Simulates signaling class 3
 Tiwari Krishna tiwarik@babraham.ac.uk Babraham Institute 2017-09-07T16:51:33Z 2017-09-07T16:51:33Z 2017-09-07T16:51:33Z tiwarik@babraham.ac.uk Tiwari Krishna Babraham Institute 2021-02-10T14:28:23Z R1_total_C3 index_k_out_1_relative_speed_C3 k_in_R1_C3 kdeg_R1 R1_total_C3 k_in_R1_C3 kdeg_R1 2 k_in_R1_C3 kdeg_R1 kdeg_R1 2 index_k_out_1_relative_speed_C3 k_in_R1_C3 kdeg_R1 2021-02-10T14:28:23Z S2_import_to_nuc_C3 cyt pS2_c cyt S2_import_to_nuc_C3 pS2_c 2021-02-10T14:28:23Z S4_c S4_import_to_nuc_C3 cyt cyt S4_c S4_import_to_nuc_C3 2021-02-10T14:28:23Z DRB K_mran S7KD hill_fact1 k_induced_S7_production_C3 mRNA_prod_C3 pS2_pS2_S4_n DRB S7KD mRNA_prod_C3 k_induced_S7_production_C3 pS2_pS2_S4_n hill_fact1 K_mran hill_fact1 pS2_pS2_S4_n hill_fact1 2021-02-10T14:28:23Z index_kb_homotrimer kb_trimmer pS2_pS2_pS2_n index_kb_homotrimer kb_trimmer pS2_pS2_pS2_n 2021-02-10T14:28:23Z S2_export_from_nuc_C3 S2_import_to_nuc_C3 S2_total_C3 kdeg_S2 S2_total_C3 S2_import_to_nuc_C3 kdeg_S2 S2_export_from_nuc_C3 kdeg_S2 kdeg_S2 2 2 S2_import_to_nuc_C3 S2_export_from_nuc_C3 kdeg_S2 2015-11-09T11:39:48Z Inactive_Rec index_seq_kb kf_Seq_S7_Rec Inactive_Rec index_seq_kb kf_Seq_S7_Rec 2017-11-05T19:10:19Z Active_Rec index_kb_R1 kf_R1_activation Active_Rec index_kb_R1 kf_R1_activation 2021-02-10T14:28:23Z S2_export_from_nuc_C3 nuc pS2_n nuc S2_export_from_nuc_C3 pS2_n 2021-02-10T14:28:23Z index_kb_homotrimer kb_trimmer pS2_pS2_pS2_c index_kb_homotrimer kb_trimmer pS2_pS2_pS2_c 2021-02-10T14:28:23Z Inactive_Rec index_induced_ligand_deg kin_deg_Ligand Inactive_Rec index_induced_ligand_deg kin_deg_Ligand 2021-02-10T14:28:23Z index_trimer_dephos k_Dephos_C3 pS2_pS2_S4_n index_trimer_dephos k_Dephos_C3 pS2_pS2_S4_n 2017-11-05T19:10:15Z Active_R2 index_kb_R2 k_medium kf_R2_activation Active_R2 index_kb_R2 kf_R2_activation k_medium 2021-02-10T14:28:23Z S2_c S2_import_to_nuc_C3 cyt cyt S2_c S2_import_to_nuc_C3 2021-02-10T14:28:23Z S4_export_from_nuc_C3 S4_n nuc nuc S4_n S4_export_from_nuc_C3 2021-02-10T14:28:23Z Smad7mRNA k_S7_protein_C3 Smad7mRNA k_S7_protein_C3 2021-02-10T14:28:23Z S2_export_from_nuc_C3 S2_n nuc nuc S2_n S2_export_from_nuc_C3 2017-11-05T19:10:11Z Active_R2 index_kb_R2 kf_R2_activation Active_R2 index_kb_R2 kf_R2_activation 2021-02-10T14:28:23Z index_kf_homotrimer kf_trimmer pS2_c index_kf_homotrimer kf_trimmer pS2_c 3 2021-02-10T14:28:23Z Active_Rec_endo S2_c k_phosphorylation Active_Rec_endo S2_c k_phosphorylation 2021-02-10T14:28:23Z Smad7mRNA1 export_cytoplasm nuc nuc Smad7mRNA1 export_cytoplasm 2021-02-10T14:28:23Z Trimer_import_to_nuc cyt pS2_pS2_S4_c cyt Trimer_import_to_nuc pS2_pS2_S4_c 2021-02-10T14:28:23Z Active_Rec index_active_Rec_internalize_C3 k_in_R1_C3 Active_Rec index_active_Rec_internalize_C3 k_in_R1_C3 2017-11-05T19:10:23Z TGFb TGFb_R2_surface k_medium kf_R2_activation TGFb TGFb_R2_surface kf_R2_activation k_medium 2021-02-10T14:28:23Z index_kf_homotrimer kf_trimmer pS2_n index_kf_homotrimer kf_trimmer pS2_n 3 