Ras
type: Protein
xref: P01112

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

pRas
type: PhysicalEntity
member physical entity: pRas
cellular location: Cell

RIGHT 1 conversion v23a pC3G STOICHIOMETRY
type: Stoichiometry
physical entity: pC3G
stoichiometric coefficient: 1.0

GO:0038004
type: UnificationXref
id: GO:0038004
db: Gene Ontology

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

Raf1
type: PhysicalEntity
member physical entity: Raf1
cellular location: Cell

pAPCpAxinGSK3B
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b
cellular location: Cell

Rap1
type: PhysicalEntity
member physical entity: Rap1
cellular location: Cell

LEFT 0 conversion v9b X STOICHIOMETRY
type: Stoichiometry
physical entity: X
stoichiometric coefficient: 1.0

RIGHT 0 conversion v18a P90Rsk STOICHIOMETRY
type: Stoichiometry
physical entity: P90Rsk
stoichiometric coefficient: 1.0

LEFT 0 conversion v23b pC3G STOICHIOMETRY
type: Stoichiometry
physical entity: pC3G
stoichiometric coefficient: 1.0

RIGHT 1 conversion v24 pRap1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRap1
stoichiometric coefficient: 1.0

P01133
type: UnificationXref
id: P01133
db: UniProt Knowledgebase

PI3K
type: PhysicalEntity
member physical entity: PI3K
cellular location: Cell

SOS dephosphorylation (pP90Rsk modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v6b pP90Rsk STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v6b SOS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v6b pP90Rsk STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v6b pSOS STOICHIOMETRY
xref: GO:0016311
right: pP90Rsk
right: SOS
left: pP90Rsk
left: pSOS

RIGHT 1 conversion v10b Raf1 STOICHIOMETRY
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

LEFT 0 conversion v25 Rap1Gap STOICHIOMETRY
type: Stoichiometry
physical entity: Rap1Gap
stoichiometric coefficient: 1.0

SOS dephosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v6a pSOS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v6a SOS STOICHIOMETRY
xref: GO:0016311
right: SOS
left: pSOS

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

Q07889
type: UnificationXref
id: Q07889
db: UniProt Knowledgebase

LEFT 0 conversion v1 pEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: pEGFR
stoichiometric coefficient: 1.0

RIGHT 0 conversion v3 null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

PKCD
type: PhysicalEntity
member physical entity: PKCD
cellular location: Cell

RIGHT 1 conversion v6b SOS STOICHIOMETRY
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

RIGHT 0 conversion v1 fEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: fEGFR
stoichiometric coefficient: 1.0

LEFT 0 conversion bRaf dephosphorylation pAkt modifier pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

GO:0043624
type: UnificationXref
id: GO:0043624
db: Gene Ontology

P01024
type: UnificationXref
id: P01024
db: UniProt Knowledgebase

pAPCpAxinGSK3BBCatenin
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b_bCatenin
cellular location: Cell

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

X
type: PhysicalEntity

GO:0016310
type: UnificationXref
id: GO:0016310
db: Gene Ontology

BIOMD0000000648
type: UnificationXref
id: BIOMD0000000648
db: BioModels Database

GO:0016311
type: UnificationXref
id: GO:0016311
db: Gene Ontology

PTEN
type: PhysicalEntity
member physical entity: PTEN
cellular location: Cell

RIGHT 0 conversion v10b pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

LEFT 0 conversion v2 fEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: fEGFR
stoichiometric coefficient: 1.0

LEFT 2 conversion v11b MEK STOICHIOMETRY
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

pbCatenin
type: Protein
xref: P35222

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

bRaf
type: Protein
xref: P15056

PP2A
type: Protein
xref: P67775

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

RIGHT 0 conversion v33a APCAxin STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxin
stoichiometric coefficient: 1.0

LEFT 0 conversion v37b null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

PP2A
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

LEFT 0 conversion v27b pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

LEFT 0 conversion v19a bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

Rap1
type: Protein
xref: P62834

Ras dephosphorylation (Ras_Gap modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v8b RasGap STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v8b RasGap STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v8b pRas STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v8b Ras STOICHIOMETRY
xref: GO:0016311
right: RasGap
right: Ras
left: RasGap
left: pRas

Ras synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v8a Ras STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v8a null STOICHIOMETRY
xref: GO:0045727
right: Ras
left: null

LEFT 1 conversion v9a Raf1 STOICHIOMETRY
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

pGSK3B
type: PhysicalEntity
member physical entity: pGSK3b
cellular location: Cell

pRaf1
type: PhysicalEntity
member physical entity: pRaf1
cellular location: Cell

pC3G
type: PhysicalEntity
member physical entity: pC3G
cellular location: Cell

ERK
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

Axin
type: PhysicalEntity
member physical entity: Axin
cellular location: Cell

pC3G
type: PhysicalEntity
member physical entity: pC3G
cellular location: Cell

LEFT 1 conversion v30 APCAxinGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxinGSK3B
stoichiometric coefficient: 1.0

P62834
type: UnificationXref
id: P62834
db: UniProt Knowledgebase

GO:0051389
type: UnificationXref
id: GO:0051389
db: Gene Ontology

X
type: PhysicalEntity
member physical entity: X
cellular location: Cell

pC3G
type: PhysicalEntity
member physical entity: pC3G
cellular location: Cell

pAPCpAxinGSK3BpBCatenin
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b_pbCatenin
cellular location: Cell

RasGap
type: PhysicalEntity
member physical entity: Ras_Gap
cellular location: Cell

LEFT 2 conversion v5 bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

pRas
type: PhysicalEntity
member physical entity: pRas
cellular location: Cell

Rap1
type: PhysicalEntity
member physical entity: Rap1
cellular location: Cell

GO:0043408
type: UnificationXref
id: GO:0043408
db: Gene Ontology

pGSK3B
type: PhysicalEntity
member physical entity: pGSK3b
cellular location: Cell

RIGHT 1 conversion v9b pRaf1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRaf1
stoichiometric coefficient: 1.0

Raf1 phosphorylation (pRas modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v9a pRas STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v9a pRaf1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v9a Raf1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v9a pRas STOICHIOMETRY
xref: GO:0016310
right: pRas
right: pRaf1
left: pRas
left: Raf1

RIGHT 0 conversion bRaf dephosphorylation RafPPtase modifier RafPPtase STOICHIOMETRY
type: Stoichiometry
physical entity: RafPPtase
stoichiometric coefficient: 1.0

pAPCpAxinGSK3B
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b
cellular location: Cell

LEFT 0 conversion v34 BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

LEFT 0 conversion v26a GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

LEFT 0 conversion v33c BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

Raf1 phosphorylation (X modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v9b X STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v9b pRaf1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v9b Raf1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v9b X STOICHIOMETRY
xref: GO:0016310
right: pRaf1
right: X
left: X
left: Raf1

RIGHT 0 conversion v39 X STOICHIOMETRY
type: Stoichiometry
physical entity: X
stoichiometric coefficient: 1.0

SOS
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

RIGHT 1 conversion v15a pRKIP STOICHIOMETRY
type: Stoichiometry
physical entity: pRKIP
stoichiometric coefficient: 1.0

LEFT 0 conversion v16a pRas STOICHIOMETRY
type: Stoichiometry
physical entity: pRas
stoichiometric coefficient: 1.0

GO:2000257
type: UnificationXref
id: GO:2000257
db: Gene Ontology

RIGHT 0 conversion v25 Rap1Gap STOICHIOMETRY
type: Stoichiometry
physical entity: Rap1Gap
stoichiometric coefficient: 1.0

