E3_MisP_Ub7
type: PhysicalEntity
member physical entity: E3_MisP_Ub7
cellular location: cytosol

RIGHT 0 conversion ProteasomeBindingUb8 E3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionGrowth2 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

E3_MisP_Ub3
type: PhysicalEntity
member physical entity: E3_MisP_Ub3
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cytosol

RIGHT 2 conversion AsynDamInclusionGrowth14 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 4.0

aggUchl1dam
type: PhysicalEntity
member physical entity: aggUchl1dam
cellular location: cytosol

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5
cellular location: cytosol

MisP_Ub8_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub8_Proteasome
cellular location: cytosol

E3_MisP_Ub2
type: PhysicalEntity
member physical entity: E3_MisP_Ub2
cellular location: cytosol

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion DeubiquitinationBoundMisP5 MisP Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub7_Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion Aggregation2 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

E3_MisP_Ub4
type: PhysicalEntity
member physical entity: E3_MisP_Ub4
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E3_MisP_Ub6
type: PhysicalEntity
member physical entity: E3_MisP_Ub6
cellular location: cytosol

LEFT 0 conversion Polyubiquitination1 E3 MisP Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub
stoichiometric coefficient: 1.0

E3_MisP_Ub6
type: PhysicalEntity
member physical entity: E3_MisP_Ub6
cellular location: cytosol

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

Parkin_asyn_dam_Ub3
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3
cellular location: cytosol

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

LEFT 1 conversion AsynDUBbindingUb2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

E1
type: PhysicalEntity
member physical entity: E1
cellular location: cytosol

RIGHT 1 conversion ProteasomeActivity3 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

AggA1ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

LEFT 1 conversion AsynDamInclusionGrowth11 Parkin asyn dam Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub_DUB
stoichiometric coefficient: 1.0

RIGHT 2 conversion DeubiquitinationBoundMisP2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDegradationUb6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 6.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

RIGHT 0 conversion AsynDUBbindingUb2 Parkin asyn dam Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2_DUB
stoichiometric coefficient: 1.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundasynDamUb7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 4 conversion InclusionGrowth11 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggP3 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDegradationUb6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDisaggregation1 AggS4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS4
stoichiometric coefficient: 1.0

E3_MisP_Ub
type: PhysicalEntity
member physical entity: E3_MisP_Ub
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggD2 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

RIGHT 3 conversion SUBInclusionGrowth10 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 1.0

RIGHT 0 conversion ProteasomeInhibition2 AggP Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: AggP_Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDUBbindingUb4 Parkin asyn dam Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4
stoichiometric coefficient: 1.0

LEFT 1 conversion AggregationAsynDam2 AggD1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 0 conversion SUBDeubiquitination3 E3SUB SUB misfolded Ub3 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
stoichiometric coefficient: 1.0

RIGHT 3 conversion InclusionGrowth16 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggA5 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBDegradationUb7 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

RIGHT 0 conversion Deubiquitination4 E3 MisP Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDeubiquitination6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth11 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

E3_MisP_Ub2_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub2_DUB
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

E3_MisP_Ub2
type: PhysicalEntity
member physical entity: E3_MisP_Ub2
cellular location: cytosol

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

Parkin_asyn_dam_Ub5
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5
cellular location: cytosol

RIGHT 1 conversion SUBInclusionGrowth14 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion SUBPolyubiquitination3 E3SUB SUB misfolded Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub3
stoichiometric coefficient: 1.0

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

asyn_Lamp2a
type: PhysicalEntity
member physical entity: asyn_Lamp2a
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 1 conversion UCHL1damage ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

E3_MisP_Ub4
type: PhysicalEntity
member physical entity: E3_MisP_Ub4
cellular location: cytosol

RIGHT 2 conversion InclusionGrowth12 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 2.0

SUB_misfolded_Ub5_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub5_Proteasome
cellular location: cytosol

RIGHT 1 conversion AsynDamInclusionGrowth12 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

E3SUBBinding
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion E3SUBBinding SUB misfolded STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion E3SUBBinding E3SUB SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion E3SUBBinding E3SUB STOICHIOMETRY
right: E3SUB_SUB_misfolded
left: SUB_misfolded
left: E3SUB

AggD5ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

LEFT 1 conversion SUBInclusionGrowth7 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

asyn_dam_Ub4_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub4_Proteasome
cellular location: cytosol

LEFT 1 conversion AsynDUBbindingUb6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBProteasomeBindingUb8 E3SUB SUB misfolded Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub8
stoichiometric coefficient: 1.0

LEFT 1 conversion Polyubiquitination2 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

RIGHT 1 conversion Deubiquitination6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth17 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBInclusionGrowth10 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynPolyubiquitination4 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

GO:0005764
type: UnificationXref
id: GO:0005764
db: Gene Ontology

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth17 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth7 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 0 conversion E3SUBBinding E3SUB SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded
stoichiometric coefficient: 1.0

RIGHT 1 conversion DeubiquitinationBoundasynDamUb4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDamInclusionGrowth18 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 3 conversion DeubiquitinationBoundMisP1 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion E3SUBRelease E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth6 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDegradationUb8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 8.0

RIGHT 1 conversion DeubiquitinationBoundasyn damUb8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

LEFT 0 conversion AsynPolyubiquitination1 Parkin asyn dam Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggU1 AggU1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU1
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth1 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

asyn_dam_Ub4_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub4_Proteasome
cellular location: cytosol

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

RIGHT 1 conversion Polyubiquitination6 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

AsynDamInclusionFormation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDamInclusionFormation asyn dam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionFormation AggD5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionFormation SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionFormation aggasyndam STOICHIOMETRY
right: aggasyndam
right: SeqAggP
left: asyn_dam
left: AggD5

aggE3
type: Protein
xref: IPR000569

LEFT 1 conversion AsynPolyubiquitination7 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

asyn_Lamp2a
type: PhysicalEntity
member physical entity: asyn_Lamp2a
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundSUB7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Polyubiquitination1
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion Polyubiquitination1 E3 MisP Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Polyubiquitination1 E2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Polyubiquitination1 E2 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Polyubiquitination1 E3 MisP Ub STOICHIOMETRY
right: E2
right: E3_MisP_Ub2
spontaneous: true
left: E3_MisP_Ub
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

LEFT 1 conversion ProteasomeActivity4 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

LEFT 0 conversion DisaggregationAsynDam4 AggD2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD2
stoichiometric coefficient: 1.0

Polyubiquitination6
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion Polyubiquitination6 E2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Polyubiquitination6 E3 MisP Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Polyubiquitination6 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Polyubiquitination6 E3 MisP Ub7 STOICHIOMETRY
right: E3_MisP_Ub7
right: E2
spontaneous: true
left: E2_Ub
left: E3_MisP_Ub6
conversion direction: RIGHT_TO_LEFT

Polyubiquitination7
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion Polyubiquitination7 E3 MisP Ub8 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Polyubiquitination7 E2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Polyubiquitination7 E3 MisP Ub7 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Polyubiquitination7 E2 Ub STOICHIOMETRY
right: E2
right: E3_MisP_Ub8
spontaneous: true
left: E2_Ub
left: E3_MisP_Ub7
conversion direction: RIGHT_TO_LEFT

Polyubiquitination2
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion Polyubiquitination2 E3 MisP Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Polyubiquitination2 E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Polyubiquitination2 E3 MisP Ub3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Polyubiquitination2 E2 Ub STOICHIOMETRY
right: E2
right: E3_MisP_Ub3
spontaneous: true
left: E3_MisP_Ub2
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

E3SUB_SUB_misfolded_Ub4
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4
cellular location: cytosol

Polyubiquitination3
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion Polyubiquitination3 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Polyubiquitination3 E2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Polyubiquitination3 E3 MisP Ub3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Polyubiquitination3 E3 MisP Ub4 STOICHIOMETRY
right: E3_MisP_Ub4
right: E2
spontaneous: true
left: E2_Ub
left: E3_MisP_Ub3
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion Deubiquitination2 E3 MisP Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2_DUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

SUB_misfolded_Ub4_Proteasome
type: Complex
xref: P62988
xref: GO:0000502

Polyubiquitination4
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion Polyubiquitination4 E3 MisP Ub5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Polyubiquitination4 E3 MisP Ub4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Polyubiquitination4 E2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Polyubiquitination4 E2 Ub STOICHIOMETRY
right: E2
right: E3_MisP_Ub5
spontaneous: true
left: E2_Ub
left: E3_MisP_Ub4
conversion direction: RIGHT_TO_LEFT

Polyubiquitination5
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion Polyubiquitination5 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Polyubiquitination5 E2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Polyubiquitination5 E3 MisP Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Polyubiquitination5 E3 MisP Ub6 STOICHIOMETRY
right: E3_MisP_Ub6
right: E2
spontaneous: true
left: E3_MisP_Ub5
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion AsynDamInclusionGrowth18 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 2 conversion SUBDeubiquitination1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

UCHL1ProteasomeBinding
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub4_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

AggP5
type: PhysicalEntity
member physical entity: AggP5
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth6 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBAggregation5 AggS4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS4
stoichiometric coefficient: 1.0

RIGHT 0 conversion Refolding NatP STOICHIOMETRY
type: Stoichiometry
physical entity: NatP
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth17 E3 MisP Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7_DUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 1 conversion InclusionGrowth16 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

SUB_misfolded_Ub4_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub4_Proteasome
cellular location: cytosol

E3_MisP_Ub4_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub4_DUB
cellular location: cytosol

LEFT 1 conversion Aggregationasyn2 AggA1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA1
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBInclusionGrowth5 E3SUB SUB misfolded Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4
stoichiometric coefficient: 1.0

ProteinSynthesis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ProteinSynthesis Source STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteinSynthesis NatP STOICHIOMETRY
right: NatP
left: Source

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth14 Parkin asyn dam Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4_DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynInclusionFormation SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

MisP_Ub8_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub8_Proteasome
cellular location: cytosol

LEFT 0 conversion Misfolding NatP STOICHIOMETRY
type: Stoichiometry
physical entity: NatP
stoichiometric coefficient: 1.0

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

E3_MisP_Ub5
type: PhysicalEntity
member physical entity: E3_MisP_Ub5
cellular location: cytosol

UCHL1Lamp2abinding
type: BiochemicalReaction

RIGHT 2 conversion AsynProteasomeActivityUb4 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AsynDamInclusionGrowth9
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth9 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth9 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth9 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth9 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth9 aggParkin STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth9 Parkin asyn dam Ub7 STOICHIOMETRY
right: SeqAggP
right: aggUb
right: aggasyndam
right: aggParkin
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub7
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion SUBInclusionGrowth8 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AsynDamInclusionGrowth7
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth7 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth7 Parkin asyn dam Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth7 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth7 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth7 aggasyndam STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth7 aggParkin STOICHIOMETRY
right: SeqAggP
right: aggParkin
right: aggUb
right: aggasyndam
spontaneous: true
left: Parkin_asyn_dam_Ub5
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion InclusionGrowth18 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AsynDamInclusionGrowth8
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth8 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth8 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth8 Parkin asyn dam Ub6 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth8 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth8 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth8 aggParkin STOICHIOMETRY
right: aggParkin
right: aggasyndam
right: aggUb
right: SeqAggP
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub6
conversion direction: RIGHT_TO_LEFT

AsynDamInclusionGrowth5
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth5 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth5 Parkin asyn dam Ub3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth5 aggasyndam STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth5 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth5 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth5 SeqAggP STOICHIOMETRY
right: aggParkin
right: aggasyndam
right: aggUb
right: SeqAggP
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub3
conversion direction: RIGHT_TO_LEFT

AsynDamInclusionGrowth6
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth6 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth6 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth6 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth6 aggasyndam STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth6 aggParkin STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth6 Parkin asyn dam Ub4 STOICHIOMETRY
right: SeqAggP
right: aggasyndam
right: aggParkin
right: aggUb
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub4
conversion direction: RIGHT_TO_LEFT

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

AsynDamInclusionGrowth3
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth3 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth3 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth3 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth3 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth3 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth3 Parkin asyn dam Ub STOICHIOMETRY
right: aggUb
right: SeqAggP
right: aggasyndam
right: aggParkin
spontaneous: true
left: Parkin_asyn_dam_Ub
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion SUBInclusionGrowth3 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

AsynDamInclusionGrowth4
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth4 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth4 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth4 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth4 aggParkin STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth4 Parkin asyn dam Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth4 SeqAggP STOICHIOMETRY
right: aggUb
right: aggParkin
right: aggasyndam
right: SeqAggP
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub2
conversion direction: RIGHT_TO_LEFT

AsynDamInclusionGrowth1
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth1 aggasyndam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth1 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth1 asyn dam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth1 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggasyndam
left: asyn_dam
left: SeqAggP

RIGHT 0 conversion radicalScavenging Sink STOICHIOMETRY
type: Stoichiometry
physical entity: Sink
stoichiometric coefficient: 1.0

AsynDamInclusionGrowth2
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth2 Parkin asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth2 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth2 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth2 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth2 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggParkin
right: aggasyndam
spontaneous: true
left: Parkin_asyn_dam
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

asynDamage
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion asynDamage ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion asynDamage asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion asynDamage asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion asynDamage ROS STOICHIOMETRY
right: ROS
right: asyn_dam
left: ROS
left: asyn

AggS5
type: PhysicalEntity
member physical entity: AggS5
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth1 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 2 conversion DeubiquitinationBoundMisP1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 4.0

SeqAggP
type: PhysicalEntity

RIGHT 2 conversion InclusionGrowth6 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 4.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggS3 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub7_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 1 conversion ProteasomeActivity4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUB_misfolded_Ub4_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub4_Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion SUBDisaggregation3 AggS2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS2
stoichiometric coefficient: 1.0

RIGHT 1 conversion Disaggregation3 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion Refolding MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

AggD5
type: PhysicalEntity
member physical entity: AggD5
cellular location: cytosol

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

Parkin_asyn_dam_Ub3
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggP2 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

LEFT 0 conversion Polyubiquitination7 E3 MisP Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDegradationUb7 SUB misfolded Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub7_Proteasome
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 0 conversion Aggregation1 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 2.0

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

RIGHT 1 conversion SUBInclusionFormation aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 7.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth6 Parkin asyn dam Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4
stoichiometric coefficient: 1.0

LEFT 0 conversion DeubiquitinationBoundSUB7 SUB misfolded Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub7_Proteasome
stoichiometric coefficient: 1.0

AggS5
type: PhysicalEntity
member physical entity: AggS5
cellular location: cytosol

LEFT 0 conversion Aggregation3 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth4 E3SUB SUB misfolded Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub3
stoichiometric coefficient: 1.0

RIGHT 0 conversion Aggregationasyn4 AggA4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA4
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth4 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 2.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

GO:0070841
type: UnificationXref
id: GO:0070841
db: Gene Ontology

LEFT 0 conversion ProteasomeInhibition3 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

asyn_damParkinRelease
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion asyn damParkinRelease Parkin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion asyn damParkinRelease Parkin asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion asyn damParkinRelease asyn dam STOICHIOMETRY
right: asyn_dam
right: Parkin
spontaneous: true
left: Parkin_asyn_dam
conversion direction: RIGHT_TO_LEFT

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion AsynDeubiquitinationUb2 Parkin asyn dam Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2_DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionGrowth17 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 1 conversion ROSgenerationSmallAggP2 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBPolyubiquitination3 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

SUBDisaggregation2
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion SUBDisaggregation2 SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDisaggregation2 AggS4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDisaggregation2 AggS3 STOICHIOMETRY
right: SUB_misfolded
right: AggS3
left: AggS4

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUBDisaggregation1
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion SUBDisaggregation1 SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDisaggregation1 AggS5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDisaggregation1 AggS4 STOICHIOMETRY
right: AggS4
right: SUB_misfolded
left: AggS5

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

E3SUB_SUB_misfolded_Ub6
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

LEFT 0 conversion AsynProteasomeBindingUb5 Parkin asyn dam Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5
stoichiometric coefficient: 1.0

AggP5
type: PhysicalEntity
member physical entity: AggP5
cellular location: cytosol

SUBDisaggregation5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBDisaggregation5 AggS1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDisaggregation5 SUB misfolded STOICHIOMETRY
right: SUB_misfolded
left: AggS1

RIGHT 0 conversion AggregationAsynDam1 AggD1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD1
stoichiometric coefficient: 1.0

SUBDisaggregation4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBDisaggregation4 AggS2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDisaggregation4 AggS1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDisaggregation4 SUB misfolded STOICHIOMETRY
right: AggS1
right: SUB_misfolded
left: AggS2

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

SUBDisaggregation3
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBDisaggregation3 AggS2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDisaggregation3 SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDisaggregation3 AggS3 STOICHIOMETRY
right: SUB_misfolded
right: AggS2
left: AggS3

RIGHT 2 conversion InclusionGrowth14 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 4.0

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth17 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cytosol

Parkin_asyn_dam_Ub7_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

AggU5
type: PhysicalEntity
member physical entity: AggU5
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3_MisP_Ub5_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub5_DUB
cellular location: cytosol

RIGHT 2 conversion AsynDegradationUb8 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

MisP_Ub4_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub4_Proteasome
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

LEFT 1 conversion Polyubiquitination4 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynPolyubiquitination4 Parkin asyn dam Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth13 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

UCHL1DamagedSequestering
type: BiochemicalReaction

LEFT 1 conversion InclusionGrowth8 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub5_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
cellular location: cytosol

SUBInclusionFormation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBInclusionFormation SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionFormation aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionFormation AggS5 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionFormation SUB misfolded STOICHIOMETRY
right: SeqAggP
right: aggSUB
left: AggS5
left: SUB_misfolded

SUB_misfolded_Ub5_Proteasome
type: Complex
xref: P62988
xref: GO:0000502

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

LEFT 0 conversion AggregationAsynDam5 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDamInclusionGrowth6 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 4.0

E3SUB_SUB_misfolded_Ub7
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7
cellular location: cytosol

LEFT 1 conversion Aggregation2 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDeubiquitinationUb1 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

asyn_dam_Ub6_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub6_Proteasome
cellular location: cytosol

RIGHT 0 conversion E1UbBinding E1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E1_Ub
stoichiometric coefficient: 1.0

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

RIGHT 0 conversion DisAggregationasyn5 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 2.0

RIGHT 1 conversion DisAggregationasyn2 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

UCHL1DamgedProteasomeBinding
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

RIGHT 1 conversion SUBInclusionGrowth7 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDeubiquitinationUb8 Parkin asyn dam Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDegradationUb7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth16 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 1 conversion Disaggregation1 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDeubiquitination2 E3SUB SUB misfolded Ub2 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
stoichiometric coefficient: 1.0

SUB
type: PhysicalEntity
member physical entity: SUB
cellular location: cytosol

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

GO:0004843
type: UnificationXref
id: GO:0004843
db: Gene Ontology

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

E3SUB_SUB_misfolded_Ub
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth2 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 0 conversion DeubiquitinationBoundSUB7 SUB misfolded Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub6_Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion Polyubiquitination5 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

SUBsynthesis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBsynthesis Source STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBsynthesis SUB STOICHIOMETRY
right: SUB
left: Source

asyn_Lamp2a
type: Complex
xref: P37840
xref: P13473

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 2 conversion AsynDamInclusionGrowth4 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 2.0

RIGHT 0 conversion DeubiquitinationBoundMisP1 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 1 conversion MisPDUBbinding3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub5
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5
cellular location: cytosol

E3_MisP_Ub8_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub8_DUB
cellular location: cytosol

LEFT 1 conversion SUBPolyubiquitination2 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

E1
type: PhysicalEntity
member physical entity: E1
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth2 Parkin asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam
stoichiometric coefficient: 1.0

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth17 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

RIGHT 0 conversion AggregationAsynDam3 AggD3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD3
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

BIOMD0000000293
type: UnificationXref
id: BIOMD0000000293
db: BioModels Database

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cytosol

LEFT 0 conversion Deubiquitination4 E3 MisP Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4_DUB
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth13 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

LEFT 1 conversion E2UbBinding E1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E1_Ub
stoichiometric coefficient: 1.0

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 0 conversion AsynProteasomeBindingUb7 Parkin asyn dam Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/20949132
type: PublicationXref
id: 20949132
db: PubMed

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion ProteasomeInhibition5 AggP5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP5
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

RIGHT 1 conversion AsynDegradationUb7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynInclusionGrowth asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggA1 AggA1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA1
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

RIGHT 3 conversion InclusionGrowth18 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

SUB
type: PhysicalEntity

LEFT 0 conversion MisPDUBbinding1 E3 MisP Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub
stoichiometric coefficient: 1.0

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 0 conversion radicalFormation ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

AggS5
type: PhysicalEntity
member physical entity: AggS5
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggU3 AggU3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU3
stoichiometric coefficient: 1.0

E3_MisP_Ub2_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub2_DUB
cellular location: cytosol

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

UCHL1DamagedProteasomeDegradation
type: ComplexAssembly
spontaneous: true
conversion direction: RIGHT_TO_LEFT

Parkin_asyn_dam_Ub6
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

asyn_dam_Ub7_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub7_Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion Aggregation4 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

AggD3ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

Parkin_asyn_dam_Ub_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub_DUB
cellular location: cytosol

LEFT 0 conversion AsynInclusionFormation asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

MisP_Ub8_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: CHEBI:36080

RIGHT 2 conversion SUBDegradationUb6 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

RIGHT 0 conversion InclusionGrowth3 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 1 conversion InclusionGrowth4 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDisaggregation3 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

RIGHT 3 conversion InclusionGrowth4 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

LEFT 1 conversion UbDegradation Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

E3_MisP_Ub4_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

RIGHT 0 conversion SUBPolyubiquitination6 E3SUB SUB misfolded Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 0 conversion MisPDUBbinding2 E3 MisP Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2_DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth15 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 1 conversion DisAggregationasyn3 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBInclusionGrowth5 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

NatP
type: PhysicalEntity
member physical entity: NatP
cellular location: cytosol

AggU5
type: PhysicalEntity
member physical entity: AggU5
cellular location: cytosol

RIGHT 0 conversion UbSynthesis Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

LEFT 1 conversion InclusionGrowth9 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AggU1ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion SUBInclusionGrowth3 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 1 conversion AsynDamInclusionGrowth10 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 3 conversion InclusionGrowth14 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

LEFT 0 conversion Disaggregation3 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub7
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7
cellular location: cytosol

E3_MisP_Ub2_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub2_DUB
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub2_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
cellular location: cytosol

LEFT 1 conversion AsynProteasomeActivityUb4 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBInclusionGrowth16 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

AggD5
type: PhysicalEntity
member physical entity: AggD5
cellular location: cytosol

Sink
type: PhysicalEntity

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 0 conversion Polyubiquitination5 E3 MisP Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5
stoichiometric coefficient: 1.0

Lamp2a
type: PhysicalEntity
member physical entity: Lamp2a
cellular location: cytosol

radicalFormation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion radicalFormation ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion radicalFormation Source STOICHIOMETRY
right: ROS
left: Source

