RANKL_secretion_by_Ob_p
type: Transport
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ob p RANKL STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ob p Ob p STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ob p Ob p STOICHIOMETRY
right: RANKL
right: Ob_p
left: Ob_p

RIGHT 1 conversion Osteocyte activation LOAD STOICHIOMETRY
type: Stoichiometry
physical entity: LOAD
stoichiometric coefficient: 1.0

RANKL_secretion_by_Ob_m
type: Transport
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ob m Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ob m Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ob m RANKL STOICHIOMETRY
right: RANKL
right: Ob_m
left: Ob_m

O00300
type: UnificationXref
id: O00300
db: UniProt Knowledgebase

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

MODEL1602290000
type: Pathway
pathway component: Bcl2_synthesis
pathway component: RANKL_secretion_by_Ob_p
pathway component: RANKL_secretion_by_Ob_m
pathway component: RANKL_secretion_by_Ob_m_PTH_enhanced
pathway component: OPG_degradation
pathway component: Osteocyte_activation_by_PTH
pathway component: Wnt_activation
pathway component: Ocl_p_RANKL_release
pathway component: Ob_precursor_differentiation
pathway component: OPG_RANKL_degradation
pathway component: MSC_differentiation_to_Ob_pro
pathway component: Ob_maturation_to_Ocy
pathway component: Runx2_degradation_via_PTH
pathway component: Ob_m_PTH_apoptosis
pathway component: Sost_secretion
pathway component: Ocl_p_RANKL_binding
pathway component: Osteocyte_inactivation
pathway component: PTH_production
pathway component: Bone_degradation
pathway component: Ob_m_apoptosis
pathway component: Tgfb_degradation_by_PTH
pathway component: HSC_differentiation_to_Ocl_p
pathway component: RANKL_degradation
pathway component: CREB_inactivation
pathway component: Ob_m_PTH_release
pathway component: RANKL_secretion_by_MSCs
pathway component: Ob_p_PTH_release
pathway component: OPG_RANKL_dissociation
pathway component: CREB_activation
pathway component: Ocy_I_bound_by_PTH
pathway component: Inactivation_of_Wnt_by_Sost
pathway component: Osteoclast_precursor_differentiation
pathway component: RANKL_secretion_by_Ob_p_PTH
pathway component: MCSF_secretion_by_Ob_p
pathway component: Ocy_apoptosis
pathway component: MCSF_secretion_by_Ob_pro
pathway component: RANKL_secretion_by_Ocy_I
pathway component: Bcl2_degradation
pathway component: Tgfb_secretion_by_Obm
pathway component: Runx2_degradation
pathway component: RANKL_secretion_by_Ob_pro
pathway component: RANKL_inhibition
pathway component: Ob_m_bound_by_PTH
pathway component: Tgfb_activation
pathway component: MCSF_secretion_by_Ob_m
pathway component: Unloading
pathway component: CREB_Runx2_release
pathway component: MCSF_secretion_by_MSC
pathway component: MCSF_secretion_by_Ob_m_PTH
pathway component: Bax_Bcl2_binding
pathway component: Ocy_I_PTH_release
pathway component: OPG_secretion_by_Ob_p_PTH
pathway component: CREB_Runx2_binding
pathway component: RANKL_secretion_by_Ocy_A
pathway component: Tgfb_degradation
pathway component: Runx2_synthesis
pathway component: Ob_maturation_to_Ocy_by_Tgfb
pathway component: PTH_degradation
pathway component: Osteoblast_progenitor_differentiation_by_Tgfb
pathway component: Ocl_p_apoptosis
pathway component: Osteoclast_apoptosis
pathway component: Ob_p_binding_by_PTH
pathway component: MCSF_degradation
pathway component: Bone_formation_Obm_PTH
pathway component: Bax_Bcl2_release
pathway component: OPG_secretion_by_Ob_m
pathway component: MCSF_secretion_by_Ob_p_PTH
pathway component: OPG_secretion_by_Ob_p
pathway component: Sost_degradation
pathway component: Osteocyte_activation
pathway component: Ob_p_Tgfb_binding
pathway component: RANKL_secretion_by_Ob_p_Tgfb_A
pathway component: Xsynthesis
pathway component: Ob_p_Tgfb_release
pathway component: Bone_formation
pathway component: Wnt_activation_by_PTH
xref: http://identifiers.org/pubmed/27379013
xref: GO:0046849
xref: MODEL1602290000

osteoblast
type: CellularLocationVocabulary

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

Wnt_activation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Wnt activation Wnt A STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Wnt activation Wnt I STOICHIOMETRY
right: Wnt_A
left: Wnt_I

Ocl_p_RANKL_release
type: Transport
participant stoichiometry: LEFT 0 conversion Ocl p RANKL release Ocl p RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Ocl p RANKL release RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ocl p RANKL release Ocl p STOICHIOMETRY
right: Ocl_p
right: RANKL
left: Ocl_p_RANKL

Ob_pro
type: PhysicalEntity
member physical entity: Ob_pro
cellular location: bone

RIGHT 0 conversion Ob p Tgfb binding Ob p Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_Tgfb_A
stoichiometric coefficient: 1.0

CREB
type: PhysicalEntity
member physical entity: CREB
cellular location: osteoblast

P04628
type: UnificationXref
id: P04628
db: UniProt Knowledgebase

OPG
type: PhysicalEntity
member physical entity: OPG
cellular location: ecm

LEFT 1 conversion Tgfb degradation by PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

Ocy_I_PTH
type: PhysicalEntity
member physical entity: Ocy_I_PTH
cellular location: bone

Wnt_I
type: Protein
xref: P04628

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

LEFT 0 conversion OPG secretion by Ob p Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

RIGHT 2 conversion HSC differentiation to Ocl p Ocl p STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p
stoichiometric coefficient: 1.0

Wnt_A
type: Protein
xref: P04628
xref: PR:000000616

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

RIGHT 0 conversion Osteoclast precursor differentiation Ocl m STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_m
stoichiometric coefficient: 1.0

RIGHT 0 conversion CREB Runx2 release CREB P STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_P
stoichiometric coefficient: 1.0

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

P01137
type: UnificationXref
id: P01137
db: UniProt Knowledgebase

Tgfb_I
type: PhysicalEntity
member physical entity: Tgfb_I
cellular location: ecm

Ob_m_PTH_release
type: Transport
participant stoichiometry: RIGHT 1 conversion Ob m PTH release PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob m PTH release Ob m STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ob m PTH release Ob m PTH STOICHIOMETRY
right: Ob_m
right: PTH
left: Ob_m_PTH

RIGHT 0 conversion Bcl2 synthesis CREB Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_Runx2
stoichiometric coefficient: 1.0

Ob_p_PTH_release
type: Transport
participant stoichiometry: RIGHT 1 conversion Ob p PTH release PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ob p PTH release Ob p PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob p PTH release Ob p STOICHIOMETRY
right: PTH
right: Ob_p
left: Ob_p_PTH

RIGHT 0 conversion HSC differentiation to Ocl p HSC STOICHIOMETRY
type: Stoichiometry
physical entity: HSC
stoichiometric coefficient: 1.0

Ocl_p_RANKL
type: PhysicalEntity
member physical entity: Ocl_p_RANKL
cellular location: bone

LEFT 0 conversion Ob m PTH release Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

MSC
type: PhysicalEntity
member physical entity: MSC
cellular location: bone

OPG
type: PhysicalEntity
member physical entity: OPG
cellular location: ecm

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

RIGHT 0 conversion RANKL secretion by Ob m PTH enhanced Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

