# # This file is automatically generated with # the System Biology Format Converter (http://sbfc.sourceforge.net/) # from an SBML file. # # # Model name = Strasen2018 ? TGF? SMAD Signalling Class 3 # # # some function definitions that are allowed in SBML but not valid in xpp ceil(x)=flr(1+x) @delay=50 # FunctionDefinition id = Function_for_reaction2, name = Function for reaction2 Function_(TGFb,TGFb_R2_surface,kf_R2_activation)=(TGFb*TGFb_R2_surface*kf_R2_activation) # FunctionDefinition id = Function_for_reaction3, name = Function for reaction3 Functio_1(TGFb,TGFb_R2_surface,kf_R2_activation)=(TGFb*TGFb_R2_surface*kf_R2_activation) # FunctionDefinition id = Function_for_reaction21_2_0, name = Function for reaction21_2 Functio_2(TGFb_R2_endo,index_k_out_2_relative_speed_C3,k_in_R2_C3)=(TGFb_R2_endo*index_k_out_2_relative_speed_C3*k_in_R2_C3) # FunctionDefinition id = Function_for_reaction4, name = Function for reaction4 Functio_3(Active_R2,index_kb_R2,kf_R2_activation)=(Active_R2*index_kb_R2*kf_R2_activation) # FunctionDefinition id = Function_for_reaction17, name = Function for reaction17 Functio_4(Inactive_Rec,index_induced_R2_deg,kdeg_R2)=(Inactive_Rec*index_induced_R2_deg*kdeg_R2) # FunctionDefinition id = Function_for_reaction5, name = Function for reaction5 Functio_5(Active_R2,index_kb_R2,kf_R2_activation)=(Active_R2*index_kb_R2*kf_R2_activation) # FunctionDefinition id = Function_for_reaction41_2, name = Function for reaction41_2 Functio_6(Trimer_import_to_nuc,cyt,pS2_pS2_S4_c)=(cyt*Trimer_import_to_nuc*pS2_pS2_S4_c) # FunctionDefinition id = Function_for_reaction42_0, name = Function for reaction42 Functio_7(Trimer_import_to_nuc,cyt,pS2_pS2_pS2_c)=(cyt*Trimer_import_to_nuc*pS2_pS2_pS2_c) # FunctionDefinition id = Function_for_reaction44_4_0, name = Function for reaction44_4 Functio_8(index_trimer_dephos,k_Dephos_C3,pS2_pS2_S4_n)=(index_trimer_dephos*k_Dephos_C3*pS2_pS2_S4_n) # FunctionDefinition id = Function_for_reaction46_3_1_0, name = Function for reaction46_3_1 Functio_9(S4_export_from_nuc_C3,S4_import_to_nuc_C3,S4_total_C3,kdeg_S4)=(S4_total_C3*(S4_import_to_nuc_C3*kdeg_S4+S4_export_from_nuc_C3*kdeg_S4+kdeg_S4^2)/(2*S4_import_to_nuc_C3+S4_export_from_nuc_C3+kdeg_S4)) # FunctionDefinition id = Function_for_reaction35_3_0, name = Function for reaction35_3 Functi_10(S2_c,S2_import_to_nuc_C3,cyt)=(cyt*S2_c*S2_import_to_nuc_C3) # FunctionDefinition id = Function_for_reaction32_3_0, name = Function for reaction32_3 Functi_11(index_kb_homotrimer,kb_trimmer,pS2_pS2_pS2_c)=(index_kb_homotrimer*kb_trimmer*pS2_pS2_pS2_c) # FunctionDefinition id = Function_for_reaction16, name = Function for reaction16 Functi_12(Inactive_Rec,index_induced_ligand_deg,kin_deg_Ligand)=(Inactive_Rec*index_induced_ligand_deg*kin_deg_Ligand) # FunctionDefinition id = Function_for_reaction8, name = Function for reaction8 Functi_13(Active_Rec,index_kb_R1,kf_R1_activation)=(Active_Rec*index_kb_R1*kf_R1_activation) # FunctionDefinition