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

UCHL1ProteasomeDegradation
type: ComplexAssembly
spontaneous: true
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion Polyubiquitination2 E3 MisP Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggU3 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion SUBRefolding SUB STOICHIOMETRY
type: Stoichiometry
physical entity: SUB
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

RIGHT 1 conversion ProteasomeActivity5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDegradationUb8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion Deubiquitination6 E3 MisP Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6_DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion AggregationAsynDam4 AggD3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD3
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDeubiquitination6 E3SUB SUB misfolded Ub6 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 1 conversion AsynMonoubiquitination E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

SUBmisfolding
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion SUBmisfolding ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBmisfolding SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBmisfolding SUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBmisfolding ROS STOICHIOMETRY
right: ROS
right: SUB_misfolded
left: ROS
left: SUB

SUB_misfolded_Ub8_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub8_Proteasome
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 3 conversion InclusionGrowth9 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

LEFT 0 conversion asynSynthesis1 Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 2.0

LEFT 0 conversion SUBPolyubiquitination1 E3SUB SUB misfolded Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub
stoichiometric coefficient: 1.0

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

LEFT 0 conversion SUBPolyubiquitination4 E3SUB SUB misfolded Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

LEFT 0 conversion AsynDUBbindingUb6 Parkin asyn dam Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6
stoichiometric coefficient: 1.0

RIGHT 2 conversion DeubiquitinationBoundasynDamUb4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 4.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

GO:0000502
type: UnificationXref
id: GO:0000502
db: Gene Ontology

LEFT 1 conversion SUBInclusionGrowth17 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

aggUb
type: Protein
xref: P62988

LEFT 0 conversion Aggregationasyn2 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

RIGHT 0 conversion DisaggregationAsynDam3 AggD2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD2
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDegradationUb7 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

RIGHT 1 conversion Deubiquitination1 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth11 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

NatP
type: PhysicalEntity
member physical entity: NatP
cellular location: cytosol

SUB_misfolded_Ub6_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub6_Proteasome
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggD2 AggD2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD2
stoichiometric coefficient: 1.0

AggD5
type: PhysicalEntity
member physical entity: AggD5
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

E3_MisP_Ub_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

E3SUB_SUB_misfolded_Ub3
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3
cellular location: cytosol

LEFT 0 conversion Aggregationasyn1 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 2.0

LEFT 0 conversion ROSgenerationSmallAggP5 AggP5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP5
stoichiometric coefficient: 1.0

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

RIGHT 0 conversion ProteasomeActivity5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 8.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 0 conversion Deubiquitination8 E3 MisP Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBInclusionGrowth6 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBDegradationUb5 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBInclusionGrowth16 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion DeubiquitinationBoundSUB5 SUB misfolded Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub4_Proteasome
stoichiometric coefficient: 1.0

AggS5
type: PhysicalEntity
member physical entity: AggS5
cellular location: cytosol

Parkin_asyn_dam
type: PhysicalEntity
member physical entity: Parkin_asyn_dam
cellular location: cytosol

LEFT 0 conversion SUBPolyubiquitination2 E3SUB SUB misfolded Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub2
stoichiometric coefficient: 1.0

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

LEFT 0 conversion SUBDeubiquitination4 E3SUB SUB misfolded Ub4 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
stoichiometric coefficient: 1.0

LEFT 0 conversion ProteasomeBindingUb6 E3 MisP Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6
stoichiometric coefficient: 1.0

RIGHT 3 conversion DeubiquitinationBoundSUB4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

MisP_Ub4_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub4_Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion Aggregation5 AggP5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP5
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 1 conversion AsynDegradationUb8 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MisP_Ub6_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub6_Proteasome
cellular location: cytosol

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion ProteasomeInhibition3 AggP Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: AggP_Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynPolyubiquitination2 Parkin asyn dam Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3
stoichiometric coefficient: 1.0

SUB
type: PhysicalEntity
member physical entity: SUB
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggA2 AggA2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA2
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggP5 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBInclusionGrowth7 E3SUB SUB misfolded Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDeubiquitination1 E3SUB SUB misfolded Ub UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
stoichiometric coefficient: 1.0

SUB_misfolded_Ub7_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub7_Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundMisP4 MisP Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub7_Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDUBbindingUb1 Parkin asyn dam Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDegradationUb5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

UCHL1DamInclusionFormation
type: BiochemicalReaction

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

LEFT 0 conversion SUBDisaggregation3 AggS3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS3
stoichiometric coefficient: 1.0

LEFT 1 conversion DeubiquitinationBoundMisP2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

LEFT 0 conversion E3SUBRelease E3SUB SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBAggregation2 AggS2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS2
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth5 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundMisP2 MisP Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub5_Proteasome
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

…
type: Stoichiometry
physical entity: E3_MisP
stoichiometric coefficient: 1.0

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth3 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 2.0

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

Parkin_asyn_dam_Ub
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub
cellular location: cytosol

LEFT 0 conversion Deubiquitination8 E3 MisP Ub8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8_DUB
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

LEFT 1 conversion ProteasomeActivity3 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth11 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

RIGHT 1 conversion ProteasomeActivity2 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

RIGHT 0 conversion asynDamage asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 1 conversion E1UbBinding AMP STOICHIOMETRY
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggU3 AggU3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU3
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth3 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

asynLamp2aBinding
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

E3_MisP_Ub6_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

LEFT 1 conversion AsynPolyubiquitination3 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

AggA5ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

E3_MisP_Ub8_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggS2 AggS2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS2
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

RIGHT 0 conversion DisAggregationasyn1 AggA4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA4
stoichiometric coefficient: 1.0

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

RIGHT 1 conversion SUBProteasomeBindingUb6 E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

RIGHT 1 conversion DisaggregationAsynDam4 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth2 E3 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth15 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBInclusionGrowth1 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

SUBDeubiquitination5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination5 E3SUB SUB misfolded Ub5 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination5 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination5 E3SUB SUB misfolded Ub4 UCHL1 STOICHIOMETRY
right: Ub
right: E3SUB_SUB_misfolded_Ub4_UCHL1
left: E3SUB_SUB_misfolded_Ub5_UCHL1

SUBDeubiquitination6
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination6 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination6 E3SUB SUB misfolded Ub6 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination6 E3SUB SUB misfolded Ub5 UCHL1 STOICHIOMETRY
right: Ub
right: E3SUB_SUB_misfolded_Ub5_UCHL1
left: E3SUB_SUB_misfolded_Ub6_UCHL1

SUBDeubiquitination7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination7 E3SUB SUB misfolded Ub7 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination7 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination7 E3SUB SUB misfolded Ub6 UCHL1 STOICHIOMETRY
right: Ub
right: E3SUB_SUB_misfolded_Ub6_UCHL1
left: E3SUB_SUB_misfolded_Ub7_UCHL1

SUBDeubiquitination8
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination8 E3SUB SUB misfolded Ub7 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination8 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination8 E3SUB SUB misfolded Ub8 UCHL1 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub7_UCHL1
right: Ub
left: E3SUB_SUB_misfolded_Ub8_UCHL1

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion Deubiquitination6 E3 MisP Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5_DUB
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 1 conversion Disaggregation2 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

SUBDeubiquitination1
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion SUBDeubiquitination1 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination1 E3SUB SUB misfolded Ub UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination1 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination1 E3SUB SUB misfolded STOICHIOMETRY
right: E3SUB_SUB_misfolded
right: UCHL1
right: Ub
spontaneous: true
left: E3SUB_SUB_misfolded_Ub_UCHL1
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion SUBDegradationUb5 SUB misfolded Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub5_Proteasome
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

SUBDeubiquitination2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination2 E3SUB SUB misfolded Ub UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination2 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination2 E3SUB SUB misfolded Ub2 UCHL1 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub_UCHL1
right: Ub
left: E3SUB_SUB_misfolded_Ub2_UCHL1

LEFT 0 conversion MisPDUBbinding7 E3 MisP Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7
stoichiometric coefficient: 1.0

SUBDeubiquitination3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination3 E3SUB SUB misfolded Ub3 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination3 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination3 E3SUB SUB misfolded Ub2 UCHL1 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub2_UCHL1
right: Ub
left: E3SUB_SUB_misfolded_Ub3_UCHL1

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 2 conversion AsynDamInclusionGrowth18 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 8.0

SUBDeubiquitination4
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBDeubiquitination4 E3SUB SUB misfolded Ub3 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDeubiquitination4 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDeubiquitination4 E3SUB SUB misfolded Ub4 UCHL1 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub3_UCHL1
right: Ub
left: E3SUB_SUB_misfolded_Ub4_UCHL1

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

RIGHT 2 conversion Deubiquitination1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

SUB_misfolded_Ub6_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub6_Proteasome
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 1 conversion AsynDamInclusionGrowth8 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 1 conversion DeubiquitinationBoundMisP5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

RIGHT 4 conversion InclusionGrowth18 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

Parkin_asyn_dam
type: Complex
xref: O60260
xref: P37840

LEFT 0 conversion SUBDeubiquitination5 E3SUB SUB misfolded Ub5 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
stoichiometric coefficient: 1.0

DisaggregationAsynDam3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DisaggregationAsynDam3 AggD3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DisaggregationAsynDam3 AggD2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DisaggregationAsynDam3 asyn dam STOICHIOMETRY
right: asyn_dam
right: AggD2
left: AggD3

LEFT 1 conversion SUBInclusionGrowth15 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

DisaggregationAsynDam2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DisaggregationAsynDam2 AggD4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DisaggregationAsynDam2 asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DisaggregationAsynDam2 AggD3 STOICHIOMETRY
right: AggD3
right: asyn_dam
left: AggD4

RIGHT 2 conversion AsynDeubiquitinationUb1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

DisaggregationAsynDam1
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion DisaggregationAsynDam1 asyn dam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DisaggregationAsynDam1 AggD5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DisaggregationAsynDam1 AggD4 STOICHIOMETRY
right: AggD4
right: asyn_dam
left: AggD5

MisP_Ub7_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub7_Proteasome
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundSUB5 SUB misfolded Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub5_Proteasome
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DisaggregationAsynDam5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion DisaggregationAsynDam5 asyn dam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DisaggregationAsynDam5 AggD1 STOICHIOMETRY
right: asyn_dam
left: AggD1

DisaggregationAsynDam4
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion DisaggregationAsynDam4 AggD1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DisaggregationAsynDam4 AggD2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DisaggregationAsynDam4 asyn dam STOICHIOMETRY
right: AggD1
right: asyn_dam
left: AggD2

RIGHT 0 conversion AsynDeubiquitinationUb3 Parkin asyn dam Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynInclusionFormation aggasyn STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyn
stoichiometric coefficient: 7.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth4 Parkin asyn dam Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 1 conversion SUBPolyubiquitination2 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBProteasomeBindingUb7 E3SUB SUB misfolded Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynProteasomeBindingUb5 Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

E3_MisP_Ub_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub_DUB
cellular location: cytosol

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggS3 AggS3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS3
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDegradationUb7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 7.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 1 conversion SUBDegradationUb8 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

LEFT 1 conversion AsynDUBbindingUb5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

E3_MisP_Ub8
type: PhysicalEntity
member physical entity: E3_MisP_Ub8
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth3 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggA1 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth17 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 7.0

E3_MisP_Ub8
type: PhysicalEntity
member physical entity: E3_MisP_Ub8
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5
cellular location: cytosol

E3SUB_SUB_misfolded_Ub6_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
cellular location: cytosol

LEFT 0 conversion Monoubiquitination E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynPolyubiquitination4 Parkin asyn dam Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4
stoichiometric coefficient: 1.0

LEFT 1 conversion DeubiquitinationBoundasynDamUb6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth15 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

E3_MisP
type: PhysicalEntity
member physical entity: E3_MisP
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

LEFT 0 conversion ProteasomeActivity1 MisP Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub4_Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggD5 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 1 conversion InclusionGrowth1 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggS5 AggS5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS5
stoichiometric coefficient: 1.0

Refolding
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Refolding MisP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Refolding NatP STOICHIOMETRY
right: NatP
left: MisP

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionGrowth14 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 0 conversion SUBProteasomeBindingUb5 E3SUB SUB misfolded Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 1 conversion AsynDUBbindingUb1 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

LEFT 1 conversion InclusionGrowth2 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

LEFT 1 conversion UCHL1damage ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion ProteasomeBindingUb8 MisP Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub8_Proteasome
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

CHEBI:16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion AsynDegradationUb7 asyn dam Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub7_Proteasome
stoichiometric coefficient: 1.0

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

LEFT 1 conversion AsynDUBbindingUb3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth5 E3 MisP Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDeubiquitination8 E3SUB SUB misfolded Ub8 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub8_UCHL1
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDisaggregation5 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 2.0

RIGHT 1 conversion SUBInclusionGrowth15 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionFormation MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDisaggregation1 AggS5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS5
stoichiometric coefficient: 1.0

RIGHT 3 conversion SUBInclusionGrowth14 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 5.0

SUB_misfolded_Ub6_Proteasome
type: Complex
xref: P62988
xref: GO:0000502

LEFT 0 conversion ROSgenerationSmallAggP4 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded
cellular location: cytosol

LEFT 1 conversion AsynPolyubiquitination2 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

AsynDegradationUb5
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDegradationUb5 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDegradationUb5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDegradationUb5 asyn dam Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDegradationUb5 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDegradationUb5 ADP STOICHIOMETRY
right: Proteasome
right: ADP
right: Ub
spontaneous: true
left: asyn_dam_Ub5_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

AsynDegradationUb6
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion AsynDegradationUb6 ADP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDegradationUb6 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDegradationUb6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDegradationUb6 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDegradationUb6 asyn dam Ub6 Proteasome STOICHIOMETRY
right: Proteasome
right: ADP
right: Ub
spontaneous: true
left: asyn_dam_Ub6_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

AsynDegradationUb7
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion AsynDegradationUb7 asyn dam Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDegradationUb7 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDegradationUb7 ADP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDegradationUb7 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDegradationUb7 Proteasome STOICHIOMETRY
right: ADP
right: Proteasome
right: Ub
spontaneous: true
left: ATP
left: asyn_dam_Ub7_Proteasome
conversion direction: RIGHT_TO_LEFT

AsynDegradationUb8
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDegradationUb8 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDegradationUb8 ADP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDegradationUb8 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDegradationUb8 asyn dam Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDegradationUb8 ATP STOICHIOMETRY
right: Proteasome
right: Ub
right: ADP
spontaneous: true
left: ATP
left: asyn_dam_Ub8_Proteasome
conversion direction: RIGHT_TO_LEFT

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

MisP_Ub5_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub5_Proteasome
cellular location: cytosol

LEFT 0 conversion InclusionGrowth7 E3 MisP Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5
stoichiometric coefficient: 1.0

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

LEFT 1 conversion SUBAggregation2 AggS1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS1
stoichiometric coefficient: 1.0

LEFT 0 conversion Aggregation5 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth5 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 2 conversion AsynDamInclusionGrowth9 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 7.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

…
type: Stoichiometry
physical entity: UCHL1
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDamInclusionGrowth10 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 8.0

RIGHT 0 conversion SUBDeubiquitination5 E3SUB SUB misfolded Ub4 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

RIGHT 1 conversion asyn damParkinRelease Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub2
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2
cellular location: cytosol

LEFT 0 conversion InclusionGrowth6 E3 MisP Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

LEFT 0 conversion AsynDUBbindingUb7 Parkin asyn dam Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7
stoichiometric coefficient: 1.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

asyn_dam_Ub8_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub8_Proteasome
cellular location: cytosol

RIGHT 0 conversion Disaggregation1 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

AsynMonoubiquitination
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion AsynMonoubiquitination E2 Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynMonoubiquitination Parkin asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynMonoubiquitination E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynMonoubiquitination Parkin asyn dam Ub STOICHIOMETRY
right: Parkin_asyn_dam_Ub
right: E2
spontaneous: true
left: Parkin_asyn_dam
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

MisP_Ub5_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub5_Proteasome
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion DisaggregationAsynDam3 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion AsynDUBbindingUb4 Parkin asyn dam Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4_DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBPolyubiquitination4 E3SUB SUB misfolded Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5
stoichiometric coefficient: 1.0

E3_MisP_Ub5
type: PhysicalEntity
member physical entity: E3_MisP_Ub5
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

InclusionFormation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion InclusionFormation SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionFormation AggP5 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionFormation aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionFormation MisP STOICHIOMETRY
right: SeqAggP
right: aggMisP
left: MisP
left: AggP5

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

E3SUB_SUB_misfolded_Ub6_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 1 conversion AsynProteasomeBindingUb4 Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub7_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
cellular location: cytosol

RIGHT 0 conversion AsynDeubiquitinationUb1 Parkin asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam
stoichiometric coefficient: 1.0

RIGHT 1 conversion ProteasomeBindingUb4 MisP Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub4_Proteasome
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

LEFT 1 conversion InclusionGrowth13 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 0 conversion MisPDUBbinding4 E3 MisP Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4_DUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 4 conversion InclusionGrowth14 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDeubiquitination6 E3SUB SUB misfolded Ub5 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
stoichiometric coefficient: 1.0

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

LEFT 0 conversion AggregationAsynDam4 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth10 E3 MisP Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8
stoichiometric coefficient: 1.0

asyn_dam_Ub7_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub7_Proteasome
cellular location: cytosol

AggregationUCHL1Dam3
type: BiochemicalReaction

RIGHT 0 conversion DeubiquitinationBoundMisP3 MisP Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub5_Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion DeubiquitinationBoundSUB4 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

AggregationUCHL1Dam2
type: BiochemicalReaction

AggregationUCHL1Dam5
type: BiochemicalReaction

AggregationUCHL1Dam4
type: BiochemicalReaction

LEFT 1 conversion SUBInclusionGrowth2 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

SUB_misfolded_Ub5_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub5_Proteasome
cellular location: cytosol

AggregationUCHL1Dam1
type: BiochemicalReaction

AggS5
type: PhysicalEntity
member physical entity: AggS5
cellular location: cytosol

Parkin
type: Protein
xref: O60260

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth6 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 3 conversion InclusionGrowth11 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

E3_MisP_Ub3_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub3_DUB
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 7.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth4 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 0 conversion AsynDeubiquitinationUb7 Parkin asyn dam Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7_DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion MisPDUBbinding3 E3 MisP Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 1 conversion InclusionGrowth3 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AggU1
type: Protein
xref: P09936

AggU2
type: Protein
xref: P09936

AggU3
type: Protein
xref: P09936

RIGHT 1 conversion ROSgenerationSmallAggP3 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

Lamp2a
type: PhysicalEntity
member physical entity: Lamp2a
cellular location: cytosol

Parkin_asyn_dam_Ub4_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

E3_MisP_Ub4_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub4_DUB
cellular location: cytosol

AggU4
type: Protein
xref: P09936

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

DOID:14330
type: UnificationXref
id: DOID:14330
db: Human Disease Ontology

AggU5
type: Protein
xref: P09936

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 4 conversion InclusionGrowth12 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

AggD1ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

Parkin_asyn_dam_Ub5
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

LEFT 1 conversion SUBInclusionFormation SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

LEFT 1 conversion DeubiquitinationBoundasynDamUb4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 3 conversion InclusionGrowth12 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBInclusionGrowth17 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

AsynDUBbindingUb6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb6 Parkin asyn dam Ub6 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb6 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb6 Parkin asyn dam Ub6 STOICHIOMETRY
right: Parkin_asyn_dam_Ub6_DUB
left: DUB
left: Parkin_asyn_dam_Ub6

AsynDUBbindingUb5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb5 Parkin asyn dam Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb5 Parkin asyn dam Ub5 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb5 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub5_DUB
left: Parkin_asyn_dam_Ub5
left: DUB

AsynDUBbindingUb8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb8 Parkin asyn dam Ub8 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb8 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb8 Parkin asyn dam Ub8 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub8_DUB
left: Parkin_asyn_dam_Ub8
left: DUB

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

AsynDUBbindingUb7
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb7 Parkin asyn dam Ub7 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb7 Parkin asyn dam Ub7 STOICHIOMETRY
right: Parkin_asyn_dam_Ub7_DUB
left: DUB
left: Parkin_asyn_dam_Ub7

E3SUB_SUB_misfolded_Ub2
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2
cellular location: cytosol

AsynDUBbindingUb2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb2 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb2 Parkin asyn dam Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb2 Parkin asyn dam Ub2 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub2_DUB
left: Parkin_asyn_dam_Ub2
left: DUB

AsynDUBbindingUb1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb1 Parkin asyn dam Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb1 Parkin asyn dam Ub DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb1 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub_DUB
left: DUB
left: Parkin_asyn_dam_Ub

AsynDUBbindingUb4
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb4 Parkin asyn dam Ub4 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb4 Parkin asyn dam Ub4 STOICHIOMETRY
right: Parkin_asyn_dam_Ub4_DUB
left: Parkin_asyn_dam_Ub4
left: DUB

AsynDUBbindingUb3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDUBbindingUb3 Parkin asyn dam Ub3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDUBbindingUb3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDUBbindingUb3 Parkin asyn dam Ub3 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub3_DUB
left: DUB
left: Parkin_asyn_dam_Ub3

E3_MisP_Ub8_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub8_DUB
cellular location: cytosol

LEFT 1 conversion SUBPolyubiquitination4 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

SUBAggregation1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBAggregation1 AggS1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBAggregation1 SUB misfolded STOICHIOMETRY
right: AggS1
left: SUB_misfolded

SUBAggregation2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion SUBAggregation2 AggS1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBAggregation2 SUB misfolded STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBAggregation2 AggS2 STOICHIOMETRY
right: AggS2
left: SUB_misfolded
left: AggS1

LEFT 0 conversion AsynDeubiquitinationUb3 Parkin asyn dam Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3_DUB
stoichiometric coefficient: 1.0

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

SUBAggregation3
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBAggregation3 AggS3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBAggregation3 SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBAggregation3 AggS2 STOICHIOMETRY
right: AggS3
left: AggS2
left: SUB_misfolded

SUBAggregation4
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBAggregation4 AggS4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBAggregation4 AggS3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBAggregation4 SUB misfolded STOICHIOMETRY
right: AggS4
left: AggS3
left: SUB_misfolded

SUBAggregation5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBAggregation5 SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBAggregation5 AggS4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBAggregation5 AggS5 STOICHIOMETRY
right: AggS5
left: AggS4
left: SUB_misfolded

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth16 Parkin asyn dam Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6_DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggD2ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion InclusionGrowth13 E3 MisP Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3_DUB
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3_MisP_Ub3_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub3_DUB
cellular location: cytosol

RIGHT 2 conversion DeubiquitinationBoundasynDamUb6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDegradationUb8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 8.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth14 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 1 conversion SUBDisaggregation4 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

Parkin_asyn_dam_Ub2
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2
cellular location: cytosol