PKCD
type: PhysicalEntity
member physical entity: PKCD
cellular location: Cell

GO:0051390
type: UnificationXref
id: GO:0051390
db: Gene Ontology

pRas
type: PhysicalEntity
member physical entity: pRas
cellular location: Cell

RIGHT 0 conversion v28 Dsha STOICHIOMETRY
type: Stoichiometry
physical entity: Dsha
stoichiometric coefficient: 1.0

RIGHT 1 conversion v18b pP90Rsk STOICHIOMETRY
type: Stoichiometry
physical entity: pP90Rsk
stoichiometric coefficient: 1.0

X
type: PhysicalEntity
member physical entity: X
cellular location: Cell

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

RIGHT 0 conversion v27d GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

LEFT 0 conversion v41 pBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: pBCatenin
stoichiometric coefficient: 1.0

GO:0045727
type: UnificationXref
id: GO:0045727
db: Gene Ontology

GO:0005623
type: UnificationXref
id: GO:0005623
db: Gene Ontology

P49841
type: UnificationXref
id: P49841
db: UniProt Knowledgebase

RKIP
type: PhysicalEntity
member physical entity: RKIP
cellular location: Cell

pAPCpAxinGSK3B
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b
cellular location: Cell

P35222
type: UnificationXref
id: P35222
db: UniProt Knowledgebase

APC_bCatenin
type: Complex
xref: P35222
xref: P25054

GO:0005515
type: UnificationXref
id: GO:0005515
db: Gene Ontology

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

X
type: PhysicalEntity
member physical entity: X
cellular location: Cell

GO:0000186
type: UnificationXref
id: GO:0000186
db: Gene Ontology

GO:0000185
type: UnificationXref
id: GO:0000185
db: Gene Ontology

GO:0000188
type: UnificationXref
id: GO:0000188
db: Gene Ontology

GO:0000187
type: UnificationXref
id: GO:0000187
db: Gene Ontology

pPI3K
type: PhysicalEntity

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

LEFT 0 conversion v11b pRKIP STOICHIOMETRY
type: Stoichiometry
physical entity: pRKIP
stoichiometric coefficient: 1.0

fEGFR
type: PhysicalEntity
member physical entity: freeEGFR
cellular location: Cell

http://identifiers.org/pubmed/21391741
type: PublicationXref
id: 21391741
db: PubMed

P01112
type: UnificationXref
id: P01112
db: UniProt Knowledgebase

LEFT 0 conversion v26b PKCD STOICHIOMETRY
type: Stoichiometry
physical entity: PKCD
stoichiometric coefficient: 1.0

LEFT 0 conversion v22b pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

PKCD
type: PhysicalEntity
member physical entity: PKCD
cellular location: Cell

LEFT 1 conversion v31 GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

RIGHT 0 conversion v9a pRas STOICHIOMETRY
type: Stoichiometry
physical entity: pRas
stoichiometric coefficient: 1.0

RafPPtase
type: PhysicalEntity
member physical entity: RafPPtase
cellular location: Cell

P30086
type: UnificationXref
id: P30086
db: UniProt Knowledgebase

bRaf phosphorylation (pRap1 modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v16b pRap1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v16b pBRaf STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v16b BRaf STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v16b pRap1 STOICHIOMETRY
xref: GO:0016310
right: pBRaf
right: pRap1
left: BRaf
left: pRap1

RKIP
type: Protein
xref: P30086

LEFT 0 conversion v15c RKIP STOICHIOMETRY
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

RIGHT 0 conversion v27a pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

TCFBCatenin
type: PhysicalEntity
member physical entity: bCatenin_TCF
cellular location: Cell

Q15418
type: UnificationXref
id: Q15418
db: UniProt Knowledgebase

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

RIGHT 0 conversion v32b APCAxinGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxinGSK3B
stoichiometric coefficient: 1.0

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

LEFT 0 conversion v37a BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

RIGHT 1 conversion v25 Rap1 STOICHIOMETRY
type: Stoichiometry
physical entity: Rap1
stoichiometric coefficient: 1.0

RIGHT 0 conversion v20 pPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: pPI3K
stoichiometric coefficient: 1.0

bRaf phosphorylation (pRas modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v16a BRaf STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v16a pRas STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v16a pBRaf STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v16a pRas STOICHIOMETRY
xref: GO:0016310
right: pRas
right: pBRaf
left: pRas
left: BRaf

BIOMD0000000149
type: UnificationXref
id: BIOMD0000000149
db: BioModels Database

BIOMD0000000033
type: UnificationXref
id: BIOMD0000000033
db: BioModels Database

RKIP dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v15b RKIP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v15b pRKIP STOICHIOMETRY
xref: GO:0016311
right: RKIP
left: pRKIP

GSK3b synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v27c RKIP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v27c GSK3B STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v27c RKIP STOICHIOMETRY
xref: GO:0009058
right: RKIP
right: GSK3B
left: RKIP

LEFT 1 conversion v8b pRas STOICHIOMETRY
type: Stoichiometry
physical entity: pRas
stoichiometric coefficient: 1.0

RKIP phosphorylation (pERK modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v15a RKIP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v15a pERK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v15a pERK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v15a pRKIP STOICHIOMETRY
xref: GO:0016310
right: pRKIP
right: pERK
left: RKIP
left: pERK

GSK3b phosphorylation (pAkt modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v27b pAkt STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v27b pAkt STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v27b pGSK3B STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v27b GSK3B STOICHIOMETRY
xref: GO:0016310
right: pGSK3B
right: pAkt
left: GSK3B
left: pAkt

RKIP degradation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v15c null STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v15c RKIP STOICHIOMETRY
xref: GO:0030163
right: null
left: RKIP

GSK3b dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v27d GSK3B STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v27d pGSK3B STOICHIOMETRY
xref: GO:0016311
right: GSK3B
left: pGSK3B

pSOS
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

LEFT 0 conversion v12 pMEK STOICHIOMETRY
type: Stoichiometry
physical entity: pMEK
stoichiometric coefficient: 1.0

RafPPtase
type: Protein
xref: P67775

GO:0000165
type: UnificationXref
id: GO:0000165
db: Gene Ontology

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion v33c TCFBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: TCFBCatenin
stoichiometric coefficient: 1.0

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

pPI3K
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

LEFT 1 conversion v11b pRaf1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRaf1
stoichiometric coefficient: 1.0

GSK3b phosphorylation (pERK modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v27a pERK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v27a GSK3B STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v27a pGSK3B STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v27a pERK STOICHIOMETRY
xref: GO:0016310
right: pGSK3B
right: pERK
left: GSK3B
left: pERK

SOS
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

RIGHT 0 conversion v26b null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

RIGHT 0 conversion v21 PTEN STOICHIOMETRY
type: Stoichiometry
physical entity: PTEN
stoichiometric coefficient: 1.0

RIGHT 1 conversion v27a pGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: pGSK3B
stoichiometric coefficient: 1.0

RIGHT 1 conversion v14 PP2A STOICHIOMETRY
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

LEFT 0 conversion v31 APCAxin STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxin
stoichiometric coefficient: 1.0

ERK
type: Protein
xref: P27361

RIGHT 0 conversion v13 pMEK STOICHIOMETRY
type: Stoichiometry
physical entity: pMEK
stoichiometric coefficient: 1.0

pAPCpAxinGSK3B
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b
cellular location: Cell

TCF
type: PhysicalEntity
member physical entity: TCF
cellular location: Cell

P47736
type: UnificationXref
id: P47736
db: UniProt Knowledgebase

RIGHT 0 conversion v27c RKIP STOICHIOMETRY
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

