TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

LEFT 0 conversion reaction25 TGFb STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb
stoichiometric coefficient: 1.0

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

reaction52
type: Transport
participant stoichiometry: RIGHT 0 conversion reaction52 Smad7mRNA STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction52 Smad7mRNA1 STOICHIOMETRY
right: Smad7mRNA
left: Smad7mRNA1

reaction51
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction51 Smad7mRNA1 STOICHIOMETRY
right: Smad7mRNA1

LEFT 0 conversion reaction10 Active Rec endo STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec_endo
stoichiometric coefficient: 1.0

pS2_pS2_pS2_n
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_n
cellular location: nuc

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

LEFT 0 conversion reaction15 Inactive Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Inactive_Rec
stoichiometric coefficient: 1.0

pS2_pS2_S4_c
type: PhysicalEntity
member physical entity: pS2_pS2_S4_c
cellular location: cyt

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

RIGHT 0 conversion reaction37 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

reaction54
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction54 S2 c STOICHIOMETRY
left: S2_c

reaction53
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction53 S7 STOICHIOMETRY
right: S7

reaction56
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction56 pS2 n STOICHIOMETRY
left: pS2_n

RIGHT 0 conversion reaction3 Active R2 STOICHIOMETRY
type: Stoichiometry
physical entity: Active_R2
stoichiometric coefficient: 1.0

reaction55
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction55 S2 n STOICHIOMETRY
left: S2_n

reaction58
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction58 S4 c STOICHIOMETRY
left: S4_c

reaction57
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction57 pS2 c STOICHIOMETRY
left: pS2_c

pS2_pS2_S4_n
type: PhysicalEntity
member physical entity: pS2_pS2_S4_n
cellular location: nuc

reaction59
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction59 S4 n STOICHIOMETRY
left: S4_n

LEFT 1 conversion reaction27 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

reaction61
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction61 pS2 pS2 S4 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction61 pS2 c STOICHIOMETRY
right: pS2_c
left: pS2_pS2_S4_c

reaction60
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction60 S4 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction60 pS2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction60 pS2 pS2 S4 c STOICHIOMETRY
right: pS2_c
right: S4_c
left: pS2_pS2_S4_c

pS2_pS2_S4_n
type: PhysicalEntity
member physical entity: pS2_pS2_S4_n
cellular location: nuc

reaction63
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction63 pS2 pS2 S4 n STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction63 pS2 n STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction63 S4 n STOICHIOMETRY
right: pS2_n
right: S4_n
left: pS2_pS2_S4_n

reaction62
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction62 pS2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction62 pS2 pS2 pS2 c STOICHIOMETRY
right: pS2_c
left: pS2_pS2_pS2_c

LEFT 0 conversion reaction43 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 1.0

Smad7mRNA1
type: PhysicalEntity
member physical entity: Smad7mRNA1
cellular location: nuc

LEFT 0 conversion reaction8 Active Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction28 pS2 pS2 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_c
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

LEFT 0 conversion reaction67 Smad7mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: Smad7mRNA
stoichiometric coefficient: 1.0

TGFb_R1_endo
type: PhysicalEntity

RIGHT 2 conversion reaction44 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

pS2_pS2_pS2_c
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_c
cellular location: cyt

LEFT 0 conversion reaction42 pS2 pS2 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_c
stoichiometric coefficient: 1.0

pS2_pS2_pS2_n
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_n
cellular location: nuc

S2_n
type: PhysicalEntity
member physical entity: S2_n
cellular location: nuc

reaction65
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction65 pS2 pS2 pS2 n STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction65 pS2 n STOICHIOMETRY
right: pS2_n
left: pS2_pS2_pS2_n

reaction64
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction64 pS2 pS2 S4 n STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction64 pS2 n STOICHIOMETRY
right: pS2_n
left: pS2_pS2_S4_n

RIGHT 1 conversion reaction15 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

reaction67
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction67 Smad7mRNA STOICHIOMETRY
left: Smad7mRNA