RIGHT 0 conversion Polyubiquitination6 E3 MisP Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7
stoichiometric coefficient: 1.0

AggS1
type: PhysicalEntity

RIGHT 0 conversion SUBDegradationUb7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 7.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

LEFT 0 conversion AggregationAsynDam1 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 2.0

LEFT 0 conversion AsynDamInclusionGrowth2 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 1 conversion DisAggregationasyn4 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

LEFT 0 conversion DisAggregationasyn5 AggA1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA1
stoichiometric coefficient: 1.0

AggS2
type: PhysicalEntity

AggS3
type: PhysicalEntity

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

AggS4
type: PhysicalEntity

RIGHT 1 conversion InclusionGrowth2 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

AggS5
type: PhysicalEntity

RIGHT 1 conversion Deubiquitination5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

aggUchl1dam
type: PhysicalEntity
member physical entity: aggUchl1dam
cellular location: cytosol

RIGHT 1 conversion SUBInclusionGrowth4 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeActivity5 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

AggP5
type: PhysicalEntity
member physical entity: AggP5
cellular location: cytosol

asyn_dam_Ub7_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub7_Proteasome
cellular location: cytosol

RIGHT 0 conversion ProteasomeActivity1 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 4.0

LEFT 0 conversion SUBPolyubiquitination5 E3SUB SUB misfolded Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5
stoichiometric coefficient: 1.0

E3SUB
type: Protein
xref: IPR000569

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

E3SUB_SUB_misfolded_Ub2_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

RIGHT 0 conversion Misfolding MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

LEFT 0 conversion MisPDUBbinding4 E3 MisP Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

AggP3
type: PhysicalEntity

AggP4
type: PhysicalEntity

RIGHT 0 conversion Polyubiquitination4 E3 MisP Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5
stoichiometric coefficient: 1.0

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

asyn_damParkinBinding
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion asyn damParkinBinding Parkin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion asyn damParkinBinding asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion asyn damParkinBinding Parkin asyn dam STOICHIOMETRY
right: Parkin_asyn_dam
spontaneous: true
left: asyn_dam
left: Parkin
conversion direction: LEFT_TO_RIGHT

AggP5
type: PhysicalEntity

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Parkin_asyn_dam_Ub8_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8_DUB
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggP5 AggP5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP5
stoichiometric coefficient: 1.0

AggP1
type: PhysicalEntity

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

AggP2
type: PhysicalEntity

RIGHT 1 conversion AsynDamInclusionGrowth16 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionGrowth7 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

SUB_misfolded_Ub7_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub7_Proteasome
cellular location: cytosol

E3_MisP_Ub7
type: PhysicalEntity
member physical entity: E3_MisP_Ub7
cellular location: cytosol

LEFT 0 conversion ProteasomeBindingUb7 E3 MisP Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDeubiquitination4 E3SUB SUB misfolded Ub3 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion UbDegradation Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 2.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

E3_MisP_Ub6
type: PhysicalEntity
member physical entity: E3_MisP_Ub6
cellular location: cytosol

E3SUB_SUB_misfolded_Ub3
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3
cellular location: cytosol

LEFT 0 conversion MisPDUBbinding6 E3 MisP Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynProteasomeBindingUb8 Parkin asyn dam Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggU5 AggU5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU5
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDeubiquitinationUb4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

E2UbBinding
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion E2UbBinding E2 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion E2UbBinding E2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion E2UbBinding E1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion E2UbBinding E1 Ub STOICHIOMETRY
right: E1
right: E2_Ub
left: E2
left: E1_Ub

LEFT 0 conversion E1UbBinding E1 STOICHIOMETRY
type: Stoichiometry
physical entity: E1
stoichiometric coefficient: 1.0

E3_MisP_Ub3
type: PhysicalEntity
member physical entity: E3_MisP_Ub3
cellular location: cytosol

asyn_dam_Ub4_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub4_Proteasome
cellular location: cytosol

RIGHT 0 conversion MisPDUBbinding7 E3 MisP Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth2 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 1 conversion InclusionGrowth11 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBsynthesis Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth9 Parkin asyn dam Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDeubiquitination7 E3SUB SUB misfolded Ub7 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDegradationUb6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDeubiquitinationUb7 Parkin asyn dam Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6_DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggD4 AggD4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD4
stoichiometric coefficient: 1.0

RIGHT 4 conversion InclusionGrowth16 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggU4 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth12 E3 MisP Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2_DUB
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

E3SUB_SUB_misfolded_Ub
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 0 conversion Deubiquitination1 E3 MisP Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub_DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBAggregation4 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

E3_MisP_Ub
type: PhysicalEntity
member physical entity: E3_MisP_Ub
cellular location: cytosol

RIGHT 0 conversion AsynDUBbindingUb7 Parkin asyn dam Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7_DUB
stoichiometric coefficient: 1.0

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion DeubiquitinationBoundasyn damUb8 asyn dam Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub7_Proteasome
stoichiometric coefficient: 1.0

AggS2ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

E3_MisP_Ub6
type: PhysicalEntity
member physical entity: E3_MisP_Ub6
cellular location: cytosol

RIGHT 0 conversion AsynPolyubiquitination1 Parkin asyn dam Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2
stoichiometric coefficient: 1.0

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion SUBmisfolding SUB STOICHIOMETRY
type: Stoichiometry
physical entity: SUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynPolyubiquitination2 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth1 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeInhibition4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

CHEBI:26523
type: UnificationXref
id: CHEBI:26523
db: ChEBI

RIGHT 0 conversion AsynPolyubiquitination7 Parkin asyn dam Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 1 conversion Aggregationasyn5 AggA4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA4
stoichiometric coefficient: 1.0

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

MisP_Ub4_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub4_Proteasome
cellular location: cytosol

IPR000011
type: UnificationXref
id: IPR000011
db: InterPro

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

Disaggregation2
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Disaggregation2 MisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Disaggregation2 AggP4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Disaggregation2 AggP3 STOICHIOMETRY
right: AggP3
right: MisP
left: AggP4

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

Disaggregation1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Disaggregation1 AggP4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Disaggregation1 MisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Disaggregation1 AggP5 STOICHIOMETRY
right: AggP4
right: MisP
left: AggP5

LEFT 0 conversion AsynDamInclusionGrowth15 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

Disaggregation4
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Disaggregation4 MisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Disaggregation4 AggP2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Disaggregation4 AggP1 STOICHIOMETRY
right: MisP
right: AggP1
left: AggP2

Disaggregation3
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Disaggregation3 MisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Disaggregation3 AggP3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Disaggregation3 AggP2 STOICHIOMETRY
right: MisP
right: AggP2
left: AggP3

Lamp2a
type: PhysicalEntity
member physical entity: Lamp2a
cellular location: cytosol

Disaggregation5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Disaggregation5 AggP1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Disaggregation5 MisP STOICHIOMETRY
right: MisP
left: AggP1

LEFT 0 conversion SUBDisaggregation2 AggS4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS4
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E3_MisP_Ub3_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

DisAggregationasyn4
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion DisAggregationasyn4 asyn STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DisAggregationasyn4 AggA2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DisAggregationasyn4 AggA1 STOICHIOMETRY
right: AggA1
right: asyn
left: AggA2

DisAggregationasyn5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DisAggregationasyn5 AggA1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DisAggregationasyn5 asyn STOICHIOMETRY
right: asyn
left: AggA1

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

E3_MisP_Ub8_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub8_DUB
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Deubiquitination4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Deubiquitination4 E3 MisP Ub4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination4 E3 MisP Ub3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Deubiquitination4 Ub STOICHIOMETRY
right: E3_MisP_Ub3_DUB
right: Ub
left: E3_MisP_Ub4_DUB

AggS5
type: PhysicalEntity
member physical entity: AggS5
cellular location: cytosol

Deubiquitination3
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Deubiquitination3 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Deubiquitination3 E3 MisP Ub3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination3 E3 MisP Ub2 DUB STOICHIOMETRY
right: Ub
right: E3_MisP_Ub2_DUB
left: E3_MisP_Ub3_DUB

LEFT 0 conversion InclusionGrowth4 E3 MisP Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

Deubiquitination6
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Deubiquitination6 E3 MisP Ub6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination6 E3 MisP Ub5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Deubiquitination6 Ub STOICHIOMETRY
right: Ub
right: E3_MisP_Ub5_DUB
left: E3_MisP_Ub6_DUB

Parkin_asyn_dam
type: PhysicalEntity
member physical entity: Parkin_asyn_dam
cellular location: cytosol

LEFT 0 conversion AsynDeubiquitinationUb4 Parkin asyn dam Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4_DUB
stoichiometric coefficient: 1.0

Deubiquitination5
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Deubiquitination5 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination5 E3 MisP Ub4 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Deubiquitination5 E3 MisP Ub5 DUB STOICHIOMETRY
right: Ub
right: E3_MisP_Ub4_DUB
left: E3_MisP_Ub5_DUB

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

CHEBI:15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Deubiquitination2
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Deubiquitination2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination2 E3 MisP Ub DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Deubiquitination2 E3 MisP Ub2 DUB STOICHIOMETRY
right: E3_MisP_Ub_DUB
right: Ub
left: E3_MisP_Ub2_DUB

RIGHT 2 conversion AsynDamInclusionGrowth17 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 7.0

Deubiquitination1
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion Deubiquitination1 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination1 E3 MisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Deubiquitination1 E3 MisP Ub DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Deubiquitination1 DUB STOICHIOMETRY
right: Ub
right: E3_MisP
right: DUB
left: E3_MisP_Ub_DUB

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

DisAggregationasyn2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion DisAggregationasyn2 AggA3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DisAggregationasyn2 AggA4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DisAggregationasyn2 asyn STOICHIOMETRY
right: AggA3
right: asyn
left: AggA4

AggU5
type: PhysicalEntity
member physical entity: AggU5
cellular location: cytosol

DisAggregationasyn3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DisAggregationasyn3 AggA3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DisAggregationasyn3 asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DisAggregationasyn3 AggA2 STOICHIOMETRY
right: AggA2
right: asyn
left: AggA3

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

DisAggregationasyn1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion DisAggregationasyn1 AggA4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DisAggregationasyn1 asyn STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DisAggregationasyn1 AggA5 STOICHIOMETRY
right: asyn
right: AggA4
left: AggA5

Deubiquitination8
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Deubiquitination8 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination8 E3 MisP Ub7 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Deubiquitination8 E3 MisP Ub8 DUB STOICHIOMETRY
right: Ub
right: E3_MisP_Ub7_DUB
left: E3_MisP_Ub8_DUB

UCHL1_Proteasome
type: PhysicalEntity
member physical entity: UCHL1_Proteasome
cellular location: cytosol

Deubiquitination7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Deubiquitination7 E3 MisP Ub7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Deubiquitination7 E3 MisP Ub6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Deubiquitination7 Ub STOICHIOMETRY
right: E3_MisP_Ub6_DUB
right: Ub
left: E3_MisP_Ub7_DUB

RIGHT 1 conversion SUBInclusionGrowth0 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

asyn_dam_Ub5_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: P37840

RIGHT 0 conversion AsynDUBbindingUb8 Parkin asyn dam Ub8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8_DUB
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth18 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 8.0

RIGHT 1 conversion SUBDeubiquitination5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

SUBUCHL1binding2
type: BiochemicalReaction

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUBUCHL1binding1
type: BiochemicalReaction

LEFT 1 conversion Polyubiquitination6 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

SUBUCHL1binding4
type: BiochemicalReaction

SUBUCHL1binding3
type: BiochemicalReaction

SUBUCHL1binding6
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth4 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

SUBUCHL1binding8
type: BiochemicalReaction

SUBUCHL1binding7
type: BiochemicalReaction

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBAggregation5 AggS5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS5
stoichiometric coefficient: 1.0

AggA4ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

asyn_Proteasome
type: PhysicalEntity
member physical entity: asyn_Proteasome
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth6 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 5.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

O60260
type: UnificationXref
id: O60260
db: UniProt Knowledgebase

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggP1 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

AggA5
type: PhysicalEntity
member physical entity: AggA5
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion ProteasomeActivity5 MisP Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub8_Proteasome
stoichiometric coefficient: 1.0

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

LEFT 1 conversion asyn damParkinBinding Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

AggD5
type: PhysicalEntity
member physical entity: AggD5
cellular location: cytosol

RIGHT 1 conversion AsynDamInclusionGrowth9 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBInclusionGrowth12 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub4_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
cellular location: cytosol

RIGHT 3 conversion SUBInclusionGrowth12 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 3.0

RIGHT 1 conversion Deubiquitination7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundSUB4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

IPR001394
type: UnificationXref
id: IPR001394
db: InterPro

UbUpregulation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion UbUpregulation MisP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion UbUpregulation Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion UbUpregulation MisP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion UbUpregulation upregUb STOICHIOMETRY
right: Ub
right: upregUb
right: MisP
left: MisP

LEFT 0 conversion ProteasomeInhibition2 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBInclusionGrowth12 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth0 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

Parkin_asyn_dam_Ub2
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2
cellular location: cytosol

RIGHT 1 conversion InclusionFormation aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 7.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth15 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggU4 AggU4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU4
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBPolyubiquitination3 E3SUB SUB misfolded Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4
stoichiometric coefficient: 1.0

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

Parkin_asyn_dam_Ub5
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5
cellular location: cytosol

LEFT 1 conversion SUBPolyubiquitination3 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3_DUB
cellular location: cytosol

LEFT 0 conversion ProteasomeActivity2 MisP Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub5_Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion Deubiquitination2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth13 Parkin asyn dam Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3_DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

RIGHT 0 conversion SUBDeubiquitination8 E3SUB SUB misfolded Ub7 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3SUB_SUB_misfolded_Ub7
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7
cellular location: cytosol

LEFT 0 conversion Polyubiquitination3 E3 MisP Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub6_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

E3SUB_SUB_misfolded_Ub7
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

LEFT 0 conversion AsynDeubiquitinationUb6 Parkin asyn dam Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6_DUB
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDeubiquitination1 E3SUB SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E1_Ub
type: PhysicalEntity
member physical entity: E1_Ub
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggD3 AggD3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD3
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub4_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4_DUB
cellular location: cytosol

E3SUB_SUB_misfolded
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded
cellular location: cytosol

LEFT 1 conversion SUBProteasomeBindingUb8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBInclusionFormation SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBInclusionGrowth16 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion ProteasomeActivity3 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 6.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundasyn damUb8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion MisPDUBbinding4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub4_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
cellular location: cytosol

asyn_Proteasome
type: Complex
xref: GO:0000502
xref: P37840

E3_MisP_Ub6_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub6_DUB
cellular location: cytosol

RIGHT 2 conversion AsynDamInclusionGrowth2 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

AsynPolyubiquitination2
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination2 E2 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination2 Parkin asyn dam Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination2 E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination2 Parkin asyn dam Ub3 STOICHIOMETRY
right: E2
right: Parkin_asyn_dam_Ub3
spontaneous: true
left: Parkin_asyn_dam_Ub2
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

AsynPolyubiquitination1
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination1 Parkin asyn dam Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination1 E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination1 Parkin asyn dam Ub2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination1 E2 Ub STOICHIOMETRY
right: E2
right: Parkin_asyn_dam_Ub2
spontaneous: true
left: E2_Ub
left: Parkin_asyn_dam_Ub
conversion direction: RIGHT_TO_LEFT

AsynPolyubiquitination4
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination4 Parkin asyn dam Ub4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination4 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination4 E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination4 Parkin asyn dam Ub5 STOICHIOMETRY
right: E2
right: Parkin_asyn_dam_Ub5
spontaneous: true
left: E2_Ub
left: Parkin_asyn_dam_Ub4
conversion direction: RIGHT_TO_LEFT

AsynPolyubiquitination3
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination3 Parkin asyn dam Ub3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination3 Parkin asyn dam Ub4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination3 E2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination3 E2 Ub STOICHIOMETRY
right: E2
right: Parkin_asyn_dam_Ub4
spontaneous: true
left: E2_Ub
left: Parkin_asyn_dam_Ub3
conversion direction: RIGHT_TO_LEFT

AsynPolyubiquitination6
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination6 Parkin asyn dam Ub7 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination6 E2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination6 Parkin asyn dam Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination6 E2 Ub STOICHIOMETRY
right: Parkin_asyn_dam_Ub7
right: E2
spontaneous: true
left: Parkin_asyn_dam_Ub6
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion SUBMonoubiquitination E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

AsynPolyubiquitination5
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination5 Parkin asyn dam Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination5 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination5 E2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination5 Parkin asyn dam Ub5 STOICHIOMETRY
right: Parkin_asyn_dam_Ub6
right: E2
spontaneous: true
left: E2_Ub
left: Parkin_asyn_dam_Ub5
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion AsynDegradationUb5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 5.0

MisP_Ub4_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub4_Proteasome
cellular location: cytosol

AsynPolyubiquitination7
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion AsynPolyubiquitination7 E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynPolyubiquitination7 Parkin asyn dam Ub8 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynPolyubiquitination7 Parkin asyn dam Ub7 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynPolyubiquitination7 E2 Ub STOICHIOMETRY
right: Parkin_asyn_dam_Ub8
right: E2
spontaneous: true
left: E2_Ub
left: Parkin_asyn_dam_Ub7
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion AsynDamInclusionGrowth11 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 0 conversion Aggregation3 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDUBbindingUb3 Parkin asyn dam Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3_DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E3SUB_SUB_misfolded_Ub3_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

LEFT 0 conversion E2UbBinding E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

AggU5
type: PhysicalEntity
member physical entity: AggU5
cellular location: cytosol

Parkin_asyn_dam_Ub4
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4
cellular location: cytosol

LEFT 0 conversion Disaggregation1 AggP5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP5
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDegradationUb4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 4.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

MisP_Ub6_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub6_Proteasome
cellular location: cytosol

LEFT 0 conversion Aggregation4 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

UCHL1_damaged_Proteasome
type: PhysicalEntity
member physical entity: UCHL1_damaged_Proteasome
cellular location: cytosol

Ub_UCHL1
type: Complex
xref: P62988
xref: P09936

RIGHT 2 conversion InclusionGrowth3 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth15 Parkin asyn dam Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5_DUB
stoichiometric coefficient: 1.0

E3_MisP_Ub5_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub5_DUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

LEFT 1 conversion ProteasomeBindingUb5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion ProteasomeBindingUb8 E3 MisP Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8
stoichiometric coefficient: 1.0

AsynDeubiquitinationUb7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb7 Parkin asyn dam Ub7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb7 Parkin asyn dam Ub6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb7 Ub STOICHIOMETRY
right: Parkin_asyn_dam_Ub6_DUB
right: Ub
left: Parkin_asyn_dam_Ub7_DUB

Aggregation5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Aggregation5 AggP5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Aggregation5 MisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Aggregation5 AggP4 STOICHIOMETRY
right: AggP5
left: AggP4
left: MisP

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

AsynDeubiquitinationUb8
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb8 Parkin asyn dam Ub7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb8 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb8 Parkin asyn dam Ub8 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub7_DUB
right: Ub
left: Parkin_asyn_dam_Ub8_DUB

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

RIGHT 0 conversion DeubiquitinationBoundMisP2 MisP Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub4_Proteasome
stoichiometric coefficient: 1.0

Aggregation2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion Aggregation2 AggP1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Aggregation2 MisP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregation2 AggP2 STOICHIOMETRY
right: AggP2
left: MisP
left: AggP1

AsynDeubiquitinationUb3
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb3 Parkin asyn dam Ub2 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb3 Parkin asyn dam Ub3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb3 Ub STOICHIOMETRY
right: Ub
right: Parkin_asyn_dam_Ub2_DUB
left: Parkin_asyn_dam_Ub3_DUB

Aggregation1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Aggregation1 AggP1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Aggregation1 MisP STOICHIOMETRY
right: AggP1
left: MisP

AsynDeubiquitinationUb4
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb4 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb4 Parkin asyn dam Ub4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb4 Parkin asyn dam Ub3 DUB STOICHIOMETRY
right: Parkin_asyn_dam_Ub3_DUB
right: Ub
left: Parkin_asyn_dam_Ub4_DUB

Aggregation4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Aggregation4 MisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Aggregation4 AggP3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregation4 AggP4 STOICHIOMETRY
right: AggP4
left: MisP
left: AggP3

AsynDeubiquitinationUb5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb5 Parkin asyn dam Ub4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb5 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb5 Parkin asyn dam Ub5 DUB STOICHIOMETRY
right: Ub
right: Parkin_asyn_dam_Ub4_DUB
left: Parkin_asyn_dam_Ub5_DUB

Aggregation3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Aggregation3 MisP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregation3 AggP3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Aggregation3 AggP2 STOICHIOMETRY
right: AggP3
left: AggP2
left: MisP

AsynDeubiquitinationUb6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb6 Parkin asyn dam Ub5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb6 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb6 Parkin asyn dam Ub6 DUB STOICHIOMETRY
right: Ub
right: Parkin_asyn_dam_Ub5_DUB
left: Parkin_asyn_dam_Ub6_DUB

LEFT 0 conversion asyn damParkinBinding asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

AsynDeubiquitinationUb1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb1 Parkin asyn dam Ub DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDeubiquitinationUb1 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb1 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb1 Parkin asyn dam STOICHIOMETRY
right: Ub
right: Parkin_asyn_dam
right: DUB
left: Parkin_asyn_dam_Ub_DUB

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AsynDeubiquitinationUb2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynDeubiquitinationUb2 Parkin asyn dam Ub2 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDeubiquitinationUb2 Parkin asyn dam Ub DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDeubiquitinationUb2 Ub STOICHIOMETRY
right: Ub
right: Parkin_asyn_dam_Ub_DUB
left: Parkin_asyn_dam_Ub2_DUB

LEFT 1 conversion MisPDUBbinding8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion asynCMAdegradation asyn Lamp2a STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_Lamp2a
stoichiometric coefficient: 1.0

LEFT 1 conversion Aggregationasyn3 AggA2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA2
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

LEFT 0 conversion Polyubiquitination4 E3 MisP Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

AggD1
type: Protein
xref: P37840

AggD2
type: Protein
xref: P37840

RIGHT 1 conversion AsynDeubiquitinationUb6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub6_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6_DUB
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth3 Parkin asyn dam Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub
stoichiometric coefficient: 1.0

AggP_Proteasome
type: Complex
xref: GO:0000502

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggD3
type: Protein
xref: P37840

AggD4
type: Protein
xref: P37840

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

AggD5
type: Protein
xref: P37840

E3SUB_SUB_misfolded_Ub6
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 0 conversion MisPDUBbinding8 E3 MisP Ub8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8_DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AsynInclusionGrowth
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AsynInclusionGrowth asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynInclusionGrowth SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynInclusionGrowth SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynInclusionGrowth aggasyn STOICHIOMETRY
right: aggasyn
right: SeqAggP
left: asyn
left: SeqAggP