id = Function_for_reaction15, name = Function for reaction15 Functi_14(Inactive_Rec,index_seq_kb,kf_Seq_S7_Rec)=(Inactive_Rec*index_seq_kb*kf_Seq_S7_Rec) # FunctionDefinition id = Function_for_reaction1, name = Function for reaction1 Functi_15(TGFb,TGFb_R2_surface,k_medium,kf_R2_activation)=(TGFb*TGFb_R2_surface*kf_R2_activation/k_medium) # FunctionDefinition id = Function_for_reaction51_3_0, name = Function for reaction51_3 Functi_16(DRB,K_mran,S7KD,hill_fact1,k_induced_S7_production_C3,mRNA_prod_C3,pS2_pS2_S4_n)=(DRB*S7KD*(mRNA_prod_C3+k_induced_S7_production_C3*pS2_pS2_S4_n^hill_fact1/(K_mran^hill_fact1+pS2_pS2_S4_n^hill_fact1))) # FunctionDefinition id = Function_for_reaction22_2_0, name = Function for reaction22_2 Functi_17(Active_Rec,index_active_Rec_internalize_C3,k_in_R1_C3)=(Active_Rec*index_active_Rec_internalize_C3*k_in_R1_C3) # FunctionDefinition id = Function_for_reaction31_2_1_0, name = Function for reaction31_2_1 Functi_18(index_kf_homotrimer,kf_trimmer,pS2_c)=(index_kf_homotrimer*kf_trimmer*pS2_c^3) # FunctionDefinition id = Function_for_reaction6, name = Function for reaction6 Functi_19(Active_R2,index_kb_R2,k_medium,kf_R2_activation)=(Active_R2*index_kb_R2*kf_R2_activation/k_medium) # FunctionDefinition id = Function_for_reaction26_0, name = Function for reaction26 Functi_20(Active_Rec_endo,S2_c,k_phosphorylation)=(Active_Rec_endo*S2_c*k_phosphorylation) # FunctionDefinition id = Function_for_reaction52_3, name = Function for reaction52_3 Functi_21(Smad7mRNA1,export_cytoplasm,nuc)=(nuc*Smad7mRNA1*export_cytoplasm) # FunctionDefinition id = Function_for_reaction47_3_1_0, name = Function for reaction47_3_1 Functi_22(R1_total_C3,index_k_out_1_relative_speed_C3,k_in_R1_C3,kdeg_R1)=(R1_total_C3*k_in_R1_C3*kdeg_R1^2/(k_in_R1_C3*kdeg_R1+kdeg_R1^2+index_k_out_1_relative_speed_C3*k_in_R1_C3*kdeg_R1)) # FunctionDefinition id = Function_for_reaction38_3_0, name = Function for reaction38_3 Functi_23(S4_export_from_nuc_C3,S4_n,nuc)=(nuc*S4_n*S4_export_from_nuc_C3) # FunctionDefinition id = Function_for_reaction53_1_0, name = Function for reaction53_1 Functi_24(Smad7mRNA,k_S7_protein_C3)=(Smad7mRNA*k_S7_protein_C3) # FunctionDefinition id = Function_for_reaction40_3_0, name = Function for reaction40_3 Functi_25(S2_export_from_nuc_C3,nuc,pS2_n)=(nuc*S2_export_from_nuc_C3*pS2_n) # FunctionDefinition id = Function_for_reaction36_3_0, name = Function for reaction36_3 Functi_26(S2_export_from_nuc_C3,S2_n,nuc)=(nuc*S2_n*S2_export_from_nuc_C3) # FunctionDefinition id = Function_for_reaction48_1_1_0, name = Function for reaction48_1_1 Functi_27(R2_total_C3,index_k_out_2_relative_speed_C3,k_in_R2_C3,kdeg_R2)=(R2_total_C3*k_in_R2_C3*kdeg_R2^2/(k_in_R2_C3*kdeg_R2+kdeg_R2^2+index_k_out_2_relative_speed_C3*k_in_R2_C3*kdeg_R2)) # FunctionDefinition id = Function_for_reaction39_3_0, name = Function for reaction39_3 Functi_28(S2_import_to_nuc_C3,cyt,pS2_c)=(cyt*S2_import_to_nuc_C3*pS2_c) # FunctionDefinition