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

reaction66
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction66 Smad7mRNA1 STOICHIOMETRY
left: Smad7mRNA1

S2_n
type: PhysicalEntity
member physical entity: S2_n
cellular location: nuc

reaction68
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction68 S7 STOICHIOMETRY
left: S7

Active_Rec_endo
type: PhysicalEntity
member physical entity: Active_Rec_endo
cellular location: cyt

LEFT 0 conversion reaction33 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 3.0

C6 Aug 2016
type: Pathway
pathway component: reaction52
pathway component: reaction51
pathway component: reaction1
pathway component: reaction18
pathway component: reaction17
pathway component: reaction19
pathway component: reaction10
pathway component: reaction54
pathway component: reaction53
pathway component: reaction12
pathway component: reaction56
pathway component: reaction11
pathway component: reaction55
pathway component: reaction14
pathway component: reaction58
pathway component: reaction13
pathway component: reaction57
pathway component: reaction16
pathway component: reaction15
pathway component: reaction59
pathway component: reaction61
pathway component: reaction60
pathway component: reaction63
pathway component: reaction62
pathway component: reaction29
pathway component: reaction28
pathway component: reaction21
pathway component: reaction65
pathway component: reaction20
pathway component: reaction64
pathway component: reaction23
pathway component: reaction67
pathway component: reaction22
pathway component: reaction66
pathway component: reaction25
pathway component: reaction24
pathway component: reaction68
pathway component: reaction27
pathway component: reaction26
pathway component: reaction30
pathway component: reaction39
pathway component: reaction32
pathway component: reaction31
pathway component: reaction34
pathway component: reaction33
pathway component: reaction36
pathway component: reaction35
pathway component: reaction38
pathway component: reaction37
pathway component: reaction41
pathway component: reaction40
pathway component: reaction9
pathway component: reaction8
pathway component: reaction7
pathway component: reaction6
pathway component: reaction5
pathway component: reaction4
pathway component: reaction3
pathway component: reaction2
pathway component: reaction43
pathway component: reaction42
pathway component: reaction45
pathway component: reaction44
pathway component: reaction47
pathway component: reaction46
pathway component: reaction48
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.

S7
type: PhysicalEntity

S2_c
type: PhysicalEntity

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

reaction30
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction30 pS2 pS2 S4 n STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction30 S4 n STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction30 pS2 n STOICHIOMETRY
right: pS2_n
right: S4_n
left: pS2_pS2_S4_n

LEFT 0 conversion reaction34 pS2 pS2 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_n
stoichiometric coefficient: 1.0

S2_n
type: PhysicalEntity

RIGHT 0 conversion reaction53 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

TGFb_In
type: PhysicalEntity

Active_Rec_endo
type: PhysicalEntity
member physical entity: Active_Rec_endo
cellular location: cyt

RIGHT 0 conversion reaction45 S2 c STOICHIOMETRY
type: Stoichiometry
physical entity: S2_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction6 TGFb STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb
stoichiometric coefficient: 1.0

reaction39
type: Transport
participant stoichiometry: LEFT 0 conversion reaction39 pS2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction39 pS2 n STOICHIOMETRY
right: pS2_n
left: pS2_c

LEFT 0 conversion reaction63 pS2 pS2 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_n
stoichiometric coefficient: 1.0

reaction32
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction32 pS2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction32 pS2 pS2 pS2 c STOICHIOMETRY
right: pS2_c
left: pS2_pS2_pS2_c

reaction31
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction31 pS2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction31 pS2 pS2 pS2 c STOICHIOMETRY
right: pS2_pS2_pS2_c
left: pS2_c

TGFb_In
type: PhysicalEntity
member physical entity: TGFb_In
cellular location: cyt

reaction34
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction34 pS2 pS2 pS2 n STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction34 pS2 n STOICHIOMETRY
right: pS2_n
left: pS2_pS2_pS2_n