Ras_Gap
type: Protein
xref: P20936

RIGHT 1 conversion v27c GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

LEFT 0 conversion v11a pBRaf STOICHIOMETRY
type: Stoichiometry
physical entity: pBRaf
stoichiometric coefficient: 1.0

pRaf1
type: PhysicalEntity
member physical entity: pRaf1
cellular location: Cell

P90Rsk dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v18a P90Rsk STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v18a pP90Rsk STOICHIOMETRY
xref: GO:0016311
right: P90Rsk
left: pP90Rsk

LEFT 0 conversion v6a pSOS STOICHIOMETRY
type: Stoichiometry
physical entity: pSOS
stoichiometric coefficient: 1.0

P90Rsk phosphorylation (pERK modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v18b P90Rsk STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v18b pP90Rsk STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v18b pERK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v18b pERK STOICHIOMETRY
xref: GO:0016311
right: pP90Rsk
right: pERK
left: pERK
left: P90Rsk

LEFT 0 conversion v27a pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

RIGHT 0 conversion v23a bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

RIGHT 0 conversion v19c PI3K STOICHIOMETRY
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

RIGHT 1 conversion v26a PKCD STOICHIOMETRY
type: Stoichiometry
physical entity: PKCD
stoichiometric coefficient: 1.0

LEFT 1 conversion v23a C3G STOICHIOMETRY
type: Stoichiometry
physical entity: C3G
stoichiometric coefficient: 1.0

Akt
type: Protein
xref: P31749

ERK phosphorylation (pMEK modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v13 pMEK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v13 pERK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v13 ERK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v13 pMEK STOICHIOMETRY
xref: GO:0004708
xref: http://identifiers.org/ec-code/2.7.12.2
xref: GO:0000187
right: pERK
right: pMEK
left: pMEK
left: ERK

MEK dephosphorylation (PP2A modifer)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v12 MEK STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v12 pMEK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v12 PP2A STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v12 PP2A STOICHIOMETRY
xref: GO:0051389
right: PP2A
right: MEK
left: PP2A
left: pMEK

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

Ras
type: PhysicalEntity
member physical entity: Ras
cellular location: Cell

ERK dephosphorylation (PP2A modifer)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v14 pERK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v14 PP2A STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v14 ERK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v14 PP2A STOICHIOMETRY
xref: GO:0000188
right: ERK
right: PP2A
left: PP2A
left: pERK

LEFT 1 conversion v37a APC STOICHIOMETRY
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

RIGHT 3 conversion v5 pSOS STOICHIOMETRY
type: Stoichiometry
physical entity: pSOS
stoichiometric coefficient: 1.0

SOS
type: Protein
xref: Q07889

pP90Rsk
type: PhysicalEntity
member physical entity: pP90Rsk
cellular location: Cell

LEFT 1 conversion v9b Raf1 STOICHIOMETRY
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

LEFT 1 conversion v25 pRap1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRap1
stoichiometric coefficient: 1.0

LEFT 0 conversion v3 fEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: fEGFR
stoichiometric coefficient: 1.0

APC_Axin
type: Complex
xref: O15169
xref: P25054

pRaf1
type: PhysicalEntity
member physical entity: pRaf1
cellular location: Cell

RIGHT 0 conversion v37c null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

RIGHT 0 conversion v11b pRKIP STOICHIOMETRY
type: Stoichiometry
physical entity: pRKIP
stoichiometric coefficient: 1.0

LEFT 0 conversion v27c RKIP STOICHIOMETRY
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

RKIP
type: PhysicalEntity
member physical entity: RKIP
cellular location: Cell

APCAxinGSK3B
type: PhysicalEntity
member physical entity: APC_Axin_GSK3b
cellular location: Cell

pPI3K
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

RIGHT 0 conversion v8b RasGap STOICHIOMETRY
type: Stoichiometry
physical entity: RasGap
stoichiometric coefficient: 1.0

PTEN
type: Protein
xref: P60484

RIGHT 0 conversion v26a GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

pAPC_pAxin_GSK3b
type: Complex
xref: O15169
xref: P49841
xref: P25054

PIP2 phosphorylated to PIP3
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v20 PIP2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v20 PIP3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v20 pPI3K STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v20 pPI3K STOICHIOMETRY
xref: GO:0016310
right: pPI3K
right: PIP3
left: pPI3K
left: PIP2

pRap1
type: PhysicalEntity
member physical entity: pRap1
cellular location: Cell

pAPC_pAxin_GSK3b_pbCatenin
type: Complex
xref: O15169
xref: P35222
xref: P49841
xref: P25054

PIP3 dephosphorylated to PIP2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v21 PTEN STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v21 PIP3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v21 PIP2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v21 PTEN STOICHIOMETRY
xref: GO:0016311
right: PIP2
right: PTEN
left: PIP3
left: PTEN

Rap1 phosphorylation (pC3G modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v24 pC3G STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v24 Rap1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v24 pC3G STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v24 pRap1 STOICHIOMETRY
xref: GO:0016310
right: pRap1
right: pC3G
left: Rap1
left: pC3G

Raf1
type: PhysicalEntity
member physical entity: Raf1
cellular location: Cell

O15169
type: UnificationXref
id: O15169
db: UniProt Knowledgebase

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

Rap1 dephosphorylation (Rap1_GAP modifer)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v25 Rap1Gap STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v25 Rap1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v25 pRap1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v25 Rap1Gap STOICHIOMETRY
xref: GO:0016311
right: Rap1
right: Rap1Gap
left: Rap1Gap
left: pRap1

Dsh activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v28 Dshi STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v28 Dsha STOICHIOMETRY
xref: GO:0072376
right: Dsha
left: Dshi

GO:0009058
type: UnificationXref
id: GO:0009058
db: Gene Ontology

pSOS
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

Dsh deactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v29 Dsha STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v29 Dshi STOICHIOMETRY
xref: GO:2000257
right: Dshi
left: Dsha

pAPCpAxinGSK3BpBCatenin
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b_pbCatenin
cellular location: Cell

Dshi
type: PhysicalEntity
member physical entity: Dshi
cellular location: Cell

LEFT 0 conversion v6b pP90Rsk STOICHIOMETRY
type: Stoichiometry
physical entity: pP90Rsk
stoichiometric coefficient: 1.0

Cell
type: CellularLocationVocabulary
xref: GO:0005623

APCAxin
type: PhysicalEntity
member physical entity: APC_Axin
cellular location: Cell

Q05655
type: UnificationXref
id: Q05655
db: UniProt Knowledgebase

pRas
type: Protein
xref: P62070

LEFT 0 conversion v16b pRap1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRap1
stoichiometric coefficient: 1.0

LEFT 1 conversion v15a RKIP STOICHIOMETRY
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

pP90Rsk
type: Protein
xref: Q15418

GO:0070851
type: UnificationXref
id: GO:0070851
db: Gene Ontology

RIGHT 0 conversion v40 null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

GO:0060828
type: UnificationXref
id: GO:0060828
db: Gene Ontology

bCatenin
type: Protein
xref: P35222

pRap1
type: PhysicalEntity
member physical entity: pRap1
cellular location: Cell

Axin
type: PhysicalEntity
member physical entity: Axin
cellular location: Cell

APC_Axin_GSK3b complex formation
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v31 GSK3B STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v31 APCAxin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v31 APCAxinGSK3B STOICHIOMETRY
xref: GO:0005515
right: APCAxinGSK3B
left: GSK3B
left: APCAxin

APC_Axin_GSK3b complex disassembly (Dsha modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v30 APCAxinGSK3B STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v30 Dsha STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion v30 Dsha STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v30 APCAxin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v30 GSK3B STOICHIOMETRY
xref: GO:0043624
right: APCAxin
right: GSK3B
right: Dsha
left: Dsha
left: APCAxinGSK3B