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion AsynProteasomeBindingUb6 asyn dam Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub6_Proteasome
stoichiometric coefficient: 1.0

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

asyn
type: Protein
xref: P37840

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

RIGHT 0 conversion Aggregationasyn1 AggA1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA1
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDamInclusionGrowth1 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion ProteasomeInhibition5 AggP Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: AggP_Proteasome
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub8_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8_DUB
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggU1 AggU1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: UCHL1
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBProteasomeBindingUb4 E3SUB SUB misfolded Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4
stoichiometric coefficient: 1.0

asyn_dam_Ub6_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub6_Proteasome
cellular location: cytosol

LEFT 1 conversion MisPDUBbinding5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

GO:0032435
type: UnificationXref
id: GO:0032435
db: Gene Ontology

E3SUB_SUB_misfolded_Ub
type: Complex
xref: P62988
xref: IPR000569

LEFT 0 conversion E3SUBBinding SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

LEFT 0 conversion MisPDUBbinding5 E3 MisP Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundMisP3 MisP Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub6_Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion UbUpregulation Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 3.0

LEFT 1 conversion SUBInclusionGrowth0 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBInclusionGrowth5 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 4.0

E3SUB_SUB_misfolded_Ub8
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8
cellular location: cytosol

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth12 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

SUB_misfolded_Ub4_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub4_Proteasome
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 3 conversion SUBInclusionGrowth13 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 4.0

asyn_dam_Ub5_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub5_Proteasome
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth13 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 0 conversion AsynDamInclusionGrowth6 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth15 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

asyn_dam_Ub4_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: P37840

MisP_Ub7_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub7_Proteasome
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

P09936
type: UnificationXref
id: P09936
db: UniProt Knowledgebase

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

asyn_dam_Ub5_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub5_Proteasome
cellular location: cytosol

Parkin_asyn_dam_Ub4
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4
cellular location: cytosol

…
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

RIGHT 0 conversion MisPDUBbinding3 E3 MisP Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBInclusionGrowth1 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion Deubiquitination5 E3 MisP Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4_DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundSUB7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub_DUB
cellular location: cytosol

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub4_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
cellular location: cytosol

AsynDamInclusionGrowth17
type: ComplexAssembly
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth17 aggParkin STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth17 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth17 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth17 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth17 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth17 Parkin asyn dam Ub7 DUB STOICHIOMETRY
right: aggUb
right: SeqAggP
right: aggasyndam
right: aggParkin
spontaneous: true
left: Parkin_asyn_dam_Ub7_DUB
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

AsynDamInclusionGrowth16
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth16 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth16 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth16 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth16 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth16 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth16 Parkin asyn dam Ub6 DUB STOICHIOMETRY
right: aggUb
right: aggasyndam
right: aggParkin
right: SeqAggP
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub6_DUB
conversion direction: RIGHT_TO_LEFT

E1_Ub
type: PhysicalEntity
member physical entity: E1_Ub
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

AsynDamInclusionGrowth18
type: ComplexAssembly
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth18 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth18 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth18 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth18 Parkin asyn dam Ub8 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth18 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth18 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggasyndam
right: aggUb
right: aggParkin
spontaneous: true
left: Parkin_asyn_dam_Ub8_DUB
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion AsynMonoubiquitination Parkin asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDeubiquitination7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub8_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

AsynDamInclusionGrowth11
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth11 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth11 Parkin asyn dam Ub DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth11 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth11 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth11 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth11 aggasyndam STOICHIOMETRY
right: aggParkin
right: SeqAggP
right: aggasyndam
right: aggUb
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub_DUB
conversion direction: RIGHT_TO_LEFT

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

AsynDamInclusionGrowth10
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth10 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth10 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth10 aggasyndam STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth10 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth10 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth10 Parkin asyn dam Ub8 STOICHIOMETRY
right: aggUb
right: aggParkin
right: SeqAggP
right: aggasyndam
spontaneous: true
left: Parkin_asyn_dam_Ub8
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

AsynDamInclusionGrowth13
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth13 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth13 Parkin asyn dam Ub3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth13 aggasyndam STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth13 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth13 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth13 SeqAggP STOICHIOMETRY
right: aggUb
right: aggasyndam
right: aggParkin
right: SeqAggP
spontaneous: true
left: Parkin_asyn_dam_Ub3_DUB
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

AsynDamInclusionGrowth12
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth12 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth12 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth12 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth12 Parkin asyn dam Ub2 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth12 aggParkin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth12 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggasyndam
right: aggParkin
right: aggUb
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub2_DUB
conversion direction: RIGHT_TO_LEFT

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

AsynDamInclusionGrowth15
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth15 Parkin asyn dam Ub5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth15 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth15 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth15 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth15 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth15 aggParkin STOICHIOMETRY
right: aggParkin
right: aggasyndam
right: aggUb
right: SeqAggP
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub5_DUB
conversion direction: RIGHT_TO_LEFT

E3SUB_SUB_misfolded_Ub6
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6
cellular location: cytosol

AsynDamInclusionGrowth14
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion AsynDamInclusionGrowth14 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynDamInclusionGrowth14 aggasyndam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynDamInclusionGrowth14 Parkin asyn dam Ub4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynDamInclusionGrowth14 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynDamInclusionGrowth14 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion AsynDamInclusionGrowth14 aggParkin STOICHIOMETRY
right: aggasyndam
right: SeqAggP
right: aggParkin
right: aggUb
spontaneous: true
left: SeqAggP
left: Parkin_asyn_dam_Ub4_DUB
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion AsynProteasomeBindingUb8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion Polyubiquitination7 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth11 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDeubiquitinationUb8 Parkin asyn dam Ub8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8_DUB
stoichiometric coefficient: 1.0

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth10 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 3 conversion InclusionGrowth3 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBInclusionGrowth2 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBInclusionGrowth15 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth6 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

AggA4
type: Protein
xref: P37840

LEFT 0 conversion ROSgenerationSmallAggS4 AggS4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS4
stoichiometric coefficient: 1.0

AggA5
type: Protein
xref: P37840

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

AggA1
type: Protein
xref: P37840

UCHL1_damaged_Proteasome
type: PhysicalEntity
member physical entity: UCHL1_damaged_Proteasome
cellular location: cytosol

AggA2
type: Protein
xref: P37840

AggA3
type: Protein
xref: P37840

E3SUB_SUB_misfolded_Ub7_UCHL1
type: Complex
xref: P62988
xref: IPR000569
xref: P09936

RIGHT 2 conversion DeubiquitinationBoundasynDamUb5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

LEFT 1 conversion SUBProteasomeBindingUb5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDegradationUb8 SUB misfolded Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub8_Proteasome
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

LEFT 1 conversion MisPDUBbinding6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

aggasyn
type: Protein
xref: P37840

LEFT 1 conversion MisPDUBbinding7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

RIGHT 4 conversion InclusionGrowth15 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

MisP_Ub4_Proteasome
type: Protein
xref: P62988
xref: CHEBI:36080

LEFT 0 conversion InclusionGrowth3 E3 MisP Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth12 Parkin asyn dam Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2_DUB
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth15 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth0 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

AggS1ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

aggasyn
type: PhysicalEntity
member physical entity: aggasyn
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

LEFT 1 conversion AsynPolyubiquitination1 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggA3 AggA3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA3
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBPolyubiquitination7 E3SUB SUB misfolded Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub8
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggA4 AggA4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA4
stoichiometric coefficient: 1.0

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 0 conversion ProteasomeBindingUb7 E3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3_MisP_Ub4_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub4_DUB
cellular location: cytosol

Parkin_asyn_dam_Ub2_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

LEFT 0 conversion SUBInclusionGrowth10 E3SUB SUB misfolded Ub UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth14 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBProteasomeBindingUb4 E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub6_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth8 E3SUB SUB misfolded Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7
stoichiometric coefficient: 1.0

Source
type: PhysicalEntity

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

AggA3ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

Lysosome
type: PhysicalEntity
member physical entity: Lysosome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Monoubiquitination
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion Monoubiquitination E3 MisP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion Monoubiquitination E2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Monoubiquitination E3 MisP Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Monoubiquitination E2 Ub STOICHIOMETRY
right: E3_MisP_Ub
right: E2
spontaneous: true
left: E3_MisP
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

E3SUB_SUB_misfolded_Ub7
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7
cellular location: cytosol

E3SUB_SUB_misfolded_Ub_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
cellular location: cytosol

LEFT 1 conversion SUBMonoubiquitination E3SUB SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded
stoichiometric coefficient: 1.0

RIGHT 0 conversion Polyubiquitination5 E3 MisP Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDeubiquitination7 E3SUB SUB misfolded Ub6 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

…
type: Stoichiometry
physical entity: UCHL1
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBPolyubiquitination5 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDamInclusionGrowth16 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 6.0

RIGHT 2 conversion AsynDamInclusionGrowth3 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBAggregation3 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

asynSynthesis1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion asynSynthesis1 asyn STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion asynSynthesis1 Source STOICHIOMETRY
right: asyn
left: Source

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

UbDegradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion UbDegradation Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion UbDegradation Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion UbDegradation Proteasome STOICHIOMETRY
right: Proteasome
left: Proteasome
left: Ub

LEFT 1 conversion Polyubiquitination7 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

E3_MisP_Ub6
type: PhysicalEntity
member physical entity: E3_MisP_Ub6
cellular location: cytosol

E3_MisP_Ub4
type: PhysicalEntity
member physical entity: E3_MisP_Ub4
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3_MisP_Ub3
type: PhysicalEntity
member physical entity: E3_MisP_Ub3
cellular location: cytosol

E3_MisP_Ub2
type: PhysicalEntity
member physical entity: E3_MisP_Ub2
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth10 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

E3_MisP_Ub8
type: PhysicalEntity
member physical entity: E3_MisP_Ub8
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggS2 AggS2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS2
stoichiometric coefficient: 1.0

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

LEFT 1 conversion ProteasomeInhibition2 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

UbSynthesis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion UbSynthesis Source STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion UbSynthesis Ub STOICHIOMETRY
right: Ub
left: Source

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion DisAggregationasyn2 AggA3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA3
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBAggregation3 AggS3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS3
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 2.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3_MisP_Ub7
type: PhysicalEntity
member physical entity: E3_MisP_Ub7
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

E3_MisP_Ub5
type: PhysicalEntity
member physical entity: E3_MisP_Ub5
cellular location: cytosol

RIGHT 1 conversion SUBPolyubiquitination6 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

LEFT 1 conversion DeubiquitinationBoundasynDamUb5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBInclusionGrowth16 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggP1 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

E3_MisP_Ub7
type: PhysicalEntity
member physical entity: E3_MisP_Ub7
cellular location: cytosol

Ub_UCHL1
type: PhysicalEntity
member physical entity: Ub_UCHL1
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundasynDamUb6 asyn dam Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub6_Proteasome
stoichiometric coefficient: 1.0

P62988
type: UnificationXref
id: P62988
db: UniProt Knowledgebase

RIGHT 0 conversion Aggregationasyn5 AggA5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA5
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub4
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth9 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Parkin_asyn_dam_Ub8
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth16 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBInclusionGrowth9 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

AMP
type: PhysicalEntity
member physical entity: AMP
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundSUB5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynPolyubiquitination6 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynProteasomeBindingUb7 Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggD4 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth10 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 1 conversion AsynDamInclusionGrowth18 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBDeubiquitination2 E3SUB SUB misfolded Ub UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionFormation AggD5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD5
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E3_MisP_Ub7_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub7_DUB
cellular location: cytosol

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

RIGHT 0 conversion SUBDegradationUb5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 5.0

RIGHT 0 conversion InclusionGrowth17 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 1 conversion Deubiquitination3 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth2 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBProteasomeBindingUb6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

aggUchl1
type: Protein
xref: P09936

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 1 conversion SUBInclusionGrowth12 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundasynDamUb6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDUBbindingUb4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Parkin_asyn_dam_Ub7_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7_DUB
cellular location: cytosol

AggA5
type: PhysicalEntity
member physical entity: AggA5
cellular location: cytosol

asyn_dam_Ub4_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub4_Proteasome
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth7 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth4 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDeubiquitinationUb2 Parkin asyn dam Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub_DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion Deubiquitination3 E3 MisP Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub3_DUB
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

RIGHT 0 conversion Deubiquitination2 E3 MisP Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub_DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion DeubiquitinationBoundSUB8 SUB misfolded Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub7_Proteasome
stoichiometric coefficient: 1.0

E3_MisP_Ub5
type: PhysicalEntity
member physical entity: E3_MisP_Ub5
cellular location: cytosol

E3_MisP_Ub3
type: PhysicalEntity
member physical entity: E3_MisP_Ub3
cellular location: cytosol

DeubiquitinationBoundSUB4
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundSUB4 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundSUB4 SUB misfolded Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundSUB4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundSUB4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundSUB4 SUB misfolded STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion DeubiquitinationBoundSUB4 DUB STOICHIOMETRY
right: Proteasome
right: SUB_misfolded
right: DUB
right: Ub
spontaneous: true
left: SUB_misfolded_Ub4_Proteasome
left: DUB
conversion direction: RIGHT_TO_LEFT

DeubiquitinationBoundSUB5
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundSUB5 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundSUB5 SUB misfolded Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundSUB5 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundSUB5 SUB misfolded Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundSUB5 DUB STOICHIOMETRY
right: DUB
right: Ub
right: SUB_misfolded_Ub4_Proteasome
left: SUB_misfolded_Ub5_Proteasome
left: DUB

LEFT 0 conversion SUBDegradationUb4 SUB misfolded Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub4_Proteasome
stoichiometric coefficient: 1.0

DeubiquitinationBoundSUB6
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundSUB6 SUB misfolded Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundSUB6 Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundSUB6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundSUB6 SUB misfolded Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundSUB6 DUB STOICHIOMETRY
right: Ub
right: SUB_misfolded_Ub5_Proteasome
right: DUB
left: SUB_misfolded_Ub6_Proteasome
left: DUB

LEFT 0 conversion AsynDeubiquitinationUb5 Parkin asyn dam Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5_DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DeubiquitinationBoundSUB7
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundSUB7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundSUB7 SUB misfolded Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundSUB7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundSUB7 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundSUB7 SUB misfolded Ub7 Proteasome STOICHIOMETRY
right: Ub
right: SUB_misfolded_Ub6_Proteasome
right: DUB
left: SUB_misfolded_Ub7_Proteasome
left: DUB

DeubiquitinationBoundSUB8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundSUB8 SUB misfolded Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundSUB8 SUB misfolded Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundSUB8 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundSUB8 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundSUB8 DUB STOICHIOMETRY
right: Ub
right: SUB_misfolded_Ub7_Proteasome
right: DUB
left: SUB_misfolded_Ub8_Proteasome
left: DUB

RIGHT 2 conversion InclusionGrowth5 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 3.0

RIGHT 1 conversion SUBProteasomeBindingUb7 E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion InclusionGrowth18 E3 MisP Ub8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8_DUB
stoichiometric coefficient: 1.0

ROSgenerationSmallAggP5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggP5 AggP5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggP5 AggP5 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggP5 ROS STOICHIOMETRY
right: AggP5
right: ROS
left: AggP5

RIGHT 1 conversion DeubiquitinationBoundMisP3 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

ROSgenerationSmallAggP1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggP1 AggP1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggP1 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggP1 AggP1 STOICHIOMETRY
right: ROS
right: AggP1
left: AggP1

ROSgenerationSmallAggP2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggP2 AggP2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggP2 AggP2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggP2 ROS STOICHIOMETRY
right: ROS
right: AggP2
left: AggP2

ROSgenerationSmallAggP3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggP3 AggP3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggP3 AggP3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggP3 ROS STOICHIOMETRY
right: AggP3
right: ROS
left: AggP3

ROSgenerationSmallAggP4
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggP4 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggP4 AggP4 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggP4 AggP4 STOICHIOMETRY
right: AggP4
right: ROS
left: AggP4

E3SUB_SUB_misfolded_Ub5_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
cellular location: cytosol

LEFT 0 conversion AsynInclusionGrowth SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

E1
type: Protein
xref: IPR000011

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

Parkin_asyn_dam_Ub6
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6
cellular location: cytosol

E2
type: Protein
xref: IPR000608

E3
type: Protein
xref: IPR000569

asyn_dam_Ub6_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: P37840

E3_MisP
type: PhysicalEntity
member physical entity: E3_MisP
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggA1 AggA1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA1
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 2 conversion E1UbBinding ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth5 Parkin asyn dam Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3
stoichiometric coefficient: 1.0

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUB_misfolded_Ub8_Proteasome
type: Complex
xref: P62988
xref: GO:0000502

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggA3 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDeubiquitinationUb5 Parkin asyn dam Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4_DUB
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub6
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6
cellular location: cytosol

LEFT 0 conversion ProteasomeActivity3 MisP Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub6_Proteasome
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E1_Ub
type: Complex
xref: IPR000011
xref: P62988

LEFT 1 conversion AsynProteasomeBindingUb6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion Aggregation4 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

LEFT 0 conversion ProteasomeInhibition4 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub6_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6_DUB
cellular location: cytosol

RIGHT 3 conversion InclusionGrowth15 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynInclusionGrowth aggasyn STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyn
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionGrowth10 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 0 conversion InclusionGrowth18 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

asynCMAdegradation
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion asynCMAdegradation asyn Lamp2a STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion asynCMAdegradation Lamp2a STOICHIOMETRY
right: Lamp2a
spontaneous: true
left: asyn_Lamp2a
conversion direction: RIGHT_TO_LEFT

E3_MisP_Ub3_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub3_DUB
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SUBMonoubiquitination
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBMonoubiquitination E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBMonoubiquitination E2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBMonoubiquitination E3SUB SUB misfolded STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBMonoubiquitination E3SUB SUB misfolded Ub STOICHIOMETRY
right: E2
right: E3SUB_SUB_misfolded_Ub
left: E3SUB_SUB_misfolded
left: E2_Ub

E3SUB_SUB_misfolded_Ub8
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBInclusionGrowth14 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 0 conversion ProteasomeActivity2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 5.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggD1 AggD1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD1
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

E3SUB_SUB_misfolded_Ub7
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7
cellular location: cytosol

RIGHT 0 conversion DisaggregationAsynDam5 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 2.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 2 conversion DeubiquitinationBoundMisP4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDamInclusionGrowth8 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

SUB_misfolded_Ub6_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub6_Proteasome
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion AsynPolyubiquitination7 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

AggP5
type: PhysicalEntity
member physical entity: AggP5
cellular location: cytosol

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

LEFT 0 conversion DisaggregationAsynDam5 AggD1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD1
stoichiometric coefficient: 1.0

ROSgenerationSmallAggS1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggS1 AggS1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggS1 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggS1 AggS1 STOICHIOMETRY
right: AggS1
right: ROS
left: AggS1

ROSgenerationSmallAggS2
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggS2 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggS2 AggS2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggS2 AggS2 STOICHIOMETRY
right: AggS2
right: ROS
left: AggS2

ROSgenerationSmallAggS3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggS3 AggS3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggS3 AggS3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggS3 ROS STOICHIOMETRY
right: ROS
right: AggS3
left: AggS3

LEFT 0 conversion SUBInclusionGrowth15 E3SUB SUB misfolded Ub6 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
stoichiometric coefficient: 1.0

MisP
type: SmallMolecule
xref: CHEBI:36080

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion SUBRefolding SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

RIGHT 2 conversion UbUpregulation upregUb STOICHIOMETRY
type: Stoichiometry
physical entity: upregUb
stoichiometric coefficient: 3.0

MisP_Ub8_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub8_Proteasome
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

RIGHT 2 conversion DeubiquitinationBoundSUB7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDeubiquitination1 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: UCHL1
stoichiometric coefficient: 1.0

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

RIGHT 0 conversion AsynPolyubiquitination3 Parkin asyn dam Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggU2 AggU2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU2
stoichiometric coefficient: 1.0

UCHL1_Proteasome
type: Complex
xref: GO:0000502
xref: P09936

RIGHT 0 conversion DeubiquitinationBoundSUB6 SUB misfolded Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub5_Proteasome
stoichiometric coefficient: 1.0

E1UbBinding
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion E1UbBinding E1 STOICHIOMETRY
participant stoichiometry: LEFT 2 conversion E1UbBinding ATP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion E1UbBinding Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion E1UbBinding E1 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion E1UbBinding AMP STOICHIOMETRY
right: E1_Ub
right: AMP
spontaneous: true
left: E1
left: Ub
left: ATP
conversion direction: LEFT_TO_RIGHT

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth11 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

E3_MisP_Ub
type: PhysicalEntity
member physical entity: E3_MisP_Ub
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth10 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

ROSgenerationSmallAggD1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggD1 AggD1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggD1 AggD1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggD1 ROS STOICHIOMETRY
right: AggD1
right: ROS
left: AggD1

Parkin_asyn_dam_Ub7
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7
cellular location: cytosol

ROSgenerationSmallAggD2
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggD2 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggD2 AggD2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggD2 AggD2 STOICHIOMETRY
right: ROS
right: AggD2
left: AggD2

ROSgenerationSmallAggD3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggD3 AggD3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggD3 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggD3 AggD3 STOICHIOMETRY
right: ROS
right: AggD3
left: AggD3

LEFT 1 conversion SUBProteasomeBindingUb7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

ROSgenerationSmallAggD4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggD4 AggD4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggD4 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggD4 AggD4 STOICHIOMETRY
right: AggD4
right: ROS
left: AggD4

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

Misfolding
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion Misfolding ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Misfolding NatP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Misfolding MisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Misfolding ROS STOICHIOMETRY
right: MisP
right: ROS
left: NatP
left: ROS

Parkin_asyn_dam_Ub8_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

RIGHT 0 conversion InclusionGrowth8 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 0 conversion SUBDegradationUb6 SUB misfolded Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub6_Proteasome
stoichiometric coefficient: 1.0

ROSgenerationSmallAggD5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggD5 AggD5 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggD5 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggD5 AggD5 STOICHIOMETRY
right: AggD5
right: ROS
left: AggD5

RIGHT 2 conversion DeubiquitinationBoundasynDamUb7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynInclusionFormation AggA5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA5
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth17 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth5 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

LEFT 0 conversion asyn damParkinRelease Parkin asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDamInclusionGrowth15 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 5.0

LEFT 0 conversion SUBInclusionGrowth14 E3SUB SUB misfolded Ub5 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
stoichiometric coefficient: 1.0

LEFT 0 conversion Deubiquitination5 E3 MisP Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5_DUB
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

E3SUB_SUB_misfolded_Ub
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub
cellular location: cytosol

RIGHT 1 conversion DisaggregationAsynDam2 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBInclusionGrowth11 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

Parkin_asyn_dam_Ub4_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4_DUB
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

AggA5
type: PhysicalEntity
member physical entity: AggA5
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 0 conversion AsynDUBbindingUb5 Parkin asyn dam Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5_DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggS5 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 0 conversion SUBAggregation2 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

