RIGHT 0 conversion Erk Feedback Deactivation Raf1 species 11
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 11
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 12 species 13
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 13
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion mTORC1 Activation Akt mTORC1Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC1Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

D10064
type: unificationXref
ID: D10064

http://identifiers.org/ec-code/2.7.12.2
type: unificationXref
ID: 2.7.12.2
DB: Enzyme Nomenclature

P67775
type: unificationXref
ID: P67775
DB: UniProt Knowledgebase

BIOMD0000000666
type: unificationXref
ID: BIOMD0000000666
DB: BioModels Database

LEFT 0 conversion reaction 19 species 6
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 6
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 15 species 15
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 15
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion PDK1 Deactivation PDK1Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: PDK1Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 22 species 20
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 20
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 16 species 14
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 14
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

Q02750
type: unificationXref
ID: Q02750
DB: UniProt Knowledgebase

Q07889
type: unificationXref
ID: Q07889
DB: UniProt Knowledgebase

CHEBI:75045
type: unificationXref
ID: CHEBI:75045
DB: ChEBI

RIGHT 0 conversion reaction 23 species 21
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 21
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

Q15118
type: unificationXref
ID: Q15118
DB: UniProt Knowledgebase

RIGHT 0 conversion Akt Activation PDK1 species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

C17660
type: unificationXref
ID: C17660

RIGHT 0 conversion reaction 13 species 3
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 3
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion S6K1 Activation mTORC1 S6K1Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: S6K1Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Akt Activation PDK1 species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/ec-code/2.7.11.1
type: unificationXref
ID: 2.7.11.1
DB: Enzyme Nomenclature

http://identifiers.org/ec-code/2.7.11.2
type: unificationXref
ID: 2.7.11.2
DB: Enzyme Nomenclature

P10301
type: unificationXref
ID: P10301
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 17 species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K06277
type: unificationXref
ID: K06277

RIGHT 0 conversion PDK1 Deactivation PDK1Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: PDK1Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Akt Feedback Deactivation CTMP species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 8 species 8
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 8
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 27 species 9
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 9
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

P42345
type: unificationXref
ID: P42345
DB: UniProt Knowledgebase

GO:0030971
type: unificationXref
ID: GO:0030971
DB: Gene Ontology

LEFT 0 conversion Erk Feedback Deactivation Raf1 species 10
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 10
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 0 species 25
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 25
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

P62834
type: unificationXref
ID: P62834
DB: UniProt Knowledgebase

P56279
type: unificationXref
ID: P56279
DB: UniProt Knowledgebase

LEFT 0 conversion Akt Feedback Activation TCL1 species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 21 species 20
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 20
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion IRS1 Feedback Deactivation S6K1 IRS1Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

map04151
type: unificationXref
ID: map04151
DB: KEGG Pathway

LEFT 0 conversion reaction 14 species 15
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 15
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 28 species 30
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 30
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/efo/0007815
type: unificationXref
ID: 0007815
DB: Experimental Factor Ontology

GO:0031932
type: unificationXref
ID: GO:0031932
DB: Gene Ontology

GO:0031931
type: unificationXref
ID: GO:0031931
DB: Gene Ontology

LEFT 0 conversion reaction 5 species 7
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 7
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

P28482
type: unificationXref
ID: P28482
DB: UniProt Knowledgebase

K16339
type: unificationXref
ID: K16339

P35568
type: unificationXref
ID: P35568
DB: UniProt Knowledgebase

K04352
type: unificationXref
ID: K04352

K04353
type: unificationXref
ID: K04353

P15056
type: unificationXref
ID: P15056
DB: UniProt Knowledgebase

P04049
type: unificationXref
ID: P04049
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 14 species 14
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 14
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion PIP3 Activation PIP3Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: PIP3Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/efo/0000756
type: unificationXref
ID: 0000756
DB: Experimental Factor Ontology

GO:1990565
type: unificationXref
ID: GO:1990565
DB: Gene Ontology

LEFT 0 conversion reaction 10 species 10
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 10
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 9 species 11
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 11
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 0 species 0
type: physicalEntityParticipant
PHYSICAL-ENTITY: species_0
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Akt Activation PIP3 species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K04688
type: unificationXref
ID: K04688

LEFT 0 conversion reaction 29 species 1
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 1
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

C40430
type: unificationXref
ID: C40430

RIGHT 0 conversion S6K1 Activation mTORC1 S6K1Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: S6K1Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K07829
type: unificationXref
ID: K07829

RIGHT 0 conversion bRafMutated Production bRafMutated
type: physicalEntityParticipant
PHYSICAL-ENTITY: bRafMutated
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 1 species 2
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 2
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

map04010
type: unificationXref
ID: map04010
DB: KEGG Pathway

RIGHT 0 conversion PDK1 Activation PDK1Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: PDK1Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K12077
type: unificationXref
ID: K12077