RIGHT 1 conversion bRaf dephosphorylation pAkt modifier BRaf STOICHIOMETRY
type: Stoichiometry
physical entity: BRaf
stoichiometric coefficient: 1.0

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

RIGHT 1 conversion v39 TCFBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: TCFBCatenin
stoichiometric coefficient: 1.0

pBRaf
type: PhysicalEntity
member physical entity: pbRaf
cellular location: Cell

bCatenin phosphorylation (in compond)
type: BiochemicalReaction
xref: GO:0016310

pAPC_pAxin_GSK3b_bCatenin complex formation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v34 BCatenin STOICHIOMETRY
xref: GO:0005515
left: BCatenin
left: pAPCpAxinGSK3B

pAPC_pAxin_GSK3b_pbCatenin complex disassembly
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v36 pBCatenin STOICHIOMETRY
xref: GO:0043624
right: pAPCpAxinGSK3B
right: pBCatenin

MEK
type: Protein
xref: Q02750

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

X synthesis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v39 TCFBCatenin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v39 X STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v39 TCFBCatenin STOICHIOMETRY
xref: GO:0009058
right: X
right: TCFBCatenin
left: TCFBCatenin

bCatenin_TCF complex binding
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion v38 BCatenin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v38 TCFBCatenin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v38 TCF STOICHIOMETRY
xref: GO:0005515
right: TCFBCatenin
spontaneous: true
left: TCF
left: BCatenin
conversion direction: LEFT_TO_RIGHT

null
type: PhysicalEntity

RIGHT 0 conversion v33c BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

PI3K phosphorylation (pRas modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v19b PI3K STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v19b pPI3K STOICHIOMETRY
xref: GO:0016310
right: pPI3K
left: PI3K

PIP3
type: PhysicalEntity

PI3K phosphorylation (boundEGFR modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v19a PI3K STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v19a bEGFR STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v19a pPI3K STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v19a bEGFR STOICHIOMETRY
xref: GO:0016310
right: bEGFR
right: pPI3K
left: PI3K
left: bEGFR

pP90Rsk
type: PhysicalEntity
member physical entity: pP90Rsk
cellular location: Cell

RIGHT 1 conversion v10a Raf1 STOICHIOMETRY
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

RIGHT 1 conversion v21 PIP2 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

PI3K dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v19c PI3K STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v19c pPI3K STOICHIOMETRY
xref: GO:0016311
right: PI3K
left: pPI3K

PIP2
type: PhysicalEntity

pBRaf
type: PhysicalEntity
member physical entity: pbRaf
cellular location: Cell

LEFT 1 conversion v27b GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

Dsha
type: Protein
xref: O14640

X degradation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v40 null STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v40 X STOICHIOMETRY
xref: GO:0030163
right: null
left: X

pbCatenin degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v41 pBCatenin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v41 null STOICHIOMETRY
xref: GO:0030163
right: null
left: pBCatenin

RKIP
type: PhysicalEntity
member physical entity: RKIP
cellular location: Cell

LEFT 1 conversion v7 Ras STOICHIOMETRY
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Dshi
type: Protein
xref: O14640

P00533
type: UnificationXref
id: P00533
db: UniProt Knowledgebase

APCAxinGSK3B
type: PhysicalEntity
member physical entity: APC_Axin_GSK3b
cellular location: Cell

TCFBCatenin
type: PhysicalEntity
member physical entity: bCatenin_TCF
cellular location: Cell

boundEGFR
type: Complex
xref: P00533
xref: P01133

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

LEFT 0 conversion v22a PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

LEFT 0 conversion v4 bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

pRaf1
type: Protein
xref: P04049

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

RIGHT 0 conversion v9b X STOICHIOMETRY
type: Stoichiometry
physical entity: X
stoichiometric coefficient: 1.0

BRaf
type: PhysicalEntity
member physical entity: bRaf
cellular location: Cell

RIGHT 0 conversion v6a SOS STOICHIOMETRY
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: BIOMD0000000648

Rap1_Gap
type: Protein
xref: P47736

GO:0004708
type: UnificationXref
id: GO:0004708
db: Gene Ontology

pBRaf
type: PhysicalEntity
member physical entity: pbRaf
cellular location: Cell

pRas
type: PhysicalEntity
member physical entity: pRas
cellular location: Cell

RIGHT 0 conversion v22a PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

LEFT 0 conversion v14 pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: pAPCpAxinGSK3B
stoichiometric coefficient: 1.0

RIGHT 0 conversion v14 ERK STOICHIOMETRY
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: MODEL1708290005

LEFT 1 conversion bRaf dephosphorylation RafPPtase modifier pBRaf STOICHIOMETRY
type: Stoichiometry
physical entity: pBRaf
stoichiometric coefficient: 1.0

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

APC
type: Protein
xref: P25054

C3G
type: Protein
xref: Q13905

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

MEK
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

GO:0004709
type: UnificationXref
id: GO:0004709
db: Gene Ontology

TCFBCatenin
type: PhysicalEntity
member physical entity: bCatenin_TCF
cellular location: Cell

LEFT 1 conversion v10a pRaf1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRaf1
stoichiometric coefficient: 1.0

LEFT 0 conversion v32a APCAxinGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxinGSK3B
stoichiometric coefficient: 1.0

MEK
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

APC and Axin phosphorylation (in compound)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v32a APCAxinGSK3B STOICHIOMETRY
xref: GO:0016310
right: pAPCpAxinGSK3B
left: APCAxinGSK3B

RIGHT 1 conversion v16b pBRaf STOICHIOMETRY
type: Stoichiometry
physical entity: pBRaf
stoichiometric coefficient: 1.0

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

APC and Axin dephosphorylation (in compound)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v32b APCAxinGSK3B STOICHIOMETRY
xref: GO:0016311
right: APCAxinGSK3B
left: pAPCpAxinGSK3B

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

X
type: PhysicalEntity
member physical entity: X
cellular location: Cell

RIGHT 0 conversion v24 pC3G STOICHIOMETRY
type: Stoichiometry
physical entity: pC3G
stoichiometric coefficient: 1.0

RafPPtase
type: PhysicalEntity
member physical entity: RafPPtase
cellular location: Cell

bRaf dephosphorylation (pAkt modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion bRaf dephosphorylation pAkt modifier pAkt STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion bRaf dephosphorylation pAkt modifier BRaf STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion bRaf dephosphorylation pAkt modifier pAkt STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion bRaf dephosphorylation pAkt modifier pBRaf STOICHIOMETRY
right: BRaf
right: pAkt
left: pAkt
left: pBRaf

PI3K
type: PhysicalEntity
member physical entity: PI3K
cellular location: Cell

PI3K
type: PhysicalEntity

PKCD
type: PhysicalEntity
member physical entity: PKCD
cellular location: Cell

pRap1
type: PhysicalEntity
member physical entity: pRap1
cellular location: Cell

PIP2
type: PhysicalEntity
member physical entity: PIP2
cellular location: Cell

APCAxinGSK3B
type: PhysicalEntity
member physical entity: APC_Axin_GSK3b
cellular location: Cell

LEFT 0 conversion v38 TCF STOICHIOMETRY
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

RIGHT 1 conversion v8b Ras STOICHIOMETRY
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.12.2
type: UnificationXref
id: 2.7.12.2
db: Enzyme Nomenclature

P67775
type: UnificationXref
id: P67775
db: UniProt Knowledgebase

Dsha
type: PhysicalEntity
member physical entity: Dsha
cellular location: Cell

RIGHT 1 conversion v5 pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: pAPCpAxinGSK3B
stoichiometric coefficient: 1.0