E3SUB_SUB_misfolded_Ub8_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8_UCHL1
cellular location: cytosol

RIGHT 2 conversion AsynDamInclusionGrowth13 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 3.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion Polyubiquitination2 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

AggA2ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

InclusionGrowth2
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion InclusionGrowth2 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth2 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth2 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth2 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth2 E3 MisP STOICHIOMETRY
right: aggE3
right: aggMisP
right: SeqAggP
spontaneous: true
left: E3_MisP
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

InclusionGrowth3
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion InclusionGrowth3 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth3 aggE3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth3 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth3 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth3 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth3 E3 MisP Ub STOICHIOMETRY
right: SeqAggP
right: aggE3
right: aggMisP
right: aggUb
spontaneous: true
left: E3_MisP_Ub
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

InclusionGrowth4
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion InclusionGrowth4 E3 MisP Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth4 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth4 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth4 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth4 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth4 aggE3 STOICHIOMETRY
right: aggE3
right: SeqAggP
right: aggMisP
right: aggUb
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub2
conversion direction: RIGHT_TO_LEFT

InclusionGrowth5
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion InclusionGrowth5 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth5 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth5 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth5 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth5 E3 MisP Ub3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth5 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggUb
right: aggE3
right: aggMisP
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub3
conversion direction: RIGHT_TO_LEFT

InclusionGrowth6
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion InclusionGrowth6 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth6 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth6 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth6 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth6 E3 MisP Ub4 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth6 aggE3 STOICHIOMETRY
right: aggE3
right: aggMisP
right: SeqAggP
right: aggUb
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub4
conversion direction: RIGHT_TO_LEFT

InclusionGrowth7
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion InclusionGrowth7 E3 MisP Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth7 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth7 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth7 aggE3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth7 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth7 aggMisP STOICHIOMETRY
right: aggMisP
right: aggUb
right: SeqAggP
right: aggE3
spontaneous: true
left: E3_MisP_Ub5
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

InclusionGrowth8
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion InclusionGrowth8 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth8 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth8 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth8 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth8 aggE3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth8 E3 MisP Ub6 STOICHIOMETRY
right: SeqAggP
right: aggMisP
right: aggE3
right: aggUb
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub6
conversion direction: RIGHT_TO_LEFT

InclusionGrowth9
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion InclusionGrowth9 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth9 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth9 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth9 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth9 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth9 E3 MisP Ub7 STOICHIOMETRY
right: SeqAggP
right: aggUb
right: aggMisP
right: aggE3
spontaneous: true
left: E3_MisP_Ub7
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

IPR000569
type: UnificationXref
id: IPR000569
db: InterPro

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub2_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2_DUB
cellular location: cytosol

InclusionGrowth1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion InclusionGrowth1 MisP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth1 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth1 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth1 SeqAggP STOICHIOMETRY
right: aggMisP
right: SeqAggP
left: SeqAggP
left: MisP

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

SUB_misfolded_Ub5_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub5_Proteasome
cellular location: cytosol

E3SUB_SUB_misfolded_Ub7
type: Complex
xref: P62988
xref: IPR000569

E3SUB_SUB_misfolded_Ub8
type: Complex
xref: P62988
xref: IPR000569

E3SUB_SUB_misfolded_Ub5
type: Complex
xref: P62988
xref: IPR000569

ProteasomeActivity1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ProteasomeActivity1 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeActivity1 MisP Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeActivity1 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeActivity1 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion ProteasomeActivity1 ADP STOICHIOMETRY
right: Proteasome
right: ADP
right: Ub
left: MisP_Ub4_Proteasome
left: ATP

Parkin_asyn_dam_Ub4
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4
cellular location: cytosol

E3SUB_SUB_misfolded_Ub6
type: Protein
xref: P62988
xref: IPR000569

ProteasomeActivity2
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion ProteasomeActivity2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion ProteasomeActivity2 ADP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeActivity2 MisP Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeActivity2 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeActivity2 ATP STOICHIOMETRY
right: ADP
right: Proteasome
right: Ub
spontaneous: true
left: MisP_Ub5_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

E3SUB_SUB_misfolded_Ub3
type: Complex
xref: P62988
xref: IPR000569

ProteasomeActivity3
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion ProteasomeActivity3 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeActivity3 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeActivity3 MisP Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeActivity3 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion ProteasomeActivity3 ADP STOICHIOMETRY
right: Proteasome
right: Ub
right: ADP
spontaneous: true
left: ATP
left: MisP_Ub6_Proteasome
conversion direction: RIGHT_TO_LEFT

Lamp2a
type: Protein
xref: P13473

E3SUB_SUB_misfolded_Ub4
type: Complex
xref: P62988
xref: IPR000569

ProteasomeActivity4
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion ProteasomeActivity4 ADP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeActivity4 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeActivity4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeActivity4 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeActivity4 MisP Ub7 Proteasome STOICHIOMETRY
right: Proteasome
right: Ub
right: ADP
spontaneous: true
left: MisP_Ub7_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

ProteasomeActivity5
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion ProteasomeActivity5 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeActivity5 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion ProteasomeActivity5 ADP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeActivity5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeActivity5 MisP Ub8 Proteasome STOICHIOMETRY
right: Ub
right: Proteasome
right: ADP
spontaneous: true
left: MisP_Ub8_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

E3SUB_SUB_misfolded_Ub2
type: Complex
xref: P62988
xref: IPR000569

RIGHT 4 conversion InclusionGrowth17 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

AggD4ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

MisP_Ub6_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: CHEBI:36080

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundMisP4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth10 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDUBbindingUb6 Parkin asyn dam Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6_DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBPolyubiquitination1 E3SUB SUB misfolded Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub2
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

MisP_Ub5_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: CHEBI:36080

asyn_dam_Ub6_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub6_Proteasome
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth10 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 8.0

asyn_dam_Ub5_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub5_Proteasome
cellular location: cytosol

SUB
type: PhysicalEntity
member physical entity: SUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion AsynDeubiquitinationUb1 Parkin asyn dam Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub_DUB
stoichiometric coefficient: 1.0

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

RIGHT 0 conversion AsynProteasomeActivityUb4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 4.0

RIGHT 1 conversion SUBDeubiquitination2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 1 conversion AsynDamInclusionGrowth17 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundasynDamUb5 asyn dam Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub5_Proteasome
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

LEFT 1 conversion InclusionGrowth10 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 0 conversion ProteasomeInhibition4 AggP Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: AggP_Proteasome
stoichiometric coefficient: 1.0

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

RIGHT 1 conversion SUBProteasomeBindingUb5 E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynProteasomeBindingUb5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

E3SUB_SUB_misfolded_Ub4
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4
cellular location: cytosol

AggU5
type: PhysicalEntity
member physical entity: AggU5
cellular location: cytosol

RIGHT 0 conversion ProteasomeBindingUb5 E3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth1 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBmisfolding SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 1 conversion AsynDUBbindingUb8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth18 Parkin asyn dam Ub8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8_DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBDegradationUb5 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cytosol

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggU5 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDisaggregation2 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

aggMisP
type: PhysicalEntity

Ub_UCHL1
type: PhysicalEntity
member physical entity: Ub_UCHL1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub5_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5_DUB
cellular location: cytosol

RIGHT 0 conversion AsynProteasomeBindingUb5 asyn dam Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub5_Proteasome
stoichiometric coefficient: 1.0

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

RIGHT 4 conversion InclusionGrowth13 aggDUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggDUB
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

E3SUB_SUB_misfolded_Ub3_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DUB
type: Protein
xref: IPR001394

RIGHT 0 conversion AsynInclusionGrowth SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 1 conversion AsynDegradationUb5 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggS1 AggS1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS1
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBPolyubiquitination2 E3SUB SUB misfolded Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub3
stoichiometric coefficient: 1.0

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

SUBDegradationUb5
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion SUBDegradationUb5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDegradationUb5 SUB misfolded Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBDegradationUb5 ADP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBDegradationUb5 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDegradationUb5 Ub STOICHIOMETRY
right: Proteasome
right: Ub
right: ADP
spontaneous: true
left: SUB_misfolded_Ub5_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

SUBDegradationUb4
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBDegradationUb4 Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBDegradationUb4 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDegradationUb4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBDegradationUb4 ADP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDegradationUb4 SUB misfolded Ub4 Proteasome STOICHIOMETRY
right: Proteasome
right: ADP
right: Ub
spontaneous: true
left: SUB_misfolded_Ub4_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

SUBDegradationUb7
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBDegradationUb7 SUB misfolded Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBDegradationUb7 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDegradationUb7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBDegradationUb7 ADP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDegradationUb7 Ub STOICHIOMETRY
right: Ub
right: Proteasome
right: ADP
spontaneous: true
left: SUB_misfolded_Ub7_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion ROSgenerationSmallAggD5 AggD5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD5
stoichiometric coefficient: 1.0

SUBDegradationUb6
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBDegradationUb6 SUB misfolded Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBDegradationUb6 ADP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDegradationUb6 Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBDegradationUb6 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDegradationUb6 Proteasome STOICHIOMETRY
right: ADP
right: Proteasome
right: Ub
spontaneous: true
left: SUB_misfolded_Ub6_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

SUBDegradationUb8
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion SUBDegradationUb8 ADP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBDegradationUb8 SUB misfolded Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBDegradationUb8 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBDegradationUb8 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBDegradationUb8 Proteasome STOICHIOMETRY
right: Ub
right: Proteasome
right: ADP
spontaneous: true
left: SUB_misfolded_Ub8_Proteasome
left: ATP
conversion direction: RIGHT_TO_LEFT

E3_MisP_Ub
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

…
type: Stoichiometry
stoichiometric coefficient: 2.0

LEFT 0 conversion AsynPolyubiquitination7 Parkin asyn dam Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub5_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5_DUB
cellular location: cytosol

RIGHT 0 conversion Deubiquitination3 E3 MisP Ub2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2_DUB
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub2_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2_DUB
cellular location: cytosol

RIGHT 0 conversion DisAggregationasyn4 AggA1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA1
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E3_MisP_Ub3_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub3_DUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth17 Parkin asyn dam Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynProteasomeActivityUb4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth2 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

RIGHT 0 conversion InclusionGrowth7 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 1 conversion DisaggregationAsynDam1 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub2
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2
cellular location: cytosol

Parkin_asyn_dam_Ub5_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5_DUB
cellular location: cytosol

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

RIGHT 1 conversion ProteasomeBindingUb7 MisP Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub7_Proteasome
stoichiometric coefficient: 1.0

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

LEFT 0 conversion Disaggregation2 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundMisP4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

LEFT 0 conversion UbSynthesis Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub4
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUB_misfolded_Ub7_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub7_Proteasome
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

LEFT 1 conversion MisPDUBbinding1 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

RIGHT 0 conversion SUBDeubiquitination3 E3SUB SUB misfolded Ub2 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

LEFT 0 conversion AsynProteasomeBindingUb4 Parkin asyn dam Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub4
stoichiometric coefficient: 1.0

RIGHT 2 conversion DeubiquitinationBoundasyn damUb8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynProteasomeBindingUb4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

UCHL1Synthesis
type: BiochemicalReaction
right: UCHL1
left: Source

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 2 conversion SUBDegradationUb7 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

RIGHT 0 conversion AsynMonoubiquitination Parkin asyn dam Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynProteasomeBindingUb7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

SUB_misfolded_Ub7_Proteasome
type: Complex
xref: P62988
xref: GO:0000502

RIGHT 2 conversion SUBDegradationUb8 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth4 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 3.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDamInclusionGrowth5 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

LEFT 0 conversion ProteinSynthesis Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3SUB_SUB_misfolded
type: Protein
xref: IPR000569

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth14 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

LEFT 1 conversion MisPDUBbinding2 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 1 conversion E3SUBBinding E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

DeubiquitinationBoundasynDamUb6
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundasynDamUb6 Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundasynDamUb6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundasynDamUb6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundasynDamUb6 asyn dam Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundasynDamUb6 asyn dam Ub6 Proteasome STOICHIOMETRY
right: asyn_dam_Ub5_Proteasome
right: Ub
right: DUB
left: asyn_dam_Ub6_Proteasome
left: DUB

DeubiquitinationBoundasynDamUb5
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundasynDamUb5 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundasynDamUb5 asyn dam Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundasynDamUb5 asyn dam Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundasynDamUb5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundasynDamUb5 DUB STOICHIOMETRY
right: Ub
right: asyn_dam_Ub4_Proteasome
right: DUB
left: asyn_dam_Ub5_Proteasome
left: DUB

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

DeubiquitinationBoundasynDamUb4
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundasynDamUb4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundasynDamUb4 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion DeubiquitinationBoundasynDamUb4 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundasynDamUb4 asyn dam Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundasynDamUb4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundasynDamUb4 asyn dam STOICHIOMETRY
right: Proteasome
right: asyn_dam
right: DUB
right: Ub
spontaneous: true
left: DUB
left: asyn_dam_Ub4_Proteasome
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion ProteasomeBindingUb8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggD5
type: PhysicalEntity
member physical entity: AggD5
cellular location: cytosol

upregUb
type: Protein
xref: P62988

Parkin_asyn_dam_Ub6_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6_DUB
cellular location: cytosol

Parkin_asyn_dam_Ub
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub
cellular location: cytosol

NatP
type: PhysicalEntity
member physical entity: NatP
cellular location: cytosol

RIGHT 2 conversion ProteasomeActivity4 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth13 E3SUB SUB misfolded Ub4 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth6 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

RIGHT 0 conversion ProteasomeBindingUb4 E3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBMonoubiquitination E3SUB SUB misfolded Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub
stoichiometric coefficient: 1.0

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

DeubiquitinationBoundMisP4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundMisP4 MisP Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundMisP4 MisP Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundMisP4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundMisP4 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundMisP4 DUB STOICHIOMETRY
right: Ub
right: DUB
right: MisP_Ub6_Proteasome
left: DUB
left: MisP_Ub7_Proteasome

…
type: Stoichiometry
stoichiometric coefficient: 1.0

DeubiquitinationBoundMisP5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundMisP5 MisP Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundMisP5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundMisP5 MisP Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundMisP5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundMisP5 Ub STOICHIOMETRY
right: MisP_Ub7_Proteasome
right: Ub
right: DUB
left: DUB
left: MisP_Ub8_Proteasome

DeubiquitinationBoundMisP2
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundMisP2 MisP Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundMisP2 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundMisP2 MisP Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundMisP2 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundMisP2 Ub STOICHIOMETRY
right: MisP_Ub4_Proteasome
right: DUB
right: Ub
spontaneous: true
left: MisP_Ub5_Proteasome
left: DUB
conversion direction: RIGHT_TO_LEFT

DeubiquitinationBoundMisP3
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundMisP3 Ub STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundMisP3 MisP Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundMisP3 MisP Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundMisP3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundMisP3 DUB STOICHIOMETRY
right: DUB
right: MisP_Ub5_Proteasome
right: Ub
left: MisP_Ub6_Proteasome
left: DUB

RIGHT 0 conversion E3SUBRelease SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

DeubiquitinationBoundMisP1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundMisP1 MisP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundMisP1 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundMisP1 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundMisP1 MisP Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundMisP1 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion DeubiquitinationBoundMisP1 DUB STOICHIOMETRY
right: Ub
right: DUB
right: MisP
right: Proteasome
left: DUB
left: MisP_Ub4_Proteasome

Parkin_asyn_dam_Ub
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub
cellular location: cytosol

DeubiquitinationBoundasynDamUb7
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundasynDamUb7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundasynDamUb7 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundasynDamUb7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundasynDamUb7 asyn dam Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundasynDamUb7 asyn dam Ub7 Proteasome STOICHIOMETRY
right: Ub
right: asyn_dam_Ub6_Proteasome
right: DUB
left: asyn_dam_Ub7_Proteasome
left: DUB

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub4_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4_UCHL1
cellular location: cytosol

RIGHT 0 conversion DeubiquitinationBoundasynDamUb6 asyn dam Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub5_Proteasome
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3
type: Complex
xref: O60260
xref: P62988
xref: P37840

SUB_misfolded_Ub7_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub7_Proteasome
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

Parkin_asyn_dam_Ub2
type: Complex
xref: O60260
xref: P62988
xref: P37840

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 2 conversion SUBDegradationUb4 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

asyn_dam
type: Protein
xref: P37840

AggA4
type: PhysicalEntity
member physical entity: AggA4
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth9 E3SUB SUB misfolded Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub8
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth3 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 1 conversion ProteasomeBindingUb5 MisP Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub5_Proteasome
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion Polyubiquitination2 E3 MisP Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggU2 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

SUB_misfolded_Ub8_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub8_Proteasome
cellular location: cytosol

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundSUB4 SUB misfolded Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub4_Proteasome
stoichiometric coefficient: 1.0

asyn_dam_Ub8_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub8_Proteasome
cellular location: cytosol

Parkin_asyn_dam_Ub8
type: Complex
xref: O60260
xref: P62988
xref: P37840

LEFT 0 conversion AsynDamInclusionGrowth9 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub7
type: Complex
xref: O60260
xref: P62988
xref: P37840

Parkin_asyn_dam_Ub6
type: Complex
xref: O60260
xref: P62988
xref: P37840

Parkin_asyn_dam_Ub5
type: Complex
xref: O60260
xref: P62988
xref: P37840

Parkin_asyn_dam_Ub4
type: Complex
xref: O60260
xref: P62988
xref: P37840

E3_MisP_Ub6_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub6_DUB
cellular location: cytosol

LEFT 0 conversion SUBInclusionFormation AggS5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS5
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDeubiquitinationUb4 Parkin asyn dam Ub3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3_DUB
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3_DUB
cellular location: cytosol

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundSUB6 SUB misfolded Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub6_Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBInclusionGrowth12 E3SUB SUB misfolded Ub3 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion Deubiquitination1 E3 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth9 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBPolyubiquitination7 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

AggU5ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

E3_MisP
type: PhysicalEntity
member physical entity: E3_MisP
cellular location: cytosol

AsynProteasomeBindingUb6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AsynProteasomeBindingUb6 asyn dam Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynProteasomeBindingUb6 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynProteasomeBindingUb6 Parkin asyn dam Ub6 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynProteasomeBindingUb6 Parkin STOICHIOMETRY
right: Parkin
right: asyn_dam_Ub6_Proteasome
left: Proteasome
left: Parkin_asyn_dam_Ub6

AsynProteasomeBindingUb5
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AsynProteasomeBindingUb5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynProteasomeBindingUb5 Parkin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynProteasomeBindingUb5 asyn dam Ub5 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynProteasomeBindingUb5 Parkin asyn dam Ub5 STOICHIOMETRY
right: Parkin
right: asyn_dam_Ub5_Proteasome
left: Parkin_asyn_dam_Ub5
left: Proteasome

AsynProteasomeBindingUb4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynProteasomeBindingUb4 Parkin asyn dam Ub4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynProteasomeBindingUb4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynProteasomeBindingUb4 asyn dam Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynProteasomeBindingUb4 Parkin STOICHIOMETRY
right: Parkin
right: asyn_dam_Ub4_Proteasome
left: Parkin_asyn_dam_Ub4
left: Proteasome

LEFT 0 conversion AsynProteasomeActivityUb4 asyn dam Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub4_Proteasome
stoichiometric coefficient: 1.0

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

AsynProteasomeBindingUb8
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AsynProteasomeBindingUb8 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynProteasomeBindingUb8 Parkin STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynProteasomeBindingUb8 asyn dam Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynProteasomeBindingUb8 Parkin asyn dam Ub8 STOICHIOMETRY
right: asyn_dam_Ub8_Proteasome
right: Parkin
left: Parkin_asyn_dam_Ub8
left: Proteasome

AsynProteasomeBindingUb7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AsynProteasomeBindingUb7 Parkin asyn dam Ub7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynProteasomeBindingUb7 asyn dam Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynProteasomeBindingUb7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynProteasomeBindingUb7 Parkin STOICHIOMETRY
right: asyn_dam_Ub7_Proteasome
right: Parkin
left: Proteasome
left: Parkin_asyn_dam_Ub7

RIGHT 1 conversion InclusionGrowth7 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

RIGHT 3 conversion InclusionGrowth13 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

UCHL1_damaged
type: Protein
xref: P09936

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 0 conversion Aggregationasyn3 AggA3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA3
stoichiometric coefficient: 1.0

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

LEFT 0 conversion InclusionGrowth14 E3 MisP Ub4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4_DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion DeubiquitinationBoundasynDamUb5 asyn dam Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub4_Proteasome
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth4 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 0 conversion Polyubiquitination6 E3 MisP Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6
stoichiometric coefficient: 1.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

UbUCHL1binding
type: ComplexAssembly
spontaneous: true
left: UCHL1
left: Ub
conversion direction: LEFT_TO_RIGHT

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth14 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

Ub
type: Protein
xref: P62988

LEFT 0 conversion DisaggregationAsynDam1 AggD5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD5
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3_MisP_Ub6_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub6_DUB
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

LEFT 0 conversion AsynDUBbindingUb3 Parkin asyn dam Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

RIGHT 0 conversion SUBAggregation1 AggS1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS1
stoichiometric coefficient: 1.0

LEFT 1 conversion E1UbBinding Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

asyn_dam_Ub5_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub5_Proteasome
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 1 conversion SUBAggregation4 AggS3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS3
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeInhibition1 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

UCHL1Lamp2aRelease
type: BiochemicalReaction

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundSUB5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 0 conversion AsynDeubiquitinationUb6 Parkin asyn dam Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5_DUB
stoichiometric coefficient: 1.0

RIGHT 1 conversion InclusionGrowth3 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth6 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 1 conversion ProteasomeInhibition3 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth12 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

LEFT 0 conversion Aggregationasyn5 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

RIGHT 1 conversion AsynPolyubiquitination1 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion DisaggregationAsynDam4 AggD1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD1
stoichiometric coefficient: 1.0

E3_MisP_Ub5_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

RIGHT 1 conversion Polyubiquitination3 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth10 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

Lysosome
type: PhysicalEntity
member physical entity: Lysosome
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

E3_MisP_Ub7_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub7_DUB
cellular location: cytosol

RIGHT 3 conversion InclusionGrowth8 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub8
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8
cellular location: cytosol

ROSgenerationSmallAggA1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggA1 AggA1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggA1 AggA1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggA1 ROS STOICHIOMETRY
right: ROS
right: AggA1
left: AggA1

SUB_misfolded
type: PhysicalEntity

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

ROSgenerationSmallAggA2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggA2 AggA2 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggA2 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggA2 AggA2 STOICHIOMETRY
right: AggA2
right: ROS
left: AggA2

Parkin_asyn_dam
type: PhysicalEntity
member physical entity: Parkin_asyn_dam
cellular location: cytosol

ROSgenerationSmallAggA3
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggA3 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggA3 AggA3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggA3 AggA3 STOICHIOMETRY
right: AggA3
right: ROS
left: AggA3