id = Function_for_reaction37_3_0, name = Function for reaction37_3 Functi_29(S4_c,S4_import_to_nuc_C3,cyt)=(cyt*S4_c*S4_import_to_nuc_C3) # FunctionDefinition id = Function_for_reaction34_2_0, name = Function for reaction34_2 Functi_30(index_kb_homotrimer,kb_trimmer,pS2_pS2_pS2_n)=(index_kb_homotrimer*kb_trimmer*pS2_pS2_pS2_n) # FunctionDefinition id = Function_for_reaction33_2_1_0, name = Function for reaction33_2_1 Functi_31(index_kf_homotrimer,kf_trimmer,pS2_n)=(index_kf_homotrimer*kf_trimmer*pS2_n^3) # FunctionDefinition id = Function_for_reaction45_3_1_0, name = Function for reaction45_3_1 Functi_32(S2_export_from_nuc_C3,S2_import_to_nuc_C3,S2_total_C3,kdeg_S2)=(S2_total_C3*(S2_import_to_nuc_C3*kdeg_S2+S2_export_from_nuc_C3*kdeg_S2+kdeg_S2^2)/(2*S2_import_to_nuc_C3+S2_export_from_nuc_C3+kdeg_S2)) # FunctionDefinition id = Function_for_reaction20_2_0, name = Function for reaction20_2 Functi_33(TGFb_R1_endo,index_k_out_1_relative_speed_C3,k_in_R1_C3)=(TGFb_R1_endo*index_k_out_1_relative_speed_C3*k_in_R1_C3) # Compartment: id = cyt, name = cyt, constant par cyt=2.0 # Compartment: id = nuc, name = nuc, constant par nuc=1.0 # Parameter: id = DRB, name = DRB, constant par DRB=1.0 # Parameter: id = K_mran, name = K_mran, constant par K_mran=223.586 # Parameter: id = R1_total_C3, name = R1_total_C3, constant par R1_total_=69.7199989056023 # Parameter: id = R2_total_C3, name = R2_total_C3, constant par R2_total_=49.1925438819563 # Parameter: id = S2_export_from_nuc_C3, name = S2_export_from_nuc_C3, constant par S2_export=3.00430865315074 # Parameter: id = S2_import_to_nuc_C3, name = S2_import_to_nuc_C3, constant par S2_import=0.248774260500559 # Parameter: id = S2_total_C3, name = S2_total_C3, constant par S2_total_=1335.77950850425 # Parameter: id = S4_export_from_nuc_C3, name = S4_export_from_nuc_C3, constant par S4_export=0.0984718694215043 # Parameter: id = S4_import_to_nuc_C3, name = S4_import_to_nuc_C3, constant par S4_import=0.0730474752631315 # Parameter: id = S4_total_C3, name = S4_total_C3, constant par S4_total_=347.505766824434 # Parameter: id = S7KD, name = S7KD, constant par S7KD=1.0 # Parameter: id = Trimer_import_to_nuc, name = Trimer_import_to_nuc, constant par Trimer_im=0.144035002432848 # Parameter: id = export_cytoplasm, name = export_cytoplasm, constant par export_cy=0.0304372961307751 # Parameter: id = hill_fact1, name = hill_fact1, constant par hill_fact=3.98630224594983 # Parameter: id = index_active_Rec_internalize_C3, name = index_active_Rec_internalize_C3, constant par index_act=1.0379108128956 # Parameter: id = index_induced_R2_deg, name = index_induced_R2_deg, constant par index_ind=1.00037776866312 # Parameter: id = index_induced_ligand_deg, name = index_induced_ligand_deg, constant par index_i_1=2.72106513634098 # Parameter: id = index_k_out_1_relative_speed_C3, name = index_k_out_1_relative_speed_C3, constant par index_k_o=1.13287434679021 # Parameter: id = index_k_out_2_relative_speed_C3, name = index_k_out_2_relative_speed_C3, constant par index_k_1=0.450697494637432 # Parameter: id = index_kb_R1, name = index_kb_R1, constant par index_kb_=1.61290474569122 # Parameter: id = index_kb_R2, name = index_kb_R2, constant par index_k_2=8.70498854136694 # Parameter: id = index_kb_homotrimer, name = index_kb_homotrimer, constant par index_k_3=0.0163921522930962 # Parameter: id = index_kf_homotrimer, name = index_kf_homotrimer, constant par index_kf_=4.4857919268227 # Parameter: id = index_seq_kb, name = index_seq_kb, constant par index_seq=8.65131944828012E-4 # Parameter: id = index_trimer_dephos, name = index_trimer_dephos, constant par index_tri=2.61013820571304 # Parameter: id = k_Dephos_C3, name = k_Dephos_C3, constant par k_Dephos_=0.0707018316477647 # Parameter: id = k_S7_protein_C3, name = k_S7_protein_C3, constant par k_S7_prot=0.123149764012103 # Parameter: id = k_disso_Active_Rec, name = k_disso_Active_Rec, constant par k_disso_A=0.00103940411358367 # Parameter: id = k_in_R1_C3, name = k_in_R1_C3, constant par k_in_R1_C=0.397836393488341 # Parameter: id = k_in_R2_C3, name = k_in_R2_C3, constant par k_in_R2_C=0.396038887562465 # Parameter: id = k_induced_S7_production_C3, name = k_induced_S7_production_C3, constant par k_induced=2.9510868497 # Parameter: id = k_medium, name = k_medium, constant par k_medium=2000000.0 # Parameter: id = k_phosphorylation, name = k_phosphorylation, constant par k_phospho=0.0701560191772152 # Parameter: id = kb_trimmer, name = kb_trimmer, constant par kb_trimme=1.6077346670684 # Parameter: id = kdeg_R1, name = kdeg_R1, constant par kdeg_R1=0.0586584495713968 # Parameter: id = kdeg_R2, name = kdeg_R2, constant par kdeg_R2=0.0010003937382472 # Parameter: id = kdeg_S2, name = kdeg_S2, constant par kdeg_S2=5.14084012175461E-4 # Parameter: id = kdeg_S4, name = kdeg_S4, constant par kdeg_S4=0.00480202699360057 # Parameter: id = kdeg_S7, name = kdeg_S7, constant par kdeg_S7=0.00102401829734485 # Parameter: id = kf_R1_activation, name = kf_R1_activation, constant par kf_R1_act=4.98548548076033 # Parameter: id = kf_R2_activation, name = kf_R2_activation, constant par kf_R2_act=4.95559496701657 # Parameter: id = kf_Seq_S7_Rec, name = kf_Seq_S7_Rec, constant par kf_Seq_S7=0.882455038106022 # Parameter: id = kf_trimmer, name = kf_trimmer, constant par kf_trimme=4.81424700307387 # Parameter: id = kin_deg_Ligand, name = kin_deg_Ligand, constant par kin_deg_L=0.720182234635314 # Parameter: id = kmRNA1deg_S7, name = kmRNA1deg_S7, constant par kmRNA1deg=0.00523181439900629 # Parameter: id = kmRNAdeg_S7, name = kmRNAdeg_S7, constant par kmRNAdeg_=0.0990158065483902 # Parameter: id = kout_deg_Ligand_100pM, name = kout_deg_Ligand_100pM, constant par kout_deg_=3.6189622E-4 # Parameter: id = mRNA_prod_C3, name = mRNA_prod_C3, constant par mRNA_prod=0.0239754962469105 # Parameter: id = NUC_CYT_SMAD2, name = NUC/CYT SMAD2, defined by