LEFT 1 conversion v20 PIP2 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

LEFT 1 conversion v38 BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

Ras
type: PhysicalEntity
member physical entity: Ras
cellular location: Cell

LEFT 0 conversion v13 pMEK STOICHIOMETRY
type: Stoichiometry
physical entity: pMEK
stoichiometric coefficient: 1.0

pAPCpAxinGSK3BBCatenin
type: PhysicalEntity
member physical entity: pAPC_pAxin_GSK3b_bCatenin
cellular location: Cell

LEFT 0 conversion v27d pGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: pGSK3B
stoichiometric coefficient: 1.0

pGSK3b
type: Protein
xref: P49841

pRKIP
type: PhysicalEntity
member physical entity: pRKIP
cellular location: Cell

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

P62070
type: UnificationXref
id: P62070
db: UniProt Knowledgebase

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

RIGHT 0 conversion v6b pP90Rsk STOICHIOMETRY
type: Stoichiometry
physical entity: pP90Rsk
stoichiometric coefficient: 1.0

APC_Axin_GSK3b
type: Complex
xref: O15169
xref: P49841
xref: P25054

LEFT 0 conversion v9a pRas STOICHIOMETRY
type: Stoichiometry
physical entity: pRas
stoichiometric coefficient: 1.0

Q02750
type: UnificationXref
id: Q02750
db: UniProt Knowledgebase

Raf1 dephosphorylation (RafPPtase modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v10a RafPPtase STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v10a Raf1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v10a pRaf1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v10a RafPPtase STOICHIOMETRY
xref: GO:0000185
right: RafPPtase
right: Raf1
left: RafPPtase
left: pRaf1

Akt dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v22b Akt STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v22b pAkt STOICHIOMETRY
xref: GO:0016311
right: Akt
left: pAkt

Akt phosphorylation (PIP3 modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion v22a pAkt STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v22a PIP3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v22a PIP3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v22a Akt STOICHIOMETRY
xref: GO:0016310
right: pAkt
right: PIP3
left: PIP3
left: Akt

Raf1 dephosphorylation (pAkt modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion v10b pRaf1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v10b Raf1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v10b pAkt STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v10b pAkt STOICHIOMETRY
xref: GO:0051390
right: pAkt
right: Raf1
left: pRaf1
left: pAkt

LEFT 0 conversion v21 PTEN STOICHIOMETRY
type: Stoichiometry
physical entity: PTEN
stoichiometric coefficient: 1.0

pPI3K
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

pBRaf
type: PhysicalEntity
member physical entity: pbRaf
cellular location: Cell

pBCatenin
type: PhysicalEntity
member physical entity: pbCatenin
cellular location: Cell

LEFT 1 conversion v14 PP2A STOICHIOMETRY
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

PIP2
type: PhysicalEntity
member physical entity: PIP2
cellular location: Cell

LEFT 0 conversion v7 pSOS STOICHIOMETRY
type: Stoichiometry
physical entity: pSOS
stoichiometric coefficient: 1.0

pRaf1
type: PhysicalEntity
member physical entity: pRaf1
cellular location: Cell

LEFT 0 conversion v18b pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: pAPCpAxinGSK3B
stoichiometric coefficient: 1.0

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

http://identifiers.org/ec-code/2.7.11.1
type: UnificationXref
id: 2.7.11.1
db: Enzyme Nomenclature

RIGHT 0 conversion v5 PKCD STOICHIOMETRY
type: Stoichiometry
physical entity: PKCD
stoichiometric coefficient: 1.0

Axin degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v33b Axin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v33b null STOICHIOMETRY
xref: GO:0030163
right: null
left: Axin

LEFT 0 conversion v28 Dshi STOICHIOMETRY
type: Stoichiometry
physical entity: Dshi
stoichiometric coefficient: 1.0

APC_Axin complex formation
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion v33a Axin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v33a APCAxin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v33a APC STOICHIOMETRY
xref: GO:0005515
right: APCAxin
spontaneous: true
left: APC
left: Axin
conversion direction: LEFT_TO_RIGHT

Axin synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion v33c Axin STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v33c TCFBCatenin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v33c BCatenin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v33c BCatenin STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v33c TCFBCatenin STOICHIOMETRY
xref: GO:0045727
right: TCFBCatenin
right: BCatenin
right: Axin
left: BCatenin
left: TCFBCatenin

pMEK
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

P90Rsk
type: PhysicalEntity
member physical entity: P90Rsk
cellular location: Cell

LEFT 1 conversion v16b BRaf STOICHIOMETRY
type: Stoichiometry
physical entity: BRaf
stoichiometric coefficient: 1.0

RIGHT 0 conversion v27b pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

pC3G
type: PhysicalEntity
member physical entity: pC3G
cellular location: Cell

pRaf1
type: PhysicalEntity
member physical entity: pRaf1
cellular location: Cell

pMEK
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

pMEK
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

LEFT 0 conversion v19b PI3K STOICHIOMETRY
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

LEFT 1 conversion v13 ERK STOICHIOMETRY
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

LEFT 0 conversion v19c pPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: pPI3K
stoichiometric coefficient: 1.0

Rap1Gap
type: PhysicalEntity
member physical entity: Rap1_Gap
cellular location: Cell

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

pRap1
type: Protein
xref: P62834

pSOS
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

GO:0030163
type: UnificationXref
id: GO:0030163
db: Gene Ontology

RIGHT 0 conversion v16b pRap1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRap1
stoichiometric coefficient: 1.0

RIGHT 0 conversion v22b Akt STOICHIOMETRY
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

pAPC_pAxin_GSK3b_bCatenin
type: Complex
xref: O15169
xref: P49841
xref: P35222
xref: P25054

APC
type: PhysicalEntity
member physical entity: APC
cellular location: Cell

LEFT 0 conversion bRaf dephosphorylation RafPPtase modifier RafPPtase STOICHIOMETRY
type: Stoichiometry
physical entity: RafPPtase
stoichiometric coefficient: 1.0

pRas
type: PhysicalEntity
member physical entity: pRas
cellular location: Cell

map04151
type: UnificationXref
id: map04151
db: KEGG Pathway

Akt
type: PhysicalEntity
member physical entity: Akt
cellular location: Cell

RIGHT 0 conversion v4 null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

pRas
type: PhysicalEntity
member physical entity: pRas
cellular location: Cell

MAMO_0000046
type: UnificationXref
id: MAMO_0000046
db: Mathematical Modelling Ontology

P28482
type: UnificationXref
id: P28482
db: UniProt Knowledgebase

MEK phosphorylation (pRaf1, pRKIP and RKIP modifiers)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v11b pRKIP STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion v11b MEK STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v11b pRaf1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v11b pRaf1 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion v11b pMEK STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v11b pRKIP STOICHIOMETRY
xref: GO:0000186
xref: GO:0004709
xref: http://identifiers.org/ec-code/2.7.11.1
right: pRKIP
right: pMEK
right: pRaf1
left: pRaf1
left: pRKIP
left: MEK

MEK phosphorylation (pbRaf modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v11a pBRaf STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v11a pBRaf STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v11a pMEK STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v11a MEK STOICHIOMETRY
xref: GO:0000186
xref: http://identifiers.org/ec-code/2.7.11.1
right: pMEK
right: pBRaf
left: pBRaf
left: MEK

C3G dephosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v23b pC3G STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v23b C3G STOICHIOMETRY
xref: GO:0016311
right: C3G
left: pC3G