Wnt_A
type: PhysicalEntity
member physical entity: Wnt_A
cellular location: ecm

RIGHT 0 conversion Wnt activation Wnt A STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_A
stoichiometric coefficient: 1.0

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

Ob_m_PTH
type: Complex
xref: P01270
xref: CL:0001039

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

LEFT 0 conversion RANKL secretion by Ob p Tgfb A Ob p Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_Tgfb_A
stoichiometric coefficient: 1.0

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

X
type: PhysicalEntity

LEFT 0 conversion Runx2 degradation Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: Runx2
stoichiometric coefficient: 1.0

RIGHT 0 conversion MSC differentiation to Ob pro MSC STOICHIOMETRY
type: Stoichiometry
physical entity: MSC
stoichiometric coefficient: 1.0

RIGHT 0 conversion OPG degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Runx2_synthesis
type: Transport
participant stoichiometry: LEFT 0 conversion Runx2 synthesis Source STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Runx2 synthesis Runx2 STOICHIOMETRY
right: Runx2
left: Source

Osteoclast_apoptosis
type: Transport
participant stoichiometry: RIGHT 0 conversion Osteoclast apoptosis Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Osteoclast apoptosis Ocl m STOICHIOMETRY
right: Sink
left: Ocl_m

MCSF_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MCSF degradation MCSF STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MCSF degradation Sink STOICHIOMETRY
right: Sink
left: MCSF

LEFT 0 conversion PTH degradation PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

LEFT 1 conversion Osteoblast progenitor differentiation by Tgfb Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

Ocl_m
type: PhysicalEntity
member physical entity: Ocl_m
cellular location: bone

Ob_pro
type: PhysicalEntity
member physical entity: Ob_pro
cellular location: bone

LEFT 0 conversion Ob precursor differentiation Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

PR:000000616
type: UnificationXref
id: PR:000000616

Osteocyte_activation
type: Transport
participant stoichiometry: LEFT 0 conversion Osteocyte activation Ocy I STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Osteocyte activation Ocy A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Osteocyte activation LOAD STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Osteocyte activation LOAD STOICHIOMETRY
right: LOAD
right: Ocy_A
left: LOAD
left: Ocy_I

P01270
type: UnificationXref
id: P01270
db: UniProt Knowledgebase

Ocl_p
type: PhysicalEntity
member physical entity: Ocl_p
cellular location: bone

Bax_Bcl2
type: Complex
xref: Q07812
xref: P10415

RIGHT 0 conversion Ob m apoptosis Bax STOICHIOMETRY
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

LEFT 1 conversion Bax Bcl2 binding Bcl2 STOICHIOMETRY
type: Stoichiometry
physical entity: Bcl2
stoichiometric coefficient: 1.0

Osteocyte_activation_by_PTH
type: Transport
participant stoichiometry: LEFT 0 conversion Osteocyte activation by PTH Ocy I PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Osteocyte activation by PTH Ocy A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Osteocyte activation by PTH PTH STOICHIOMETRY
right: PTH
right: Ocy_A
left: Ocy_I_PTH

Ob_pro
type: PhysicalEntity
member physical entity: Ob_pro
cellular location: bone

Bax
type: PhysicalEntity
member physical entity: Bax
cellular location: osteoblast

RIGHT 0 conversion Ob m PTH apoptosis Bax STOICHIOMETRY
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

Ocl_p
type: PhysicalEntity
member physical entity: Ocl_p
cellular location: bone

LEFT 0 conversion Ob m PTH apoptosis Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

LEFT 0 conversion Tgfb secretion by Obm Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

CL:1001610
type: UnificationXref
id: CL:1001610

RIGHT 1 conversion OPG secretion by Ob p OPG STOICHIOMETRY
type: Stoichiometry
physical entity: OPG
stoichiometric coefficient: 1.0

HSC
type: PhysicalEntity
xref: CL:1001610

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

RIGHT 1 conversion CREB Runx2 release Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: Runx2
stoichiometric coefficient: 1.0

LEFT 1 conversion Ocy I bound by PTH PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion Tgfb degradation by PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

LEFT 0 conversion Ob p PTH release Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/27379013
type: PublicationXref
id: 27379013
db: PubMed

LEFT 1 conversion Ob m apoptosis Bax STOICHIOMETRY
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

Bax_Bcl2
type: PhysicalEntity
member physical entity: Bax_Bcl2
cellular location: osteoblast

RIGHT 1 conversion Sost secretion Sost STOICHIOMETRY
type: Stoichiometry
physical entity: Sost
stoichiometric coefficient: 1.0

LEFT 0 conversion Unloading LOAD STOICHIOMETRY
type: Stoichiometry
physical entity: LOAD
stoichiometric coefficient: 1.0

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

RIGHT 0 conversion OPG secretion by Ob p PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

Ocy_I_PTH
type: PhysicalEntity
member physical entity: Ocy_I_PTH
cellular location: bone

RIGHT 0 conversion Bone degradation Ocl m STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_m
stoichiometric coefficient: 1.0

OPG_RANKL
type: Complex
xref: O14788
xref: O00300

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

LEFT 0 conversion PTH production Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

MCSF_secretion_by_Ob_p
type: Transport
participant stoichiometry: RIGHT 0 conversion MCSF secretion by Ob p Ob p STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MCSF secretion by Ob p Ob p STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion MCSF secretion by Ob p MCSF STOICHIOMETRY
right: Ob_p
right: MCSF
left: Ob_p

LOAD
type: PhysicalEntity

RANKL_secretion_by_Ocy_I
type: Transport
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ocy I Ocy I STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ocy I Ocy I STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ocy I RANKL STOICHIOMETRY
right: Ocy_I
right: RANKL
left: Ocy_I

Bcl2_degradation
type: Transport
participant stoichiometry: RIGHT 0 conversion Bcl2 degradation Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Bcl2 degradation Bcl2 STOICHIOMETRY
right: Sink
left: Bcl2

Ocl_m
type: PhysicalEntity
member physical entity: Ocl_m
cellular location: bone

Ob_m_bound_by_PTH
type: Transport
participant stoichiometry: LEFT 0 conversion Ob m bound by PTH Ob m STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ob m bound by PTH PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob m bound by PTH Ob m PTH STOICHIOMETRY
right: Ob_m_PTH
left: PTH
left: Ob_m

LEFT 1 conversion Ob p binding by PTH PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

MCSF_secretion_by_Ob_m
type: Transport
participant stoichiometry: RIGHT 0 conversion MCSF secretion by Ob m Ob m STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MCSF secretion by Ob m Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion MCSF secretion by Ob m MCSF STOICHIOMETRY
right: MCSF
right: Ob_m
left: Ob_m

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

Bone
type: PhysicalEntity
member physical entity: Bone
cellular location: bone

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RIGHT 0 conversion OPG secretion by Ob p Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

Ocy_I_PTH_release
type: Transport
participant stoichiometry: RIGHT 1 conversion Ocy I PTH release PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ocy I PTH release Ocy I PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ocy I PTH release Ocy I STOICHIOMETRY
right: Ocy_I
right: PTH
left: Ocy_I_PTH

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RIGHT 2 conversion Bone formation Obm PTH newbone STOICHIOMETRY
type: Stoichiometry
physical entity: newbone
stoichiometric coefficient: 1.0

RANKL_secretion_by_Ocy_A
type: Transport
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ocy A Ocy A STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ocy A Ocy A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ocy A RANKL STOICHIOMETRY
right: Ocy_A
right: RANKL
left: Ocy_A

Ob_pro
type: PhysicalEntity
member physical entity: Ob_pro
cellular location: bone