ROSgenerationSmallAggA4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggA4 AggA4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggA4 AggA4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggA4 ROS STOICHIOMETRY
right: ROS
right: AggA4
left: AggA4

AggD5
type: PhysicalEntity
member physical entity: AggD5
cellular location: cytosol

asyn_Proteasome
type: PhysicalEntity
member physical entity: asyn_Proteasome
cellular location: cytosol

ROSgenerationSmallAggA5
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggA5 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggA5 AggA5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggA5 AggA5 STOICHIOMETRY
right: ROS
right: AggA5
left: AggA5

aggUchl1dam
type: Protein
xref: P09936

RIGHT 2 conversion ProteasomeActivity5 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

Parkin_asyn_dam_Ub6_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6_DUB
cellular location: cytosol

E3_MisP
type: PhysicalEntity
member physical entity: E3_MisP
cellular location: cytosol

RIGHT 1 conversion Monoubiquitination E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDeubiquitination3 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Lysosome
type: PhysicalEntity
xref: GO:0005764

AggA5
type: PhysicalEntity
member physical entity: AggA5
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 0 conversion radicalScavenging ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion E2UbBinding E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3_MisP
type: PhysicalEntity
member physical entity: E3_MisP
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

radicalScavenging
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion radicalScavenging Sink STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion radicalScavenging ROS STOICHIOMETRY
right: Sink
left: ROS

SUB_misfolded
type: PhysicalEntity
member physical entity: SUB_misfolded
cellular location: cytosol

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggA5 AggA5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA5
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth1 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion DeubiquitinationBoundMisP1 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth16 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 3 conversion InclusionGrowth5 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggP4 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDeubiquitinationUb8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3_MisP_Ub5_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub5_DUB
cellular location: cytosol

RIGHT 0 conversion asyn damParkinRelease asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Parkin_asyn_dam_Ub7_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7_DUB
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth8 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

RIGHT 0 conversion Polyubiquitination7 E3 MisP Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8
stoichiometric coefficient: 1.0

AggU2ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion AsynPolyubiquitination5 Parkin asyn dam Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth16 E3 MisP Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6_DUB
stoichiometric coefficient: 1.0

DeubiquitinationBoundasyn_damUb8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion DeubiquitinationBoundasyn damUb8 asyn dam Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion DeubiquitinationBoundasyn damUb8 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion DeubiquitinationBoundasyn damUb8 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion DeubiquitinationBoundasyn damUb8 asyn dam Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion DeubiquitinationBoundasyn damUb8 Ub STOICHIOMETRY
right: DUB
right: asyn_dam_Ub7_Proteasome
right: Ub
left: asyn_dam_Ub8_Proteasome
left: DUB

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

…
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

LEFT 1 conversion Polyubiquitination1 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBAggregation5 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

E3_MisP_Ub4
type: PhysicalEntity
member physical entity: E3_MisP_Ub4
cellular location: cytosol

LEFT 0 conversion AggregationAsynDam3 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

AggD3
type: PhysicalEntity
member physical entity: AggD3
cellular location: cytosol

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

Parkin_asyn_dam_Ub3_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3_DUB
cellular location: cytosol

RIGHT 1 conversion AsynPolyubiquitination6 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 3 conversion SUBInclusionGrowth11 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 2.0

Parkin_asyn_dam_Ub2
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2
cellular location: cytosol

LEFT 0 conversion AsynPolyubiquitination2 Parkin asyn dam Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2
stoichiometric coefficient: 1.0

Source
type: PhysicalEntity
member physical entity: Source
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundMisP1 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

AggregationAsynDam2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion AggregationAsynDam2 AggD1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AggregationAsynDam2 AggD2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AggregationAsynDam2 asyn dam STOICHIOMETRY
right: AggD2
left: AggD1
left: asyn_dam

AggregationAsynDam3
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion AggregationAsynDam3 AggD3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AggregationAsynDam3 asyn dam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AggregationAsynDam3 AggD2 STOICHIOMETRY
right: AggD3
left: AggD2
left: asyn_dam

LEFT 0 conversion DeubiquitinationBoundasynDamUb4 asyn dam Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub4_Proteasome
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub4
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4
cellular location: cytosol

AggregationAsynDam1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AggregationAsynDam1 asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AggregationAsynDam1 AggD1 STOICHIOMETRY
right: AggD1
left: asyn_dam

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

RIGHT 0 conversion Polyubiquitination3 E3 MisP Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4
stoichiometric coefficient: 1.0

LEFT 1 conversion AggregationAsynDam3 AggD2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD2
stoichiometric coefficient: 1.0

AggregationAsynDam4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AggregationAsynDam4 asyn dam STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AggregationAsynDam4 AggD3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AggregationAsynDam4 AggD4 STOICHIOMETRY
right: AggD4
left: asyn_dam
left: AggD3

E3SUB_SUB_misfolded_Ub5_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5_UCHL1
cellular location: cytosol

LEFT 0 conversion AsynDegradationUb6 asyn dam Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub6_Proteasome
stoichiometric coefficient: 1.0

AggregationAsynDam5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AggregationAsynDam5 asyn dam STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AggregationAsynDam5 AggD5 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AggregationAsynDam5 AggD4 STOICHIOMETRY
right: AggD5
left: AggD4
left: asyn_dam

LEFT 0 conversion SUBInclusionGrowth1 E3SUB SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded
stoichiometric coefficient: 1.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

RIGHT 3 conversion InclusionGrowth17 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynProteasomeBindingUb4 asyn dam Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub4_Proteasome
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

LEFT 0 conversion AsynPolyubiquitination5 Parkin asyn dam Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

Parkin_asyn_dam_Ub8_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8_DUB
cellular location: cytosol

Parkin_asyn_dam_Ub8
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5
cellular location: cytosol

MisP_Ub5_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub5_Proteasome
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 0 conversion SUBDegradationUb6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 6.0

E3_MisP_Ub7_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub7_DUB
cellular location: cytosol

AggS3ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

E3SUB_SUB_misfolded_Ub3
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

E3SUB
type: PhysicalEntity
member physical entity: E3SUB
cellular location: cytosol

RIGHT 1 conversion AsynDeubiquitinationUb2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

SUB_misfolded_Ub5_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub5_Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Lamp2a
type: PhysicalEntity
member physical entity: Lamp2a
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 2 conversion InclusionGrowth13 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 3.0

E3SUB_SUB_misfolded_Ub_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
cellular location: cytosol

RIGHT 0 conversion AsynDUBbindingUb1 Parkin asyn dam Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub_DUB
stoichiometric coefficient: 1.0

Parkin_asyn_dam
type: PhysicalEntity
member physical entity: Parkin_asyn_dam
cellular location: cytosol

LEFT 0 conversion DeubiquitinationBoundasynDamUb7 asyn dam Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub7_Proteasome
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub2
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2
cellular location: cytosol

LEFT 0 conversion radicalFormation Source STOICHIOMETRY
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

RIGHT 0 conversion UCHL1damage UCHL1 damaged STOICHIOMETRY
type: Stoichiometry
physical entity: UCHL1_damaged
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
xref: GO:0000502

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub2_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2_DUB
cellular location: cytosol

RIGHT 0 conversion AsynProteasomeBindingUb7 asyn dam Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub7_Proteasome
stoichiometric coefficient: 1.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

RIGHT 1 conversion E2UbBinding E1 STOICHIOMETRY
type: Stoichiometry
physical entity: E1
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDamInclusionGrowth5 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 3.0

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

UbUCHL1release
type: ComplexAssembly
right: Ub
right: UCHL1
spontaneous: true
conversion direction: RIGHT_TO_LEFT

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion Polyubiquitination5 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion SUBDisaggregation4 AggS1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

LEFT 1 conversion ProteasomeBindingUb6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 0 conversion Aggregation1 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

Parkin_asyn_dam_Ub6
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundasynDamUb7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggU1 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBInclusionGrowth7 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 6.0

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Parkin_asyn_dam_Ub4_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4_DUB
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth12 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 0 conversion SUBInclusionGrowth11 E3SUB SUB misfolded Ub2 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth9 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 7.0

UCHL1_Proteasome
type: PhysicalEntity
member physical entity: UCHL1_Proteasome
cellular location: cytosol

E3SUB_SUB_misfolded_Ub3_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E3_MisP_Ub_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub_DUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 1 conversion SUBInclusionGrowth5 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 1 conversion Deubiquitination4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion AggregationAsynDam4 AggD4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD4
stoichiometric coefficient: 1.0

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

RIGHT 3 conversion DeubiquitinationBoundasynDamUb4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDamInclusionGrowth12 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

LEFT 1 conversion Aggregation3 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub6_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggP2 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub3_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth14 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth7 Parkin asyn dam Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5
stoichiometric coefficient: 1.0

MisP_Ub7_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub7_Proteasome
cellular location: cytosol

LEFT 1 conversion SUBPolyubiquitination1 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeActivity2 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionFormation AggP5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP5
stoichiometric coefficient: 1.0

RIGHT 1 conversion InclusionGrowth5 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

E3_MisP_Ub7_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

…
type: Stoichiometry
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

aggasyn
type: PhysicalEntity
member physical entity: aggasyn
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth13 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

LEFT 0 conversion DeubiquitinationBoundasyn damUb8 asyn dam Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub8_Proteasome
stoichiometric coefficient: 1.0

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

MisPE3Release
type: ComplexAssembly
right: MisP
right: E3
spontaneous: true
left: E3_MisP
conversion direction: RIGHT_TO_LEFT

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth3 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

AggP5
type: PhysicalEntity
member physical entity: AggP5
cellular location: cytosol

RIGHT 0 conversion AsynPolyubiquitination6 Parkin asyn dam Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub7
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundSUB4 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

AggU4
type: PhysicalEntity
member physical entity: AggU4
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 0 conversion MisPDUBbinding5 E3 MisP Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5_DUB
stoichiometric coefficient: 1.0

Lysosome
type: PhysicalEntity
member physical entity: Lysosome
cellular location: cytosol

LEFT 0 conversion SUBAggregation1 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 2.0

E3_MisP_Ub
type: PhysicalEntity
member physical entity: E3_MisP_Ub
cellular location: cytosol

LEFT 1 conversion SUBPolyubiquitination5 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

RIGHT 3 conversion InclusionGrowth6 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeInhibition5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

P13473
type: UnificationXref
id: P13473
db: UniProt Knowledgebase

RIGHT 1 conversion ROSgenerationSmallAggD3 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 0 conversion ProteasomeActivity4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 7.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

Sink
type: PhysicalEntity
member physical entity: Sink
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth7 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

RIGHT 2 conversion DeubiquitinationBoundSUB4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 4.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth14 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

LEFT 0 conversion DisAggregationasyn3 AggA3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA3
stoichiometric coefficient: 1.0

LEFT 1 conversion DeubiquitinationBoundSUB6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

IPR000608
type: UnificationXref
id: IPR000608
db: InterPro

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth16 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggS3 AggS3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS3
stoichiometric coefficient: 1.0

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth3 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion ProteinSynthesis NatP STOICHIOMETRY
type: Stoichiometry
physical entity: NatP
stoichiometric coefficient: 1.0

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

RIGHT 1 conversion SUBInclusionGrowth13 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

AggU5
type: PhysicalEntity
member physical entity: AggU5
cellular location: cytosol

MisP_Ub6_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub6_Proteasome
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

MODEL0912070000
type: UnificationXref
id: MODEL0912070000
db: BioModels Database

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 2 conversion DeubiquitinationBoundSUB8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SUB_misfolded_Ub4_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub4_Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

UCHL1damage
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion UCHL1damage UCHL1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion UCHL1damage ROS STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion UCHL1damage ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion UCHL1damage UCHL1 damaged STOICHIOMETRY
right: UCHL1_damaged
right: ROS
left: ROS
left: UCHL1

RIGHT 2 conversion DeubiquitinationBoundMisP3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth13 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

UCHL1DamagedLamp2aSequestering
type: BiochemicalReaction

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion InclusionGrowth5 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

cytosol
type: CellularLocationVocabulary

RIGHT 1 conversion Polyubiquitination4 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 2 conversion DeubiquitinationBoundMisP5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

AggS4ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundSUB8 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

RIGHT 1 conversion AsynDamInclusionGrowth1 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

RIGHT 1 conversion AsynProteasomeBindingUb8 Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

AggP5
type: PhysicalEntity
member physical entity: AggP5
cellular location: cytosol

E2_Ub
type: Complex
xref: P62988
xref: IPR000608

asynProt20Sbinding
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

E3_MisP
type: Complex
xref: CHEBI:36080
xref: IPR000569

RIGHT 0 conversion Disaggregation2 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

RIGHT 1 conversion Deubiquitination8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 0 conversion Disaggregation5 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

LEFT 0 conversion MisPDUBbinding2 E3 MisP Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
xref: CHEBI:16761

RIGHT 1 conversion AsynDamInclusionGrowth7 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

AggU4ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion InclusionGrowth8 E3 MisP Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggD2 AggD2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD2
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDUBbindingUb7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggU4 AggU4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU4
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeActivity1 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggA2 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

BIOMD0000000105
type: UnificationXref
id: BIOMD0000000105
db: BioModels Database

RIGHT 0 conversion asynCMAdegradation Lamp2a STOICHIOMETRY
type: Stoichiometry
physical entity: Lamp2a
stoichiometric coefficient: 1.0

LEFT 0 conversion DeubiquitinationBoundMisP5 MisP Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub8_Proteasome
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 1 conversion AsynDamInclusionGrowth8 Parkin asyn dam Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6
stoichiometric coefficient: 1.0

upregUb
type: PhysicalEntity
member physical entity: upregUb
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

E3SUB_SUB_misfolded_Ub8_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8_UCHL1
cellular location: cytosol

E3SUB_SUB_misfolded_Ub_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub_UCHL1
cellular location: cytosol

LEFT 0 conversion DisAggregationasyn4 AggA2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA2
stoichiometric coefficient: 1.0

AggU3ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

…
type: Stoichiometry
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUBPolyubiquitination5
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination5 E3SUB SUB misfolded Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination5 E3SUB SUB misfolded Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination5 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination5 E2 STOICHIOMETRY
right: E2
right: E3SUB_SUB_misfolded_Ub6
spontaneous: true
left: E3SUB_SUB_misfolded_Ub5
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

SUBPolyubiquitination4
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination4 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination4 E3SUB SUB misfolded Ub5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination4 E3SUB SUB misfolded Ub4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination4 E2 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub5
right: E2
spontaneous: true
left: E3SUB_SUB_misfolded_Ub4
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

SUBPolyubiquitination7
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination7 E3SUB SUB misfolded Ub8 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination7 E3SUB SUB misfolded Ub7 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination7 E2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination7 E2 Ub STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub8
right: E2
spontaneous: true
left: E3SUB_SUB_misfolded_Ub7
left: E2_Ub
conversion direction: RIGHT_TO_LEFT

SUBPolyubiquitination6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination6 E3SUB SUB misfolded Ub7 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination6 E3SUB SUB misfolded Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination6 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination6 E2 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub7
right: E2
left: E3SUB_SUB_misfolded_Ub6
left: E2_Ub

SUBPolyubiquitination1
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination1 E3SUB SUB misfolded Ub2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination1 E3SUB SUB misfolded Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination1 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination1 E2 STOICHIOMETRY
right: E2
right: E3SUB_SUB_misfolded_Ub2
spontaneous: true
left: E2_Ub
left: E3SUB_SUB_misfolded_Ub
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion asynDamage asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

SUBPolyubiquitination3
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination3 E3SUB SUB misfolded Ub4 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination3 E3SUB SUB misfolded Ub3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination3 E2 Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination3 E2 STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub4
right: E2
spontaneous: true
left: E2_Ub
left: E3SUB_SUB_misfolded_Ub3
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion SUBDeubiquitination4 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

SUBPolyubiquitination2
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBPolyubiquitination2 E3SUB SUB misfolded Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBPolyubiquitination2 E3SUB SUB misfolded Ub3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBPolyubiquitination2 E2 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBPolyubiquitination2 E2 Ub STOICHIOMETRY
right: E3SUB_SUB_misfolded_Ub3
right: E2
spontaneous: true
left: E2_Ub
left: E3SUB_SUB_misfolded_Ub2
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion DisAggregationasyn2 AggA4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA4
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth12 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggD3 AggD3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD3
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBDegradationUb6 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub3
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggU2 AggU2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU2
stoichiometric coefficient: 1.0

RIGHT 3 conversion SUBInclusionGrowth15 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 6.0

RIGHT 0 conversion UbUpregulation MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub6
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6
cellular location: cytosol

LEFT 1 conversion DeubiquitinationBoundMisP3 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

AsynInclusionFormation
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion AsynInclusionFormation aggasyn STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion AsynInclusionFormation AggA5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynInclusionFormation SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynInclusionFormation asyn STOICHIOMETRY
right: SeqAggP
right: aggasyn
left: AggA5
left: asyn

SUBInclusionGrowth15
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth15 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth15 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth15 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth15 E3SUB SUB misfolded Ub6 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth15 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth15 aggUchl1 STOICHIOMETRY
right: SeqAggP
right: aggSUB
right: aggUchl1
right: aggUb
spontaneous: true
left: SeqAggP
left: E3SUB_SUB_misfolded_Ub6_UCHL1
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion SUBPolyubiquitination1 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 0 conversion Aggregationasyn2 AggA2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA2
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SUBInclusionGrowth16
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth16 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth16 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth16 E3SUB SUB misfolded Ub7 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth16 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth16 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth16 aggUchl1 STOICHIOMETRY
right: aggSUB
right: aggUb
right: aggUchl1
right: SeqAggP
spontaneous: true
left: E3SUB_SUB_misfolded_Ub7_UCHL1
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion AsynDamInclusionGrowth14 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

SUBInclusionGrowth17
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth17 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth17 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth17 E3SUB SUB misfolded Ub8 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth17 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth17 aggUchl1 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth17 aggUb STOICHIOMETRY
right: aggUchl1
right: aggSUB
right: SeqAggP
right: aggUb
spontaneous: true
left: E3SUB_SUB_misfolded_Ub8_UCHL1
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion AsynProteasomeBindingUb6 Parkin STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

RIGHT 0 conversion SUBProteasomeBindingUb4 SUB misfolded Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub4_Proteasome
stoichiometric coefficient: 1.0

E3_MisP_Ub6
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

E3_MisP_Ub7
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

E3_MisP_Ub8
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

SUBInclusionGrowth10
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth10 E3SUB SUB misfolded Ub UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth10 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth10 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth10 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth10 aggUchl1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth10 SeqAggP STOICHIOMETRY
right: aggUb
right: aggSUB
right: aggUchl1
right: SeqAggP
spontaneous: true
left: E3SUB_SUB_misfolded_Ub_UCHL1
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

E3_MisP_Ub2
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

SUBInclusionGrowth11
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth11 aggUchl1 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth11 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth11 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth11 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth11 aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth11 E3SUB SUB misfolded Ub2 UCHL1 STOICHIOMETRY
right: aggUchl1
right: SeqAggP
right: aggSUB
right: aggUb
spontaneous: true
left: E3SUB_SUB_misfolded_Ub2_UCHL1
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

E3_MisP_Ub3
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

SUBInclusionGrowth12
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth12 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth12 aggUchl1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth12 E3SUB SUB misfolded Ub3 UCHL1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth12 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth12 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth12 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggUb
right: aggSUB
right: aggUchl1
spontaneous: true
left: SeqAggP
left: E3SUB_SUB_misfolded_Ub3_UCHL1
conversion direction: RIGHT_TO_LEFT

E3_MisP_Ub4
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

SUBInclusionGrowth13
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth13 E3SUB SUB misfolded Ub4 UCHL1 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth13 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth13 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth13 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth13 aggUchl1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth13 SeqAggP STOICHIOMETRY
right: aggSUB
right: aggUchl1
right: aggUb
right: SeqAggP
spontaneous: true
left: SeqAggP
left: E3SUB_SUB_misfolded_Ub4_UCHL1
conversion direction: RIGHT_TO_LEFT

E3_MisP_Ub5
type: Complex
xref: P62988
xref: CHEBI:36080
xref: IPR000569

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SUBInclusionGrowth14
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth14 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth14 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth14 aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth14 E3SUB SUB misfolded Ub5 UCHL1 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth14 aggUchl1 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion SUBInclusionGrowth14 aggUb STOICHIOMETRY
right: aggUchl1
right: SeqAggP
right: aggSUB
right: aggUb
spontaneous: true
left: E3SUB_SUB_misfolded_Ub5_UCHL1
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion ROSgenerationSmallAggD1 AggD1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD1
stoichiometric coefficient: 1.0

Lysosome
type: PhysicalEntity
member physical entity: Lysosome
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth12 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

RIGHT 0 conversion Monoubiquitination E3 MisP Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub
stoichiometric coefficient: 1.0

RIGHT 0 conversion SUBPolyubiquitination5 E3SUB SUB misfolded Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6
stoichiometric coefficient: 1.0

RIGHT 0 conversion ProteasomeBindingUb6 E3 STOICHIOMETRY
type: Stoichiometry
physical entity: E3
stoichiometric coefficient: 1.0

aggE3
type: PhysicalEntity
member physical entity: aggE3
cellular location: cytosol

LEFT 0 conversion Aggregationasyn3 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