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

C3G phosphorylation (boundEGFR modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v23a bEGFR STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v23a pC3G STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v23a bEGFR STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v23a C3G STOICHIOMETRY
xref: GO:0016310
right: bEGFR
right: pC3G
left: bEGFR
left: C3G

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

P15056
type: UnificationXref
id: P15056
db: UniProt Knowledgebase

P04049
type: UnificationXref
id: P04049
db: UniProt Knowledgebase

pbRaf
type: Protein
xref: P15056

fEGFR
type: PhysicalEntity
member physical entity: freeEGFR
cellular location: Cell

RIGHT 1 conversion v33c TCFBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: TCFBCatenin
stoichiometric coefficient: 1.0

RIGHT 0 conversion v7 pSOS STOICHIOMETRY
type: Stoichiometry
physical entity: pSOS
stoichiometric coefficient: 1.0

LEFT 0 conversion v30 Dsha STOICHIOMETRY
type: Stoichiometry
physical entity: Dsha
stoichiometric coefficient: 1.0

LEFT 0 conversion v8a null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

RIGHT 1 conversion v19a pPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: pPI3K
stoichiometric coefficient: 1.0

Rap1Gap
type: PhysicalEntity
member physical entity: Rap1_Gap
cellular location: Cell

LEFT 1 conversion v6b pSOS STOICHIOMETRY
type: Stoichiometry
physical entity: pSOS
stoichiometric coefficient: 1.0

RIGHT 2 conversion v5 bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

LEFT 1 conversion bRaf dephosphorylation pAkt modifier pBRaf STOICHIOMETRY
type: Stoichiometry
physical entity: pBRaf
stoichiometric coefficient: 1.0

RIGHT 1 conversion v12 PP2A STOICHIOMETRY
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

pMEK
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

PKCD degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v26b PKCD STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v26b null STOICHIOMETRY
xref: GO:0030163
right: null
left: PKCD

PKCD synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion v26a PKCD STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v26a GSK3B STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v26a GSK3B STOICHIOMETRY
xref: GO:0009058
right: PKCD
right: GSK3B
left: GSK3B

null
type: PhysicalEntity
member physical entity: null
cellular location: Cell

TCFBCatenin
type: PhysicalEntity
member physical entity: bCatenin_TCF
cellular location: Cell

RIGHT 0 conversion v38 TCFBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: TCFBCatenin
stoichiometric coefficient: 1.0

pRKIP
type: PhysicalEntity
member physical entity: pRKIP
cellular location: Cell

pAkt
type: Protein
xref: P31749

PP2A
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

pRaf1
type: PhysicalEntity
member physical entity: pRaf1
cellular location: Cell

LEFT 0 conversion v20 pPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: pPI3K
stoichiometric coefficient: 1.0

pP90Rsk
type: PhysicalEntity
member physical entity: pP90Rsk
cellular location: Cell

RIGHT 1 conversion v7 pRas STOICHIOMETRY
type: Stoichiometry
physical entity: pRas
stoichiometric coefficient: 1.0

map04010
type: UnificationXref
id: map04010
db: KEGG Pathway

P90Rsk
type: Protein
xref: Q15418

Dsha
type: PhysicalEntity
member physical entity: Dsha
cellular location: Cell

Q9UJU2
type: UnificationXref
id: Q9UJU2
db: UniProt Knowledgebase

LEFT 0 conversion v33b Axin STOICHIOMETRY
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

pBCatenin
type: PhysicalEntity
member physical entity: pbCatenin
cellular location: Cell

LEFT 1 conversion v24 Rap1 STOICHIOMETRY
type: Stoichiometry
physical entity: Rap1
stoichiometric coefficient: 1.0

bCatenin synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v37b BCatenin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v37b null STOICHIOMETRY
xref: GO:0045727
right: BCatenin
left: null

RIGHT 0 conversion v15b RKIP STOICHIOMETRY
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

APC_bCatenin complex formation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion v37a BCatenin STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v37a APC STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v37a APCBCatenin STOICHIOMETRY
xref: GO:0043624
right: APCBCatenin
spontaneous: true
left: APC
left: BCatenin
conversion direction: LEFT_TO_RIGHT

bCatenin degradation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v37c null STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v37c BCatenin STOICHIOMETRY
xref: GO:0030163
right: null
left: BCatenin

RIGHT 0 conversion v16a pRas STOICHIOMETRY
type: Stoichiometry
physical entity: pRas
stoichiometric coefficient: 1.0

LEFT 0 conversion v40 X STOICHIOMETRY
type: Stoichiometry
physical entity: X
stoichiometric coefficient: 1.0

RIGHT 0 conversion v19a bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

LEFT 0 conversion v23a bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

BRaf
type: PhysicalEntity
member physical entity: bRaf
cellular location: Cell

RIGHT 1 conversion v16a pBRaf STOICHIOMETRY
type: Stoichiometry
physical entity: pBRaf
stoichiometric coefficient: 1.0

APCAxin
type: PhysicalEntity
member physical entity: APC_Axin
cellular location: Cell

RIGHT 1 conversion v11a pMEK STOICHIOMETRY
type: Stoichiometry
physical entity: pMEK
stoichiometric coefficient: 1.0

LEFT 0 conversion v33a APC STOICHIOMETRY
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

RKIP
type: PhysicalEntity
member physical entity: RKIP
cellular location: Cell

APCAxin
type: PhysicalEntity
member physical entity: APC_Axin
cellular location: Cell

pERK
type: Protein
xref: P28482

RafPPtase
type: PhysicalEntity
member physical entity: RafPPtase
cellular location: Cell

…
type: Stoichiometry
physical entity: pAPCpAxinGSK3B
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion bRaf dephosphorylation RafPPtase modifier BRaf STOICHIOMETRY
type: Stoichiometry
physical entity: BRaf
stoichiometric coefficient: 1.0

LEFT 1 conversion v21 PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

PI3K
type: PhysicalEntity
member physical entity: PI3K
cellular location: Cell

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

APCAxinGSK3B
type: PhysicalEntity
member physical entity: APC_Axin_GSK3b
cellular location: Cell

C3G
type: PhysicalEntity
member physical entity: C3G
cellular location: Cell

pEGFR
type: Protein
xref: P00533

http://identifiers.org/pubmed/28367561
type: PublicationXref
id: 28367561
db: PubMed

Q13905
type: UnificationXref
id: Q13905
db: UniProt Knowledgebase

RIGHT 1 conversion v22a pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

P25054
type: UnificationXref
id: P25054
db: UniProt Knowledgebase

bCatenin_TCF
type: Complex
xref: Q9UJU2
xref: P35222

RasGap
type: PhysicalEntity
member physical entity: Ras_Gap
cellular location: Cell

MEK
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

LEFT 1 conversion v18b P90Rsk STOICHIOMETRY
type: Stoichiometry
physical entity: P90Rsk
stoichiometric coefficient: 1.0

LEFT 1 conversion v19a PI3K STOICHIOMETRY
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

RIGHT 0 conversion v15a pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

BRaf
type: PhysicalEntity
member physical entity: bRaf
cellular location: Cell

LEFT 0 conversion v24 pC3G STOICHIOMETRY
type: Stoichiometry
physical entity: pC3G
stoichiometric coefficient: 1.0

RIGHT 0 conversion v8a Ras STOICHIOMETRY
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

MODEL1708290005
type: UnificationXref
id: MODEL1708290005
db: BioModels Database

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ERK
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

RIGHT 1 conversion v20 PIP3 STOICHIOMETRY
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

RIGHT 0 conversion v37a APCBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: APCBCatenin
stoichiometric coefficient: 1.0

RIGHT 1 conversion v11b pRaf1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRaf1
stoichiometric coefficient: 1.0

