OBI_1110204
type: UnificationXref
id: OBI_1110204
db: Ontology for Biomedical Investigations

http://identifiers.org/pubmed/33757357
type: PublicationXref
id: 33757357
db: PubMed

GO:0002837
type: UnificationXref
id: GO:0002837
db: Gene Ontology

C15438
type: UnificationXref
id: C15438
db: NCIt

Normal_T_cells
type: PhysicalEntity
xref: CL:0000084

Kimmel2021 T cell competition and stochastic extinction events in CAR T cell therapy
type: Pathway
pathway component: CAR_T_cell_population_growth
pathway component: Normal_T_cell_population_growth
pathway component: Tumour_killing
pathway component: Tumour_growth
xref: C126102
xref: http://identifiers.org/pubmed/33757357
xref: GO:0002837
xref: C15438
xref: DOID:0060060
xref: BIOMD0000001041
xref: MODEL2109010001
xref: MAMO_0000046
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Kimmel2021___T_cell_competition_and_stochastic_extinction_events_in_CAR_T_cell_therapy', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

GO:0042098
type: UnificationXref
id: GO:0042098
db: Gene Ontology

RIGHT 0 conversion Normal T cell population growth Normal T cells STOICHIOMETRY
type: Stoichiometry
physical entity: Normal_T_cells
stoichiometric coefficient: 1.0

Normal_T_cell_population_growth
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Normal T cell population growth Normal T cells STOICHIOMETRY
xref: GO:0042098
right: Normal_T_cells

Total_lymphocyte_count
type: PhysicalEntity
xref: CL:0000084
xref: C122157

CL:0001201
type: UnificationXref
id: CL:0001201

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

CL:0001063
type: UnificationXref
id: CL:0001063

GO:0008283
type: UnificationXref
id: GO:0008283
db: Gene Ontology

CAR_T_cell_population_growth
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion CAR T cell population growth CAR T cells STOICHIOMETRY
xref: GO:0042098
right: CAR_T_cells

compartment
type: CellularLocationVocabulary

RIGHT 0 conversion Tumour growth Antigen presenting tumour cells STOICHIOMETRY
type: Stoichiometry
physical entity: Antigen_presenting_tumour_cells
stoichiometric coefficient: 1.0

Tumour_killing
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Tumour killing Antigen presenting tumour cells STOICHIOMETRY
xref: OBI_1110204
xref: GO:0001906
left: Antigen_presenting_tumour_cells

GO:0001906
type: UnificationXref
id: GO:0001906
db: Gene Ontology

CHEBI:144829
type: UnificationXref
id: CHEBI:144829
db: ChEBI

CAR_T_cells
type: PhysicalEntity
xref: CL:0000084
xref: C137999

MAMO_0000046
type: UnificationXref
id: MAMO_0000046
db: Mathematical Modelling Ontology

BioModels Database
type: Provenance
xref: BIOMD0000001041

CAR_T_cells
type: PhysicalEntity
member physical entity: CAR_T_cells
cellular location: compartment

Antigen_presenting_tumour_cells
type: PhysicalEntity
member physical entity: Antigen-presenting_tumour_cells
cellular location: compartment

DOID:0060060
type: UnificationXref
id: DOID:0060060
db: Human Disease Ontology

LEFT 0 conversion Tumour killing Antigen presenting tumour cells STOICHIOMETRY
type: Stoichiometry
physical entity: Antigen_presenting_tumour_cells
stoichiometric coefficient: 1.0

BIOMD0000001041
type: UnificationXref
id: BIOMD0000001041
db: BioModels Database

C122157
type: UnificationXref
id: C122157

RIGHT 0 conversion CAR T cell population growth CAR T cells STOICHIOMETRY
type: Stoichiometry
physical entity: CAR_T_cells
stoichiometric coefficient: 1.0

Normal_T_cells
type: PhysicalEntity
member physical entity: Normal_T_cells
cellular location: compartment

Tumour_growth
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Tumour growth Antigen presenting tumour cells STOICHIOMETRY
xref: GO:0008283
right: Antigen_presenting_tumour_cells

Antigen-presenting_tumour_cells
type: SmallMolecule
xref: CL:0001201
xref: CL:0001063
xref: CHEBI:144829

BioModels Database
type: Provenance
xref: MODEL2109010001

C126102
type: UnificationXref
id: C126102
db: NCIt

CL:0000084
type: UnificationXref
id: CL:0000084

C137999
type: UnificationXref
id: C137999

MODEL2109010001
type: UnificationXref
id: MODEL2109010001
db: BioModels Database

Antigen_presenting_tumour_cells
type: PhysicalEntity
member physical entity: Antigen-presenting_tumour_cells
cellular location: compartment