Proctor2010 UCHL1 ProteinAggregation
type: Pathway
pathway component: MisPE3Release
pathway component: MisPE3Binding
pathway component: Refolding
pathway component: UbSynthesis
pathway component: UbUpregulation
pathway component: AggA1ProteasomeInhibition
pathway component: UCHL1Synthesis
pathway component: AggD3ProteasomeInhibition
pathway component: E3SUBRelease
pathway component: DeubiquitinationBoundasynDamUb6
pathway component: DeubiquitinationBoundasynDamUb5
pathway component: DeubiquitinationBoundasynDamUb4
pathway component: AsynDegradationUb5
pathway component: AsynDegradationUb6
pathway component: AsynDegradationUb7
pathway component: AsynDegradationUb8
pathway component: SUBUCHL1binding5Ub_UCHL1
pathway component: DeubiquitinationBoundMisP4
pathway component: DeubiquitinationBoundMisP5
pathway component: DeubiquitinationBoundMisP2
pathway component: UCHL1damage
pathway component: DeubiquitinationBoundMisP3
pathway component: DeubiquitinationBoundMisP1
pathway component: DeubiquitinationBoundasynDamUb7
pathway component: AggS4ProteasomeInhibition
pathway component: DeubiquitinationBoundSUB4
pathway component: DeubiquitinationBoundSUB5
pathway component: DeubiquitinationBoundSUB6
pathway component: DeubiquitinationBoundSUB7
pathway component: DeubiquitinationBoundSUB8
pathway component: AsynPolyubiquitination2
pathway component: AsynPolyubiquitination1
pathway component: AsynPolyubiquitination4
pathway component: AsynMonoubiquitination
pathway component: AsynPolyubiquitination3
pathway component: AsynPolyubiquitination6
pathway component: AsynPolyubiquitination5
pathway component: E3SUBBinding
pathway component: AsynPolyubiquitination7
pathway component: AggD5ProteasomeInhibition
pathway component: AggU1ProteasomeInhibition
pathway component: asynProt20Sbinding
pathway component: ROSgenerationSmallAggP5
pathway component: ROSgenerationSmallAggP1
pathway component: ROSgenerationSmallAggP2
pathway component: ROSgenerationSmallAggP3
pathway component: ROSgenerationSmallAggP4
pathway component: AggU5ProteasomeInhibition
pathway component: AggU4ProteasomeInhibition
pathway component: AsynProteasomeBindingUb6
pathway component: AsynProteasomeBindingUb5
pathway component: InclusionFormation
pathway component: AsynProteasomeBindingUb4
pathway component: AsynProteasomeBindingUb8
pathway component: AsynProteasomeBindingUb7
pathway component: radicalFormation
pathway component: UCHL1ProteasomeDegradation
pathway component: AggU3ProteasomeInhibition
pathway component: UbUCHL1binding
pathway component: AsynDeubiquitinationUb7
pathway component: Aggregation5
pathway component: AsynDeubiquitinationUb8
pathway component: SUBRefolding
pathway component: Aggregation2
pathway component: AsynDeubiquitinationUb3
pathway component: Aggregation1
pathway component: AsynDeubiquitinationUb4
pathway component: Aggregation4
pathway component: AsynDeubiquitinationUb5
pathway component: Aggregation3
pathway component: AsynDeubiquitinationUb6
pathway component: SUBPolyubiquitination5
pathway component: SUBPolyubiquitination4
pathway component: SUBPolyubiquitination7
pathway component: AsynDeubiquitinationUb1
pathway component: SUBPolyubiquitination6
pathway component: asynCMAdegradation
pathway component: AsynDeubiquitinationUb2
pathway component: SUBPolyubiquitination1

asyn_dam_Ub8_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: P37840

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

E3_MisP_Ub7
type: PhysicalEntity
member physical entity: E3_MisP_Ub7
cellular location: cytosol

LEFT 1 conversion AggregationAsynDam5 AggD4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD4
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynDegradationUb8 asyn dam Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub8_Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth9 E3 MisP Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7
stoichiometric coefficient: 1.0

E3_MisP_Ub_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub_DUB
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

MisP_Ub6_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub6_Proteasome
cellular location: cytosol

Parkin_asyn_dam_Ub7_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7_DUB
cellular location: cytosol

LEFT 0 conversion AsynDamInclusionGrowth4 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub2_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggS4 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

LEFT 0 conversion Disaggregation4 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

AggU2
type: PhysicalEntity
member physical entity: AggU2
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth15 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

SUB_misfolded_Ub6_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub6_Proteasome
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

LEFT 1 conversion InclusionGrowth1 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub7_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

MisPDUBbinding8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MisPDUBbinding8 E3 MisP Ub8 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MisPDUBbinding8 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding8 E3 MisP Ub8 DUB STOICHIOMETRY
right: E3_MisP_Ub8_DUB
left: DUB
left: E3_MisP_Ub8

MisPDUBbinding7
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion MisPDUBbinding7 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding7 E3 MisP Ub7 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MisPDUBbinding7 E3 MisP Ub7 STOICHIOMETRY
right: E3_MisP_Ub7_DUB
left: DUB
left: E3_MisP_Ub7

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

MisPDUBbinding6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding6 E3 MisP Ub6 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MisPDUBbinding6 E3 MisP Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MisPDUBbinding6 DUB STOICHIOMETRY
right: E3_MisP_Ub6_DUB
left: DUB
left: E3_MisP_Ub6

LEFT 1 conversion SUBAggregation3 AggS2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS2
stoichiometric coefficient: 1.0

MisPDUBbinding5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MisPDUBbinding5 E3 MisP Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding5 E3 MisP Ub5 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MisPDUBbinding5 DUB STOICHIOMETRY
right: E3_MisP_Ub5_DUB
left: DUB
left: E3_MisP_Ub5

LEFT 0 conversion ProteasomeBindingUb5 E3 MisP Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5
stoichiometric coefficient: 1.0

MisPDUBbinding4
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion MisPDUBbinding4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding4 E3 MisP Ub4 DUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion MisPDUBbinding4 E3 MisP Ub4 STOICHIOMETRY
right: E3_MisP_Ub4_DUB
left: DUB
left: E3_MisP_Ub4

MisPDUBbinding3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MisPDUBbinding3 E3 MisP Ub3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding3 E3 MisP Ub3 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MisPDUBbinding3 DUB STOICHIOMETRY
right: E3_MisP_Ub3_DUB
left: DUB
left: E3_MisP_Ub3

LEFT 0 conversion AsynDamInclusionFormation asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

MisPDUBbinding2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MisPDUBbinding2 E3 MisP Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding2 E3 MisP Ub2 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MisPDUBbinding2 DUB STOICHIOMETRY
right: E3_MisP_Ub2_DUB
left: DUB
left: E3_MisP_Ub2

MisPDUBbinding1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion MisPDUBbinding1 E3 MisP Ub STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion MisPDUBbinding1 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion MisPDUBbinding1 E3 MisP Ub DUB STOICHIOMETRY
right: E3_MisP_Ub_DUB
left: DUB
left: E3_MisP_Ub

LEFT 1 conversion SUBInclusionGrowth13 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth8 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 6.0

Parkin_asyn_dam_Ub5
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion ProteasomeBindingUb4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth17 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

E3_MisP_Ub2_DUB
type: Complex
xref: P62988
xref: IPR001394
xref: CHEBI:36080
xref: IPR000569

RIGHT 0 conversion Aggregation2 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynPolyubiquitination5 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: Source
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

LEFT 1 conversion SUBProteasomeBindingUb4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion DisAggregationasyn1 AggA5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA5
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub
cellular location: cytosol

RIGHT 1 conversion SUBPolyubiquitination4 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDeubiquitinationUb3 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

aggUchl1dam
type: PhysicalEntity
member physical entity: aggUchl1dam
cellular location: cytosol

E3
type: PhysicalEntity
member physical entity: E3
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

LEFT 0 conversion UCHL1damage UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: UCHL1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggD2
type: PhysicalEntity
member physical entity: AggD2
cellular location: cytosol

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggA2 AggA2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA2
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub4
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub4
cellular location: cytosol

E3SUB_SUB_misfolded_Ub8_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8_UCHL1
cellular location: cytosol

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

AggU1
type: PhysicalEntity
member physical entity: AggU1
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth13 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 2 conversion AsynDamInclusionGrowth8 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 6.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundSUB6 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

AggD1
type: PhysicalEntity
member physical entity: AggD1
cellular location: cytosol

P37840
type: UnificationXref
id: P37840
db: UniProt Knowledgebase

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion AsynProteasomeBindingUb8 asyn dam Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub8_Proteasome
stoichiometric coefficient: 1.0

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

MisP_Ub5_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub5_Proteasome
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

E3_MisP_Ub2
type: PhysicalEntity
member physical entity: E3_MisP_Ub2
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBPolyubiquitination6 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDegradationUb6 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

E3_MisP_Ub6_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub6_DUB
cellular location: cytosol

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 0 conversion Disaggregation3 AggP2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP2
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDamInclusionGrowth11 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDeubiquitinationUb7 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

RIGHT 0 conversion InclusionGrowth12 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

DOID:1289
type: UnificationXref
id: DOID:1289
db: Human Disease Ontology

Lamp2a_UCHL1_damaged
type: Protein
xref: P13473
xref: P09936

RIGHT 1 conversion AsynDamInclusionFormation aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 7.0

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

LEFT 0 conversion MisPDUBbinding8 E3 MisP Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub8
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggUchl1
type: PhysicalEntity
member physical entity: aggUchl1
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth9 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

RIGHT 0 conversion AggregationAsynDam5 AggD5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD5
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth8 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

LEFT 1 conversion InclusionGrowth11 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBInclusionGrowth3 E3SUB SUB misfolded Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub2
stoichiometric coefficient: 1.0

LEFT 0 conversion ProteasomeActivity4 MisP Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub7_Proteasome
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub2
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2
cellular location: cytosol

LEFT 0 conversion InclusionGrowth11 E3 MisP Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub_DUB
stoichiometric coefficient: 1.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion ProteasomeInhibition1 AggP Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: AggP_Proteasome
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBPolyubiquitination6 E3SUB SUB misfolded Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

RIGHT 0 conversion ROSgenerationSmallAggP1 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBDegradationUb4 ATP STOICHIOMETRY
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth8 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth2 E3SUB SUB misfolded Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub
stoichiometric coefficient: 1.0

AMP
type: SmallMolecule
xref: CHEBI:16027

Parkin_asyn_dam_Ub7
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7
cellular location: cytosol

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

RIGHT 0 conversion SUBProteasomeBindingUb5 SUB misfolded Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub5_Proteasome
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 0 conversion InclusionFormation SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

Parkin_asyn_dam_Ub7_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7_DUB
cellular location: cytosol

LEFT 0 conversion SUBDisaggregation4 AggS2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS2
stoichiometric coefficient: 1.0

ROS
type: SmallMolecule
xref: CHEBI:26523

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

…
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggS4 AggS4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS4
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggA4 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 2 conversion SUBInclusionGrowth10 aggUchl1 STOICHIOMETRY
type: Stoichiometry
physical entity: aggUchl1
stoichiometric coefficient: 1.0

AggU3
type: PhysicalEntity
member physical entity: AggU3
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

RIGHT 0 conversion Disaggregation5 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 2.0

LEFT 0 conversion ProteasomeInhibition1 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggA5 AggA5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA5
stoichiometric coefficient: 1.0

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

RIGHT 2 conversion InclusionGrowth16 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 6.0

MisP_Ub7_Proteasome
type: PhysicalEntity
member physical entity: MisP_Ub7_Proteasome
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth8 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 7.0

…
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

E3SUB_SUB_misfolded_Ub6_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6_UCHL1
cellular location: cytosol

Parkin_asyn_dam_Ub_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub_DUB
cellular location: cytosol

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

BioModels Database
type: Provenance
xref: BIOMD0000000293

LEFT 0 conversion ROSgenerationSmallAggA4 AggA4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA4
stoichiometric coefficient: 1.0

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

Parkin_asyn_dam_Ub7
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7
cellular location: cytosol

BioModels Database
type: Provenance
xref: MODEL0912070000

LEFT 1 conversion DeubiquitinationBoundMisP5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

asyn_dam_Ub7_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub7_Proteasome
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth16 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion MisPDUBbinding6 E3 MisP Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6_DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBPolyubiquitination7 E3SUB SUB misfolded Ub7 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDeubiquitination8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

asyn_dam_Ub8_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub8_Proteasome
cellular location: cytosol

RIGHT 1 conversion ROSgenerationSmallAggD1 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

AggP2
type: PhysicalEntity
member physical entity: AggP2
cellular location: cytosol

RIGHT 0 conversion SUBProteasomeBindingUb8 SUB misfolded Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub8_Proteasome
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3
cellular location: cytosol

RIGHT 3 conversion AsynDamInclusionGrowth8 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynDamInclusionGrowth10 Parkin asyn dam Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8
stoichiometric coefficient: 1.0

RIGHT 2 conversion ProteasomeActivity2 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth7 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 5.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

aggasyndam
type: Protein
xref: P37840

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggA5
type: PhysicalEntity
member physical entity: AggA5
cellular location: cytosol

RIGHT 1 conversion InclusionGrowth18 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynPolyubiquitination3 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

MisPE3Binding
type: ComplexAssembly
spontaneous: true
left: E3
left: MisP
conversion direction: LEFT_TO_RIGHT

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggD5 AggD5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD5
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub3_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub3_DUB
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynPolyubiquitination4 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

RIGHT 0 conversion Deubiquitination7 E3 MisP Ub6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub6_DUB
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub8
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundasynDamUb5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

LEFT 0 conversion Deubiquitination7 E3 MisP Ub7 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub7_DUB
stoichiometric coefficient: 1.0

Lamp2a_UCHL1_damaged
type: PhysicalEntity
member physical entity: Lamp2a_UCHL1_damaged
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 2 conversion ProteasomeActivity3 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionFormation SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

RIGHT 2 conversion ProteasomeActivity1 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub7_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
cellular location: cytosol

LEFT 1 conversion asynDamage ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 1 conversion Disaggregation4 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

LEFT 0 conversion InclusionGrowth15 E3 MisP Ub5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub5_DUB
stoichiometric coefficient: 1.0

LEFT 0 conversion SUBDisaggregation5 AggS1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS1
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

E3SUBRelease
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion E3SUBRelease E3SUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion E3SUBRelease E3SUB SUB misfolded STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion E3SUBRelease SUB misfolded STOICHIOMETRY
right: E3SUB
right: SUB_misfolded
left: E3SUB_SUB_misfolded

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion DeubiquitinationBoundMisP4 MisP Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub6_Proteasome
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth7 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth5 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBPolyubiquitination7 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

SUBUCHL1binding5Ub_UCHL1
type: BiochemicalReaction

aggasyndam
type: PhysicalEntity
member physical entity: aggasyndam
cellular location: cytosol

aggDUB
type: Protein
xref: IPR001394

RIGHT 2 conversion AsynDamInclusionGrowth12 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 2.0

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

E3SUB_SUB_misfolded_Ub5
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub5
cellular location: cytosol

AggA3
type: PhysicalEntity
member physical entity: AggA3
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

LEFT 1 conversion SUBInclusionGrowth9 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

AggP1
type: PhysicalEntity
member physical entity: AggP1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 2 conversion AsynDegradationUb6 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AggS1
type: PhysicalEntity
member physical entity: AggS1
cellular location: cytosol

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 0 conversion ROSgenerationSmallAggA3 AggA3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA3
stoichiometric coefficient: 1.0

LEFT 0 conversion AggregationAsynDam2 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub4_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4_DUB
cellular location: cytosol

ATP
type: SmallMolecule
xref: CHEBI:15422

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

LEFT 1 conversion SUBmisfolding ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

RIGHT 1 conversion DeubiquitinationBoundSUB8 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Parkin
type: PhysicalEntity
member physical entity: Parkin
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth6 E3SUB SUB misfolded Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub5
stoichiometric coefficient: 1.0

RIGHT 1 conversion SUBDegradationUb4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

E3_MisP_Ub2_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub2_DUB
cellular location: cytosol

RIGHT 0 conversion SUBInclusionGrowth2 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

AggD4
type: PhysicalEntity
member physical entity: AggD4
cellular location: cytosol

UCHL1
type: Protein
xref: P09936

AggP4
type: PhysicalEntity
member physical entity: AggP4
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth17 E3SUB SUB misfolded Ub8 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub8_UCHL1
stoichiometric coefficient: 1.0

aggDUB
type: PhysicalEntity
member physical entity: aggDUB
cellular location: cytosol

Parkin_asyn_dam_Ub_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub_DUB
cellular location: cytosol

RIGHT 1 conversion SUBmisfolding ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggP3
type: PhysicalEntity
member physical entity: AggP3
cellular location: cytosol

E3SUB_SUB_misfolded_Ub2_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggS5 AggS5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS5
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub5_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

SUBRefolding
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBRefolding SUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBRefolding SUB misfolded STOICHIOMETRY
right: SUB
left: SUB_misfolded

UCHL1_damaged_Proteasome
type: Complex
xref: GO:0000502
xref: P09936

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth9 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

E3SUB_SUB_misfolded_Ub2_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub2_UCHL1
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

E3SUB_SUB_misfolded
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded
cellular location: cytosol

RIGHT 1 conversion SUBInclusionGrowth8 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 0 conversion AsynPolyubiquitination6 Parkin asyn dam Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6
stoichiometric coefficient: 1.0

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

RIGHT 0 conversion Polyubiquitination1 E3 MisP Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub2
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

aggParkin
type: Protein
xref: O60260

RIGHT 1 conversion asynDamage ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

UCHL1_damaged
type: PhysicalEntity
member physical entity: UCHL1_damaged
cellular location: cytosol

LEFT 0 conversion DisaggregationAsynDam2 AggD4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD4
stoichiometric coefficient: 1.0

LEFT 0 conversion AsynPolyubiquitination3 Parkin asyn dam Ub3 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub3
stoichiometric coefficient: 1.0

LEFT 0 conversion DisaggregationAsynDam3 AggD3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD3
stoichiometric coefficient: 1.0

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

AggA5
type: PhysicalEntity
member physical entity: AggA5
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

UCHL1LysosomalDegradation
type: BiochemicalReaction

Parkin_asyn_dam_Ub_DUB
type: Complex
xref: O60260
xref: P62988
xref: P37840

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion Aggregationasyn4 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

RIGHT 0 conversion DisaggregationAsynDam2 AggD3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD3
stoichiometric coefficient: 1.0

RIGHT 3 conversion SUBInclusionGrowth16 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 7.0

E3_MisP_Ub4_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub4_DUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

E2_Ub
type: PhysicalEntity
member physical entity: E2_Ub
cellular location: cytosol

RIGHT 0 conversion DisaggregationAsynDam1 AggD4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD4
stoichiometric coefficient: 1.0

RIGHT 3 conversion SUBInclusionGrowth17 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 8.0

AggP_Proteasome
type: PhysicalEntity
member physical entity: AggP_Proteasome
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

LEFT 0 conversion DeubiquitinationBoundMisP1 MisP Ub4 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub4_Proteasome
stoichiometric coefficient: 1.0

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

RIGHT 2 conversion AsynDegradationUb7 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 3 conversion InclusionGrowth7 aggE3 STOICHIOMETRY
type: Stoichiometry
physical entity: aggE3
stoichiometric coefficient: 1.0

LEFT 1 conversion AsynPolyubiquitination5 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion AsynDUBbindingUb8 Parkin asyn dam Ub8 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub8
stoichiometric coefficient: 1.0

LEFT 0 conversion UbUpregulation MisP STOICHIOMETRY
type: Stoichiometry
physical entity: MisP
stoichiometric coefficient: 1.0

RIGHT 1 conversion DeubiquitinationBoundMisP2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

UCHL1DamagedLysosomalDegradation
type: BiochemicalReaction

SUBInclusionGrowth9
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth9 aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth9 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth9 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth9 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth9 E3SUB SUB misfolded Ub8 STOICHIOMETRY
right: aggUb
right: aggSUB
right: SeqAggP
spontaneous: true
left: E3SUB_SUB_misfolded_Ub8
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

SUBInclusionGrowth8
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth8 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth8 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth8 aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth8 E3SUB SUB misfolded Ub7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth8 SeqAggP STOICHIOMETRY
right: aggUb
right: aggSUB
right: SeqAggP
spontaneous: true
left: E3SUB_SUB_misfolded_Ub7
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion DeubiquitinationBoundSUB8 SUB misfolded Ub8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub8_Proteasome
stoichiometric coefficient: 1.0

SUBInclusionGrowth5
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth5 E3SUB SUB misfolded Ub4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth5 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth5 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth5 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth5 SeqAggP STOICHIOMETRY
right: aggSUB
right: SeqAggP
right: aggUb
spontaneous: true
left: SeqAggP
left: E3SUB_SUB_misfolded_Ub4
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion AsynMonoubiquitination E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SUBInclusionGrowth4
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth4 E3SUB SUB misfolded Ub3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth4 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth4 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth4 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth4 SeqAggP STOICHIOMETRY
right: aggSUB
right: SeqAggP
right: aggUb
spontaneous: true
left: SeqAggP
left: E3SUB_SUB_misfolded_Ub3
conversion direction: RIGHT_TO_LEFT

SUBInclusionGrowth7
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth7 aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth7 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth7 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth7 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth7 E3SUB SUB misfolded Ub6 STOICHIOMETRY
right: aggSUB
right: SeqAggP
right: aggUb
left: E3SUB_SUB_misfolded_Ub6
left: SeqAggP

LEFT 0 conversion AsynDUBbindingUb5 Parkin asyn dam Ub5 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub5
stoichiometric coefficient: 1.0

SUBInclusionGrowth6
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth6 E3SUB SUB misfolded Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth6 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth6 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth6 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth6 aggUb STOICHIOMETRY
right: aggSUB
right: aggUb
right: SeqAggP
spontaneous: true
left: E3SUB_SUB_misfolded_Ub5
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

ROSgenerationSmallAggU2
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggU2 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggU2 AggU2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggU2 AggU2 STOICHIOMETRY
right: ROS
right: AggU2
left: AggU2

SUBInclusionGrowth1
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth1 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth1 aggSUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth1 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth1 E3SUB SUB misfolded STOICHIOMETRY
right: SeqAggP
right: aggSUB
left: SeqAggP
left: E3SUB_SUB_misfolded

ROSgenerationSmallAggU3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggU3 AggU3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggU3 AggU3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggU3 ROS STOICHIOMETRY
right: AggU3
right: ROS
left: AggU3

SUBInclusionGrowth0
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth0 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth0 SUB misfolded STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth0 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth0 aggSUB STOICHIOMETRY
right: aggSUB
right: SeqAggP
left: SUB_misfolded
left: SeqAggP

RIGHT 3 conversion AsynDamInclusionGrowth6 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

ROSgenerationSmallAggU4
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggU4 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggU4 AggU4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggU4 AggU4 STOICHIOMETRY
right: AggU4
right: ROS
left: AggU4

SUBInclusionGrowth3
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth3 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth3 E3SUB SUB misfolded Ub2 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth3 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth3 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth3 aggSUB STOICHIOMETRY
right: SeqAggP
right: aggSUB
right: aggUb
spontaneous: true
left: E3SUB_SUB_misfolded_Ub2
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

ROSgenerationSmallAggU5
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggU5 ROS STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggU5 AggU5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggU5 AggU5 STOICHIOMETRY
right: AggU5
right: ROS
left: AggU5

SUBInclusionGrowth2
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion SUBInclusionGrowth2 E3SUB SUB misfolded Ub STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBInclusionGrowth2 aggSUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBInclusionGrowth2 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion SUBInclusionGrowth2 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBInclusionGrowth2 SeqAggP STOICHIOMETRY
right: SeqAggP
right: aggSUB
right: aggUb
spontaneous: true
left: SeqAggP
left: E3SUB_SUB_misfolded_Ub
conversion direction: RIGHT_TO_LEFT

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

ROSgenerationSmallAggU1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggU1 AggU1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggU1 AggU1 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggU1 ROS STOICHIOMETRY
right: ROS
right: AggU1
left: AggU1

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

RIGHT 0 conversion SUBProteasomeBindingUb7 SUB misfolded Ub7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub7_Proteasome
stoichiometric coefficient: 1.0