2021-02-10T14:28:23Z TGFb_R1_endo index_k_out_1_relative_speed_C3 k_in_R1_C3 TGFb_R1_endo index_k_out_1_relative_speed_C3 k_in_R1_C3 2021-02-10T14:28:23Z Active_R2 index_kb_R2 kf_R2_activation Active_R2 index_kb_R2 kf_R2_activation 2021-02-10T14:28:23Z R2_total_C3 index_k_out_2_relative_speed_C3 k_in_R2_C3 kdeg_R2 R2_total_C3 k_in_R2_C3 kdeg_R2 2 k_in_R2_C3 kdeg_R2 kdeg_R2 2 index_k_out_2_relative_speed_C3 k_in_R2_C3 kdeg_R2 2021-02-10T14:28:23Z S4_export_from_nuc_C3 S4_import_to_nuc_C3 S4_total_C3 kdeg_S4 S4_total_C3 S4_import_to_nuc_C3 kdeg_S4 S4_export_from_nuc_C3 kdeg_S4 kdeg_S4 2 2 S4_import_to_nuc_C3 S4_export_from_nuc_C3 kdeg_S4 2015-11-09T11:40:05Z TGFb TGFb_R2_surface kf_R2_activation TGFb TGFb_R2_surface kf_R2_activation 2021-02-10T14:28:23Z Inactive_Rec index_induced_R2_deg kdeg_R2 Inactive_Rec index_induced_R2_deg kdeg_R2 2021-02-10T14:28:23Z TGFb_R2_endo index_k_out_2_relative_speed_C3 k_in_R2_C3 TGFb_R2_endo index_k_out_2_relative_speed_C3 k_in_R2_C3 2021-02-10T14:28:23Z Trimer_import_to_nuc cyt pS2_pS2_pS2_c cyt Trimer_import_to_nuc pS2_pS2_pS2_c 2021-02-10T14:28:23Z TGFb TGFb_R2_surface kf_R2_activation TGFb TGFb_R2_surface kf_R2_activation 2017-10-17T17:51:15Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2017-10-17T17:46:13Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2017-10-17T17:52:07Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2017-11-10T11:07:13Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2021-02-10T14:28:23Z 2017-09-07T16:51:42Z R1_total_C3 kdeg_R1 kdeg_R1 index_k_out_1_relative_speed_C3 k_in_R1_C3 k_in_R1_C3 kdeg_R1 kdeg_R1 2 index_k_out_1_relative_speed_C3 k_in_R1_C3 kdeg_R1 R2_total_C3 kdeg_R2 kdeg_R2 index_k_out_2_relative_speed_C3 k_in_R2_C3 k_in_R2_C3 kdeg_R2 kdeg_R2 2 index_k_out_2_relative_speed_C3 k_in_R2_C3 kdeg_R2 R1_total_C3 k_in_R1_C3 kdeg_R1 k_in_R1_C3 kdeg_R1 kdeg_R1 2 index_k_out_1_relative_speed_C3 k_in_R1_C3 kdeg_R1 R2_total_C3 k_in_R2_C3 kdeg_R2 k_in_R2_C3 kdeg_R2 kdeg_R2 2 index_k_out_2_relative_speed_C3 k_in_R2_C3 kdeg_R2 S2_total_C3 S2_export_from_nuc_C3 kdeg_S2 2 S2_import_to_nuc_C3 S2_export_from_nuc_C3 kdeg_S2 S4_total_C3 S4_export_from_nuc_C3 kdeg_S4 2 S4_import_to_nuc_C3 S4_export_from_nuc_C3 kdeg_S4 export_cytoplasm mRNA_prod_C3 2 kmRNAdeg_S7 export_cytoplasm kmRNA1deg_S7 mRNA_prod_C3 export_cytoplasm kmRNA1deg_S7 export_cytoplasm k_S7_protein_C3 mRNA_prod_C3 2 kdeg_S7 kmRNAdeg_S7 export_cytoplasm kmRNA1deg_S7 2 S2_total_C3 S2_import_to_nuc_C3 2 S2_import_to_nuc_C3 S2_export_from_nuc_C3 kdeg_S2 2 S4_total_C3 S4_import_to_nuc_C3 2 S4_import_to_nuc_C3 S4_export_from_nuc_C3 kdeg_S4 2 pS2_pS2_S4_n pS2_n S2_n 3 pS2_pS2_pS2_n 2 pS2_pS2_S4_c pS2_c S2_c 3 pS2_pS2_pS2_c cyt Function_for_reaction1 TGFb TGFb_R2_surface k_medium kf_R2_activation cyt Function_for_reaction2 TGFb TGFb_R2_surface kf_R2_activation cyt Function_for_reaction3 TGFb TGFb_R2_surface kf_R2_activation cyt Function_for_reaction4 Active_R2 index_kb_R2 kf_R2_activation cyt Function_for_reaction5 Active_R2 index_kb_R2 