a Rule # assignmentRule: variable = NUC_CYT_SMAD2 NUC_CYT_S=(2*pS2_pS2_1+pS2_n+S2_n+3*pS2_pS2_2)/(2*pS2_pS2_S+pS2_c+S2_c+3*pS2_pS2_p) aux NUC_CYT_S=NUC_CYT_S # Reaction: id = reaction1, name = reaction1 reaction1=cyt*Functi_15(TGFb, TGFb_R2_s, k_medium, kf_R2_act) # Reaction: id = reaction2, name = reaction2 reaction2=cyt*Function_(TGFb, TGFb_R2_s, kf_R2_act) # Reaction: id = reaction3, name = reaction3 reaction3=cyt*Functio_1(TGFb, TGFb_R2_s, kf_R2_act) # Reaction: id = reaction4, name = reaction4 reaction4=cyt*Functio_3(Active_R2, index_k_2, kf_R2_act) # Reaction: id = reaction5, name = reaction5 reaction5=cyt*Functio_5(Active_R2, index_k_2, kf_R2_act) # Reaction: id = reaction6, name = reaction6 reaction6=cyt*Functi_19(Active_R2, index_k_2, k_medium, kf_R2_act) # Reaction: id = reaction7, name = reaction7 reaction7=cyt*kf_R1_act*TGFb_R1_s*Active_R2 # Reaction: id = reaction8, name = reaction8 reaction8=cyt*Functi_13(Active_Re, index_kb_, kf_R1_act) # Reaction: id = reaction9, name = reaction9 reaction9=cyt*kdeg_R2*Active__1 # Reaction: id = reaction10, name = reaction10 reactio_1=cyt*kdeg_R1*Active__1 # Reaction: id = reaction11, name = reaction11 reactio_2=cyt*kin_deg_L*Active__1 # Reaction: id = reaction12, name = reaction12 reactio_3=cyt*kdeg_R1*TGFb_R1_e # Reaction: id = reaction13, name = reaction13 reactio_4=cyt*kdeg_R2*TGFb_R2_e # Reaction: id = reaction14, name = reaction14 reactio_5=cyt*kf_Seq_S7*Active_Re*S7 # Reaction: id = reaction15, name = reaction15 reactio_6=cyt*Functi_14(Inactive_, index_seq, kf_Seq_S7) # Reaction: id = reaction16, name = reaction16 reactio_7=cyt*Functi_12(Inactive_, index_i_1, kin_deg_L) # Reaction: id = reaction17, name = reaction17 reactio_8=cyt*Functio_4(Inactive_, index_ind, kdeg_R2) # Reaction: id = reaction18, name = reaction18 reactio_9=cyt*k_in_R1_C*TGFb_R1_s # Reaction: id = reaction19, name = reaction19 reacti_10=cyt*k_in_R2_C*TGFb_R2_s # Reaction: id = reaction20, name = reaction20 reacti_11=cyt*Functi_33(TGFb_R1_e, index_k_o, k_in_R1_C) # Reaction: id = reaction21, name = reaction21 reacti_12=cyt*Functio_2(TGFb_R2_e, index_k_1, k_in_R2_C) # Reaction: id = reaction22, name = reaction22 reacti_13=cyt*Functi_17(Active_Re, index_act, k_in_R1_C) # Reaction: id = reaction23, name = reaction23 reacti_14=cyt*k_disso_A*Active__1 # Reaction: id = reaction24, name = reaction24 reacti_15=cyt*kin_deg_L*TGFb_In # Reaction: id = reaction25, name = reaction25 reacti_16=cyt*kout_deg_*TGFb # Reaction: id = reaction26, name = reaction26 reacti_17=cyt*Functi_20(Active__1, S2_c, k_phospho) # Reaction: id = reaction27, name = reaction27 reacti_18=cyt*kf_trimme*pS2_c^2*S4_c # Reaction: id = reaction28, name = reaction28 reacti_19=cyt*kb_trimme*pS2_pS2_S # Reaction: id = reaction29, name = reaction29 reacti_20=nuc*kf_trimme*pS2_n^2*S4_n # Reaction: id = reaction30, name = reaction30 reacti_21=nuc*kb_trimme*pS2_pS2_1 # Reaction: id = reaction31, name = reaction31 