Bone_formation_Obm_PTH
type: Transport
participant stoichiometry: RIGHT 0 conversion Bone formation Obm PTH Ob m PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Bone formation Obm PTH Ob m PTH STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion Bone formation Obm PTH newbone STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Bone formation Obm PTH Bone STOICHIOMETRY
right: Ob_m_PTH
right: newbone
right: Bone
left: Ob_m_PTH

CREB_P
type: Protein
xref: P16220
xref: PR:000037070

CREB_P
type: PhysicalEntity
member physical entity: CREB_P
cellular location: osteoblast

Bax_Bcl2_release
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion Bax Bcl2 release Bax Bcl2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Bax Bcl2 release Bcl2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Bax Bcl2 release Bax STOICHIOMETRY
right: Bax
right: Bcl2
spontaneous: true
left: Bax_Bcl2
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion Wnt activation by PTH Wnt A STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_A
stoichiometric coefficient: 1.0

LEFT 0 conversion Osteoclast precursor differentiation Ocl p RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p_RANKL
stoichiometric coefficient: 1.0

OPG_secretion_by_Ob_m
type: Transport
participant stoichiometry: RIGHT 0 conversion OPG secretion by Ob m Ob m STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion OPG secretion by Ob m Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion OPG secretion by Ob m OPG STOICHIOMETRY
right: Ob_m
right: OPG
left: Ob_m

MCSF_secretion_by_Ob_p_PTH
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MCSF secretion by Ob p PTH Ob p PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MCSF secretion by Ob p PTH Ob p PTH STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion MCSF secretion by Ob p PTH MCSF STOICHIOMETRY
right: MCSF
right: Ob_p_PTH
left: Ob_p_PTH

OPG_secretion_by_Ob_p
type: Transport
participant stoichiometry: RIGHT 1 conversion OPG secretion by Ob p OPG STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion OPG secretion by Ob p Ob p STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion OPG secretion by Ob p Ob p STOICHIOMETRY
right: OPG
right: Ob_p
left: Ob_p

RIGHT 2 conversion Bone formation newbone STOICHIOMETRY
type: Stoichiometry
physical entity: newbone
stoichiometric coefficient: 1.0

LEFT 1 conversion Ob m PTH apoptosis Bax STOICHIOMETRY
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

RIGHT 1 conversion MCSF secretion by Ob m PTH MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

Ocy_A
type: PhysicalEntity
member physical entity: Ocy_A
cellular location: bone

RIGHT 0 conversion Ob maturation to Ocy by Tgfb Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

LEFT 0 conversion MCSF secretion by Ob pro Ob pro STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_pro
stoichiometric coefficient: 1.0

MODEL1602290000
type: UnificationXref
id: MODEL1602290000
db: BioModels Database

PR:000037070
type: UnificationXref
id: PR:000037070

Ob_p_Tgfb_release
type: Transport
participant stoichiometry: RIGHT 0 conversion Ob p Tgfb release Ob p STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Ob p Tgfb release Tgfb A STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ob p Tgfb release Ob p Tgfb A STOICHIOMETRY
right: Ob_p
right: Tgfb_A
left: Ob_p_Tgfb_A

Bone
type: PhysicalEntity
member physical entity: Bone
cellular location: bone

Ob_p
type: PhysicalEntity
xref: CL:0007010

RANKL
type: Protein
xref: O14788

LEFT 0 conversion Tgfb degradation Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
xref: CL:0001039

RIGHT 0 conversion Ocy I bound by PTH Ocy I PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I_PTH
stoichiometric coefficient: 1.0

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

Runx2
type: PhysicalEntity
member physical entity: Runx2
cellular location: osteoblast

RIGHT 1 conversion Bax Bcl2 release Bcl2 STOICHIOMETRY
type: Stoichiometry
physical entity: Bcl2
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

OPG
type: PhysicalEntity
member physical entity: OPG
cellular location: ecm

RIGHT 1 conversion Ob m PTH release PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion RANKL secretion by Ocy A Ocy A STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_A
stoichiometric coefficient: 1.0

RIGHT 0 conversion RANKL secretion by Ob pro Ob pro STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_pro
stoichiometric coefficient: 1.0

Wnt_A
type: PhysicalEntity
member physical entity: Wnt_A
cellular location: ecm

LEFT 0 conversion OPG RANKL dissociation OPG RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: OPG_RANKL
stoichiometric coefficient: 1.0

Ob_p_Tgfb_A
type: PhysicalEntity
member physical entity: Ob_p_Tgfb_A
cellular location: bone

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

LEFT 0 conversion Wnt activation by PTH Wnt I STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_I
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

LEFT 1 conversion Inactivation of Wnt by Sost Sost STOICHIOMETRY
type: Stoichiometry
physical entity: Sost
stoichiometric coefficient: 1.0

RIGHT 0 conversion Ob p Tgfb release Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

RIGHT 0 conversion RANKL secretion by MSCs MSC STOICHIOMETRY
type: Stoichiometry
physical entity: MSC
stoichiometric coefficient: 1.0

MSC
type: PhysicalEntity
member physical entity: MSC
cellular location: bone

RIGHT 0 conversion Bone formation Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

PTH_production
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PTH production PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PTH production Source STOICHIOMETRY
right: PTH
left: Source

Ob_m_apoptosis
type: Transport
participant stoichiometry: LEFT 1 conversion Ob m apoptosis Bax STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob m apoptosis Bax STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ob m apoptosis Ob m STOICHIOMETRY
right: Bax
left: Ob_m
left: Bax

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

Runx2
type: PhysicalEntity
member physical entity: Runx2
cellular location: osteoblast

Ocy_I_PTH
type: PhysicalEntity
member physical entity: Ocy_I_PTH
cellular location: bone

GO:0046849
type: UnificationXref
id: GO:0046849
db: Gene Ontology

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

HSC_differentiation_to_Ocl_p
type: Transport
participant stoichiometry: RIGHT 1 conversion HSC differentiation to Ocl p MCSF STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion HSC differentiation to Ocl p MCSF STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion HSC differentiation to Ocl p Ocl p STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion HSC differentiation to Ocl p HSC STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion HSC differentiation to Ocl p HSC STOICHIOMETRY
right: Ocl_p
right: HSC
right: MCSF
left: MCSF
left: HSC

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

OPG_RANKL_dissociation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion OPG RANKL dissociation OPG RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion OPG RANKL dissociation OPG STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion OPG RANKL dissociation RANKL STOICHIOMETRY
right: OPG
right: RANKL
spontaneous: true
left: OPG_RANKL
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion Ob m bound by PTH PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

Ocy_I_bound_by_PTH
type: Transport
participant stoichiometry: LEFT 0 conversion Ocy I bound by PTH Ocy I STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ocy I bound by PTH Ocy I PTH STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ocy I bound by PTH PTH STOICHIOMETRY
right: Ocy_I_PTH
left: PTH
left: Ocy_I

LEFT 0 conversion CREB inactivation CREB P STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_P
stoichiometric coefficient: 1.0

RANKL_secretion_by_Ob_p_PTH
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ob p PTH RANKL STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ob p PTH Ob p PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ob p PTH Ob p PTH STOICHIOMETRY
right: RANKL
right: Ob_p_PTH
left: Ob_p_PTH

MSC
type: PhysicalEntity
member physical entity: MSC
cellular location: bone

LEFT 0 conversion Osteocyte inactivation Ocy A STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_A
stoichiometric coefficient: 1.0

LEFT 0 conversion Sost secretion Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

RIGHT 1 conversion OPG secretion by Ob m OPG STOICHIOMETRY
type: Stoichiometry
physical entity: OPG
stoichiometric coefficient: 1.0

LEFT 1 conversion Ob p Tgfb binding Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

