosol

M_akg_c
type: PhysicalEntity
member physical entity: M_Ketoglutarate
cellular location: Cytosol

LEFT 0 conversion R02910 M amet c STOICHIOMETRY
type: Stoichiometry
physical entity: M_amet_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion R02910 M ahcys c STOICHIOMETRY
type: Stoichiometry
physical entity: M_ahcys_c
stoichiometric coefficient: 1.0

LEFT 2 conversion R01814 Tph1 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

Q9UHI5
type: UnificationXref
id: Q9UHI5
db: UniProt Knowledgebase

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

RIGHT 1 conversion R01959 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

M_coa_c
type: PhysicalEntity
member physical entity: M_CoA
cellular location: Cytosol

M_co2_c
type: PhysicalEntity
member physical entity: M_CO2
cellular location: Cytosol

http://identifiers.org/ec-code/1.14.16.4
type: UnificationXref
id: 1.14.16.4
db: Enzyme Nomenclature

M_hLkynr_c
type: PhysicalEntity
member physical entity: M_3HKyn
cellular location: Cytosol

M_Trp
type: SmallMolecule
xref: CHEBI:27897

LEFT 1 conversion R01956 Kat3 M akg c STOICHIOMETRY
type: Stoichiometry
physical entity: M_akg_c
stoichiometric coefficient: 1.0

R01814
type: UnificationXref
id: R01814
db: KEGG Reaction

CHEBI:29235
type: UnificationXref
id: CHEBI:29235
db: ChEBI

CHEBI:995
type: UnificationXref
id: CHEBI:995
db: ChEBI

LEFT 0 conversion R02173 Maob M trypta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trypta_c
stoichiometric coefficient: 1.0

GO:0006587
type: UnificationXref
id: GO:0006587
db: Gene Ontology

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

LEFT 1 conversion R02174 M trypta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trypta_c
stoichiometric coefficient: 1.0

M_IndolAc
type: SmallMolecule
xref: CHEBI:28311

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

LEFT 1 conversion R02174 metTrypta M nmtrpta c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nmtrpta_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/11676605
type: UnificationXref
id: 11676605
db: PubMed

CHEBI:18344
type: UnificationXref
id: CHEBI:18344
db: ChEBI

M_Lkynr_c
type: PhysicalEntity
member physical entity: M_L-Kyn
cellular location: Cytosol

M_ala_DASH_L_c
type: PhysicalEntity
member physical entity: M_L_ALA
cellular location: Cytosol

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

http://identifiers.org/pubmed/12672479
type: UnificationXref
id: 12672479
db: PubMed

M_amet_c
type: PhysicalEntity
member physical entity: M_AMet
cellular location: Cytosol

ACMSD
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R04323 M am6sa c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R04323 M co2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R04323 M cmusa c STOICHIOMETRY
xref: http://identifiers.org/ec-code/4.1.1.45
xref: http://identifiers.org/ncbigene/130013
xref: R04323
xref: http://identifiers.org/pubmed/17288562
right: M_am6sa_c
right: M_co2_c
left: M_cmusa_c

RIGHT 0 conversion TRPtrans Slc7a5 M trp DASH L c STOICHIOMETRY
type: Stoichiometry
physical entity: M_trp_DASH_L_c
stoichiometric coefficient: 1.0

M_nh4_c
type: PhysicalEntity
member physical entity: M_NH4
cellular location: Cytosol

M_5htrp_c
type: PhysicalEntity
member physical entity: M_5HTrp
cellular location: Cytosol

M_f5hoxkyn_c
type: PhysicalEntity
member physical entity: M_F5HKyn
cellular location: Cytosol

M_Lkynr_ex
type: PhysicalEntity
member physical entity: M_LKyn_ex
cellular location: Cytosol

RIGHT 1 conversion R02911 M coa c STOICHIOMETRY
type: Stoichiometry
physical entity: M_coa_c
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/18370401
type: UnificationXref
id: 18370401
db: PubMed

CHEBI:18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

R04171
type: UnificationXref
id: R04171
db: KEGG Reaction

M_nh4_c
type: PhysicalEntity
member physical entity: M_NH4
cellular location: Cytosol

CHEBI:28171
type: UnificationXref
id: CHEBI:28171
db: ChEBI

BIOMD0000000602
type: UnificationXref
id: BIOMD0000000602
db: BioModels Database

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

RIGHT 1 conversion R03348 M nicrnt c STOICHIOMETRY
type: Stoichiometry
physical entity: M_nicrnt_c
stoichiometric coefficient: 1.0