reacti_22=cyt*Functi_18(index_kf_, kf_trimme, pS2_c) # Reaction: id = reaction32, name = reaction32 reacti_23=cyt*Functi_11(index_k_3, kb_trimme, pS2_pS2_p) # Reaction: id = reaction33, name = reaction33 reacti_24=nuc*Functi_31(index_kf_, kf_trimme, pS2_n) # Reaction: id = reaction34, name = reaction34 reacti_25=nuc*Functi_30(index_k_3, kb_trimme, pS2_pS2_2) # Reaction: id = reaction35, name = reaction35 reacti_26=Functi_10(S2_c, S2_import, cyt) # Reaction: id = reaction36, name = reaction36 reacti_27=Functi_26(S2_export, S2_n, nuc) # Reaction: id = reaction37, name = reaction37 reacti_28=Functi_29(S4_c, S4_import, cyt) # Reaction: id = reaction38, name = reaction38 reacti_29=Functi_23(S4_export, S4_n, nuc) # Reaction: id = reaction39, name = reaction39 reacti_30=Functi_28(S2_import, cyt, pS2_c) # Reaction: id = reaction40, name = reaction40 reacti_31=Functi_25(S2_export, nuc, pS2_n) # Reaction: id = reaction41, name = reaction41 reacti_32=Functio_6(Trimer_im, cyt, pS2_pS2_S) # Reaction: id = reaction42, name = reaction42 reacti_33=Functio_7(Trimer_im, cyt, pS2_pS2_p) # Reaction: id = reaction43, name = reaction43 reacti_34=nuc*k_Dephos_*pS2_n # Reaction: id = reaction44, name = reaction44 reacti_35=nuc*Functio_8(index_tri, k_Dephos_, pS2_pS2_1) # Reaction: id = reaction45, name = reaction45 reacti_36=cyt*Functi_32(S2_export, S2_import, S2_total_, kdeg_S2) # Reaction: id = reaction46, name = reaction46 reacti_37=cyt*Functio_9(S4_export, S4_import, S4_total_, kdeg_S4) # Reaction: id = reaction47, name = reaction47 reacti_38=cyt*Functi_22(R1_total_, index_k_o, k_in_R1_C, kdeg_R1) # Reaction: id = reaction48, name = reaction48 reacti_39=cyt*Functi_27(R2_total_, index_k_1, k_in_R2_C, kdeg_R2) # Reaction: id = reaction51, name = reaction51 reacti_40=nuc*Functi_16(DRB, K_mran, S7KD, hill_fact, k_induced, mRNA_prod, pS2_pS2_1) # Reaction: id = reaction52, name = reaction52 reacti_41=Functi_21(Smad7mR_1, export_cy, nuc) # Reaction: id = reaction53, name = reaction53 reacti_42=cyt*Functi_24(Smad7mRNA, k_S7_prot) # Reaction: id = reaction54, name = reaction54 reacti_43=cyt*kdeg_S2*S2_c # Reaction: id = reaction55, name = reaction55 reacti_44=nuc*kdeg_S2*S2_n # Reaction: id = reaction56, name = reaction56 reacti_45=nuc*kdeg_S2*pS2_n # Reaction: id = reaction57, name = reaction57 reacti_46=cyt*kdeg_S2*pS2_c # Reaction: id = reaction58, name = reaction58 reacti_47=cyt*kdeg_S4*S4_c # Reaction: id = reaction59, name = reaction59 reacti_48=nuc*kdeg_S4*S4_n # Reaction: id = reaction60, name = reaction60 reacti_49=cyt*kdeg_S2*pS2_pS2_S # Reaction: id = reaction61, name = reaction61 reacti_50=cyt*kdeg_S4*pS2_pS2_S # Reaction: id = reaction62, name = reaction62 reacti_51=cyt*kdeg_S2*pS2_pS2_p # Reaction: id = reaction63, name = reaction63 reacti_52=nuc*kdeg_S2*pS2_pS2_1 # Reaction: id = reaction64, name = reaction64 reacti_53=nuc*kdeg_S4*pS2_pS2_1 # Reaction: id = reaction65, name = reaction65 reacti_54=nuc*kdeg_S2*pS2_pS2_2 # Reaction: id = reaction66, name = reaction66 reacti_55=nuc*kmRNA1deg*Smad7mR_1 # Reaction: id = reaction67, name = reaction67 reacti_56=cyt*kmRNAdeg_*Smad7mRNA # Reaction: id = reaction68, name = reaction68 reacti_57=cyt*kdeg_S7*S7 # Species: id = TGFb_R1_surface, name = TGFb_R1_surface, affected by kineticLaw par TGFb_R1_s=39.1453163247034 aux TGFb_R1_s=TGFb_R1_s dTGFb_R1_s/dt=(1/(cyt))*((-1.0 * reaction7) + ( 1.0 * reaction8) + (-1.0 * reactio_9) + ( 1.0 * reacti_11) + ( 1.0 * reacti_38)) # Species: id = TGFb_R2_surface, name = TGFb_R2_surface, affected by kineticLaw par TGFb_R2_s=15.3419048677147 aux TGFb_R2_s=TGFb_R2_s dTGFb_R2_s/dt=(1/(cyt))*((-1.0 * reaction2) + ( 1.0 * reaction5) + (-1.0 * reacti_10) + ( 1.0 * reacti_12) + ( 1.0 * reacti_39)) # Species: id = TGFb_R1_endo, name = TGFb_R1_endo, affected by kineticLaw par TGFb_R1_e=30.5746825808989 aux TGFb_R1_e=TGFb_R1_e dTGFb_R1_e/dt=(1/(cyt))*(( 1.0 * reaction9) + ( 1.0 * reactio_2) + (-1.0 * reactio_3) + ( 1.0 * reactio_7) + ( 1.0 * reactio_8) + ( 1.0 * reactio_9) + (-1.0 * reacti_11) + ( 1.0 * reacti_14)) # Species: id = TGFb_R2_endo, name = TGFb_R2_endo, affected by kineticLaw par TGFb_R2_e=33.8506390142416 aux TGFb_R2_e=TGFb_R2_e dTGFb_R2_e/dt=(1/(cyt))*(( 1.0 * reactio_1) + ( 1.0 * reactio_2) + (-1.0 * reactio_4) + ( 1.0 * reactio_7) + ( 1.0 * reacti_10) + (-1.0 * reacti_12) + ( 1.0 * reacti_14)) # Species: id = TGFb, name = TGFb, affected by kineticLaw init TGFb=100.0 dTGFb/dt=(1/(cyt))*((-1.0 * reaction1) + ( 1.0 * reaction6) + (-1.0 * reacti_16)) # Species: id = TGFb_In, name = TGFb_In, affected by kineticLaw init TGFb_In=0.0 dTGFb_In/dt=(1/(cyt))*(( 1.0 * reaction9) + ( 1.0 * reactio_1) + ( 1.0 * reactio_8) + ( 1.0 * reacti_14) + (-1.0 * reacti_15)) # Species: id = Active_R2, name = Active_R2, affected by kineticLaw init Active_R2=0.0 dActive_R2/dt=(1/(cyt))*(( 1.0 * reaction3) + (-1.0 * reaction4) + (-1.0 * reaction7) + ( 1.0 * reaction8)) # Species: id = Active_Rec, name = Active_Rec, affected by kineticLaw par Active_Re=0.0 aux Active_Re=Active_Re dActive_Re/dt=(1/(cyt))*(( 1.0 * reaction7) + (-1.0 * reaction8) + (-1.0 * reactio_5) + ( 1.0 * reactio_6) + (-1.0 * reacti_13)) # Species: id = Active_Rec_endo, name = Active_Rec_endo, affected by kineticLaw par Active__1=0.0 aux Active__1=Active__1 dActive__1/dt=(1/(cyt))*((-1.0 * reaction9) + (-1.0 * reactio_1) + (-1.0 * reactio_2) + ( 1.0 * reacti_13) + (-1.0 * reacti_14)) # Species: id = Inactive_Rec, name = Inactive_Rec, affected by kineticLaw par Inactive_=0.0 aux Inactive_=Inactive_ dInactive_/dt=(1/(cyt))*(( 1.0 * reactio_5) + (-1.0 * reactio_6) + (-1.0 * reactio_7) + (-1.0 * reactio_8)) # Species: id = pS2_c, name = pS2_c, affected by kineticLaw init pS2_c=0.0 dpS2_c/dt=(1/(cyt))*(( 1.0 * reacti_17) + (-2.0 * reacti_18) + ( 2.0 * reacti_19) + (-3.0 * reacti_22) + ( 3.0 * reacti_23) + (-1.0 * reacti_30) + ( 1.0 * reacti_31) + (-1.0 * reacti_46) + ( 1.0 * reacti_49) + ( 