kf_R2_activation cyt Function_for_reaction6 Active_R2 index_kb_R2 k_medium kf_R2_activation cyt kf_R1_activation TGFb_R1_surface Active_R2 cyt Function_for_reaction8 Active_Rec index_kb_R1 kf_R1_activation cyt kdeg_R2 Active_Rec_endo cyt kdeg_R1 Active_Rec_endo cyt kin_deg_Ligand Active_Rec_endo cyt kdeg_R1 TGFb_R1_endo cyt kdeg_R2 TGFb_R2_endo cyt kf_Seq_S7_Rec Active_Rec S7 cyt Function_for_reaction15 Inactive_Rec index_seq_kb kf_Seq_S7_Rec cyt Function_for_reaction16 Inactive_Rec index_induced_ligand_deg kin_deg_Ligand cyt Function_for_reaction17 Inactive_Rec index_induced_R2_deg kdeg_R2 cyt k_in_R1_C3 TGFb_R1_surface cyt k_in_R2_C3 TGFb_R2_surface cyt Function_for_reaction20_2_0 TGFb_R1_endo index_k_out_1_relative_speed_C3 k_in_R1_C3 cyt Function_for_reaction21_2_0 TGFb_R2_endo index_k_out_2_relative_speed_C3 k_in_R2_C3 cyt Function_for_reaction22_2_0 Active_Rec index_active_Rec_internalize_C3 k_in_R1_C3 cyt k_disso_Active_Rec Active_Rec_endo cyt kin_deg_Ligand TGFb_In cyt kout_deg_Ligand_100pM TGFb cyt Function_for_reaction26_0 Active_Rec_endo S2_c k_phosphorylation cyt kf_trimmer pS2_c 2 S4_c cyt kb_trimmer pS2_pS2_S4_c nuc kf_trimmer pS2_n 2 S4_n nuc kb_trimmer pS2_pS2_S4_n cyt Function_for_reaction31_2_1_0 index_kf_homotrimer kf_trimmer pS2_c cyt Function_for_reaction32_3_0 index_kb_homotrimer kb_trimmer pS2_pS2_pS2_c nuc Function_for_reaction33_2_1_0 index_kf_homotrimer kf_trimmer pS2_n nuc Function_for_reaction34_2_0 index_kb_homotrimer kb_trimmer pS2_pS2_pS2_n Function_for_reaction35_3_0 S2_c S2_import_to_nuc_C3 cyt Function_for_reaction36_3_0 S2_export_from_nuc_C3 S2_n nuc Function_for_reaction37_3_0 S4_c S4_import_to_nuc_C3 cyt Function_for_reaction38_3_0 S4_export_from_nuc_C3 S4_n nuc Function_for_reaction39_3_0 S2_import_to_nuc_C3 cyt pS2_c Function_for_reaction40_3_0 S2_export_from_nuc_C3 nuc pS2_n Function_for_reaction41_2 Trimer_import_to_nuc cyt pS2_pS2_S4_c Function_for_reaction42_0 Trimer_import_to_nuc cyt pS2_pS2_pS2_c nuc k_Dephos_C3 pS2_n nuc Function_for_reaction44_4_0 index_trimer_dephos k_Dephos_C3 pS2_pS2_S4_n cyt Function_for_reaction45_3_1_0 S2_export_from_nuc_C3 S2_import_to_nuc_C3 S2_total_C3 kdeg_S2 cyt Function_for_reaction46_3_1_0 S4_export_from_nuc_C3 S4_import_to_nuc_C3 S4_total_C3 kdeg_S4 cyt Function_for_reaction47_3_1_0 R1_total_C3 index_k_out_1_relative_speed_C3 k_in_R1_C3 kdeg_R1 cyt Function_for_reaction48_1_1_0 R2_total_C3 index_k_out_2_relative_speed_C3 k_in_R2_C3 kdeg_R2 nuc Function_for_reaction51_3_0 DRB K_mran S7KD hill_fact1 k_induced_S7_production_C3 mRNA_prod_C3 pS2_pS2_S4_n Function_for_reaction52_3 Smad7mRNA1 export_cytoplasm nuc cyt Function_for_reaction53_1_0 Smad7mRNA k_S7_protein_C3 cyt kdeg_S2 S2_c nuc kdeg_S2 S2_n nuc kdeg_S2 pS2_n cyt kdeg_S2 pS2_c cyt kdeg_S4 S4_c nuc kdeg_S4 S4_n cyt kdeg_S2 pS2_pS2_S4_c cyt kdeg_S4 pS2_pS2_S4_c cyt kdeg_S2 pS2_pS2_pS2_c nuc kdeg_S2 pS2_pS2_S4_n nuc kdeg_S4 pS2_pS2_S4_n nuc kdeg_S2 pS2_pS2_pS2_n nuc kmRNA1deg_S7 Smad7mRNA1 cyt kmRNAdeg_S7 Smad7mRNA cyt kdeg_S7 S7