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

LEFT 0 conversion reaction13 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

reaction33
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction33 pS2 n STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction33 pS2 pS2 pS2 n STOICHIOMETRY
right: pS2_pS2_pS2_n
left: pS2_n

reaction36
type: Transport
participant stoichiometry: RIGHT 0 conversion reaction36 S2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction36 S2 n STOICHIOMETRY
right: S2_c
left: S2_n

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

reaction35
type: Transport
participant stoichiometry: RIGHT 0 conversion reaction35 S2 n STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction35 S2 c STOICHIOMETRY
right: S2_n
left: S2_c

RIGHT 0 conversion reaction61 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 2.0

reaction38
type: Transport
participant stoichiometry: RIGHT 0 conversion reaction38 S4 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction38 S4 n STOICHIOMETRY
right: S4_c
left: S4_n

LEFT 0 conversion reaction62 pS2 pS2 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_c
stoichiometric coefficient: 1.0

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

reaction37
type: Transport
participant stoichiometry: LEFT 0 conversion reaction37 S4 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction37 S4 n STOICHIOMETRY
right: S4_n
left: S4_c

RIGHT 0 conversion reaction26 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction66 Smad7mRNA1 STOICHIOMETRY
type: Stoichiometry
physical entity: Smad7mRNA1
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction58 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction36 S2 c STOICHIOMETRY
type: Stoichiometry
physical entity: S2_c
stoichiometric coefficient: 1.0

reaction41
type: Transport
participant stoichiometry: RIGHT 0 conversion reaction41 pS2 pS2 S4 n STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction41 pS2 pS2 S4 c STOICHIOMETRY
right: pS2_pS2_S4_n
left: pS2_pS2_S4_c

reaction40
type: Transport
participant stoichiometry: RIGHT 0 conversion reaction40 pS2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction40 pS2 n STOICHIOMETRY
right: pS2_c
left: pS2_n

pS2_pS2_S4_n
type: PhysicalEntity

Inactive_Rec
type: PhysicalEntity
member physical entity: Inactive_Rec
cellular location: cyt

RIGHT 1 conversion reaction44 S2 n STOICHIOMETRY
type: Stoichiometry
physical entity: S2_n
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction18 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction19 TGFb R2 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_surface
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction9 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction38 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction52 Smad7mRNA1 STOICHIOMETRY
type: Stoichiometry
physical entity: Smad7mRNA1
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction60 pS2 pS2 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_c
stoichiometric coefficient: 1.0

S2_c
type: PhysicalEntity
member physical entity: S2_c
cellular location: cyt

RIGHT 0 conversion reaction21 TGFb R2 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_surface
stoichiometric coefficient: 1.0

S7
type: PhysicalEntity
member physical entity: S7
cellular location: cyt

Active_Rec
type: PhysicalEntity
member physical entity: Active_Rec
cellular location: cyt

pS2_pS2_pS2_n
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_n
cellular location: nuc

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

reaction43
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction43 S2 n STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction43 pS2 n STOICHIOMETRY
right: S2_n
left: pS2_n

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

reaction42
type: Transport
participant stoichiometry: LEFT 0 conversion reaction42 pS2 pS2 pS2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction42 pS2 pS2 pS2 n STOICHIOMETRY
right: pS2_pS2_pS2_n
left: pS2_pS2_pS2_c

reaction45
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction45 S2 c STOICHIOMETRY
right: S2_c

Active_R2
type: PhysicalEntity

reaction44
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction44 pS2 n STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction44 S4 n STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction44 pS2 pS2 S4 n STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction44 S2 n STOICHIOMETRY
right: S2_n
right: S4_n
right: pS2_n
left: pS2_pS2_S4_n

reaction47
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction47 TGFb R1 surface STOICHIOMETRY
right: TGFb_R1_surface

pS2_pS2_S4_c
type: PhysicalEntity

reaction46
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction46 S4 c STOICHIOMETRY
right: S4_c