RIGHT 1 conversion MCSF secretion by Ob p PTH MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

LEFT 0 conversion Wnt activation Wnt I STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_I
stoichiometric coefficient: 1.0

RIGHT 1 conversion Tgfb secretion by Obm Tgfb I STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_I
stoichiometric coefficient: 1.0

LEFT 0 conversion MCSF degradation MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

CREB
type: Protein
xref: P16220

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

LEFT 0 conversion Bax Bcl2 release Bax Bcl2 STOICHIOMETRY
type: Stoichiometry
physical entity: Bax_Bcl2
stoichiometric coefficient: 1.0

MCSF_secretion_by_MSC
type: Transport
participant stoichiometry: LEFT 0 conversion MCSF secretion by MSC MSC STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MCSF secretion by MSC MSC STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion MCSF secretion by MSC MCSF STOICHIOMETRY
right: MSC
right: MCSF
left: MSC

LEFT 1 conversion Wnt activation by PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

CL:0000778
type: UnificationXref
id: CL:0000778

RIGHT 1 conversion OPG secretion by Ob p PTH OPG STOICHIOMETRY
type: Stoichiometry
physical entity: OPG
stoichiometric coefficient: 1.0

CL:0000779
type: UnificationXref
id: CL:0000779

CREB_Runx2_binding
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion CREB Runx2 binding Runx2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion CREB Runx2 binding CREB Runx2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion CREB Runx2 binding CREB P STOICHIOMETRY
right: CREB_Runx2
spontaneous: true
left: CREB_P
left: Runx2
conversion direction: LEFT_TO_RIGHT

RIGHT 1 conversion MCSF secretion by MSC MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

LEFT 0 conversion MCSF secretion by Ob m PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

Tgfb_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Tgfb degradation Tgfb A STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Tgfb degradation Sink STOICHIOMETRY
right: Sink
left: Tgfb_A

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

LEFT 0 conversion Ocl p RANKL binding RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

RIGHT 1 conversion Ob p Tgfb release Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

LEFT 0 conversion RANKL secretion by Ob m Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

LEFT 1 conversion Osteocyte activation LOAD STOICHIOMETRY
type: Stoichiometry
physical entity: LOAD
stoichiometric coefficient: 1.0

RIGHT 0 conversion Bax Bcl2 release Bax STOICHIOMETRY
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

Sost_degradation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Sost degradation Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Sost degradation Sost STOICHIOMETRY
right: Sink
left: Sost

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

RIGHT 1 conversion Osteoblast progenitor differentiation by Tgfb Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

Bcl2
type: Protein
xref: P10415

CREB
type: PhysicalEntity
member physical entity: CREB
cellular location: osteoblast

Bcl2_synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Bcl2 synthesis CREB Runx2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Bcl2 synthesis Bcl2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Bcl2 synthesis CREB Runx2 STOICHIOMETRY
right: Bcl2
right: CREB_Runx2
left: CREB_Runx2

OPG_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion OPG degradation OPG STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion OPG degradation Sink STOICHIOMETRY
right: Sink
left: OPG

RIGHT 0 conversion MCSF secretion by Ob pro Ob pro STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_pro
stoichiometric coefficient: 1.0

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

Runx2_degradation_via_PTH
type: Transport
participant stoichiometry: RIGHT 0 conversion Runx2 degradation via PTH Ob m PTH STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Runx2 degradation via PTH Runx2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Runx2 degradation via PTH Ob m PTH STOICHIOMETRY
right: Ob_m_PTH
left: Runx2
left: Ob_m_PTH

Sost_secretion
type: Transport
participant stoichiometry: LEFT 0 conversion Sost secretion Ocy I STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Sost secretion Sost STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Sost secretion Ocy I STOICHIOMETRY
right: Ocy_I
right: Sost
left: Ocy_I

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

Wnt_I
type: PhysicalEntity
member physical entity: Wnt_I
cellular location: ecm

Bax
type: PhysicalEntity
member physical entity: Bax
cellular location: osteoblast

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

LEFT 0 conversion Bcl2 degradation Bcl2 STOICHIOMETRY
type: Stoichiometry
physical entity: Bcl2
stoichiometric coefficient: 1.0

LEFT 0 conversion MCSF secretion by Ob p Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

LEFT 0 conversion Osteoclast apoptosis Ocl m STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_m
stoichiometric coefficient: 1.0

Ocl_m
type: PhysicalEntity
member physical entity: Ocl_m
cellular location: bone

LEFT 0 conversion OPG RANKL degradation OPG RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: OPG_RANKL
stoichiometric coefficient: 1.0

LEFT 0 conversion RANKL inhibition OPG STOICHIOMETRY
type: Stoichiometry
physical entity: OPG
stoichiometric coefficient: 1.0

RIGHT 0 conversion Osteocyte activation by PTH Ocy A STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_A
stoichiometric coefficient: 1.0

LEFT 0 conversion Bone formation Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

LEFT 0 conversion Ocl p apoptosis Ocl p STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

LEFT 0 conversion RANKL secretion by Ob pro Ob pro STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_pro
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RANKL_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion RANKL degradation RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RANKL degradation Sink STOICHIOMETRY
right: Sink
left: RANKL

RIGHT 0 conversion MCSF secretion by Ob m Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

RANKL_secretion_by_MSCs
type: Transport
participant stoichiometry: RIGHT 1 conversion RANKL secretion by MSCs RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RANKL secretion by MSCs MSC STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by MSCs MSC STOICHIOMETRY
right: MSC
right: RANKL
left: MSC

CREB_activation
type: Transport
participant stoichiometry: LEFT 1 conversion CREB activation CREB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion CREB activation Ob m PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion CREB activation Ob m PTH STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion CREB activation CREB P STOICHIOMETRY
right: CREB_P
right: Ob_m_PTH
left: Ob_m_PTH
left: CREB

Inactivation_of_Wnt_by_Sost
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Inactivation of Wnt by Sost Wnt I STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Inactivation of Wnt by Sost Wnt A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Inactivation of Wnt by Sost Sost STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Inactivation of Wnt by Sost Sost STOICHIOMETRY
right: Wnt_I
right: Sost
left: Wnt_A
left: Sost

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

OPG
type: PhysicalEntity
member physical entity: OPG
cellular location: ecm

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

CL:0007010
type: UnificationXref
id: CL:0007010

LEFT 0 conversion RANKL degradation RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

MCSF_secretion_by_Ob_pro
type: Transport
participant stoichiometry: RIGHT 1 conversion MCSF secretion by Ob pro MCSF STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MCSF secretion by Ob pro Ob pro STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MCSF secretion by Ob pro Ob pro STOICHIOMETRY
right: MCSF
right: Ob_pro
left: Ob_pro

RIGHT 1 conversion RANKL secretion by Ob p Tgfb A RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

LEFT 0 conversion CREB Runx2 binding CREB P STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_P
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Ocl_p_RANKL
type: PhysicalEntity
member physical entity: Ocl_p_RANKL
cellular location: bone

X
type: PhysicalEntity
member physical entity: X
cellular location: ecm

Sost
type: PhysicalEntity
member physical entity: Sost
cellular location: ecm

Bax_Bcl2_binding
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion Bax Bcl2 binding Bax STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Bax Bcl2 binding Bcl2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Bax Bcl2 binding Bax Bcl2 STOICHIOMETRY
right: Bax_Bcl2
spontaneous: true
left: Bcl2
left: Bax
conversion direction: LEFT_TO_RIGHT

Bax
type: PhysicalEntity
member physical entity: Bax
cellular location: osteoblast

RIGHT 0 conversion Tgfb secretion by Obm Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

