C00025
type: UnificationXref
id: C00025
db: KEGG Compound

RIGHT 1 conversion FolC ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Glycine
type: PhysicalEntity
member physical entity: Glycine
cellular location: compartment

P31057
type: UnificationXref
id: P31057
db: UniProt Knowledgebase

CHEBI:25523
type: UnificationXref
id: CHEBI:25523
db: ChEBI

Thiaville2016 Folate pathway model with induced PanB reaction
type: Pathway
pathway component: FolK
pathway component: CH2-THF_drain
pathway component: FolP
pathway component: GlyA
pathway component: FolA
pathway component: p-ABA_production
pathway component: FolC
pathway component: PanB
pathway component: H2-HMPt_production
pathway component: THF_drain
xref: http://identifiers.org/ec-code/2.1.2.11
xref: CHEBI:67016
xref: MODEL1602280002
xref: http://identifiers.org/pubmed/27065985
xref: BIOMD0000000689
xref: GO:0046656
organism: biosource 1
comment: The original model, 'Thiaville2016___Folate_pathway_model_with_induced_PanB_reaction', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
comment: This BioPAX Level3 file was automatically generated on Mar 13, 2018 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
data source: BioModels Database

CHEBI:38797
type: UnificationXref
id: CHEBI:38797
db: ChEBI

R03503
type: UnificationXref
id: R03503
db: KEGG Reaction

CHEBI:38793
type: UnificationXref
id: CHEBI:38793
db: ChEBI

L_Glutamate
type: PhysicalEntity
member physical entity: L-Glutamate
cellular location: compartment

R03066
type: UnificationXref
id: R03066
db: KEGG Reaction

R03067
type: UnificationXref
id: R03067
db: KEGG Reaction

CH2_THF
type: PhysicalEntity
member physical entity: CH2-THF
cellular location: compartment

LEFT 0 conversion THF drain THF STOICHIOMETRY
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

GlyA
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion GlyA CH2 THF STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion GlyA THF STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion GlyA L serine STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion GlyA Glycine STOICHIOMETRY
xref: R00945
xref: P0A825
right: Glycine
right: CH2_THF
left: THF
left: L_serine

compartment
type: CellularLocationVocabulary

p_ABA
type: PhysicalEntity
member physical entity: p-ABA
cellular location: compartment

L-Glutamate
type: SmallMolecule
xref: C00025
xref: CHEBI:29987

RIGHT 1 conversion FolK H2 HMPterinPP STOICHIOMETRY
type: Stoichiometry
physical entity: H2_HMPterinPP
stoichiometric coefficient: 1.0

p_ABA
type: PhysicalEntity
member physical entity: p-ABA
cellular location: compartment

C00013
type: UnificationXref
id: C00013
db: KEGG Compound

C00415
type: UnificationXref
id: C00415
db: KEGG Compound

RIGHT 0 conversion H2 HMPt production H2 HMPt STOICHIOMETRY
type: Stoichiometry
physical entity: H2_HMPt
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/562
type: UnificationXref
id: 562
db: Taxonomy

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: compartment

RIGHT 0 conversion p ABA production p ABA STOICHIOMETRY
type: Stoichiometry
physical entity: p_ABA
stoichiometric coefficient: 1.0

CHEBI:16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

C00143
type: UnificationXref
id: C00143
db: KEGG Compound

C00020
type: UnificationXref
id: C00020
db: KEGG Compound

H2_HMPt
type: PhysicalEntity
member physical entity: H2-HMPt
cellular location: compartment

CH2_THF
type: PhysicalEntity
member physical entity: CH2-THF
cellular location: compartment

LEFT 0 conversion FolK ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

LEFT 0 conversion GlyA THF STOICHIOMETRY
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

DHF
type: SmallMolecule
xref: C00415
xref: CHEBI:57451

CH2_THF
type: PhysicalEntity
member physical entity: CH2-THF
cellular location: compartment

P0A825
type: UnificationXref
id: P0A825
db: UniProt Knowledgebase

C00568
type: UnificationXref
id: C00568
db: KEGG Compound

CHEBI:29987
type: UnificationXref
id: CHEBI:29987
db: ChEBI

CHEBI:57451
type: UnificationXref
id: CHEBI:57451
db: ChEBI

RIGHT 0 conversion FolA NADP STOICHIOMETRY
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Glycine
type: SmallMolecule
xref: C00037
xref: CHEBI:15428

H2-HMPt_production
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion H2 HMPt production H2 HMPt STOICHIOMETRY
right: H2_HMPt

CHEBI:12071
type: UnificationXref
id: CHEBI:12071
db: ChEBI

R02237
type: UnificationXref
id: R02237
db: KEGG Reaction

LEFT 0 conversion FolC L Glutamate STOICHIOMETRY
type: Stoichiometry
physical entity: L_Glutamate
stoichiometric coefficient: 1.0