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

reaction48
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction48 TGFb R2 surface STOICHIOMETRY
right: TGFb_R2_surface

TGFb_R1_surface
type: PhysicalEntity
member physical entity: TGFb_R1_surface
cellular location: cyt

pS2_c
type: PhysicalEntity

RIGHT 0 conversion reaction22 Active Rec endo STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec_endo
stoichiometric coefficient: 1.0

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

pS2_pS2_pS2_n
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_n
cellular location: nuc

S2_c
type: PhysicalEntity
member physical entity: S2_c
cellular location: cyt

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

TGFb
type: PhysicalEntity
member physical entity: TGFb
cellular location: cyt

RIGHT 0 conversion reaction8 TGFb R1 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_surface
stoichiometric coefficient: 1.0

Active_Rec_endo
type: PhysicalEntity
member physical entity: Active_Rec_endo
cellular location: cyt

pS2_pS2_S4_n
type: PhysicalEntity
member physical entity: pS2_pS2_S4_n
cellular location: nuc

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

Smad7mRNA1
type: PhysicalEntity

RIGHT 2 conversion reaction16 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

pS2_n
type: PhysicalEntity

pS2_pS2_pS2_n
type: PhysicalEntity

TGFb_R2_surface
type: PhysicalEntity
member physical entity: TGFb_R2_surface
cellular location: cyt

LEFT 0 conversion reaction31 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 3.0

pS2_pS2_pS2_c
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_c
cellular location: cyt

RIGHT 0 conversion reaction5 TGFb R2 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_surface
stoichiometric coefficient: 1.0

Smad7mRNA
type: PhysicalEntity

RIGHT 0 conversion reaction17 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction30 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

pS2_pS2_pS2_c
type: PhysicalEntity

RIGHT 0 conversion reaction44 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 1.0

TGFb_R1_surface
type: PhysicalEntity
member physical entity: TGFb_R1_surface
cellular location: cyt

RIGHT 0 conversion reaction40 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 1.0

pS2_pS2_S4_n
type: PhysicalEntity
member physical entity: pS2_pS2_S4_n
cellular location: nuc

TGFb
type: PhysicalEntity

RIGHT 0 conversion reaction31 pS2 pS2 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_c
stoichiometric coefficient: 1.0

pS2_pS2_pS2_c
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_c
cellular location: cyt

RIGHT 1 conversion reaction17 TGFb In STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_In
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

LEFT 0 conversion reaction24 TGFb In STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_In
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction61 pS2 pS2 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_c
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction22 Active Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec
stoichiometric coefficient: 1.0

Active_R2
type: PhysicalEntity
member physical entity: Active_R2
cellular location: cyt

RIGHT 0 conversion reaction65 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 2.0

cyt
type: CellularLocationVocabulary

Active_R2
type: PhysicalEntity
member physical entity: Active_R2
cellular location: cyt

RIGHT 1 conversion reaction16 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction46 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

TGFb_R1_surface
type: PhysicalEntity
member physical entity: TGFb_R1_surface
cellular location: cyt

LEFT 0 conversion reaction36 S2 n STOICHIOMETRY
type: Stoichiometry
physical entity: S2_n
stoichiometric coefficient: 1.0

Inactive_Rec
type: PhysicalEntity
member physical entity: Inactive_Rec
cellular location: cyt

pS2_pS2_pS2_c
type: PhysicalEntity
member physical entity: pS2_pS2_pS2_c
cellular location: cyt

TGFb_In
type: PhysicalEntity
member physical entity: TGFb_In
cellular location: cyt

RIGHT 0 conversion reaction35 S2 n STOICHIOMETRY
type: Stoichiometry
physical entity: S2_n
stoichiometric coefficient: 1.0

TGFb_R2_surface
type: PhysicalEntity
member physical entity: TGFb_R2_surface
cellular location: cyt

LEFT 0 conversion reaction14 Active Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction38 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction64 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 2.0