2.0 * reacti_50) + ( 2.0 * reacti_51)) # Species: id = S2_c, name = S2_c, affected by kineticLaw init S2_c=1146.01803838863 dS2_c/dt=(1/(cyt))*((-1.0 * reacti_17) + (-1.0 * reacti_26) + ( 1.0 * reacti_27) + ( 1.0 * reacti_36) + (-1.0 * reacti_43)) # Species: id = S4_c, name = S4_c, affected by kineticLaw init S4_c=143.916431450302 dS4_c/dt=(1/(cyt))*((-1.0 * reacti_18) + ( 1.0 * reacti_19) + (-1.0 * reacti_28) + ( 1.0 * reacti_29) + ( 1.0 * reacti_37) + (-1.0 * reacti_47) + ( 1.0 * reacti_49)) # Species: id = pS2_pS2_S4_c, name = pS2_pS2_S4_c, affected by kineticLaw par pS2_pS2_S=0.0 aux pS2_pS2_S=pS2_pS2_S dpS2_pS2_S/dt=(1/(cyt))*(( 1.0 * reacti_18) + (-1.0 * reacti_19) + (-1.0 * reacti_32) + (-1.0 * reacti_49) + (-1.0 * reacti_50)) # Species: id = pS2_pS2_pS2_c, name = pS2_pS2_pS2_c, affected by kineticLaw par pS2_pS2_p=0.0 aux pS2_pS2_p=pS2_pS2_p dpS2_pS2_p/dt=(1/(cyt))*(( 1.0 * reacti_22) + (-1.0 * reacti_23) + (-1.0 * reacti_33) + (-1.0 * reacti_51)) # Species: id = Smad7mRNA, name = Smad7mRNA, affected by kineticLaw init Smad7mRNA=0.103311072468942 dSmad7mRNA/dt=(1/(cyt))*(( 1.0 * reacti_41) + (-1.0 * reacti_56)) # Species: id = Smad7mRNA1, name = Smad7mRNA1, affected by kineticLaw par Smad7mR_1=0.67216411877982 aux Smad7mR_1=Smad7mR_1 dSmad7mR_1/dt=(1/(nuc))*(( 1.0 * reacti_40) + (-1.0 * reacti_41) + (-1.0 * reacti_55)) # Species: id = S7, name = S7, affected by kineticLaw init S7=12.4243231076787 dS7/dt=(1/(cyt))*((-1.0 * reactio_5) + ( 1.0 * reactio_6) + ( 1.0 * reactio_7) + ( 1.0 * reactio_8) + ( 1.0 * reacti_42) + (-1.0 * reacti_57)) # Species: id = pS2_n, name = pS2_n, affected by kineticLaw init pS2_n=0.0 dpS2_n/dt=(1/(nuc))*((-2.0 * reacti_20) + ( 2.0 * reacti_21) + (-3.0 * reacti_24) + ( 3.0 * reacti_25) + ( 1.0 * reacti_30) + (-1.0 * reacti_31) + (-1.0 * reacti_34) + ( 1.0 * reacti_35) + (-1.0 * reacti_45) + ( 1.0 * reacti_52) + ( 2.0 * reacti_53) + ( 2.0 * reacti_54)) # Species: id = pS2_pS2_S4_n, name = pS2_pS2_S4_n, affected by kineticLaw par pS2_pS2_1=0.0 aux pS2_pS2_1=pS2_pS2_1 dpS2_pS2_1/dt=(1/(nuc))*(( 1.0 * reacti_20) + (-1.0 * reacti_21) + ( 1.0 * reacti_32) + (-1.0 * reacti_35) + (-1.0 * reacti_52) + (-1.0 * reacti_53)) # Species: id = pS2_pS2_pS2_n, name = pS2_pS2_pS2_n, affected by kineticLaw par pS2_pS2_2=0.0 aux pS2_pS2_2=pS2_pS2_2 dpS2_pS2_2/dt=(1/(nuc))*(( 1.0 * reacti_24) + (-1.0 * reacti_25) + ( 1.0 * reacti_33) + (-1.0 * reacti_54)) # Species: id = S2_n, name = S2_n, affected by kineticLaw init S2_n=189.761470115617 dS2_n/dt=(1/(nuc))*(( 1.0 * reacti_26) + (-1.0 * reacti_27) + ( 1.0 * reacti_34) + ( 1.0 * reacti_35) + (-1.0 * reacti_44)) # Species: id = S4_n, name = S4_n, affected by kineticLaw init S4_n=203.589335374132 dS4_n/dt=(1/(nuc))*((-1.0 * reacti_20) + ( 1.0 * reacti_21) + ( 1.0 * reacti_28) + (-1.0 * reacti_29) + ( 1.0 * reacti_35) + (-1.0 * reacti_48) + ( 1.0 * reacti_52)) @ meth=cvode, tol=1e-6, atol=1e-8 # @ maxstor=1e6 @ bound=40000, total=200 done