ROSgenerationSmallAggS4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggS4 AggS4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggS4 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggS4 AggS4 STOICHIOMETRY
right: AggS4
right: ROS
left: AggS4

ROSgenerationSmallAggS5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ROSgenerationSmallAggS5 AggS5 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ROSgenerationSmallAggS5 ROS STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ROSgenerationSmallAggS5 AggS5 STOICHIOMETRY
right: ROS
right: AggS5
left: AggS5

…
type: Stoichiometry
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion AsynDegradationUb5 asyn dam Ub5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub5_Proteasome
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

E3_MisP_Ub8
type: PhysicalEntity
member physical entity: E3_MisP_Ub8
cellular location: cytosol

ROS
type: PhysicalEntity
member physical entity: ROS
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggD4 AggD4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD4
stoichiometric coefficient: 1.0

E3_MisP_Ub_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub_DUB
cellular location: cytosol

AggA1
type: PhysicalEntity
member physical entity: AggA1
cellular location: cytosol

Parkin_asyn_dam_Ub7
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub7
cellular location: cytosol

aggParkin
type: PhysicalEntity
member physical entity: aggParkin
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

CHEBI:36080
type: UnificationXref
id: CHEBI:36080
db: ChEBI

LEFT 1 conversion ProteasomeBindingUb7 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub6
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub6
cellular location: cytosol

Lamp2a_UCHL1_damaged
type: PhysicalEntity
member physical entity: Lamp2a_UCHL1_damaged
cellular location: cytosol

E3_MisP_Ub5_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub5_DUB
cellular location: cytosol

RIGHT 0 conversion DeubiquitinationBoundasynDamUb4 asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggS1 AggS1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS1
stoichiometric coefficient: 1.0

RIGHT 0 conversion AsynDamInclusionGrowth11 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SUBProteasomeBindingUb8
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion SUBProteasomeBindingUb8 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBProteasomeBindingUb8 E3SUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBProteasomeBindingUb8 E3SUB SUB misfolded Ub8 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBProteasomeBindingUb8 SUB misfolded Ub8 Proteasome STOICHIOMETRY
right: E3SUB
right: SUB_misfolded_Ub8_Proteasome
left: E3SUB_SUB_misfolded_Ub8
left: Proteasome

SUBProteasomeBindingUb7
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion SUBProteasomeBindingUb7 E3SUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBProteasomeBindingUb7 SUB misfolded Ub7 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBProteasomeBindingUb7 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBProteasomeBindingUb7 E3SUB SUB misfolded Ub7 STOICHIOMETRY
right: SUB_misfolded_Ub7_Proteasome
right: E3SUB
left: E3SUB_SUB_misfolded_Ub7
left: Proteasome

RIGHT 1 conversion AsynDamInclusionGrowth14 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

SUBProteasomeBindingUb6
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion SUBProteasomeBindingUb6 SUB misfolded Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBProteasomeBindingUb6 E3SUB SUB misfolded Ub6 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBProteasomeBindingUb6 E3SUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBProteasomeBindingUb6 Proteasome STOICHIOMETRY
right: E3SUB
right: SUB_misfolded_Ub6_Proteasome
spontaneous: true
left: Proteasome
left: E3SUB_SUB_misfolded_Ub6
conversion direction: LEFT_TO_RIGHT

SUBProteasomeBindingUb5
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion SUBProteasomeBindingUb5 E3SUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion SUBProteasomeBindingUb5 E3SUB SUB misfolded Ub5 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBProteasomeBindingUb5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBProteasomeBindingUb5 SUB misfolded Ub5 Proteasome STOICHIOMETRY
right: SUB_misfolded_Ub5_Proteasome
right: E3SUB
left: Proteasome
left: E3SUB_SUB_misfolded_Ub5

SUBProteasomeBindingUb4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion SUBProteasomeBindingUb4 E3SUB SUB misfolded Ub4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion SUBProteasomeBindingUb4 E3SUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion SUBProteasomeBindingUb4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion SUBProteasomeBindingUb4 SUB misfolded Ub4 Proteasome STOICHIOMETRY
right: E3SUB
right: SUB_misfolded_Ub4_Proteasome
left: E3SUB_SUB_misfolded_Ub4
left: Proteasome

RIGHT 1 conversion AsynDegradationUb8 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub8
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub8
cellular location: cytosol

InclusionGrowth14
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion InclusionGrowth14 E3 MisP Ub4 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth14 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth14 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth14 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth14 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth14 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth14 aggDUB STOICHIOMETRY
right: aggMisP
right: aggDUB
right: aggUb
right: SeqAggP
right: aggE3
spontaneous: true
left: E3_MisP_Ub4_DUB
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

InclusionGrowth13
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion InclusionGrowth13 E3 MisP Ub3 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth13 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth13 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth13 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth13 aggDUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth13 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth13 aggMisP STOICHIOMETRY
right: SeqAggP
right: aggMisP
right: aggUb
right: aggE3
right: aggDUB
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub3_DUB
conversion direction: RIGHT_TO_LEFT

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

InclusionGrowth16
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion InclusionGrowth16 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth16 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth16 aggE3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth16 E3 MisP Ub6 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth16 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth16 aggDUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth16 SeqAggP STOICHIOMETRY
right: aggE3
right: aggMisP
right: aggDUB
right: SeqAggP
right: aggUb
spontaneous: true
left: E3_MisP_Ub6_DUB
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

NatP
type: SmallMolecule
xref: CHEBI:36080

RIGHT 1 conversion InclusionGrowth4 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

InclusionGrowth15
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion InclusionGrowth15 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth15 E3 MisP Ub5 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth15 aggDUB STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth15 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth15 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth15 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth15 aggE3 STOICHIOMETRY
right: aggE3
right: aggUb
right: aggDUB
right: SeqAggP
right: aggMisP
spontaneous: true
left: E3_MisP_Ub5_DUB
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

InclusionGrowth10
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion InclusionGrowth10 E3 MisP Ub8 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth10 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth10 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth10 SeqAggP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth10 SeqAggP STOICHIOMETRY
right: aggE3
right: aggUb
right: SeqAggP
spontaneous: true
left: E3_MisP_Ub8
left: SeqAggP
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion InclusionGrowth13 aggMisP STOICHIOMETRY
type: Stoichiometry
physical entity: aggMisP
stoichiometric coefficient: 1.0

InclusionGrowth12
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion InclusionGrowth12 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth12 E3 MisP Ub2 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth12 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth12 aggDUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth12 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth12 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth12 aggMisP STOICHIOMETRY
right: aggMisP
right: SeqAggP
right: aggDUB
right: aggUb
right: aggE3
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub2_DUB
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion SUBInclusionGrowth13 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

InclusionGrowth11
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion InclusionGrowth11 E3 MisP Ub DUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth11 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth11 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth11 aggDUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth11 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth11 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth11 SeqAggP STOICHIOMETRY
right: aggMisP
right: aggDUB
right: aggUb
right: aggE3
right: SeqAggP
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub_DUB
conversion direction: RIGHT_TO_LEFT

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

AggA2
type: PhysicalEntity
member physical entity: AggA2
cellular location: cytosol

RIGHT 1 conversion DisAggregationasyn1 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

AggS5ProteasomeInhibition
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT

Lamp2a_UCHL1_damaged
type: PhysicalEntity
member physical entity: Lamp2a_UCHL1_damaged
cellular location: cytosol

E3_MisP_Ub5
type: PhysicalEntity
member physical entity: E3_MisP_Ub5
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 0 conversion SUBProteasomeBindingUb6 SUB misfolded Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded_Ub6_Proteasome
stoichiometric coefficient: 1.0

LEFT 1 conversion Polyubiquitination3 E2 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: E2_Ub
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ProteasomeBindingUb6
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion ProteasomeBindingUb6 MisP Ub6 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeBindingUb6 E3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeBindingUb6 E3 MisP Ub6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeBindingUb6 Proteasome STOICHIOMETRY
right: MisP_Ub6_Proteasome
right: E3
left: Proteasome
left: E3_MisP_Ub6

RIGHT 1 conversion SUBProteasomeBindingUb8 E3SUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB
stoichiometric coefficient: 1.0

ProteasomeBindingUb7
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ProteasomeBindingUb7 E3 MisP Ub7 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeBindingUb7 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeBindingUb7 E3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeBindingUb7 MisP Ub7 Proteasome STOICHIOMETRY
right: MisP_Ub7_Proteasome
right: E3
left: Proteasome
left: E3_MisP_Ub7

ProteasomeBindingUb8
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion ProteasomeBindingUb8 E3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeBindingUb8 MisP Ub8 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeBindingUb8 E3 MisP Ub8 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeBindingUb8 Proteasome STOICHIOMETRY
right: MisP_Ub8_Proteasome
right: E3
left: E3_MisP_Ub8
left: Proteasome

RIGHT 1 conversion ProteasomeActivity1 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggS2 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

ProteasomeBindingUb4
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion ProteasomeBindingUb4 E3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeBindingUb4 MisP Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeBindingUb4 E3 MisP Ub4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeBindingUb4 Proteasome STOICHIOMETRY
right: MisP_Ub4_Proteasome
right: E3
spontaneous: true
left: Proteasome
left: E3_MisP_Ub4
conversion direction: RIGHT_TO_LEFT

ProteasomeBindingUb5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion ProteasomeBindingUb5 E3 MisP Ub5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeBindingUb5 E3 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeBindingUb5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion ProteasomeBindingUb5 MisP Ub5 Proteasome STOICHIOMETRY
right: MisP_Ub5_Proteasome
right: E3
left: Proteasome
left: E3_MisP_Ub5

UCHL1
type: PhysicalEntity
member physical entity: UCHL1
cellular location: cytosol

RIGHT 0 conversion asynSynthesis1 asyn STOICHIOMETRY
type: Stoichiometry
physical entity: asyn
stoichiometric coefficient: 1.0

LEFT 0 conversion ROSgenerationSmallAggP3 AggP3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP3
stoichiometric coefficient: 1.0

InclusionGrowth18
type: ComplexAssembly
participant stoichiometry: RIGHT 2 conversion InclusionGrowth18 aggUb STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion InclusionGrowth18 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth18 aggMisP STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth18 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth18 aggDUB STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth18 E3 MisP Ub8 DUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth18 aggE3 STOICHIOMETRY
right: SeqAggP
right: aggDUB
right: aggMisP
right: aggE3
right: aggUb
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub8_DUB
conversion direction: RIGHT_TO_LEFT

InclusionGrowth17
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion InclusionGrowth17 SeqAggP STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion InclusionGrowth17 aggDUB STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion InclusionGrowth17 aggE3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion InclusionGrowth17 aggMisP STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion InclusionGrowth17 aggUb STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion InclusionGrowth17 E3 MisP Ub7 DUB STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion InclusionGrowth17 SeqAggP STOICHIOMETRY
right: aggMisP
right: SeqAggP
right: aggDUB
right: aggUb
right: aggE3
spontaneous: true
left: SeqAggP
left: E3_MisP_Ub7_DUB
conversion direction: RIGHT_TO_LEFT

asyn
type: PhysicalEntity
member physical entity: asyn
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

CHEBI:16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

RIGHT 0 conversion asyn damParkinBinding Parkin asyn dam STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam
stoichiometric coefficient: 1.0

LEFT 1 conversion Aggregationasyn4 AggA3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA3
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDegradationUb5 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 1 conversion Aggregation5 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

RIGHT 0 conversion ROSgenerationSmallAggP4 AggP4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP4
stoichiometric coefficient: 1.0

RIGHT 0 conversion Disaggregation4 AggP1 STOICHIOMETRY
type: Stoichiometry
physical entity: AggP1
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDamInclusionGrowth11 aggasyndam STOICHIOMETRY
type: Stoichiometry
physical entity: aggasyndam
stoichiometric coefficient: 1.0

RIGHT 0 conversion UbDegradation Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: Proteasome
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded
cellular location: cytosol

LEFT 1 conversion Misfolding ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

ADP
type: PhysicalEntity
member physical entity: ADP
cellular location: cytosol

asynProt20Sdegradation
type: ComplexAssembly
spontaneous: true
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion Polyubiquitination1 E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

E2
type: PhysicalEntity
member physical entity: E2
cellular location: cytosol

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

Parkin_asyn_dam_Ub
type: Complex
xref: O60260
xref: P62988
xref: P37840

RIGHT 2 conversion AsynDamInclusionGrowth7 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 5.0

Parkin_asyn_dam_Ub5_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub5_DUB
cellular location: cytosol

Parkin_asyn_dam_Ub
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub
cellular location: cytosol

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

RIGHT 2 conversion DeubiquitinationBoundSUB6 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

MisP_Ub7_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: CHEBI:36080

RIGHT 1 conversion SUBInclusionGrowth9 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

E3_MisP_Ub4
type: PhysicalEntity
member physical entity: E3_MisP_Ub4
cellular location: cytosol

RIGHT 1 conversion SUBMonoubiquitination E2 STOICHIOMETRY
type: Stoichiometry
physical entity: E2
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub8
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub8
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggS2
type: PhysicalEntity
member physical entity: AggS2
cellular location: cytosol

ProteasomeInhibition3
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion ProteasomeInhibition3 AggP Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeInhibition3 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeInhibition3 AggP3 STOICHIOMETRY
right: AggP_Proteasome
spontaneous: true
left: AggP3
left: Proteasome
conversion direction: LEFT_TO_RIGHT

ProteasomeInhibition4
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion ProteasomeInhibition4 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeInhibition4 AggP4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeInhibition4 AggP Proteasome STOICHIOMETRY
right: AggP_Proteasome
spontaneous: true
left: Proteasome
left: AggP4
conversion direction: LEFT_TO_RIGHT

ProteasomeInhibition1
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion ProteasomeInhibition1 AggP Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion ProteasomeInhibition1 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeInhibition1 AggP1 STOICHIOMETRY
right: AggP_Proteasome
spontaneous: true
left: AggP1
left: Proteasome
conversion direction: LEFT_TO_RIGHT

ProteasomeInhibition2
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion ProteasomeInhibition2 Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeInhibition2 AggP2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeInhibition2 AggP Proteasome STOICHIOMETRY
right: AggP_Proteasome
spontaneous: true
left: Proteasome
left: AggP2
conversion direction: LEFT_TO_RIGHT

ATP
type: PhysicalEntity
member physical entity: ATP
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

ProteasomeInhibition5
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion ProteasomeInhibition5 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion ProteasomeInhibition5 AggP Proteasome STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion ProteasomeInhibition5 AggP5 STOICHIOMETRY
right: AggP_Proteasome
spontaneous: true
left: AggP5
left: Proteasome
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion SUBAggregation4 AggS4 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS4
stoichiometric coefficient: 1.0

RIGHT 2 conversion DeubiquitinationBoundSUB5 DUB STOICHIOMETRY
type: Stoichiometry
physical entity: DUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

aggSUB
type: PhysicalEntity
member physical entity: aggSUB
cellular location: cytosol

RIGHT 0 conversion MisPDUBbinding1 E3 MisP Ub DUB STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub_DUB
stoichiometric coefficient: 1.0

RIGHT 2 conversion InclusionGrowth15 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 5.0

RIGHT 1 conversion SUBInclusionGrowth11 aggSUB STOICHIOMETRY
type: Stoichiometry
physical entity: aggSUB
stoichiometric coefficient: 1.0

E3_MisP_Ub7_DUB
type: PhysicalEntity
member physical entity: E3_MisP_Ub7_DUB
cellular location: cytosol

RIGHT 0 conversion SUBsynthesis SUB STOICHIOMETRY
type: Stoichiometry
physical entity: SUB
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion AggregationAsynDam2 AggD2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggD2
stoichiometric coefficient: 1.0

DisaggregationUCHL1Dam2
type: BiochemicalReaction

DisaggregationUCHL1Dam3
type: BiochemicalReaction

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

asyn_dam_Ub6_Proteasome
type: PhysicalEntity
member physical entity: asyn_dam_Ub6_Proteasome
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

DisaggregationUCHL1Dam4
type: BiochemicalReaction

DisaggregationUCHL1Dam5
type: BiochemicalReaction

SUB_misfolded_Ub8_Proteasome
type: PhysicalEntity
member physical entity: SUB_misfolded_Ub8_Proteasome
cellular location: cytosol

asyn_dam
type: PhysicalEntity
member physical entity: asyn_dam
cellular location: cytosol

DisaggregationUCHL1Dam1
type: BiochemicalReaction

LEFT 0 conversion SUBProteasomeBindingUb6 E3SUB SUB misfolded Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub6
stoichiometric coefficient: 1.0

RIGHT 0 conversion DeubiquitinationBoundasynDamUb7 asyn dam Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: asyn_dam_Ub6_Proteasome
stoichiometric coefficient: 1.0

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

RIGHT 2 conversion SUBInclusionGrowth9 aggUb STOICHIOMETRY
type: Stoichiometry
physical entity: aggUb
stoichiometric coefficient: 8.0

LEFT 1 conversion InclusionGrowth5 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

RIGHT 0 conversion SUBDisaggregation2 AggS3 STOICHIOMETRY
type: Stoichiometry
physical entity: AggS3
stoichiometric coefficient: 1.0

RIGHT 1 conversion ROSgenerationSmallAggS1 ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub4
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub4
cellular location: cytosol

LEFT 0 conversion AsynProteasomeBindingUb6 Parkin asyn dam Ub6 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub6
stoichiometric coefficient: 1.0

LEFT 1 conversion SUBInclusionGrowth4 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 1.0

Proteasome
type: PhysicalEntity
member physical entity: Proteasome
cellular location: cytosol

aggMisP
type: PhysicalEntity
member physical entity: aggMisP
cellular location: cytosol

LEFT 0 conversion ProteasomeBindingUb4 E3 MisP Ub4 STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP_Ub4
stoichiometric coefficient: 1.0

…
type: Stoichiometry
stoichiometric coefficient: 1.0

AggS3
type: PhysicalEntity
member physical entity: AggS3
cellular location: cytosol

…
type: Stoichiometry
stoichiometric coefficient: 1.0

E3SUB_SUB_misfolded_Ub3_UCHL1
type: PhysicalEntity
member physical entity: E3SUB_SUB_misfolded_Ub3_UCHL1
cellular location: cytosol

Parkin_asyn_dam
type: PhysicalEntity
member physical entity: Parkin_asyn_dam
cellular location: cytosol

DUB
type: PhysicalEntity
member physical entity: DUB
cellular location: cytosol

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion ROSgenerationSmallAggU5 AggU5 STOICHIOMETRY
type: Stoichiometry
physical entity: AggU5
stoichiometric coefficient: 1.0

RIGHT 2 conversion AsynDegradationUb5 ADP STOICHIOMETRY
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

RIGHT 1 conversion AsynDeubiquitinationUb5 Ub STOICHIOMETRY
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

LEFT 1 conversion Monoubiquitination E3 MisP STOICHIOMETRY
type: Stoichiometry
physical entity: E3_MisP
stoichiometric coefficient: 1.0

RIGHT 3 conversion AsynDamInclusionGrowth18 aggParkin STOICHIOMETRY
type: Stoichiometry
physical entity: aggParkin
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

AggS4
type: PhysicalEntity
member physical entity: AggS4
cellular location: cytosol

LEFT 0 conversion SUBInclusionGrowth16 E3SUB SUB misfolded Ub7 UCHL1 STOICHIOMETRY
type: Stoichiometry
physical entity: E3SUB_SUB_misfolded_Ub7_UCHL1
stoichiometric coefficient: 1.0

MisP
type: PhysicalEntity
member physical entity: MisP
cellular location: cytosol

RIGHT 1 conversion SUBDisaggregation1 SUB misfolded STOICHIOMETRY
type: Stoichiometry
physical entity: SUB_misfolded
stoichiometric coefficient: 1.0

ko05012
type: UnificationXref
id: ko05012
db: KEGG Pathway

RIGHT 1 conversion Misfolding ROS STOICHIOMETRY
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

RIGHT 0 conversion DisAggregationasyn3 AggA2 STOICHIOMETRY
type: Stoichiometry
physical entity: AggA2
stoichiometric coefficient: 1.0

Ub
type: PhysicalEntity
member physical entity: Ub
cellular location: cytosol

Parkin_asyn_dam_Ub6
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub6
cellular location: cytosol

RIGHT 0 conversion InclusionGrowth6 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

Aggregationasyn3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Aggregationasyn3 asyn STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Aggregationasyn3 AggA2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregationasyn3 AggA3 STOICHIOMETRY
right: AggA3
left: asyn
left: AggA2

aggUb
type: PhysicalEntity
member physical entity: aggUb
cellular location: cytosol

Aggregationasyn2
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion Aggregationasyn2 AggA1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Aggregationasyn2 asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregationasyn2 AggA2 STOICHIOMETRY
right: AggA2
left: asyn
left: AggA1

AsynProteasomeActivityUb4
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion AsynProteasomeActivityUb4 ATP STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion AsynProteasomeActivityUb4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion AsynProteasomeActivityUb4 ADP STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion AsynProteasomeActivityUb4 asyn dam Ub4 Proteasome STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion AsynProteasomeActivityUb4 Ub STOICHIOMETRY
right: Ub
right: Proteasome
right: ADP
spontaneous: true
left: ATP
left: asyn_dam_Ub4_Proteasome
conversion direction: RIGHT_TO_LEFT

Aggregationasyn1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Aggregationasyn1 asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregationasyn1 AggA1 STOICHIOMETRY
right: AggA1
left: asyn

Aggregationasyn5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Aggregationasyn5 asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregationasyn5 AggA5 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Aggregationasyn5 AggA4 STOICHIOMETRY
right: AggA5
left: asyn
left: AggA4

Aggregationasyn4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Aggregationasyn4 asyn STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Aggregationasyn4 AggA4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Aggregationasyn4 AggA3 STOICHIOMETRY
right: AggA4
left: AggA3
left: asyn

RIGHT 1 conversion ProteasomeBindingUb6 MisP Ub6 Proteasome STOICHIOMETRY
type: Stoichiometry
physical entity: MisP_Ub6_Proteasome
stoichiometric coefficient: 1.0

SeqAggP
type: PhysicalEntity
member physical entity: SeqAggP
cellular location: cytosol

LEFT 0 conversion AsynDUBbindingUb2 Parkin asyn dam Ub2 STOICHIOMETRY
type: Stoichiometry
physical entity: Parkin_asyn_dam_Ub2
stoichiometric coefficient: 1.0

Parkin_asyn_dam_Ub2_DUB
type: PhysicalEntity
member physical entity: Parkin_asyn_dam_Ub2_DUB
cellular location: cytosol

RIGHT 0 conversion AsynDamInclusionGrowth4 SeqAggP STOICHIOMETRY
type: Stoichiometry
physical entity: SeqAggP
stoichiometric coefficient: 2.0

asyn_dam_Ub7_Proteasome
type: Complex
xref: P62988
xref: GO:0000502
xref: P37840