RIGHT 0 conversion reaction43 S2 n STOICHIOMETRY
type: Stoichiometry
physical entity: S2_n
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction56 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction10 TGFb In STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_In
stoichiometric coefficient: 1.0

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

pS2_pS2_S4_n
type: PhysicalEntity
member physical entity: pS2_pS2_S4_n
cellular location: nuc

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

LEFT 1 conversion reaction14 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction41 pS2 pS2 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_c
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction23 Active Rec endo STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec_endo
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

Smad7mRNA1
type: PhysicalEntity
member physical entity: Smad7mRNA1
cellular location: nuc

LEFT 0 conversion reaction44 pS2 pS2 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_n
stoichiometric coefficient: 1.0

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

TGFb
type: PhysicalEntity
member physical entity: TGFb
cellular location: cyt

Active_R2
type: PhysicalEntity
member physical entity: Active_R2
cellular location: cyt

RIGHT 0 conversion reaction63 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction63 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction68 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction29 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction12 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction26 S2 c STOICHIOMETRY
type: Stoichiometry
physical entity: S2_c
stoichiometric coefficient: 1.0

TGFb_R1_surface
type: PhysicalEntity
member physical entity: TGFb_R1_surface
cellular location: cyt

Inactive_Rec
type: PhysicalEntity
member physical entity: Inactive_Rec
cellular location: cyt

TGFb_R2_endo
type: PhysicalEntity

TGFb_R2_surface
type: PhysicalEntity

LEFT 0 conversion reaction9 Active Rec endo STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec_endo
stoichiometric coefficient: 1.0

S2_c
type: PhysicalEntity
member physical entity: S2_c
cellular location: cyt

RIGHT 0 conversion reaction48 TGFb R2 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_surface
stoichiometric coefficient: 1.0

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

RIGHT 0 conversion reaction16 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction30 pS2 pS2 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_n
stoichiometric coefficient: 1.0

pS2_pS2_S4_c
type: PhysicalEntity
member physical entity: pS2_pS2_S4_c
cellular location: cyt

Smad7mRNA
type: PhysicalEntity
member physical entity: Smad7mRNA
cellular location: cyt

RIGHT 0 conversion reaction42 pS2 pS2 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_n
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction27 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 2.0

LEFT 0 conversion reaction20 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction27 pS2 pS2 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_c
stoichiometric coefficient: 1.0

S2_c
type: PhysicalEntity
member physical entity: S2_c
cellular location: cyt

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

RIGHT 2 conversion reaction17 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction7 Active Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction17 Inactive Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Inactive_Rec
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction28 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction7 Active R2 STOICHIOMETRY
type: Stoichiometry
physical entity: Active_R2
stoichiometric coefficient: 1.0

Active_Rec
type: PhysicalEntity
member physical entity: Active_Rec
cellular location: cyt

S7
type: PhysicalEntity
member physical entity: S7
cellular location: cyt

RIGHT 0 conversion reaction51 Smad7mRNA1 STOICHIOMETRY
type: Stoichiometry
physical entity: Smad7mRNA1
stoichiometric coefficient: 1.0

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

RIGHT 0 conversion reaction30 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 2.0

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

TGFb_R2_surface
type: PhysicalEntity
member physical entity: TGFb_R2_surface
cellular location: cyt

RIGHT 1 conversion reaction60 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction39 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 1.0

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

LEFT 0 conversion reaction59 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: S4_n
stoichiometric coefficient: 1.0

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

LEFT 0 conversion reaction64 pS2 pS2 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_n
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction15 Active Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

LEFT 0 conversion reaction37 S4 c STOICHIOMETRY
type: Stoichiometry
physical entity: S4_c
stoichiometric coefficient: 1.0

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

Active_Rec
type: PhysicalEntity
member physical entity: Active_Rec
cellular location: cyt

pS2_pS2_S4_c
type: PhysicalEntity
member physical entity: pS2_pS2_S4_c
cellular location: cyt

TGFb_In
type: PhysicalEntity
member physical entity: TGFb_In
cellular location: cyt