Q07812
type: UnificationXref
id: Q07812
db: UniProt Knowledgebase

LEFT 0 conversion RANKL secretion by Ocy I Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

BioModels Database
type: Provenance
xref: BIOMD0000000612

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

MSC
type: PhysicalEntity
member physical entity: MSC
cellular location: bone

Bcl2
type: PhysicalEntity
member physical entity: Bcl2
cellular location: osteoblast

Wnt_I
type: PhysicalEntity
member physical entity: Wnt_I
cellular location: ecm

Q9BQB4
type: UnificationXref
id: Q9BQB4
db: UniProt Knowledgebase

LEFT 0 conversion Ob m apoptosis Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

RIGHT 1 conversion RANKL secretion by Ob m PTH enhanced RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

BioModels Database
type: Provenance
xref: MODEL1602290000

Ocy_A
type: PhysicalEntity
member physical entity: Ocy_A
cellular location: bone

RIGHT 0 conversion PTH degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Bcl2
type: PhysicalEntity
member physical entity: Bcl2
cellular location: osteoblast

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

Ob_p_Tgfb_A
type: PhysicalEntity
member physical entity: Ob_p_Tgfb_A
cellular location: bone

OPG
type: PhysicalEntity
member physical entity: OPG
cellular location: ecm

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

Sost
type: Protein
xref: Q9BQB4

RIGHT 1 conversion Bcl2 synthesis Bcl2 STOICHIOMETRY
type: Stoichiometry
physical entity: Bcl2
stoichiometric coefficient: 1.0

Wnt_activation_by_PTH
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion Wnt activation by PTH Ob m PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Wnt activation by PTH Wnt I STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Wnt activation by PTH Wnt A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Wnt activation by PTH Ob m PTH STOICHIOMETRY
right: Ob_m_PTH
right: Wnt_A
left: Ob_m_PTH
left: Wnt_I

LEFT 0 conversion HSC differentiation to Ocl p HSC STOICHIOMETRY
type: Stoichiometry
physical entity: HSC
stoichiometric coefficient: 1.0

Ob_pro
type: PhysicalEntity
xref: CL:0001040

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

LEFT 0 conversion RANKL secretion by Ob p Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

RIGHT 0 conversion PTH production PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

RIGHT 0 conversion Unloading Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

OPG_RANKL_degradation
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion OPG RANKL degradation Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion OPG RANKL degradation OPG RANKL STOICHIOMETRY
right: Sink
spontaneous: true
left: OPG_RANKL
conversion direction: RIGHT_TO_LEFT

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

RIGHT 0 conversion Ocl p RANKL binding Ocl p RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p_RANKL
stoichiometric coefficient: 1.0

Ob_maturation_to_Ocy
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Ob maturation to Ocy Ocy I STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ob maturation to Ocy Ob m STOICHIOMETRY
right: Ocy_I
left: Ob_m

Wnt_A
type: PhysicalEntity
member physical entity: Wnt_A
cellular location: ecm

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

Ocl_p_RANKL_binding
type: Transport
participant stoichiometry: LEFT 0 conversion Ocl p RANKL binding RANKL STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ocl p RANKL binding Ocl p STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ocl p RANKL binding Ocl p RANKL STOICHIOMETRY
right: Ocl_p_RANKL
left: RANKL
left: Ocl_p

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

RIGHT 1 conversion CREB activation CREB P STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_P
stoichiometric coefficient: 1.0

LEFT 0 conversion MCSF secretion by Ob m Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

RIGHT 0 conversion CREB inactivation CREB STOICHIOMETRY
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

RIGHT 1 conversion Ocl p RANKL release RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

Osteocyte_inactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Osteocyte inactivation Ocy A STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Osteocyte inactivation Ocy I STOICHIOMETRY
right: Ocy_I
left: Ocy_A

Bax_Bcl2
type: PhysicalEntity
member physical entity: Bax_Bcl2
cellular location: osteoblast

RIGHT 0 conversion Inactivation of Wnt by Sost Wnt I STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_I
stoichiometric coefficient: 1.0

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

RIGHT 0 conversion Ob m PTH release Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

Ob_pro
type: PhysicalEntity
member physical entity: Ob_pro
cellular location: bone

Ocl_m
type: PhysicalEntity
member physical entity: Ocl_m
cellular location: bone

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

LEFT 0 conversion OPG secretion by Ob p PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

RIGHT 1 conversion RANKL secretion by Ocy I RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

RIGHT 0 conversion RANKL secretion by Ob p Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

Ocl_p
type: PhysicalEntity
member physical entity: Ocl_p
cellular location: bone

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

CREB_P
type: PhysicalEntity
member physical entity: CREB_P
cellular location: osteoblast

RIGHT 0 conversion Osteoblast progenitor differentiation by Tgfb Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

RIGHT 0 conversion Runx2 degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Ob_p_PTH
type: Complex
xref: CL:0007010
xref: P01270

Ocl_p_RANKL
type: PhysicalEntity
member physical entity: Ocl_p_RANKL
cellular location: bone

RIGHT 1 conversion RANKL secretion by MSCs RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

CREB_P
type: PhysicalEntity
member physical entity: CREB_P
cellular location: osteoblast

Ocl_p
type: PhysicalEntity
member physical entity: Ocl_p
cellular location: bone

Ocy_I_PTH
type: Complex
xref: P01270
xref: CL:0000137

Bone
type: PhysicalEntity
member physical entity: Bone
cellular location: bone

Wnt_A
type: PhysicalEntity
member physical entity: Wnt_A
cellular location: ecm

MCSF
type: Protein
xref: P09603

RIGHT 0 conversion Ob m bound by PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RIGHT 0 conversion Runx2 synthesis Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: Runx2
stoichiometric coefficient: 1.0

LOAD
type: PhysicalEntity
member physical entity: LOAD
cellular location: ecm

CL:0000134
type: UnificationXref
id: CL:0000134

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

RIGHT 1 conversion Inactivation of Wnt by Sost Sost STOICHIOMETRY
type: Stoichiometry
physical entity: Sost
stoichiometric coefficient: 1.0

CL:0000137
type: UnificationXref
id: CL:0000137

Ocl_m
type: PhysicalEntity
xref: CL:0000779

Ocl_p_apoptosis
type: Transport
participant stoichiometry: RIGHT 0 conversion Ocl p apoptosis Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ocl p apoptosis Ocl p STOICHIOMETRY
right: Sink
left: Ocl_p

RIGHT 0 conversion OPG RANKL degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

newbone
type: PhysicalEntity

LEFT 0 conversion CREB activation Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

RIGHT 1 conversion Osteocyte activation by PTH PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

Ocl_p
type: PhysicalEntity
xref: CL:0000778

RIGHT 0 conversion OPG secretion by Ob m Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

BTO:0000140
type: UnificationXref
id: BTO:0000140
db: Brenda Tissue Ontology

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

Bcl2
type: PhysicalEntity
member physical entity: Bcl2
cellular location: osteoblast

LEFT 0 conversion RANKL secretion by Ob m PTH enhanced Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

P10415
type: UnificationXref
id: P10415
db: UniProt Knowledgebase

OPG
type: Protein
xref: O00300

RANKL_secretion_by_Ob_m_PTH_enhanced
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ob m PTH enhanced Ob m PTH STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ob m PTH enhanced RANKL STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ob m PTH enhanced Ob m PTH STOICHIOMETRY
right: Ob_m_PTH
right: RANKL
left: Ob_m_PTH

P09603
type: UnificationXref
id: P09603
db: UniProt Knowledgebase

Ob_precursor_differentiation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Ob precursor differentiation Ob p STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob precursor differentiation Ob m STOICHIOMETRY
right: Ob_m
left: Ob_p