RIGHT 0 conversion reaction 10 species 11
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 11
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 21 species 19
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 19
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 4 species 4
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 4
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 12 species 12
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 12
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion PI3K Activation IRS1 species 14
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 14
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 15 species 14
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 14
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion PDK1 Activation PDK1Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: PDK1Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K05111
type: unificationXref
ID: K05111

Q13905
type: unificationXref
ID: Q13905
DB: UniProt Knowledgebase

RIGHT 0 conversion Akt Feedback Deactivation PP2A species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 6 species 7
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 7
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 13 species 2
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 2
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Akt Feedback Activation mTORC2 species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 23 species 22
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 22
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion PI3K Activation IRS1 species 15
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 15
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion bRafMutated Production probRafMutated
type: physicalEntityParticipant
PHYSICAL-ENTITY: probRafMutated
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 3 species 5
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 5
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

PR:000005201
type: unificationXref
ID: PR:000005201

RIGHT 0 conversion reaction 7 species 8
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 8
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion PIP3 Activation PIP3Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: PIP3Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/ec-code/2.7.1.137
type: unificationXref
ID: 2.7.1.137
DB: Enzyme Nomenclature

K04365
type: unificationXref
ID: K04365

K04366
type: unificationXref
ID: K04366

P47736
type: unificationXref
ID: P47736
DB: UniProt Knowledgebase

K04368
type: unificationXref
ID: K04368

K16340
type: unificationXref
ID: K16340

RIGHT 0 conversion reaction 8 species 9
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 9
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 16 species 15
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 15
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

C20424
type: unificationXref
ID: C20424

RIGHT 0 conversion bRaf Deactivation Dabrafenib bRafMutatedInactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: bRafMutatedInactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

Q5T1C6
type: unificationXref
ID: Q5T1C6
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 9 species 10
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 10
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Akt Feedback Activation HSP90 Cdc37 species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Akt Feedback Activation mTORC2 species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

C05981
type: unificationXref
ID: C05981
DB: KEGG Compound

K01090
type: unificationXref
ID: K01090

RIGHT 0 conversion reaction 28 species 1
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 1
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 5 species 6
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 6
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion PIP3 Feedback Deactivation PTEN PIP3Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: PIP3Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

P23443
type: unificationXref
ID: P23443
DB: UniProt Knowledgebase

RIGHT 0 conversion reaction 19 species 7
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 7
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K03099
type: unificationXref
ID: K03099

LEFT 0 conversion reaction 17 species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Sos Feedback Deactivation Erk species 2
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 2
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 11 species 13
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 13
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Akt Feedback Deactivation PHLPP species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 24 species 22
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 22
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K01110
type: unificationXref
ID: K01110

LEFT 0 conversion bRaf Deactivation Dabrafenib bRafMutated
type: physicalEntityParticipant
PHYSICAL-ENTITY: bRafMutated
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K17700
type: unificationXref
ID: K17700

http://identifiers.org/ec-code/2.7.10.1
type: unificationXref
ID: 2.7.10.1
DB: Enzyme Nomenclature

RIGHT 0 conversion Akt Feedback Activation HSP90 Cdc37 species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 3 species 4
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 4
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 1 conversion reaction 0 species 1
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 1
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion IRS1 Activation IRS1Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Dabrafenib degradation Dabrafenib
type: physicalEntityParticipant
PHYSICAL-ENTITY: Dabrafenib
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K16172
type: unificationXref
ID: K16172

http://identifiers.org/pubmed/27015094
type: publicationXref
ID: 27015094
DB: PubMed

RIGHT 0 conversion Akt Feedback Deactivation PHLPP species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

…
type: physicalEntityParticipant
PHYSICAL-ENTITY: mTORC1Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion PIP3 Feedback Deactivation PTEN PIP3Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: PIP3Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 6 species 6
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 6
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 24 species 21
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 21
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

MODEL1609190000
type: unificationXref
ID: MODEL1609190000
DB: BioModels Database

K10167
type: unificationXref
ID: K10167

RIGHT 0 conversion IRS1 Feedback Deactivation S6K1 IRS1Inactive
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1Inactive
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 4 species 5
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 5
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

BTO:0000848
type: unificationXref
ID: BTO:0000848
DB: Brenda Tissue Ontology

LEFT 0 conversion reaction 7 species 9
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 9
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

K00914
type: unificationXref
ID: K00914

P20936
type: unificationXref
ID: P20936
DB: UniProt Knowledgebase

P60484
type: unificationXref
ID: P60484
DB: UniProt Knowledgebase

LEFT 0 conversion Akt Feedback Deactivation PP2A species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

datasource 2
type: dataSource
XREF: MODEL1609190000
NAME: BioModels Database

LEFT 0 conversion reaction 22 species 19
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 19
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

PR:000029187
type: unificationXref
ID: PR:000029187

PR:000029189
type: unificationXref
ID: PR:000029189

RIGHT 0 conversion Sos Feedback Deactivation Erk species 3
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 3
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Akt Feedback Activation TCL1 species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

datasource 1
type: dataSource
XREF: BIOMD0000000666
NAME: BioModels Database

LEFT 0 conversion Akt Activation PIP3 species 17
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 17
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/ec-code/3.1.3.16
type: unificationXref
ID: 3.1.3.16
DB: Enzyme Nomenclature