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

RIGHT 0 conversion reaction33 pS2 pS2 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_n
stoichiometric coefficient: 1.0

S2_c
type: PhysicalEntity
member physical entity: S2_c
cellular location: cyt

RIGHT 0 conversion reaction52 Smad7mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: Smad7mRNA
stoichiometric coefficient: 1.0

TGFb_In
type: PhysicalEntity
member physical entity: TGFb_In
cellular location: cyt

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

S2_n
type: PhysicalEntity
member physical entity: S2_n
cellular location: nuc

Smad7mRNA1
type: PhysicalEntity
member physical entity: Smad7mRNA1
cellular location: nuc

LEFT 0 conversion reaction40 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 1.0

TGFb
type: PhysicalEntity
member physical entity: TGFb
cellular location: cyt

Active_Rec_endo
type: PhysicalEntity
member physical entity: Active_Rec_endo
cellular location: cyt

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

LEFT 0 conversion reaction55 S2 n STOICHIOMETRY
type: Stoichiometry
physical entity: S2_n
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction23 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

S2_n
type: PhysicalEntity
member physical entity: S2_n
cellular location: nuc

LEFT 0 conversion reaction11 Active Rec endo STOICHIOMETRY
type: Stoichiometry
physical entity: Active_Rec_endo
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

RIGHT 2 conversion reaction23 TGFb In STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_In
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction4 Active R2 STOICHIOMETRY
type: Stoichiometry
physical entity: Active_R2
stoichiometric coefficient: 1.0

Inactive_Rec
type: PhysicalEntity

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

RIGHT 0 conversion reaction60 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 1.0

nuc
type: CellularLocationVocabulary

Active_Rec
type: PhysicalEntity

S7
type: PhysicalEntity
member physical entity: S7
cellular location: cyt

LEFT 0 conversion reaction32 pS2 pS2 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_c
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction16 Inactive Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Inactive_Rec
stoichiometric coefficient: 1.0

Active_R2
type: PhysicalEntity
member physical entity: Active_R2
cellular location: cyt

RIGHT 0 conversion reaction34 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 3.0

RIGHT 0 conversion reaction10 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction47 TGFb R1 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_surface
stoichiometric coefficient: 1.0

reaction1
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction1 TGFb STOICHIOMETRY
left: TGFb

reaction18
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction18 TGFb R1 endo STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction18 TGFb R1 surface STOICHIOMETRY
right: TGFb_R1_endo
left: TGFb_R1_surface

reaction17
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction17 Inactive Rec STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction17 TGFb In STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction17 TGFb R1 endo STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction17 S7 STOICHIOMETRY
right: TGFb_R1_endo
right: TGFb_In
right: S7
left: Inactive_Rec

Active_Rec_endo
type: PhysicalEntity

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

reaction19
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction19 TGFb R2 surface STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction19 TGFb R2 endo STOICHIOMETRY
right: TGFb_R2_endo
left: TGFb_R2_surface

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

reaction10
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction10 Active Rec endo STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction10 TGFb In STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction10 TGFb R2 endo STOICHIOMETRY
right: TGFb_In
right: TGFb_R2_endo
left: Active_Rec_endo

RIGHT 0 conversion reaction41 pS2 pS2 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_n
stoichiometric coefficient: 1.0

reaction12
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction12 TGFb R1 endo STOICHIOMETRY
left: TGFb_R1_endo

reaction11
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction11 Active Rec endo STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction11 TGFb R2 endo STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction11 TGFb R1 endo STOICHIOMETRY
right: TGFb_R1_endo
right: TGFb_R2_endo
left: Active_Rec_endo

reaction14
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction14 Active Rec STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction14 S7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction14 Inactive Rec STOICHIOMETRY
right: Inactive_Rec
left: S7
left: Active_Rec

reaction13
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction13 TGFb R2 endo STOICHIOMETRY
left: TGFb_R2_endo

reaction16
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction16 TGFb R2 endo STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction16 TGFb R1 endo STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction16 S7 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction16 Inactive Rec STOICHIOMETRY
right: TGFb_R2_endo
right: TGFb_R1_endo
right: S7
left: Inactive_Rec

reaction15
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction15 Active Rec STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction15 S7 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction15 Inactive Rec STOICHIOMETRY
right: S7
right: Active_Rec
left: Inactive_Rec

pS2_pS2_S4_c
type: PhysicalEntity
member physical entity: pS2_pS2_S4_c
cellular location: cyt