THF
type: SmallMolecule
xref: CHEBI:67016
xref: C00101

Phosphate
type: SmallMolecule
xref: CHEBI:26020

DHF
type: PhysicalEntity
member physical entity: DHF
cellular location: compartment

GO:0016310
type: UnificationXref
id: GO:0016310
db: Gene Ontology

RIGHT 0 conversion FolC DHF STOICHIOMETRY
type: Stoichiometry
physical entity: DHF
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
xref: C00006
xref: CHEBI:25523

H2-Pteroate
type: SmallMolecule
xref: C00921
xref: CHEBI:38793

P26281
type: UnificationXref
id: P26281
db: UniProt Knowledgebase

C00037
type: UnificationXref
id: C00037
db: KEGG Compound

LEFT 0 conversion CH2 THF drain CH2 THF STOICHIOMETRY
type: Stoichiometry
physical entity: CH2_THF
stoichiometric coefficient: 1.0

RIGHT 0 conversion FolP PPi STOICHIOMETRY
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PPi
type: SmallMolecule
xref: C00013

P0AC13
type: UnificationXref
id: P0AC13
db: UniProt Knowledgebase

RIGHT 0 conversion PanB H2 HMPt STOICHIOMETRY
type: Stoichiometry
physical entity: H2_HMPt
stoichiometric coefficient: 1.0

CHEBI:67016
type: UnificationXref
id: CHEBI:67016
db: ChEBI

H2-HMPt
type: SmallMolecule
xref: C01300
xref: CHEBI:38797

MODEL1602280002
type: UnificationXref
id: MODEL1602280002
db: BioModels Database

LEFT 1 conversion FolC ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

THF
type: PhysicalEntity
member physical entity: THF
cellular location: compartment

CHEBI:16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

LEFT 1 conversion FolP H2 HMPterinPP STOICHIOMETRY
type: Stoichiometry
physical entity: H2_HMPterinPP
stoichiometric coefficient: 1.0

p-ABA_production
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion p ABA production p ABA STOICHIOMETRY
right: p_ABA

LEFT 1 conversion FolA NADPH STOICHIOMETRY
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
xref: C00002
xref: CHEBI:15422

L_serine
type: PhysicalEntity
member physical entity: L-serine
cellular location: compartment

RIGHT 0 conversion FolK AMP STOICHIOMETRY
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

RIGHT 0 conversion GlyA CH2 THF STOICHIOMETRY
type: Stoichiometry
physical entity: CH2_THF
stoichiometric coefficient: 1.0

C00101
type: UnificationXref
id: C00101
db: KEGG Compound

CH2-THF_drain
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion CH2 THF drain CH2 THF STOICHIOMETRY
left: CH2_THF

RIGHT 1 conversion FolA THF STOICHIOMETRY
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

DHF
type: PhysicalEntity
member physical entity: DHF
cellular location: compartment

CH2-THF
type: SmallMolecule
xref: C00143
xref: CHEBI:12071

P0ABQ4
type: UnificationXref
id: P0ABQ4
db: UniProt Knowledgebase

ADP
type: SmallMolecule
xref: CHEBI:16761
xref: C00008

H2_HMPt
type: PhysicalEntity
member physical entity: H2-HMPt
cellular location: compartment

RIGHT 2 conversion FolC Phosphate STOICHIOMETRY
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

AMP
type: PhysicalEntity
member physical entity: AMP
cellular location: compartment

CHEBI:17822
type: UnificationXref
id: CHEBI:17822
db: ChEBI

H2_Pteroate
type: PhysicalEntity
member physical entity: H2-Pteroate
cellular location: compartment

L-serine
type: SmallMolecule
xref: CHEBI:17822
xref: C00065

RIGHT 1 conversion FolP H2 Pteroate STOICHIOMETRY
type: Stoichiometry
physical entity: H2_Pteroate
stoichiometric coefficient: 1.0

H2-HMPterinPP
type: SmallMolecule
xref: C01300
xref: GO:0016310
xref: CHEBI:38797

PPi
type: PhysicalEntity
member physical entity: PPi
cellular location: compartment

P08192
type: UnificationXref
id: P08192
db: UniProt Knowledgebase

p_ABA
type: PhysicalEntity
member physical entity: p-ABA
cellular location: compartment

NADP
type: PhysicalEntity
member physical entity: NADP
cellular location: compartment

LEFT 0 conversion FolP p ABA STOICHIOMETRY
type: Stoichiometry
physical entity: p_ABA
stoichiometric coefficient: 1.0

C01300
type: UnificationXref
id: C01300
db: KEGG Compound

AMP
type: SmallMolecule
xref: CHEBI:16027
xref: C00020

p-ABA
type: SmallMolecule
xref: C00568
xref: CHEBI:17836

FolA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion FolA DHF STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion FolA THF STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion FolA NADP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion FolA NADPH STOICHIOMETRY
xref: R00939
xref: P0ABQ4
right: THF
right: NADP
left: DHF
left: NADPH