LEFT 0 conversion Akt Feedback Deactivation CTMP species 16
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 16
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

Pappalardo2016 PI3K AKT and MAPK Signaling Pathways in Melanoma Cancer
type: pathway
XREF: BIOMD0000000666
XREF: map04151
XREF: http://identifiers.org/pubmed/27015094
XREF: http://identifiers.org/efo/0007815
XREF: http://identifiers.org/efo/0000756
XREF: map04010
XREF: MODEL1609190000
XREF: BTO:0000848
PATHWAY-COMPONENTS: conversion reaction 19
PATHWAY-COMPONENTS: conversion Akt Feedback Deactivation PHLPP
PATHWAY-COMPONENTS: conversion reaction 0
PATHWAY-COMPONENTS: conversion reaction 17
PATHWAY-COMPONENTS: conversion reaction 1
PATHWAY-COMPONENTS: conversion reaction 6
PATHWAY-COMPONENTS: conversion Erk Feedback Deactivation Raf1
PATHWAY-COMPONENTS: conversion reaction 7
PATHWAY-COMPONENTS: conversion PDK1 Deactivation
PATHWAY-COMPONENTS: conversion reaction 8
PATHWAY-COMPONENTS: conversion Akt Feedback Activation HSP90 Cdc37
PATHWAY-COMPONENTS: conversion reaction 9
PATHWAY-COMPONENTS: conversion reaction 3
PATHWAY-COMPONENTS: conversion Akt Feedback Deactivation PP2A
PATHWAY-COMPONENTS: conversion reaction 4
PATHWAY-COMPONENTS: conversion reaction 5
PATHWAY-COMPONENTS: conversion IRS1 Feedback Deactivation S6K1
PATHWAY-COMPONENTS: conversion PIP3 Activation
PATHWAY-COMPONENTS: conversion Akt Activation PIP3
PATHWAY-COMPONENTS: conversion reaction 11
PATHWAY-COMPONENTS: conversion reaction 12
PATHWAY-COMPONENTS: conversion S6K1 Activation mTORC1
PATHWAY-COMPONENTS: conversion reaction 10
PATHWAY-COMPONENTS: conversion reaction 15
PATHWAY-COMPONENTS: conversion reaction 16
PATHWAY-COMPONENTS: conversion PIP3 Feedback Deactivation PTEN
PATHWAY-COMPONENTS: conversion bRafMutated Production
PATHWAY-COMPONENTS: conversion reaction 13
PATHWAY-COMPONENTS: conversion reaction 14
PATHWAY-COMPONENTS: conversion reaction 28
PATHWAY-COMPONENTS: conversion reaction 29
PATHWAY-COMPONENTS: conversion Sos Feedback Deactivation Erk
PATHWAY-COMPONENTS: conversion Dabrafenib degradation
PATHWAY-COMPONENTS: conversion IRS1 Activation
PATHWAY-COMPONENTS: conversion Akt Feedback Activation mTORC2
PATHWAY-COMPONENTS: conversion Akt Feedback Deactivation CTMP
PATHWAY-COMPONENTS: conversion PI3K Activation IRS1
PATHWAY-COMPONENTS: conversion bRaf Deactivation Dabrafenib
PATHWAY-COMPONENTS: conversion Akt Activation PDK1
PATHWAY-COMPONENTS: conversion mTORC1 Activation Akt
PATHWAY-COMPONENTS: conversion reaction 22
PATHWAY-COMPONENTS: conversion reaction 23
PATHWAY-COMPONENTS: conversion reaction 20
PATHWAY-COMPONENTS: conversion reaction 21
PATHWAY-COMPONENTS: conversion reaction 27
PATHWAY-COMPONENTS: conversion PDK1 Activation
PATHWAY-COMPONENTS: conversion Akt Feedback Activation TCL1
PATHWAY-COMPONENTS: conversion reaction 24
COMMENT: The original model, 'Pappalardo2016___PI3K_AKT_and_MAPK_Signaling_Pathways_in_Melanoma_Cancer', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
COMMENT: This BioPAX Level2 file was automatically generated on Mar 15, 2018 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
DATA-SOURCE: datasource 2
DATA-SOURCE: datasource 1

LEFT 0 conversion reaction 1 species 3
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 3
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion reaction 20 species 0
type: physicalEntityParticipant
PHYSICAL-ENTITY: species_0
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion reaction 27 species 8
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 8
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion IRS1 Activation IRS1Active
type: physicalEntityParticipant
PHYSICAL-ENTITY: IRS1Active
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0

compartment_0
type: openControlledVocabulary
XREF: BTO:0000848
TERM: Melanoma cell

RIGHT 0 conversion reaction 11 species 12
type: physicalEntityParticipant
PHYSICAL-ENTITY: species 12
CELLULAR-LOCATION: compartment_0
STOICHIOMETRIC-COEFFICIENT: 1.0