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

SOS
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

RIGHT 0 conversion v37b BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

pBRaf
type: PhysicalEntity
member physical entity: pbRaf
cellular location: Cell

RIGHT 0 conversion v23b C3G STOICHIOMETRY
type: Stoichiometry
physical entity: C3G
stoichiometric coefficient: 1.0

PP2A
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

pPI3K
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

pSOS
type: Protein
xref: Q07889

pMEK
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

bEGFR
type: PhysicalEntity
member physical entity: boundEGFR
cellular location: Cell

RIGHT 1 conversion v13 pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

Raf1
type: Protein
xref: P04049

RIGHT 0 conversion v2 bEGFR STOICHIOMETRY
type: Stoichiometry
physical entity: bEGFR
stoichiometric coefficient: 1.0

bRaf dephosphorylation (RafPPtase modifier)
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion bRaf dephosphorylation RafPPtase modifier pBRaf STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion bRaf dephosphorylation RafPPtase modifier RafPPtase STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion bRaf dephosphorylation RafPPtase modifier BRaf STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion bRaf dephosphorylation RafPPtase modifier RafPPtase STOICHIOMETRY
right: BRaf
right: RafPPtase
left: RafPPtase
left: pBRaf

EGFR dephosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion v1 pEGFR STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v1 fEGFR STOICHIOMETRY
xref: GO:0038004
right: fEGFR
left: pEGFR

pRKIP
type: PhysicalEntity
member physical entity: pRKIP
cellular location: Cell

LEFT 0 conversion v15a pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

EGFR binding
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion v2 EGF STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v2 bEGFR STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v2 fEGFR STOICHIOMETRY
xref: GO:0070851
right: bEGFR
spontaneous: true
left: EGF
left: fEGFR
conversion direction: LEFT_TO_RIGHT

freeEGFR degradation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v3 null STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v3 fEGFR STOICHIOMETRY
xref: GO:0030163
right: null
left: fEGFR

boundEGFR degradation
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion v4 null STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v4 bEGFR STOICHIOMETRY
xref: GO:0030163
right: null
spontaneous: true
left: bEGFR
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion v29 Dshi STOICHIOMETRY
type: Stoichiometry
physical entity: Dshi
stoichiometric coefficient: 1.0

SOS phosphorylation (PKCD. pERK and boundEGFR modifiers)
type: BiochemicalReaction
participant stoichiometry: RIGHT 3 conversion v5 pSOS STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v5 pERK STOICHIOMETRY
participant stoichiometry: LEFT 3 conversion v5 SOS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v5 PKCD STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion v5 bEGFR STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v5 pERK STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion v5 bEGFR STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion v5 PKCD STOICHIOMETRY
xref: GO:0016310
right: bEGFR
right: PKCD
right: pERK
right: pSOS
left: PKCD
left: pERK
left: SOS
left: bEGFR

RIGHT 2 conversion v11b pMEK STOICHIOMETRY
type: Stoichiometry
physical entity: pMEK
stoichiometric coefficient: 1.0

Ras phosphorylation (pSOS modifier)
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion v7 pSOS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion v7 pSOS STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion v7 pRas STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion v7 Ras STOICHIOMETRY
xref: GO:0016310
right: pRas
right: pSOS
left: pSOS
left: Ras

RIGHT 0 conversion v10a RafPPtase STOICHIOMETRY
type: Stoichiometry
physical entity: RafPPtase
stoichiometric coefficient: 1.0

LEFT 1 conversion v12 PP2A STOICHIOMETRY
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

PIP3
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

LEFT 0 conversion v29 Dsha STOICHIOMETRY
type: Stoichiometry
physical entity: Dsha
stoichiometric coefficient: 1.0

pPI3K
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

LEFT 1 conversion v2 EGF STOICHIOMETRY
type: Stoichiometry
physical entity: EGF
stoichiometric coefficient: 1.0

LEFT 1 conversion v5 pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

RIGHT 1 conversion v27b pGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: pGSK3B
stoichiometric coefficient: 1.0

PTEN
type: PhysicalEntity
member physical entity: PTEN
cellular location: Cell

P31749
type: UnificationXref
id: P31749
db: UniProt Knowledgebase

LEFT 1 conversion v11a MEK STOICHIOMETRY
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Axin
type: PhysicalEntity
member physical entity: Axin
cellular location: Cell

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

RIGHT 1 conversion v9a pRaf1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRaf1
stoichiometric coefficient: 1.0

Dsha
type: PhysicalEntity
member physical entity: Dsha
cellular location: Cell

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion v16a BRaf STOICHIOMETRY
type: Stoichiometry
physical entity: BRaf
stoichiometric coefficient: 1.0

RIGHT 0 conversion v36 pBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: pBCatenin
stoichiometric coefficient: 1.0

O14640
type: UnificationXref
id: O14640
db: UniProt Knowledgebase

Raf1
type: PhysicalEntity
member physical entity: Raf1
cellular location: Cell

RIGHT 0 conversion v18b pERK STOICHIOMETRY
type: Stoichiometry
physical entity: pERK
stoichiometric coefficient: 1.0

APCBCatenin
type: PhysicalEntity
member physical entity: APC_bCatenin
cellular location: Cell

PP2A
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

C3G
type: PhysicalEntity
member physical entity: C3G
cellular location: Cell

pMEK
type: Protein
xref: Q02750

Dshi
type: PhysicalEntity
member physical entity: Dshi
cellular location: Cell

RKIP
type: PhysicalEntity
member physical entity: RKIP
cellular location: Cell

P27361
type: UnificationXref
id: P27361
db: UniProt Knowledgebase

GO:0051896
type: UnificationXref
id: GO:0051896
db: Gene Ontology

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

APC
type: PhysicalEntity
member physical entity: APC
cellular location: Cell

RIGHT 2 conversion v33c Axin STOICHIOMETRY
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

GSK3b
type: Protein
xref: P49841

EGF
type: PhysicalEntity
member physical entity: EGF
cellular location: Cell

LEFT 1 conversion v33a Axin STOICHIOMETRY
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

RIGHT 0 conversion v19b pPI3K STOICHIOMETRY
type: Stoichiometry
physical entity: pPI3K
stoichiometric coefficient: 1.0

pSOS
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

Akt
type: PhysicalEntity
member physical entity: Akt
cellular location: Cell

pRap1
type: PhysicalEntity
member physical entity: pRap1
cellular location: Cell

LEFT 0 conversion v8b RasGap STOICHIOMETRY
type: Stoichiometry
physical entity: RasGap
stoichiometric coefficient: 1.0

pGSK3B
type: PhysicalEntity
member physical entity: pGSK3b
cellular location: Cell

map04310
type: UnificationXref
id: map04310
db: KEGG Pathway

RIGHT 0 conversion v12 MEK STOICHIOMETRY
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

LEFT 1 conversion v27a GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

Dsha
type: PhysicalEntity
member physical entity: Dsha
cellular location: Cell

RIGHT 0 conversion v33b null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

LEFT 0 conversion v15b pRKIP STOICHIOMETRY
type: Stoichiometry
physical entity: pRKIP
stoichiometric coefficient: 1.0

LEFT 3 conversion v5 SOS STOICHIOMETRY
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

BIOMD0000000623
type: UnificationXref
id: BIOMD0000000623
db: BioModels Database

Axin
type: Protein
xref: O15169

RIGHT 0 conversion v41 null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

RIGHT 0 conversion bRaf dephosphorylation pAkt modifier pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

RIGHT 1 conversion v30 APCAxin STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxin
stoichiometric coefficient: 1.0