Ob_p_Tgfb_A
type: PhysicalEntity
member physical entity: Ob_p_Tgfb_A
cellular location: bone

RIGHT 1 conversion RANKL secretion by Ob p PTH RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

LEFT 0 conversion Tgfb activation Tgfb I STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_I
stoichiometric coefficient: 1.0

LEFT 0 conversion Ob p Tgfb binding Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

RIGHT 1 conversion RANKL secretion by Ob p RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

Sink
type: PhysicalEntity

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

CREB_Runx2
type: PhysicalEntity
member physical entity: CREB_Runx2
cellular location: osteoblast

LEFT 0 conversion RANKL secretion by MSCs MSC STOICHIOMETRY
type: Stoichiometry
physical entity: MSC
stoichiometric coefficient: 1.0

Runx2
type: PhysicalEntity
member physical entity: Runx2
cellular location: osteoblast

RIGHT 1 conversion Tgfb activation Ocl m STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_m
stoichiometric coefficient: 1.0

RIGHT 0 conversion Xsynthesis X STOICHIOMETRY
type: Stoichiometry
physical entity: X
stoichiometric coefficient: 1.0

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

RIGHT 1 conversion Bone formation Obm PTH Bone STOICHIOMETRY
type: Stoichiometry
physical entity: Bone
stoichiometric coefficient: 1.0

RIGHT 0 conversion Ocy apoptosis Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

RIGHT 1 conversion RANKL secretion by Ocy A RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

LEFT 0 conversion OPG secretion by Ob m Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

LEFT 1 conversion CREB Runx2 binding Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: Runx2
stoichiometric coefficient: 1.0

Sost
type: PhysicalEntity
member physical entity: Sost
cellular location: ecm

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

RIGHT 0 conversion CREB Runx2 binding CREB Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_Runx2
stoichiometric coefficient: 1.0

LEFT 0 conversion Runx2 synthesis Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

LEFT 0 conversion Inactivation of Wnt by Sost Wnt A STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_A
stoichiometric coefficient: 1.0

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

HSC
type: PhysicalEntity
member physical entity: HSC
cellular location: bone

RIGHT 1 conversion MCSF secretion by Ob p MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RIGHT 0 conversion Ocl p RANKL release Ocl p STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p
stoichiometric coefficient: 1.0

CREB_inactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion CREB inactivation CREB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion CREB inactivation CREB P STOICHIOMETRY
right: CREB
left: CREB_P

RIGHT 0 conversion Ob precursor differentiation Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

CREB_Runx2
type: Complex
xref: Q13950
xref: P16220

Bax
type: PhysicalEntity
member physical entity: Bax
cellular location: osteoblast

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

LEFT 0 conversion Tgfb degradation by PTH Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

Runx2
type: PhysicalEntity
member physical entity: Runx2
cellular location: osteoblast

CREB_Runx2
type: PhysicalEntity
member physical entity: CREB_Runx2
cellular location: osteoblast

Osteoclast_precursor_differentiation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion Osteoclast precursor differentiation Ocl p RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Osteoclast precursor differentiation Ocl m STOICHIOMETRY
right: Ocl_m
spontaneous: true
left: Ocl_p_RANKL
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion Osteocyte activation Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

PTH
type: Protein
xref: P01270

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

MSC
type: PhysicalEntity
member physical entity: MSC
cellular location: bone

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

LOAD
type: PhysicalEntity
member physical entity: LOAD
cellular location: ecm

RANKL_inhibition
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion RANKL inhibition RANKL STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RANKL inhibition OPG RANKL STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL inhibition OPG STOICHIOMETRY
right: OPG_RANKL
spontaneous: true
left: RANKL
left: OPG
conversion direction: LEFT_TO_RIGHT

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

LEFT 1 conversion Tgfb activation Ocl m STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_m
stoichiometric coefficient: 1.0

RIGHT 1 conversion MCSF secretion by Ob m MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

Tgfb_activation
type: Transport
participant stoichiometry: LEFT 0 conversion Tgfb activation Tgfb I STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Tgfb activation Tgfb A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Tgfb activation Ocl m STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Tgfb activation Ocl m STOICHIOMETRY
right: Tgfb_A
right: Ocl_m
left: Tgfb_I
left: Ocl_m

LEFT 1 conversion RANKL inhibition RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

CREB_Runx2
type: PhysicalEntity
member physical entity: CREB_Runx2
cellular location: osteoblast

LEFT 0 conversion Ocy I PTH release Ocy I PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I_PTH
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Tgfb_I
type: PhysicalEntity
member physical entity: Tgfb_I
cellular location: ecm

Ocy_A
type: PhysicalEntity
member physical entity: Ocy_A
cellular location: bone

OPG_secretion_by_Ob_p_PTH
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion OPG secretion by Ob p PTH OPG STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion OPG secretion by Ob p PTH Ob p PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion OPG secretion by Ob p PTH Ob p PTH STOICHIOMETRY
right: OPG
right: Ob_p_PTH
left: Ob_p_PTH

RIGHT 1 conversion MSC differentiation to Ob pro Wnt A STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_A
stoichiometric coefficient: 1.0

Runx2
type: Protein
xref: Q13950

LEFT 0 conversion MCSF secretion by MSC MSC STOICHIOMETRY
type: Stoichiometry
physical entity: MSC
stoichiometric coefficient: 1.0

PTH_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion PTH degradation PTH STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion PTH degradation Sink STOICHIOMETRY
right: Sink
left: PTH

RIGHT 0 conversion Runx2 degradation via PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

Osteoblast_progenitor_differentiation_by_Tgfb
type: Transport
participant stoichiometry: LEFT 0 conversion Osteoblast progenitor differentiation by Tgfb Ob pro STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Osteoblast progenitor differentiation by Tgfb Ob p STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Osteoblast progenitor differentiation by Tgfb Tgfb A STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Osteoblast progenitor differentiation by Tgfb Tgfb A STOICHIOMETRY
right: Tgfb_A
right: Ob_p
left: Ob_pro
left: Tgfb_A

Ob_p_binding_by_PTH
type: Transport
participant stoichiometry: LEFT 0 conversion Ob p binding by PTH Ob p STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob p binding by PTH Ob p PTH STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ob p binding by PTH PTH STOICHIOMETRY
right: Ob_p_PTH
left: PTH
left: Ob_p

Ocy_A
type: PhysicalEntity
member physical entity: Ocy_A
cellular location: bone

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

bone
type: CellularLocationVocabulary
xref: BTO:0000140

Wnt_I
type: PhysicalEntity
member physical entity: Wnt_I
cellular location: ecm

RIGHT 0 conversion OPG RANKL dissociation OPG STOICHIOMETRY
type: Stoichiometry
physical entity: OPG
stoichiometric coefficient: 1.0

RIGHT 0 conversion RANKL secretion by Ob p Tgfb A Ob p Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_Tgfb_A
stoichiometric coefficient: 1.0

LEFT 0 conversion Bone formation Obm PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion Ocy I PTH release Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

Bone
type: PhysicalEntity

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RIGHT 0 conversion RANKL secretion by Ob p PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

Ocy_I
type: PhysicalEntity
xref: CL:0000137

Sost
type: PhysicalEntity
member physical entity: Sost
cellular location: ecm

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

CREB_Runx2
type: PhysicalEntity
member physical entity: CREB_Runx2
cellular location: osteoblast