LEFT 0 conversion reaction2 TGFb R2 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_surface
stoichiometric coefficient: 1.0

TGFb_R2_surface
type: PhysicalEntity
member physical entity: TGFb_R2_surface
cellular location: cyt

TGFb_R1_surface
type: PhysicalEntity
member physical entity: TGFb_R1_surface
cellular location: cyt

RIGHT 0 conversion reaction62 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 2.0

RIGHT 0 conversion reaction32 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 3.0

RIGHT 0 conversion reaction28 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 2.0

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

reaction29
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction29 pS2 pS2 S4 n STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction29 pS2 n STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction29 S4 n STOICHIOMETRY
right: pS2_pS2_S4_n
left: S4_n
left: pS2_n

reaction28
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction28 pS2 c STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction28 S4 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction28 pS2 pS2 S4 c STOICHIOMETRY
right: S4_c
right: pS2_c
left: pS2_pS2_S4_c

TGFb_R2_endo
type: PhysicalEntity
member physical entity: TGFb_R2_endo
cellular location: cyt

RIGHT 0 conversion reaction29 pS2 pS2 S4 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_S4_n
stoichiometric coefficient: 1.0

reaction21
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction21 TGFb R2 endo STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction21 TGFb R2 surface STOICHIOMETRY
right: TGFb_R2_surface
left: TGFb_R2_endo

Smad7mRNA
type: PhysicalEntity
member physical entity: Smad7mRNA
cellular location: cyt

Active_Rec_endo
type: PhysicalEntity
member physical entity: Active_Rec_endo
cellular location: cyt

reaction20
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction20 TGFb R1 surface STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction20 TGFb R1 endo STOICHIOMETRY
right: TGFb_R1_surface
left: TGFb_R1_endo

reaction23
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion reaction23 TGFb In STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction23 TGFb R2 endo STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction23 TGFb R1 endo STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction23 Active Rec endo STOICHIOMETRY
right: TGFb_R2_endo
right: TGFb_In
right: TGFb_R1_endo
left: Active_Rec_endo

RIGHT 0 conversion reaction11 TGFb R1 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_endo
stoichiometric coefficient: 1.0

reaction22
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction22 Active Rec endo STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction22 Active Rec STOICHIOMETRY
right: Active_Rec_endo
left: Active_Rec

RIGHT 0 conversion reaction19 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

reaction25
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction25 TGFb STOICHIOMETRY
left: TGFb

reaction24
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction24 TGFb In STOICHIOMETRY
left: TGFb_In

reaction27
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction27 S4 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction27 pS2 c STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction27 pS2 pS2 S4 c STOICHIOMETRY
right: pS2_pS2_S4_c
left: S4_c
left: pS2_c

reaction26
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction26 pS2 c STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction26 S2 c STOICHIOMETRY
right: pS2_c
left: S2_c

Active_Rec
type: PhysicalEntity
member physical entity: Active_Rec
cellular location: cyt

S7
type: PhysicalEntity
member physical entity: S7
cellular location: cyt

S4_c
type: PhysicalEntity

LEFT 0 conversion reaction65 pS2 pS2 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_pS2_pS2_n
stoichiometric coefficient: 1.0

TGFb_R1_endo
type: PhysicalEntity
member physical entity: TGFb_R1_endo
cellular location: cyt