LEFT 0 conversion v10b pAkt STOICHIOMETRY
type: Stoichiometry
physical entity: pAkt
stoichiometric coefficient: 1.0

fEGFR
type: PhysicalEntity
member physical entity: freeEGFR
cellular location: Cell

RIGHT 0 conversion v31 APCAxinGSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: APCAxinGSK3B
stoichiometric coefficient: 1.0

LEFT 0 conversion v39 TCFBCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: TCFBCatenin
stoichiometric coefficient: 1.0

P90Rsk
type: PhysicalEntity
member physical entity: P90Rsk
cellular location: Cell

pC3G
type: Protein
xref: P01024

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

TCF
type: Protein
xref: Q9UJU2

PKCD
type: Protein
xref: Q05655

pEGFR
type: PhysicalEntity
member physical entity: pEGFR
cellular location: Cell

LEFT 1 conversion v22a Akt STOICHIOMETRY
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

Raf1
type: PhysicalEntity
member physical entity: Raf1
cellular location: Cell

RIGHT 0 conversion v30 GSK3B STOICHIOMETRY
type: Stoichiometry
physical entity: GSK3B
stoichiometric coefficient: 1.0

pRKIP
type: Protein
xref: P30086

RafPPtase
type: PhysicalEntity
member physical entity: RafPPtase
cellular location: Cell

RIGHT 0 conversion v11a pBRaf STOICHIOMETRY
type: Stoichiometry
physical entity: pBRaf
stoichiometric coefficient: 1.0

BRaf
type: PhysicalEntity
member physical entity: bRaf
cellular location: Cell

RIGHT 0 conversion v15c null STOICHIOMETRY
type: Stoichiometry
physical entity: null
stoichiometric coefficient: 1.0

pRKIP
type: PhysicalEntity
member physical entity: pRKIP
cellular location: Cell

pSOS
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

GSK3B
type: PhysicalEntity
member physical entity: GSK3b
cellular location: Cell

LEFT 0 conversion v5 PKCD STOICHIOMETRY
type: Stoichiometry
physical entity: PKCD
stoichiometric coefficient: 1.0

P20936
type: UnificationXref
id: P20936
db: UniProt Knowledgebase

pERK
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

pBRaf
type: PhysicalEntity
member physical entity: pbRaf
cellular location: Cell

pP90Rsk
type: PhysicalEntity
member physical entity: pP90Rsk
cellular location: Cell

LEFT 0 conversion v18a pP90Rsk STOICHIOMETRY
type: Stoichiometry
physical entity: pP90Rsk
stoichiometric coefficient: 1.0

P60484
type: UnificationXref
id: P60484
db: UniProt Knowledgebase

LEFT 0 conversion v37c BCatenin STOICHIOMETRY
type: Stoichiometry
physical entity: BCatenin
stoichiometric coefficient: 1.0

Ras
type: PhysicalEntity
member physical entity: Ras
cellular location: Cell

LEFT 0 conversion v10a RafPPtase STOICHIOMETRY
type: Stoichiometry
physical entity: RafPPtase
stoichiometric coefficient: 1.0

EGF
type: Protein
xref: P01133

LEFT 1 conversion v10b pRaf1 STOICHIOMETRY
type: Stoichiometry
physical entity: pRaf1
stoichiometric coefficient: 1.0

RIGHT 2 conversion v30 Dsha STOICHIOMETRY
type: Stoichiometry
physical entity: Dsha
stoichiometric coefficient: 1.0

GO:0072376
type: UnificationXref
id: GO:0072376
db: Gene Ontology

freeEGFR
type: Protein
xref: P00533

pAkt
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

BCatenin
type: PhysicalEntity
member physical entity: bCatenin
cellular location: Cell

Padala2017 ERK PI3K Akt and Wnt signalling network normal
type: Pathway
pathway component: APC and Axin phosphorylation (in compound)
pathway component: APC and Axin dephosphorylation (in compound)
pathway component: bRaf phosphorylation (pRap1 modifier)
pathway component: PIP2 phosphorylated to PIP3
pathway component: PIP3 dephosphorylated to PIP2
pathway component: Rap1 phosphorylation (pC3G modifier)
pathway component: bRaf dephosphorylation (pAkt modifier)
pathway component: Rap1 dephosphorylation (Rap1_GAP modifer)
pathway component: Dsh activation
pathway component: Raf1 phosphorylation (pRas modifier)
pathway component: Dsh deactivation
pathway component: Raf1 phosphorylation (X modifier)
pathway component: bRaf phosphorylation (pRas modifier)
pathway component: MEK phosphorylation (pRaf1, pRKIP and RKIP modifiers)
pathway component: MEK phosphorylation (pbRaf modifier)
pathway component: C3G dephosphorylation
pathway component: RKIP dephosphorylation
pathway component: GSK3b synthesis
pathway component: RKIP phosphorylation (pERK modifier)
pathway component: GSK3b phosphorylation (pAkt modifier)
pathway component: C3G phosphorylation (boundEGFR modifier)
pathway component: RKIP degradation
pathway component: GSK3b dephosphorylation
pathway component: APC_Axin_GSK3b complex formation
pathway component: APC_Axin_GSK3b complex disassembly (Dsha modifier)
pathway component: bCatenin phosphorylation (in compond)
pathway component: pAPC_pAxin_GSK3b_bCatenin complex formation
pathway component: pAPC_pAxin_GSK3b_pbCatenin complex disassembly
pathway component: X synthesis
pathway component: bCatenin_TCF complex binding
pathway component: PI3K phosphorylation (pRas modifier)
pathway component: SOS dephosphorylation (pP90Rsk modifier)
pathway component: PI3K phosphorylation (boundEGFR modifier)
pathway component: SOS dephosphorylation
pathway component: GSK3b phosphorylation (pERK modifier)
pathway component: PI3K dephosphorylation
pathway component: bRaf dephosphorylation (RafPPtase modifier)
pathway component: Raf1 dephosphorylation (RafPPtase modifier)
pathway component: Akt dephosphorylation
pathway component: Akt phosphorylation (PIP3 modifier)
pathway component: Raf1 dephosphorylation (pAkt modifier)
pathway component: EGFR dephosphorylation
pathway component: PKCD degradation
pathway component: EGFR binding
pathway component: PKCD synthesis
pathway component: freeEGFR degradation
pathway component: boundEGFR degradation
pathway component: X degradation
pathway component: SOS phosphorylation (PKCD. pERK and boundEGFR modifiers)
pathway component: Ras phosphorylation (pSOS modifier)
pathway component: pbCatenin degradation
pathway component: P90Rsk dephosphorylation
pathway component: P90Rsk phosphorylation (pERK modifier)
pathway component: Axin degradation
pathway component: APC_Axin complex formation
pathway component: Axin synthesis
pathway component: bCatenin synthesis
pathway component: APC_bCatenin complex formation
pathway component: bCatenin degradation
pathway component: ERK phosphorylation (pMEK modifier)
pathway component: MEK dephosphorylation (PP2A modifer)
pathway component: ERK dephosphorylation (PP2A modifer)
pathway component: Ras dephosphorylation (Ras_Gap modifier)
pathway component: Ras synthesis
xref: BIOMD0000000033
xref: GO:0060828
xref: MODEL1708290005
xref: GO:0000165
xref: GO:0043408
xref: http://identifiers.org/pubmed/21391741
xref: http://identifiers.org/pubmed/28367561
xref: map04310
xref: map04151
xref: BIOMD0000000648
xref: map04010
xref: BIOMD0000000623
xref: GO:0051896
xref: BIOMD0000000149
xref: MAMO_0000046

TCFBCatenin
type: PhysicalEntity
member physical entity: bCatenin_TCF
cellular location: Cell