Ocy_A
type: PhysicalEntity
xref: CL:0000137

MSC_differentiation_to_Ob_pro
type: Transport
participant stoichiometry: LEFT 0 conversion MSC differentiation to Ob pro MSC STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MSC differentiation to Ob pro Wnt A STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion MSC differentiation to Ob pro Ob pro STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MSC differentiation to Ob pro MSC STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion MSC differentiation to Ob pro Wnt A STOICHIOMETRY
right: Wnt_A
right: Ob_pro
right: MSC
left: MSC
left: Wnt_A

RIGHT 0 conversion Bcl2 degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

Bcl2
type: PhysicalEntity
member physical entity: Bcl2
cellular location: osteoblast

RIGHT 1 conversion Ob p PTH release PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

Ob_p
type: PhysicalEntity
member physical entity: Ob_p
cellular location: bone

LEFT 0 conversion Ob p binding by PTH Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

LEFT 1 conversion Ocl p RANKL binding Ocl p STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p
stoichiometric coefficient: 1.0

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

Bone_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Bone degradation Ocl m STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Bone degradation Bone STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Bone degradation Ocl m STOICHIOMETRY
right: Ocl_m
left: Bone
left: Ocl_m

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

OPG_RANKL
type: PhysicalEntity
member physical entity: OPG_RANKL
cellular location: ecm

LEFT 0 conversion RANKL secretion by Ob p PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

CL:0001040
type: UnificationXref
id: CL:0001040

Ocl_p_RANKL
type: Complex
xref: O14788
xref: CL:0000778

LEFT 0 conversion Runx2 degradation via PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

P16220
type: UnificationXref
id: P16220
db: UniProt Knowledgebase

LEFT 0 conversion Sost degradation Sost STOICHIOMETRY
type: Stoichiometry
physical entity: Sost
stoichiometric coefficient: 1.0

RIGHT 1 conversion OPG RANKL dissociation RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

LEFT 0 conversion MCSF secretion by Ob p PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

LEFT 0 conversion Ob maturation to Ocy by Tgfb Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

O14788
type: UnificationXref
id: O14788
db: UniProt Knowledgebase

LEFT 0 conversion Xsynthesis Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

RIGHT 0 conversion Tgfb degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Ob_p_Tgfb_A
type: Complex
xref: P01137
xref: CL:0007010

Ob_p_Tgfb_A
type: PhysicalEntity
member physical entity: Ob_p_Tgfb_A
cellular location: bone

Ocl_m
type: PhysicalEntity
member physical entity: Ocl_m
cellular location: bone

CL:0001039
type: UnificationXref
id: CL:0001039

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

RIGHT 1 conversion Ocy I PTH release PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion Ob p binding by PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion MCSF secretion by MSC MSC STOICHIOMETRY
type: Stoichiometry
physical entity: MSC
stoichiometric coefficient: 1.0

LEFT 0 conversion Osteocyte activation by PTH Ocy I PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I_PTH
stoichiometric coefficient: 1.0

Ob_m_PTH
type: PhysicalEntity
member physical entity: Ob_m_PTH
cellular location: ecm

LEFT 0 conversion Bax Bcl2 binding Bax STOICHIOMETRY
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

Ocy_apoptosis
type: Transport
participant stoichiometry: LEFT 0 conversion Ocy apoptosis Ocy I STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ocy apoptosis Sink STOICHIOMETRY
right: Sink
left: Ocy_I

RIGHT 0 conversion Osteocyte activation Ocy A STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_A
stoichiometric coefficient: 1.0

newbone
type: PhysicalEntity
member physical entity: newbone
cellular location: ecm

Tgfb_secretion_by_Obm
type: Transport
participant stoichiometry: LEFT 0 conversion Tgfb secretion by Obm Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Tgfb secretion by Obm Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Tgfb secretion by Obm Tgfb I STOICHIOMETRY
right: Tgfb_I
right: Ob_m
left: Ob_m

Runx2_degradation
type: Transport
participant stoichiometry: RIGHT 0 conversion Runx2 degradation Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Runx2 degradation Runx2 STOICHIOMETRY
right: Sink
left: Runx2

RIGHT 0 conversion CREB activation Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion MCSF secretion by Ob p PTH Ob p PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_PTH
stoichiometric coefficient: 1.0

Unloading
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Unloading LOAD STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Unloading Sink STOICHIOMETRY
right: Sink
left: LOAD

LEFT 1 conversion HSC differentiation to Ocl p MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

CREB_Runx2_release
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion CREB Runx2 release CREB Runx2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion CREB Runx2 release CREB P STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion CREB Runx2 release Runx2 STOICHIOMETRY
right: CREB_P
right: Runx2
spontaneous: true
left: CREB_Runx2
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion Ocl p RANKL release Ocl p RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_p_RANKL
stoichiometric coefficient: 1.0

LEFT 1 conversion Runx2 degradation via PTH Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: Runx2
stoichiometric coefficient: 1.0

MCSF_secretion_by_Ob_m_PTH
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion MCSF secretion by Ob m PTH MCSF STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MCSF secretion by Ob m PTH Ob m PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MCSF secretion by Ob m PTH Ob m PTH STOICHIOMETRY
right: Ob_m_PTH
right: MCSF
left: Ob_m_PTH

LEFT 1 conversion MSC differentiation to Ob pro Wnt A STOICHIOMETRY
type: Stoichiometry
physical entity: Wnt_A
stoichiometric coefficient: 1.0

RIGHT 0 conversion MCSF secretion by Ob m PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

LEFT 0 conversion Ob p Tgfb release Ob p Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p_Tgfb_A
stoichiometric coefficient: 1.0

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

MSC
type: PhysicalEntity
xref: CL:0000134

LEFT 0 conversion Ob maturation to Ocy Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

newbone
type: PhysicalEntity
member physical entity: newbone
cellular location: ecm

Ocl_m
type: PhysicalEntity
member physical entity: Ocl_m
cellular location: bone

LEFT 1 conversion Ob maturation to Ocy by Tgfb Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

RIGHT 1 conversion RANKL secretion by Ob m RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

RIGHT 1 conversion HSC differentiation to Ocl p MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

Ob_maturation_to_Ocy_by_Tgfb
type: Transport
participant stoichiometry: LEFT 0 conversion Ob maturation to Ocy by Tgfb Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob maturation to Ocy by Tgfb Ocy I STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ob maturation to Ocy by Tgfb Tgfb A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Ob maturation to Ocy by Tgfb Tgfb A STOICHIOMETRY
right: Ocy_I
right: Tgfb_A
left: Ob_m
left: Tgfb_A

HSC
type: PhysicalEntity
member physical entity: HSC
cellular location: bone

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

LEFT 0 conversion RANKL secretion by Ocy A Ocy A STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_A
stoichiometric coefficient: 1.0

RIGHT 1 conversion RANKL secretion by Ob pro RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: RANKL
stoichiometric coefficient: 1.0

RIGHT 0 conversion Bax Bcl2 binding Bax Bcl2 STOICHIOMETRY
type: Stoichiometry
physical entity: Bax_Bcl2
stoichiometric coefficient: 1.0

RIGHT 0 conversion MCSF degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

MSC
type: PhysicalEntity
member physical entity: MSC
cellular location: bone

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

RIGHT 0 conversion RANKL secretion by Ob m Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

Xsynthesis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Xsynthesis Source STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Xsynthesis X STOICHIOMETRY
right: X
left: Source

OPG_RANKL
type: PhysicalEntity
member physical entity: OPG_RANKL
cellular location: ecm

RIGHT 1 conversion Wnt activation by PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

OPG_RANKL
type: PhysicalEntity
member physical entity: OPG_RANKL
cellular location: ecm

RIGHT 0 conversion Sost degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Wnt_A
type: PhysicalEntity
member physical entity: Wnt_A
cellular location: ecm

