RIGHT 0 conversion R7 GSH STOICHIOMETRY
type: Stoichiometry
physical entity: GSH
stoichiometric coefficient: 1.0

RIGHT 0 conversion R4 Protein adducts STOICHIOMETRY
type: Stoichiometry
physical entity: Protein_adducts
stoichiometric coefficient: 1.0

NAPQI
type: PhysicalEntity
member physical entity: NAPQI
cellular location: compartment

NAPQI
type: PhysicalEntity
member physical entity: NAPQI
cellular location: compartment

CHEBI:17980
type: UnificationXref
id: CHEBI:17980
db: ChEBI

LEFT 0 conversion R4 NAPQI STOICHIOMETRY
type: Stoichiometry
physical entity: NAPQI
stoichiometric coefficient: 1.0

LEFT 1 conversion R5 GSH STOICHIOMETRY
type: Stoichiometry
physical entity: GSH
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

RIGHT 0 conversion R10 Sulphate PAPS STOICHIOMETRY
type: Stoichiometry
physical entity: Sulphate__PAPS
stoichiometric coefficient: 1.0

LEFT 1 conversion R8 Sulphate PAPS STOICHIOMETRY
type: Stoichiometry
physical entity: Sulphate__PAPS
stoichiometric coefficient: 1.0

LEFT 0 conversion R9 Sulphate PAPS STOICHIOMETRY
type: Stoichiometry
physical entity: Sulphate__PAPS
stoichiometric coefficient: 1.0

compartment
type: CellularLocationVocabulary
xref: BTO:0000759

CHEBI:16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Paracetamol_APAP
type: PhysicalEntity

GSH
type: PhysicalEntity
member physical entity: GSH
cellular location: compartment

Paracetamol_APAP
type: PhysicalEntity
member physical entity: Paracetamol_APAP
cellular location: compartment

BTO:0000759
type: UnificationXref
id: BTO:0000759
db: Brenda Tissue Ontology

Sulphate__PAPS
type: PhysicalEntity
member physical entity: Sulphate_PAPS
cellular location: compartment

LEFT 0 conversion R6 GSH STOICHIOMETRY
type: Stoichiometry
physical entity: GSH
stoichiometric coefficient: 1.0

Sulphate_PAPS
type: SmallMolecule
xref: CHEBI:17980

R1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 1 NAPQI STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 1 Paracetamol APAP STOICHIOMETRY
right: NAPQI
left: Paracetamol_APAP

Paracetamol_APAP
type: PhysicalEntity
member physical entity: Paracetamol_APAP
cellular location: compartment

LEFT 0 conversion R2 NAPQI STOICHIOMETRY
type: Stoichiometry
physical entity: NAPQI
stoichiometric coefficient: 1.0

CHEBI:36080
type: UnificationXref
id: CHEBI:36080
db: ChEBI

NAPQI
type: PhysicalEntity
member physical entity: NAPQI
cellular location: compartment

Sulphate__PAPS
type: PhysicalEntity
member physical entity: Sulphate_PAPS
cellular location: compartment

RIGHT 0 conversion reaction 1 NAPQI STOICHIOMETRY
type: Stoichiometry
physical entity: NAPQI
stoichiometric coefficient: 1.0

NAPQI
type: Protein
xref: P15559

GSH
type: PhysicalEntity
member physical entity: GSH
cellular location: compartment

http://identifiers.org/pubmed/26966512
type: PublicationXref
id: 26966512
db: PubMed

Protein_adducts
type: PhysicalEntity
member physical entity: Protein_adducts
cellular location: compartment

LEFT 0 conversion R8 Paracetamol APAP STOICHIOMETRY
type: Stoichiometry
physical entity: Paracetamol_APAP
stoichiometric coefficient: 1.0

R10
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R10 Sulphate PAPS STOICHIOMETRY
right: Sulphate__PAPS

http://identifiers.org/pubmed/26348886
type: PublicationXref
id: 26348886
db: PubMed

GSH
type: PhysicalEntity
member physical entity: GSH
cellular location: compartment

Reddyhoff2015
type: Pathway
pathway component: R9
pathway component: R2
pathway component: R10
pathway component: R3
pathway component: R4
pathway component: R5
pathway component: R1
pathway component: R6
pathway component: R7
pathway component: R8
xref: BTO:0000759
xref: GO:1901554
xref: BIOMD0000000609
xref: http://identifiers.org/pubmed/26966512
xref: MODEL1603080000
xref: http://identifiers.org/pubmed/26348886
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Reddyhoff2015', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

CHEMBL112
type: UnificationXref
id: CHEMBL112

LEFT 0 conversion R3 Paracetamol APAP STOICHIOMETRY
type: Stoichiometry
physical entity: Paracetamol_APAP
stoichiometric coefficient: 1.0

BIOMD0000000609
type: UnificationXref
id: BIOMD0000000609
db: BioModels Database

Paracetamol_APAP
type: PhysicalEntity
member physical entity: Paracetamol_APAP
cellular location: compartment

LEFT 0 conversion reaction 1 Paracetamol APAP STOICHIOMETRY
type: Stoichiometry
physical entity: Paracetamol_APAP
stoichiometric coefficient: 1.0

GSH
type: SmallMolecule
xref: CHEBI:16856

Protein_adducts
type: Complex
xref: CHEMBL112
xref: CHEBI:36080

Sulphate__PAPS
type: PhysicalEntity
member physical entity: Sulphate_PAPS
cellular location: compartment

BioModels Database
type: Provenance
xref: BIOMD0000000609

P15559
type: UnificationXref
id: P15559
db: UniProt Knowledgebase

MODEL1603080000
type: UnificationXref
id: MODEL1603080000
db: BioModels Database

R2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R2 NAPQI STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R2 Paracetamol APAP STOICHIOMETRY
right: Paracetamol_APAP
left: NAPQI

R3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R3 Paracetamol APAP STOICHIOMETRY
left: Paracetamol_APAP

R4
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion R4 Protein adducts STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R4 NAPQI STOICHIOMETRY
right: Protein_adducts
spontaneous: true
left: NAPQI
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion R2 Paracetamol APAP STOICHIOMETRY
type: Stoichiometry
physical entity: Paracetamol_APAP
stoichiometric coefficient: 1.0

R5
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R5 GSH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R5 NAPQI STOICHIOMETRY
left: GSH
left: NAPQI

R6
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R6 GSH STOICHIOMETRY
left: GSH

R7
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R7 GSH STOICHIOMETRY
right: GSH

BioModels Database
type: Provenance
xref: MODEL1603080000

R8
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R8 Sulphate PAPS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R8 Paracetamol APAP STOICHIOMETRY
left: Sulphate__PAPS
left: Paracetamol_APAP

Paracetamol_APAP
type: PhysicalEntity
member physical entity: Paracetamol_APAP
cellular location: compartment

R9
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R9 Sulphate PAPS STOICHIOMETRY
left: Sulphate__PAPS

GO:1901554
type: UnificationXref
id: GO:1901554
db: Gene Ontology

LEFT 0 conversion R5 NAPQI STOICHIOMETRY
type: Stoichiometry
physical entity: NAPQI
stoichiometric coefficient: 1.0

NAPQI
type: PhysicalEntity
member physical entity: NAPQI
cellular location: compartment