FolC
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion FolC L Glutamate STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion FolC ADP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion FolC ATP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion FolC DHF STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion FolC H2 Pteroate STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion FolC Phosphate STOICHIOMETRY
xref: P08192
xref: R02237
right: DHF
right: Phosphate
right: ADP
left: L_Glutamate
left: ATP
left: H2_Pteroate

LEFT 0 conversion PanB CH2 THF STOICHIOMETRY
type: Stoichiometry
physical entity: CH2_THF
stoichiometric coefficient: 1.0

RIGHT 1 conversion GlyA Glycine STOICHIOMETRY
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

LEFT 2 conversion FolC H2 Pteroate STOICHIOMETRY
type: Stoichiometry
physical entity: H2_Pteroate
stoichiometric coefficient: 1.0

FolK
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion FolK AMP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion FolK ATP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion FolK H2 HMPt STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion FolK H2 HMPterinPP STOICHIOMETRY
xref: R03503
xref: P26281
right: AMP
right: H2_HMPterinPP
left: ATP
left: H2_HMPt

LEFT 0 conversion FolA DHF STOICHIOMETRY
type: Stoichiometry
physical entity: DHF
stoichiometric coefficient: 1.0

FolP
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion FolP PPi STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion FolP H2 HMPterinPP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion FolP H2 Pteroate STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion FolP p ABA STOICHIOMETRY
xref: R03067
xref: P0AC13
right: H2_Pteroate
right: PPi
left: p_ABA
left: H2_HMPterinPP

http://identifiers.org/pubmed/27065985
type: PublicationXref
id: 27065985
db: PubMed

Phosphate
type: PhysicalEntity
member physical entity: Phosphate
cellular location: compartment

C00065
type: UnificationXref
id: C00065
db: KEGG Compound

NADPH
type: SmallMolecule
xref: C00005
xref: CHEBI:16474

C00005
type: UnificationXref
id: C00005
db: KEGG Compound

C00002
type: UnificationXref
id: C00002
db: KEGG Compound

C00921
type: UnificationXref
id: C00921
db: KEGG Compound

C00008
type: UnificationXref
id: C00008
db: KEGG Compound

C00006
type: UnificationXref
id: C00006
db: KEGG Compound

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: compartment

PanB
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion PanB p ABA STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion PanB CH2 THF STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion PanB H2 HMPt STOICHIOMETRY
xref: P31057
xref: R03066
right: H2_HMPt
right: p_ABA
left: CH2_THF

NADPH
type: PhysicalEntity
member physical entity: NADPH
cellular location: compartment

GO:0046656
type: UnificationXref
id: GO:0046656
db: Gene Ontology

THF_drain
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion THF drain THF STOICHIOMETRY
left: THF

H2_HMPterinPP
type: PhysicalEntity
member physical entity: H2-HMPterinPP
cellular location: compartment

http://identifiers.org/ec-code/2.1.2.11
type: UnificationXref
id: 2.1.2.11
db: Enzyme Nomenclature

CHEBI:16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

H2_HMPterinPP
type: PhysicalEntity
member physical entity: H2-HMPterinPP
cellular location: compartment

THF
type: PhysicalEntity
member physical entity: THF
cellular location: compartment

CHEBI:15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

CHEBI:15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

RIGHT 1 conversion PanB p ABA STOICHIOMETRY
type: Stoichiometry
physical entity: p_ABA
stoichiometric coefficient: 1.0

LEFT 1 conversion GlyA L serine STOICHIOMETRY
type: Stoichiometry
physical entity: L_serine
stoichiometric coefficient: 1.0

LEFT 1 conversion FolK H2 HMPt STOICHIOMETRY
type: Stoichiometry
physical entity: H2_HMPt
stoichiometric coefficient: 1.0

BIOMD0000000689
type: UnificationXref
id: BIOMD0000000689
db: BioModels Database

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: compartment

BioModels Database
type: Provenance
xref: BIOMD0000000689

BioModels Database
type: Provenance
xref: MODEL1602280002

R00945
type: UnificationXref
id: R00945
db: KEGG Reaction

H2_HMPt
type: PhysicalEntity
member physical entity: H2-HMPt
cellular location: compartment

H2_Pteroate
type: PhysicalEntity
member physical entity: H2-Pteroate
cellular location: compartment

BioModels Database
type: Provenance
xref: MODEL1602280002

THF
type: PhysicalEntity
member physical entity: THF
cellular location: compartment

R00939
type: UnificationXref
id: R00939
db: KEGG Reaction

CHEBI:17836
type: UnificationXref
id: CHEBI:17836
db: ChEBI

CHEBI:26020
type: UnificationXref
id: CHEBI:26020
db: ChEBI