LEFT 1 conversion R00678 Tdo M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

INMT_MTrypta
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R02174 metTrypta M nndmtrpta c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R02174 metTrypta M amet c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R02174 metTrypta M nmtrpta c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R02174 metTrypta M ahcys c STOICHIOMETRY
xref: http://identifiers.org/pubmed/9852119
xref: http://identifiers.org/ncbigene/11185
xref: http://identifiers.org/ec-code/2.1.1.49
right: M_ahcys_c
right: M_nndmtrpta_c
left: M_nmtrpta_c
left: M_amet_c

http://identifiers.org/pubmed/9852119
type: UnificationXref
id: 9852119
db: PubMed

LEFT 0 conversion R01956 Kat3 M hLkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_hLkynr_c
stoichiometric coefficient: 1.0

M_glu_DASH_L_c
type: PhysicalEntity
member physical entity: M_LGlu
cellular location: Cytosol

CHEBI:18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

LEFT 1 conversion R02702 M o2 c STOICHIOMETRY
type: Stoichiometry
physical entity: M_o2_c
stoichiometric coefficient: 1.0

M_nadph_c
type: PhysicalEntity
member physical entity: M_NADPH
cellular location: Cytosol

QPRT
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R03348 M co2 c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion R03348 M ppi c STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion R03348 M quln c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R03348 M h c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R03348 M nicrnt c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R03348 M prpp c STOICHIOMETRY
xref: http://identifiers.org/pubmed/17868694
xref: http://identifiers.org/ec-code/2.4.2.19
xref: http://identifiers.org/ncbigene/23475
xref: R03348
right: M_ppi_c
right: M_nicrnt_c
right: M_co2_c
left: M_h_c
left: M_quln_c
left: M_prpp_c

M_ahcys_c
type: PhysicalEntity
member physical entity: M_AHCys
cellular location: Cytosol

M_o2_c
type: PhysicalEntity
member physical entity: M_O2
cellular location: Cytosol

M_trp_DASH_L_c
type: PhysicalEntity
member physical entity: M_Trp
cellular location: Cytosol

RIGHT 1 conversion R01814 Tph2 M dhbpt c STOICHIOMETRY
type: Stoichiometry
physical entity: M_dhbpt_c
stoichiometric coefficient: 1.0

LEFT 1 conversion R04171 Kat3 M akg c STOICHIOMETRY
type: Stoichiometry
physical entity: M_akg_c
stoichiometric coefficient: 1.0

GO:0006568
type: UnificationXref
id: GO:0006568
db: Gene Ontology

RIGHT 2 conversion R01960 M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

M_akg_c
type: PhysicalEntity
member physical entity: M_Ketoglutarate
cellular location: Cytosol

http://identifiers.org/ncbigene/883
type: UnificationXref
id: 883
db: NCBI Gene

http://identifiers.org/pubmed/16973376
type: UnificationXref
id: 16973376
db: PubMed

http://identifiers.org/pubmed/3949799
type: UnificationXref
id: 3949799
db: PubMed

M_ahcys_c
type: PhysicalEntity
member physical entity: M_AHCys
cellular location: Cytosol

M_h2o_c
type: PhysicalEntity
member physical entity: M_H2O
cellular location: Cytosol

M_srtn_c
type: PhysicalEntity
member physical entity: M_Serotonin
cellular location: Cytosol

CHEBI:18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

LEFT 1 conversion R02173 Maoa M h2o c STOICHIOMETRY
type: Stoichiometry
physical entity: M_h2o_c
stoichiometric coefficient: 1.0

AANAT_Trypta
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AANAT Trypta M accoa c STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AANAT Trypta M trypta c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AANAT Trypta M coa c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AANAT Trypta M Nactrypta c STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AANAT Trypta M h c STOICHIOMETRY
xref: http://identifiers.org/pubmed/18771288
xref: http://identifiers.org/ec-code/2.3.1.87
xref: http://identifiers.org/pubmed/15477086
xref: http://identifiers.org/ncbigene/15
right: M_Nactrypta_c
right: M_coa_c
right: M_h_c
left: M_accoa_c
left: M_trypta_c

LEFT 0 conversion Lkynr trans Slc7a5 M Lkynr c STOICHIOMETRY
type: Stoichiometry
physical entity: M_Lkynr_c
stoichiometric coefficient: 1.0

http://identifiers.org/ncbigene/4128
type: UnificationXref
id: 4128
db: NCBI Gene

http://identifiers.org/ncbigene/4129
type: UnificationXref
id: 4129
db: NCBI Gene