RIGHT 1 conversion reaction23 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction20 TGFb R1 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_surface
stoichiometric coefficient: 1.0

Active_Rec
type: PhysicalEntity
member physical entity: Active_Rec
cellular location: cyt

LEFT 0 conversion reaction54 S2 c STOICHIOMETRY
type: Stoichiometry
physical entity: S2_c
stoichiometric coefficient: 1.0

Inactive_Rec
type: PhysicalEntity
member physical entity: Inactive_Rec
cellular location: cyt

LEFT 0 conversion reaction1 TGFb STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb
stoichiometric coefficient: 1.0

S4_c
type: PhysicalEntity
member physical entity: S4_c
cellular location: cyt

TGFb_R1_surface
type: PhysicalEntity

pS2_c
type: PhysicalEntity
member physical entity: pS2_c
cellular location: cyt

S4_n
type: PhysicalEntity
member physical entity: S4_n
cellular location: nuc

S4_n
type: PhysicalEntity

RIGHT 1 conversion reaction8 Active R2 STOICHIOMETRY
type: Stoichiometry
physical entity: Active_R2
stoichiometric coefficient: 1.0

S7
type: PhysicalEntity
member physical entity: S7
cellular location: cyt

S7
type: PhysicalEntity
member physical entity: S7
cellular location: cyt

RIGHT 0 conversion reaction14 Inactive Rec STOICHIOMETRY
type: Stoichiometry
physical entity: Inactive_Rec
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction21 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

TGFb_In
type: PhysicalEntity
member physical entity: TGFb_In
cellular location: cyt

reaction9
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction9 TGFb R1 endo STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction9 Active Rec endo STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction9 TGFb In STOICHIOMETRY
right: TGFb_R1_endo
right: TGFb_In
left: Active_Rec_endo

pS2_pS2_S4_c
type: PhysicalEntity
member physical entity: pS2_pS2_S4_c
cellular location: cyt

pS2_pS2_S4_n
type: PhysicalEntity
member physical entity: pS2_pS2_S4_n
cellular location: nuc

reaction8
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction8 Active R2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction8 TGFb R1 surface STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction8 Active Rec STOICHIOMETRY
right: TGFb_R1_surface
right: Active_R2
left: Active_Rec

TGFb_R2_surface
type: PhysicalEntity
member physical entity: TGFb_R2_surface
cellular location: cyt

reaction7
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction7 Active Rec STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction7 Active R2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction7 TGFb R1 surface STOICHIOMETRY
right: Active_Rec
left: Active_R2
left: TGFb_R1_surface

reaction6
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction6 TGFb STOICHIOMETRY
right: TGFb

reaction5
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction5 TGFb R2 surface STOICHIOMETRY
right: TGFb_R2_surface

S2_n
type: PhysicalEntity
member physical entity: S2_n
cellular location: nuc

reaction4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction4 Active R2 STOICHIOMETRY
left: Active_R2

reaction3
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction3 Active R2 STOICHIOMETRY
right: Active_R2

LEFT 0 conversion reaction18 TGFb R1 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_surface
stoichiometric coefficient: 1.0

reaction2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction2 TGFb R2 surface STOICHIOMETRY
left: TGFb_R2_surface

LEFT 0 conversion reaction39 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction57 pS2 c STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_c
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction7 TGFb R1 surface STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R1_surface
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction29 pS2 n STOICHIOMETRY
type: Stoichiometry
physical entity: pS2_n
stoichiometric coefficient: 2.0

RIGHT 1 conversion reaction11 TGFb R2 endo STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_R2_endo
stoichiometric coefficient: 1.0

pS2_n
type: PhysicalEntity
member physical entity: pS2_n
cellular location: nuc

RIGHT 1 conversion reaction9 TGFb In STOICHIOMETRY
type: Stoichiometry
physical entity: TGFb_In
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction35 S2 c STOICHIOMETRY
type: Stoichiometry
physical entity: S2_c
stoichiometric coefficient: 1.0