This is a mathematical model describing the treatment of tumors using oncolytic virus and chemotherapy. The model is comprised of nonlinear ordinary differential equations describing the interactions between uninfected tumor cells, infected tumor cells, an oncolytic virus, and chemotherapy.

Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-11-27T15:46:32Z 2019-11-27T15:46:32Z 2019-11-27T15:46:32Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI 2019-11-27T15:50:49Z

v v

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r U I K r U 1 U I K

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delta U C K_c delta U C K_c C

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beta U V I alpha beta U V U I alpha

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delta_I I C K_c delta_I I C K_c C

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b delta I b delta I

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compartment Function_for_Tumor_Growth r U I K

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compartment Function_for_Tumor_Cell_Infection beta U V I alpha

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compartment Function_for_Uninfected_Tumor_Lysis_Drug delta_u U C K_c

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compartment Function_for_Infected_Tumor_Lysis_Drug delta_i I C K_c

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compartment delta I

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compartment Function_for_Virus_Production b delta I

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compartment gamma V

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compartment Constant_flux__irreversible mu

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compartment psi C