LEFT 0 conversion Bone degradation Ocl m STOICHIOMETRY
type: Stoichiometry
physical entity: Ocl_m
stoichiometric coefficient: 1.0

RANKL
type: PhysicalEntity
member physical entity: RANKL
cellular location: ecm

Source
type: PhysicalEntity
member physical entity: Source
cellular location: ecm

Q13950
type: UnificationXref
id: Q13950
db: UniProt Knowledgebase

RIGHT 0 conversion Sost secretion Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

LEFT 0 conversion OPG degradation OPG STOICHIOMETRY
type: Stoichiometry
physical entity: OPG
stoichiometric coefficient: 1.0

ecm
type: CellularLocationVocabulary

LEFT 0 conversion MSC differentiation to Ob pro MSC STOICHIOMETRY
type: Stoichiometry
physical entity: MSC
stoichiometric coefficient: 1.0

Ob_m_PTH_apoptosis
type: Transport
participant stoichiometry: RIGHT 1 conversion Ob m PTH apoptosis PTH STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ob m PTH apoptosis Bax STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob m PTH apoptosis Bax STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Ob m PTH apoptosis Ob m PTH STOICHIOMETRY
right: PTH
right: Bax
left: Ob_m_PTH
left: Bax

Runx2
type: PhysicalEntity
member physical entity: Runx2
cellular location: osteoblast

LEFT 0 conversion Ocy apoptosis Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

RIGHT 0 conversion RANKL inhibition OPG RANKL STOICHIOMETRY
type: Stoichiometry
physical entity: OPG_RANKL
stoichiometric coefficient: 1.0

Bax
type: PhysicalEntity
member physical entity: Bax
cellular location: osteoblast

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

RIGHT 0 conversion RANKL degradation Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

RIGHT 1 conversion Ob maturation to Ocy by Tgfb Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

OPG
type: PhysicalEntity
member physical entity: OPG
cellular location: ecm

RIGHT 1 conversion Bone formation Bone STOICHIOMETRY
type: Stoichiometry
physical entity: Bone
stoichiometric coefficient: 1.0

RIGHT 0 conversion Ocl p apoptosis Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Tgfb_A
type: Protein
xref: P01137

LOAD
type: PhysicalEntity
member physical entity: LOAD
cellular location: ecm

Sost
type: PhysicalEntity
member physical entity: Sost
cellular location: ecm

Tgfb_degradation_by_PTH
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion Tgfb degradation by PTH Ob m PTH STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Tgfb degradation by PTH Tgfb A STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Tgfb degradation by PTH Ob m PTH STOICHIOMETRY
right: Ob_m_PTH
left: Tgfb_A
left: Ob_m_PTH

Tgfb_I
type: Protein
xref: P01137

LEFT 0 conversion Bcl2 synthesis CREB Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_Runx2
stoichiometric coefficient: 1.0

RIGHT 0 conversion Ob p PTH release Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

RIGHT 0 conversion Bone formation Obm PTH Ob m PTH STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m_PTH
stoichiometric coefficient: 1.0

LEFT 1 conversion CREB activation CREB STOICHIOMETRY
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

PTH
type: PhysicalEntity
member physical entity: PTH
cellular location: ecm

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

LEFT 0 conversion Osteoblast progenitor differentiation by Tgfb Ob pro STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_pro
stoichiometric coefficient: 1.0

RIGHT 0 conversion Tgfb activation Tgfb A STOICHIOMETRY
type: Stoichiometry
physical entity: Tgfb_A
stoichiometric coefficient: 1.0

RIGHT 0 conversion Osteoclast apoptosis Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

Source
type: PhysicalEntity
member physical entity: Source
cellular location: ecm

LEFT 0 conversion Ob m bound by PTH Ob m STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_m
stoichiometric coefficient: 1.0

Ocy_I
type: PhysicalEntity
member physical entity: Ocy_I
cellular location: bone

RANKL_secretion_by_Ob_pro
type: Transport
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ob pro Ob pro STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ob pro RANKL STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ob pro Ob pro STOICHIOMETRY
right: RANKL
right: Ob_pro
left: Ob_pro

Source
type: PhysicalEntity
member physical entity: Source
cellular location: ecm

Source
type: PhysicalEntity

Ocy_A
type: PhysicalEntity
member physical entity: Ocy_A
cellular location: bone

Bax
type: PhysicalEntity
member physical entity: Bax
cellular location: osteoblast

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: ecm

LEFT 0 conversion Ocy I bound by PTH Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

CREB_P
type: PhysicalEntity
member physical entity: CREB_P
cellular location: osteoblast

RIGHT 0 conversion Ob maturation to Ocy Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

RIGHT 2 conversion MSC differentiation to Ob pro Ob pro STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_pro
stoichiometric coefficient: 1.0

RIGHT 1 conversion Ob m PTH apoptosis PTH STOICHIOMETRY
type: Stoichiometry
physical entity: PTH
stoichiometric coefficient: 1.0

RIGHT 0 conversion MCSF secretion by Ob p Ob p STOICHIOMETRY
type: Stoichiometry
physical entity: Ob_p
stoichiometric coefficient: 1.0

LEFT 0 conversion CREB Runx2 release CREB Runx2 STOICHIOMETRY
type: Stoichiometry
physical entity: CREB_Runx2
stoichiometric coefficient: 1.0

Ob_pro
type: PhysicalEntity
member physical entity: Ob_pro
cellular location: bone

Tgfb_A
type: PhysicalEntity
member physical entity: Tgfb_A
cellular location: ecm

Ob_m
type: PhysicalEntity
member physical entity: Ob_m
cellular location: bone

MCSF
type: PhysicalEntity
member physical entity: MCSF
cellular location: ecm

RIGHT 1 conversion MCSF secretion by Ob pro MCSF STOICHIOMETRY
type: Stoichiometry
physical entity: MCSF
stoichiometric coefficient: 1.0

RIGHT 0 conversion RANKL secretion by Ocy I Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

LEFT 1 conversion Bone degradation Bone STOICHIOMETRY
type: Stoichiometry
physical entity: Bone
stoichiometric coefficient: 1.0

Ob_p_PTH
type: PhysicalEntity
member physical entity: Ob_p_PTH
cellular location: ecm

Bax
type: Protein
xref: Q07812

Ob_p_Tgfb_binding
type: Transport
participant stoichiometry: LEFT 0 conversion Ob p Tgfb binding Ob p STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Ob p Tgfb binding Tgfb A STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Ob p Tgfb binding Ob p Tgfb A STOICHIOMETRY
right: Ob_p_Tgfb_A
left: Ob_p
left: Tgfb_A

RANKL_secretion_by_Ob_p_Tgfb_A
type: Transport
participant stoichiometry: RIGHT 0 conversion RANKL secretion by Ob p Tgfb A Ob p Tgfb A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RANKL secretion by Ob p Tgfb A RANKL STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RANKL secretion by Ob p Tgfb A Ob p Tgfb A STOICHIOMETRY
right: RANKL
right: Ob_p_Tgfb_A
left: Ob_p_Tgfb_A

RIGHT 0 conversion Osteocyte inactivation Ocy I STOICHIOMETRY
type: Stoichiometry
physical entity: Ocy_I
stoichiometric coefficient: 1.0

BIOMD0000000612
type: UnificationXref
id: BIOMD0000000612
db: BioModels Database

Bone_formation
type: Transport
participant stoichiometry: RIGHT 1 conversion Bone formation Bone STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Bone formation Ob m STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Bone formation Ob m STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion Bone formation newbone STOICHIOMETRY
right: Bone
right: Ob_m
right: newbone
left: Ob_m